Caffeic Acid Phenethyl Ester Protects Neurons Against Oxidative Stress and Neurodegeneration During Traumatic Brain Injury by Nurul Sulimai, Jason Brown, David Lominadze

“…Traumatic brain injury (TBI) is an inflammatory disease causing neurodegeneration. One of the consequences of inflammation is an elevated blood level of fibrinogen (Fg). …”
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Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model. by Manuel E Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E Crawford, Stuart Bunting, Mika Aoyagi-Scharber

“…Enzyme replacement therapy was administered by repeat intracerebroventricular injections in Sandhoff disease model mice with dosing beginning before and after signs of neurodegeneration. As previously observed, HexA effectively increased the lifespan of Sandhoff disease mice by 3.5-fold only when treatment was started before onset of neurodegeneration. …”
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Dietary Natural Melanin Nanozymes Delay Aging and Ameliorate Neurodegeneration via Improving Gut Microbiota and Redox Homeostasis by Yao Xiao, Shikun Zhang, Hailong Zhuo, Xiaoyong Zhang, Kai Zhu, Wanyi Chen, Guoxing You, Hongwei Chen, Qun Luo, Hong Zhou, Gan Chen

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Editorial: Molecular and cellular pathways leading to mitochondrial dysfunction and neurodegeneration: lessons from in vivo models, volume II by Shabab B. Hannan, Shabab B. Hannan, Federica De Lazzari, Aurora Gomez-Duran, Juan A. Navarro, Gloria Brea-Calvo, Alvaro Sanchez-Martinez

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Disrupting the interaction between AMBRA1 and DLC1 prevents apoptosis while enhancing autophagy and mitophagy by Kate Hawkins, Meg Watt, Sébastien Gillotin, Maya Hanspal, Martin Helley, Jill Richardson, Nicola Corbett, Janet Brownlees

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Mitochondria as a Therapeutic Target: Focusing on Traumatic Brain Injury by Randhall Bruce Carteri

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Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis by Shumin Zhao, Shumin Zhao, Ranran Chen, Ranran Chen, Yi An, Yali Zhang, Yali Zhang, Cheng Ma, Ying Gao, Ying Gao, Yanchao Lu, Yanchao Lu, Fei Yang, Fei Yang, Xue Bai, Xue Bai, Jingjing Zhang, Jingjing Zhang, Jingjing Zhang

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Serum neurofilament heavy chains as a biomarker of neuronal damage in multiple sclerosis relapse by P. Beliaziūnas, R. Godelienė, L. Malcienė, V. Natkevičius, V. Gintauskienė, B. Šitkauskienė, M. Malciūtė

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The Science of Memory Loss: Insights into Alzheimer’s Disease by Agnieszka Starzyk, Piotr Charzewski

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Microglia depletion reduces neurodegeneration and remodels extracellular matrix in a mouse Parkinson’s disease model triggered by α-synuclein overexpression by Zhen Zhang, Kun Niu, Taoying Huang, Jiali Guo, Gongbikai Xarbat, Xiaoli Gong, Yunke Gao, Feiyang Liu, Shan Cheng, Wenting Su, Fei Yang, Zhaoyuan Liu, Florent Ginhoux, Ting Zhang

“…Abstract Chronic neuroinflammation with sustained microglial activation occurs in Parkinson’s disease (PD), yet the mechanisms and exact contribution of these cells to the neurodegeneration remains poorly understood. In this study, we induced progressive dopaminergic neuron loss in mice via rAAV-hSYN injection to cause the neuronal expression of α-synuclein, which produced neuroinflammation and behavioral alterations. …”
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Insights and Considerations for “Higher Intraocular Levels of Inflammatory Factors are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy” [Letter] by Cao H, Ma X

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Functional investigation suggests CNTNAP5 involvement in glaucomatous neurodegeneration obtained from a GWAS in primary angle closure glaucoma. by Sudipta Chakraborty, Jyotishman Sarma, Shantanu Saha Roy, Sukanya Mitra, Sayani Bagchi, Sankhadip Das, Sreemoyee Saha, Surajit Mahapatra, Samsiddhi Bhattacharjee, Mahua Maulik, Moulinath Acharya

“…This study provides the first direct functional evidence of a putative role of CNTNAP5 in visual neurodegeneration.…”
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Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids by Xianwei Chen, Guoqiang Sun, Lizhao Feng, E Tian, Yanhong Shi

“…Furthermore, we showed that microglia in the LT-ABO could protect neurons from neurodegeneration by increasing synaptic density and reducing p-Tau level and cell death in the LT-ABO. …”
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Insights and Considerations for “Higher Intraocular Levels of Inflammatory Factors Are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy” [Response to Letter] by Zeng L, Yang Z, Li X, Xu H

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Fluorescent identification of axons, dendrites and soma of neuronal retinal ganglion cells with a genetic marker as a tool for facilitating the study of neurodegeneration by Puttipong Sripinun, Wennan Lu, Sergei Nikonov, Suhani Patel, Sarah Hennessy, Tianyuan Yao, Qi N. Cui, Brent A. Bell, Claire H. Mitchell

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DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model by Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Hölscher

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Case of phenotype of optic nerve atrophy due to mutation in С19orf12 gene (neurodegeneration with the brain iron accumulation (nbia)) by M.E. Ivanova, V.V. Kadyshev, D.S. Atarshchikov, I.V. Zolnikova, N.P. Akchurina, N.K. Serova, F.A. Konovalov, E.R. Lozier, E.A. Pomerantseva, N.V. Vetrova, D. Barh, L.M. Balashova, J.M. Salmasi

“…Case of phenotype of optic nerve atrophy due to mutation in С19orf12 gene (neurodegeneration with the brain iron accumulation (nbia)). …”
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Editorial: 15 years of Frontiers in Cellular Neuroscience: the dual role of microglia in (neuro)inflammation by Antonio J. Herrera, Antonio J. Herrera

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Inflammasomes in neurodegenerative diseases by Qianchen Wang, Songwei Yang, Xuan Zhang, Shanshan Zhang, Liping Chen, Wanxue Wang, Naihong Chen, Jiaqing Yan

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Editorial: Latest advances in neuroscience at the 9th Croatian Neuroscience Congress by Kristina Mlinac-Jerkovic, Kristina Mlinac-Jerkovic, Marija Heffer, Svjetlana Kalanj-Bognar, Svjetlana Kalanj-Bognar, Senka Blažetić

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