The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation by Ekta Bajwa, Caitlin B. Pointer, Andis Klegeris

“…In this review, we highlight the mitochondrial DAMPs cytochrome c (CytC), mitochondrial transcription factor A (TFAM), and cardiolipin and explore their potential role in the central nervous system disorders including Alzheimer’s disease and Parkinson’s disease, which are characterized by neurodegeneration and chronic neuroinflammation.…”
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Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

“…Probiotic supplementation could offer a novel early intervention strategy for AD, highlighting the pivotal role of gut health in neurodegeneration.…”
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

“…In a murine NP-C2 model, otherwise successful intravenous Niemann-Pick C2 protein (NPC2) replacement therapy fails to alleviate progressive neurodegeneration as infused NPC2 cannot cross the blood–brain barrier (BBB). …”
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Pediatric Multiple Sclerosis and Cognition: A Review of Clinical, Neuropsychologic, and Neuroradiologic Features by Ozgul Ekmekci

“…A young age at disease onset is the strongest risk factor for these impairments, which may be due to the effect of inflammatory demyelination and neurodegeneration on the developing central nervous system and neural networks in children. …”
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Amyloid-Related Imaging Abnormalities in Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer’s Disease: Expert Recommendation for Standard MRI Protocol by Jimin Kim, Eunhee Kim, Mina Park, Yun Jung Bae, Chong Hyun Suh, Sung-Hye You, Younghee Yim, Ho-Joon Lee, Jin Wook Choi, Se Won Oh, Won-Jin Moon

“…To optimize ARIA monitoring in Korean clinical settings, the Korean Society of Neuroradiology (KSNR) and the Age and Neurodegeneration Imaging (ANDI) Study Group proposed MRI protocol recommendations on essential MR sequences, MRI acquisition parameters, timing and condition of MRI examinations, and essential details to provide a scientific basis for maximizing the safety and efficacy of AD treatment. …”
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The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration by Eliasz Engelhardt, Lea Tenenholz Grinberg

“…ABSTRACT Frontotemporal Lobar Degeneration (FTLD) encompasses progressive neurodegeneration primarily affecting the frontal and/or temporal lobes, presenting in varied pathological entities. …”
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Advances in Research Related to MicroRNA for Diabetic Retinopathy by Yahan Luo, Chunxia Li

“…MicroRNAs have been shown to play a significant role in DR, particularly in the molecular mechanisms of inflammation, oxidative stress, and neurodegeneration. The aim of this review is to systematically summarize the signaling pathways and molecular mechanisms of miRNAs involved in the occurrence and development of DR, mainly from the pathogenesis of oxidative stress, inflammation, and neovascularization. …”
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Regulation of Glial Cell Functions by PPAR-𝜸 Natural and Synthetic Agonists by Antonietta Bernardo, Luisa Minghetti

“…In the present article, we will review the recent findings supporting a major role for PPAR-𝛾 agonists in controlling neuroinflammation and neurodegeneration through their activities on glial cells, with a particular emphasis on microglial cells as major macrophage population of the brain parenchyma and main actors in brain inflammation.…”
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Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease by Enrico Desideri, L. Miguel Martins

“…Mitochondria have a crucial role in supplying energy to the brain, and their deterioration can affect the function and viability of neurons, contributing to neurodegeneration. These organelles can sow the seeds of their own demise because they generate damaging oxygen-free radicals as a byproduct of their intrinsic physiological functions. …”
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The link between optic neuritis and multiple sclerosis. Literature review by A. Kubiliūtė, R. Liutkevičienė

“… Optic neuritis and multiple sclerosis are connected via processes of demyelination and neurodegeneration in the central nervous system. Immuno-modulated myelin sheathing and axonal loss causing irreversible neurological dysfunction can be found in both pathologies. …”
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Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor by Seong-Hoon Yun, Sang-Heum Han, Joo-In Park

“…The role of PGC-1α in diabetes, neurodegeneration, and cardiovascular disease is particularly well known. …”
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Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain by Sarah Taves, Temugin Berta, Gang Chen, Ru-Rong Ji

“…Microglial activation has been strongly implicated in neurodegeneration in the brain. Increasing evidence also suggests an important role of spinal cord microglia in the genesis of persistent pain, by releasing the proinflammatory cytokines tumor necrosis factor-alpha (TNFα), Interleukine-1beta (IL-1β), and brain derived neurotrophic factor (BDNF). …”
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LncRNAs: New Players in Apoptosis Control by Marianna Nicoletta Rossi, Fabrizio Antonangeli

“…Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators involved not only in physiological processes, such as imprinting and differentiation, but also in cancer progression and neurodegeneration. Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis. …”
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Chemogenomics for steroid hormone receptors (NR3) by Espen Schallmayer, Laura Isigkeit, Lewis Elson, Susanne Müller, Stefan Knapp, Julian A. Marschner, Daniel Merk

“…Although several NR3 ligands such as glucocorticoids are invaluable drugs, this family is only partially explored, for example, in autoimmune diseases and neurodegeneration, but may hold therapeutic potential in new areas. …”
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Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus by Pavel P. Tregub, Yulia K. Komleva, Maria V. Kukla, Anton S. Averchuk, Anna S. Vetchinova, Natalia A. Rozanova, Sergey N. Illarioshkin, Alla B. Salmina

“…In this review, we analyze the current understanding of the role of IEGs (c-Fos, c-Myc, Arg3.1/Arc) in controlling brain plasticity in physiological and pathological conditions, including brain aging and neurodegeneration. This work might inspire new gene therapy strategies targeting IEGs to regulate synaptic plasticity, and potentially prevent or mitigate neurodegenerative diseases.…”
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Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo by G. D. Rabinovici, W. J. Jagust

“…As patients progress to dementia, clinical decline and neurodegeneration accelerate and proceed independently of amyloid accumulation. …”
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The Robustness of White Matter Brain Networks Decreases with Aging by Chenye Huang, Xie Wang, Daojun Xie

“…We then calculated the robustness of these networks by simulating neurodegeneration based on network attack analysis, and studied the correlations between WM network robustness, age, and the proportion of WMHs. …”
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Navigating the Role and Approach of Gut Microbiota in Addressing Alzheimer's Disease Pathogenesis by Imrana Jazuli, Akeela Jazeel, Lakshmi Selvaratnam, Deepa Alex, Yatinesh Kumari

“…Dysregulation of microbiota taxa can trigger systemic inflammation by increasing gut permeability, ultimately leading to neural damage and neurodegeneration. Poor dietary habits and aging exacerbate gut dysbiosis, worsening AD pathology. …”
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Modelling Peroxisomal Disorders in Zebrafish by Chenxing S. Jiang, Michael Schrader

“…They have been linked to healthy ageing, neurodegeneration, cancer, the combat of pathogens and viruses, and infection and immune responses. …”
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Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis by Siddhartha Mondragón-Rodríguez, Humberto Salgado-Burgos, Fernando Peña-Ortega

“…Confronting this leading hypothesis, a few years ago, we reported that the increase in phosphorylation levels of dendritic Tau, at its microtubule domain (MD), acts as a neuroprotective mechanism that prevents N-methyl-D-aspartate receptor (NMDAr) overexcitation, which allowed us to propose that Tau protein phosphorylated near MD sites is involved in neuroprotection, rather than in neurodegeneration. Further supporting this alternative role of pTau, we have recently shown that early increases in pTau close to MD sites prevent hippocampal circuit overexcitation in a transgenic AD mouse model. …”
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