Obstacles to Early Diagnosis of Gaucher Disease by Nishimura S, Ma C, Sidransky E, Ryan E

“…Patients may present with a wide spectrum of disease manifestations, including hepatosplenomegaly, thrombocytopenia, bone manifestations, and in the case of GD types 2 and 3, neurodegeneration, cognitive delay, and/or oculomotor abnormalities. …”
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Resting state BOLD-perfusion coupling patterns using multiband multi-echo pseudo-continuous arterial spin label imaging by Alexander D. Cohen, Stefano Moia, G. Bruce Pike, César Caballero-Gaudes, Yang Wang

“…Abstract The alteration of neurovascular coupling (NVC), where acute localized blood flow increases following neural activity, plays a key role in several neurovascular processes including aging and neurodegeneration. While not equivalent to NVC, the coupling between simultaneously measured cerebral blood flow (CBF) with arterial spin labeling (ASL) and blood oxygenation dependent (BOLD) signals, can also be affected. …”
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Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation by Dale O. Starkie, Charles Arber, Terry Baker, Daniel J. Lightwood, Selina Wray

“…The mechanisms by which increased 4 R results in neuronal dysfunction and neurodegeneration are not fully understood, and progress has been limited partly by a lack of suitable tools to investigate tau isoform imbalance. …”
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The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus by Thiquynhnga Nguyen, Min Gong, Song Wen, Xinlu Yuan, Chaoxun Wang, Jianlan Jin, Ligang Zhou

“…As an incretin hormone, glucagon-like peptide-1 (GLP-1) possesses multiple metabolic benefits such as optimizing energy usage, maintaining body weight, β cell preservation, and suppressing neurodegeneration. However, recent studies indicate that oral antidiabetic medications interact with endogenous or exogenous GLP-1. …”
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Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease by Amtul Rahman, Zeenath Banu

“…This accumulation affects cognitive functions and behaviour, with histological analyses showing signs of neurodegeneration. Behavioural changes and impaired cognitive abilities observed in animal and cellular models suggest that AlCl3 disrupts neural pathways critical to learning and memory. …”
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Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus by Khushbu Jain, Dipti Prasad, Shashi Bala Singh, Ekta Kohli

“…Brain is predominantly susceptible to oxidative stress and mitochondrial dysfunction during hypobaric hypoxia, and therefore undergoes neurodegeneration due to energy crisis. Evidences illustrate a high degree of association for mitochondrial fusion/fission imbalance and mitochondrial dysfunction. …”
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Generation, interrogation, and future applications of microglia-containing brain organoids by Julia Di Stefano, Federica Di Marco, Ilaria Cicalini, Una FitzGerald, Damiana Pieragostino, Marleen Verhoye, Peter Ponsaerts, Elise Van Breedam

“…Finally, we would like to stress that even though the development of immune-competent brain organoids has largely evolved over the past decade, their full potential as a pre-clinical tool to study novel therapeutic approaches to halt or reduce inflammation-mediated neurodegeneration still needs to be explored and validated.…”
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QSPR Analysis of Some Alzheimer’s Compounds via Topological Indices and Regression Models by Muhammad Shoaib Sardar, Khalil Hadi Hakami

“…Alzheimer’s disease (AD) is of particular importance among pathologies, and despite approved drugs for its treatment, there is no effective pharmacological therapy to stop, halt, or repair neurodegeneration. The U.S. Food and Drug Administration (FDA) has approved certain medications to treat AD, including galantamine, donepezil, rivastigmine, memantine, tacrine, suvorexant, brexpiprazole, butein, and Licochalcone A. …”
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Chronic Restraint Stress Induces an Isoform-Specific Regulation on the Neural Cell Adhesion Molecule in the Hippocampus by K. Touyarot, C. Sandi

“…As NCAM-140 is involved in cell-cell adhesion and neurite outgrowth, these findings suggest that this molecule might be one of the molecular mechanisms involved in the complex interactions among neurodegeneration-related events.…”
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Association of cognitive reserve with stroke outcome: a protocol for a systematic review by Laura Gallucci, Roza M Umarova

“…Though several mechanisms and risk factors are shared between neurodegeneration and stroke, the effect of CR on poststroke functional outcome has been poorly addressed. …”
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Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis by Marcelo Ananias Teocchi, Lília D’Souza-Li

“…Seizure models have demonstrated that neuroinflammation and neurodegeneration are preponderant characteristics of epilepsy. …”
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Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness by Sandip Ghosh, Yun‐Han Su, Chia‐Jung Yang, Jui‐Yang Lai

“…Nevertheless, it suffers from poor ocular drug retention and cannot comprehensively address corneal dryness‐related symptoms such as oxidative stress, angiogenesis, and neurodegeneration. Inspired by nanotechnology‐mediated material/biological interactions, in this study, a highly adhesive metallic nanoplatform with an urchin‐like structure is designed for topical quercetin administration in dry eye therapy. …”
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Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants by Yanru Long, Houhui Shi, Jiatian Ye, Xiaorong Qi

“…Oxidative stress may be associated with a variety of diseases, such as ovarian cancer, diabetes mellitus, and neurodegeneration. The generation of oxidative stress in ovarian cancer, one of the common and refractory malignancies among gynaecological tumours, may be associated with several factors. …”
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Influence of immune cells and inflammatory factors on Alzheimer’s disease axis: evidence from mediation Mendelian randomization study by Linzhu, Jianxin Zhang, Wenhui Fan, Chen Su, Zhi Jin

“…Abstract Background Alzheimer’s disease (AD) is one of the most common forms of dementia in the elderly, characterized by progressive neurodegeneration. While the exact etiology of AD remains unclear, immune inflammation is known to play a significant role in the disease. …”
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Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges by Kamran Sheikhi, Salah Ghaderi, Hassan Firouzi, Sarvenaz Rahimibarghani, Ehsan Shabani, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Aref Yarahmadi

“…Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, and cognitive dysfunction. …”
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The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients by Zeynep Tuncer, Gamze Dereli Can, Hava Dönmez Keklikoğlu, Fatma Ayşen Eren, Fatma Yülek, Orhan Deniz

“…Visual dysfunction in PD cannot be attributed only to retinal pathology; however, the retina may provide monitoring of the status of dopaminergic neurodegeneration and axonal loss in PD.…”
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Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression by Giampaolo Perna, Giuseppe Iannone, Alessandra Alciati, Daniela Caldirola

“…We reviewed animal and human findings that suggest an overlap between processes of impaired neurogenesis, neurodegeneration, structural, functional, molecular, and cellular modifications in AnxDs, and aging. …”
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Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology by Hirohisa Watanabe, Sayuri Shima, Kazuya Kawabata, Yasuaki Mizutani, Akihiro Ueda, Akihiro Ueda, Mizuki Ito, Mizuki Ito

“…This ATP decline may result in α-synuclein accumulation, autophagy-lysosomal system impairment, neuronal network breakdown and accelerated neurodegeneration. We propose an “ATP Supply–Demand Mismatch Model” to help explain the pathogenesis of PD. …”
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N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells by Benxu Cheng, Pinki Anand, Anxiu Kuang, Feroz Akhtar, Virginia L. Scofield

“…Therefore, we conclude that the simultaneous use of growth/neurotrophic factors and a free radical scavenger may increase overall protection against UPS dysfunction-mediated cytotoxicity and neurodegeneration.…”
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Environmental Factors Promoting Neural Plasticity: Insights from Animal and Human Studies by Laura Mandolesi, Francesca Gelfo, Laura Serra, Simone Montuori, Arianna Polverino, Giuseppe Curcio, Giuseppe Sorrentino

“…There are patients with advanced neurodegeneration, such as Alzheimer’s disease (AD), that, despite this, have mild cognitive impairment. …”
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