A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease by Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng

“…In summary, our network-based systems genetics framework identifies potential risk genes and repurposable drugs for PD and other neurodegenerative diseases if broadly applied.…”
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Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models by Lorenza Mautone, Federica Cordella, Alessandro Soloperto, Silvia Ghirga, Giorgia Di Gennaro, Ylenia Gigante, Silvia Di Angelantonio

“…These models offer essential insights into the development of therapeutic strategies for neurodegenerative diseases characterized by tau aggregation.…”
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TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD by Zhuhe Liu, Yunmeng Bai, Bingtian Xu, Haixia Wen, Kechun Chen, Jingfang Lin, Yuanyuan Wang, Jiangping Xu, Haitao Wang, Fudong Shi, Jigang Wang, Honghao Wang

“…Abstract Abnormality in transactivating response region DNA binding protein 43 (TDP43) is well-recognized as the pathological hallmark of neurodegenerative diseases. However, the role of TDP43 in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. …”
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Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein by N. V. Ivanisenko, L. Hillert, V. A. Ivanisenko, I. N. Lavrik

“…The search for the inhibitors that would block the interactions of FA DD with the other core proteins of the DISC is essential for the studies of the structure and function of this complex, investigation of the apoptosis mechanisms and development of new treatments for neurodegenerative diseases. In the course of this work, the screening for small inhibitors in silico that selectively interact with DED has been performed. …”
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Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells by Xixi Hou, Xixi Hou, Longfei Mao, Huibin Zhang, Lan Wang, Baoyu He, Jingjing Guo, Jianji Wang

“…Given the potent anti-inflammatory properties of the 1,2,3-triazole structure and the wide use of 2H-1,4-benzoxazin-3(4H)-one in developing treatments for neurodegenerative diseases, a series of 2H-1,4-benzoxazin-3(4H)-one derivatives were synthesized by introducing a 1,2,3-triazole moiety. …”
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Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model by Min Wang, Tianxiong Xu, Li Gao, Chujun Huang, Piao Xu, Congcong Gong, William Kwame Amakye, Linfeng Liao, Maojin Yao, Jiaoyan Ren

“…It also holds potential application in mitochondrial-impaired senile neurodegenerative diseases, especially in AD.…”
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S100A9 protein activates microglia and stimulates phagocytosis, resulting in synaptic and neuronal loss by Katryna Pampuscenko, Silvija Jankeviciute, Ramune Morkuniene, Darius Sulskis, Vytautas Smirnovas, Guy C. Brown, Vilmante Borutaite

“…There is a large increase in S100A9 expression in the brains of patients with neurodegenerative diseases, such as Alzheimer's disease, and S100A9 has been suggested to contribute to neurodegeneration, but the mechanisms are unclear. …”
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Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects by Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang

“…Neuroinflammation and neuronal cell death are leading causes of death in the elderly and underlie various neurodegenerative diseases. These diseases involve complex pathophysiological mechanisms, including inflammatory responses, oxidative stress, and ferroptosis. …”
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

“…The review highlights NRF2’s therapeutic implications for neurodegenerative diseases and cardiovascular conditions, emphasizing its role in improving proteostasis and redox homeostasis Additionally, it summarizes current research into NRF2 as a therapeutic target, offering hope for innovative treatments to counteract the effects of aging and associated diseases.…”
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In vitro neuroprotective potentials of aqueous and methanol extracts from Heinsia crinita leaves by Ganiyu Oboh, Esther E. Nwanna, Sunday I. Oyeleye, Tosin A. Olasehinde, Opeyemi B. Ogunsuyi, Aline A. Boligon

“…Therefore, H. crinita leaves could be used as a functional food and dietary intervention for the management of some neurodegenerative diseases. Nevertheless, the aqueous extracts exhibited better neuroprotective properties.…”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…The asynchronous release of OACDP hydrogel provides a new conception for PD treatment and other neurodegenerative diseases.…”
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Exploring neuropsychiatric symptoms in Friedreich ataxia by Simona Karamazovova, Lucie Stovickova, Dylan J. Jester, Veronika Matuskova, Jaroslava Paulasova-Schwabova, Michaela Kuzmiak, Alena Zumrova, Ross Andel, Martin Vyhnalek

“…Mild Behavioral Impairment Checklist (MBI-C), a questionnaire designed for screening NPS in the early stages of neurodegenerative diseases, was administered to informants of individuals with FRDA and healthy controls and to people with FRDA themselves. …”
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Barcelona scale for buccophonatory apraxia: Quantitative assessment tool by N. Montagut, S. Borrego-Écija, J. Herrero, A. Lladó, M. Balasa, E. Muñoz, F. Valldeoriola, R. Sánchez-Valle

“…Conclusions: The Barcelona scale for buccophonatory apraxia could be useful to quantitatively evaluate buccophonatory apraxia in different neurodegenerative diseases, and compare patients, especially in nfvPPA. …”
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The impact of creatine supplementation on the development of kidney disease – literature review by Mateusz Matczak, Karol Jasiński, Aleksandra Broda, Kacper Hoksa, Krzysztof Jodłowski, Ewa Dubniewicz, Paula Majewska, Alicja Staszek, Wiktoria Łoskot, Jan Szwech

“…State of knowledge: Research supports creatine’s efficacy in improving athletic performance, recovery, and muscle strength, with therapeutic benefits in neurodegenerative diseases, type 2 diabetes, aging, and chronic conditions. …”
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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β by Rebecca Faresjö, Elisabet O. Sjöström, Tiffany Dallas, Magnus M. Berglund, Jonas Eriksson, Dag Sehlin, Stina Syvänen

“…Neurodegenerative diseases such as Alzheimer’s disease (AD) pose substantial challenges to patients and health-care systems, particularly in countries with aging populations. …”
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Safety and performance of oropharyngeal muscle strength training in the treatment of post-stroke dysphagia during oral feeding: protocol for a systematic review and meta-analysis by Xin Wang, Ying Wang, Fenghua Zhou, Minxing Gao, Lingyuan Xu, Heying Wang, Jinan Song, Xiaoqiu Yang

“…Oropharyngeal muscle strength training is a major method of swallowing training, and recent studies have focused on healthy adults, elderly persons, and patients with head and neck cancer or neurodegenerative diseases; but there have been few studies on such training in patients with post-stroke dysphagia. …”
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RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection by Ignacio Silva-Llanes, Ignacio Silva-Llanes, Ignacio Silva-Llanes, Enrique Madruga, Enrique Madruga, Ana Martínez, Ana Martínez, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker

“…Tauopathies are a group of neurodegenerative diseases characterized by the alteration/aggregation of TAU protein. …”
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Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels by Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber, Gracjan Michlewski

“…Elevated HuR levels are associated with multiple disorders, including cancer and neurodegenerative diseases. Despite the identification of small molecule inhibitors targeting HuR, their detailed characterization remains limited. …”
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GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection by Ying Wang, Lanjie Li, Danni Chen, Jiaheng Shan, Meijuan Yi, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi

“…The findings provide a new perspective on treating neurodegenerative diseases by activating AMPK for the energy metabolism disorder.…”
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Antioxidant, Anti-α-Glucosidase, Anti-Tyrosinase, and Anti-Acetylcholinesterase Components from Stem of <i>Rhamnus formosana</i> with Molecular Docking Study by Chia-Hsuan Tsai, Ya-Lun Liou, Sin-Min Li, Hsiang-Ruei Liao, Jih-Jung Chen

“…These findings suggest that bioactive extracts and compounds from the stems of <i>R. formosana</i> may have potential as natural antioxidant, anti-α-glucosidase, anti-AChE, and anti-tyrosinase drug candidates or dietary supplements for the management of oxidative stress-related conditions, including hyperglycemia, pigmentation disorders, and neurodegenerative diseases.…”
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