Sex differences and determinants of coronary microvascular function in asymptomatic adults with type 2 diabetes by Jian L. Yeo, Abhishek Dattani, Joanna M. Bilak, Alice L. Wood, Lavanya Athithan, Aparna Deshpande, Anvesha Singh, J.Ranjit Arnold, Emer M. Brady, David Adlam, John D. Biglands, Peter Kellman, Hui Xue, Thomas Yates, Melanie J. Davies, Gaurav S. Gulsin, Gerry P. McCann

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Point-of-care tests in the emergency medical services: a scoping review by T. H. M. Moore, S. Dawson, K. Kirby, R. Body, A. Thompson, Y. O. Adepoju, R. Perry, H. Nicholson, J. Dinnes, K. Mitchell, J. Savović, S. Voss, J. R. Benger

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Reducing health inequalities in disasters: A cross-sectional study of the viability of ‘vulnerability’ terminology and of priority lists in the UK by Poppy Ellis Logan, Gabriella Rundblad, Marian Brooke Rogers, Richard Amlôt, Gideon James Rubin

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FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial by Laith Alrubaiy, Rachel Cooney, Tariq Iqbal, Mohammed Nabil Quraishi, Susan Manzoor, Christopher Quince, Palak J Trivedi, Andrew D Beggs, Alexandra Vince, Chris Weston, Benjamin Mullish, Sahida Shabir, Nicola Jackson, Anna Rowe, Victoria Homer, Willem van Schaik, Peter Rimmer, Sarah Al-Shakhshir, Arzoo Patel, Derick Gyimah, Miriam Hares, Elena Efstathiou

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Understanding how, for whom and under what circumstances telecare can support independence in community-dwelling older adults: a realist review by Lauren Fothergill, Niall Hayes, Yvonne Latham, Jenny Hamilton, Saiqa Ahmed, Carol Holland

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Automated characterisation of cerebral microbleeds using their size and spatial distribution on brain MRI by Vaanathi Sundaresan, Giovanna Zamboni, Robert A. Dineen, Dorothee P. Auer, Stamatios N. Sotiropoulos, Nikola Sprigg, Mark Jenkinson, Ludovica Griffanti

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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

“…Funding: This work is a further extension of the CONSORT-DEFINE study, which was funded by the UK Medical Research Council (MRC)-National Institute for Health and Care Research (NIHR) Methodology Research Programme (MR/T044934/1). …”
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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…Funding This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 14/216/01. …”
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Lower respiratory tract infection admissions and deaths among children under 5 years in public sector facilities in the Western Cape Province, South Africa, before and during the C... by K Kehoe, E Morden, N Zinyakatira, A Heekes, H E Jones, S R Walter, T Jacobs, J Murray, H Buys, M T Redaniel, M-A Davies

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A qualitative study exploring the acceptability of the TEXTPAD telehealth and virtual supervised exercise intervention and trial for patients with peripheral arterial disease livin... by Maddey Patterson, MPH, Letitia Sermin-Reed, MSc, James Prentis, MBBS, Arathi Radhakrishnan, MBBS, Eileen Kaner, PhD, Sandip Nandhra, MBBS, Maisie Rowland, BSc, Gabriel Cucato, PhD, Mackenzie Fong, PhD

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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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Tools for assessing risk of reporting biases in studies and syntheses of studies: a systematic review by Julian P T Higgins, Joanne E McKenzie, Matthew J Page

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Building ADMISSION – A research collaborative to transform understanding of multiple long-term conditions for people admitted to hospital by Miles D Witham, Victoria Bartle, Sue Bellass, Jonathan G Bunn, Duncan Cartner, Heather J Cordell, Rominique Doal, Felicity Evison, Suzy Gallier, Steve Harris, Susan J Hillman, Ray Holding, Peta Leroux, Tom Marshall, Fiona E Matthews, Paolo Missier, Anand Nair, Mo Osman, Ewan R Pearson, Chris Plummer, Sara Pretorius, Sarah J Richardson, Sian M Robinson, Elizabeth Sapey, Thomas Scharf, Rupal Shah, Marzieh Shahmandi, Mervyn Singer, Jana Suklan, James MS Wason, Rachel Cooper, Avan A Sayer

“…Purpose To describe the rationale and content of ADMISSION: a four-year UK Research and Innovation and National Institute of Health and Care Research funded interdisciplinary programme that seeks, in partnership with public contributors, to transform care for people living with MLTCs admitted to hospital. …”
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Association of sildenafil use with age-related macular degeneration: a retrospective cohort study by Nicola Jaime Adderley, Krishnarajah Nirantharakumar, Anuradhaa Subramanian, Alastair K Denniston, Wen Hwa Lee, Ji Eun Diana Han, Jesse Coker

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Opportunities and challenges for enhancing preconception health in primary care: qualitative study with women from ethnically diverse communities by Joe Kai, Nadeem Qureshi, Helena Tuomainen, Laura Cross-Bardell, Mandeep Bhoday

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Impact of tiered restrictions in December 2020 on COVID-19 hospitalisations in England: a synthetic control study by Daniel Hungerford, Benjamin Barr, Mark Green, Marta García-Fiñana, Iain Buchan, Xingna Zhang

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Operationalizing goal setting as an outcome measure in trials involving patients with frailty, multimorbidity or complexity by Emma Tenison, Katherine Lloyd, Yoav Ben-Shlomo, Emily J. Henderson

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Changing the trajectories of mental health difficulties in Norfolk and Suffolk: a research-priority-setting project with patients, the public, clinicians, policymakers and other st... by Caitlin Notley, Jayati Das-Munshi, Craig Morgan, Kristy Sanderson, Sherifat Oduola, Zarnie Khadjesari, Helen Parretti, Niall Broomfield, Amy Zile, Sol Morrissey, Joni Holmes

“…This National Institute of Health and Care Research-funded project aims to bring together key stakeholders to conduct extensive scoping work to identify mental health needs and priorities as a basis for conducting larger research to address the identified priorities over the next 5 years.Methods and analysis This 12-month mixed-methods research-priority-setting project consists of five phases. …”
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Use of the chronic illness research recruitment taxonomy to evaluate recruitment strategies in an eHealth feasibility study. by Rosalynn C. Austin, Anne Marie Lunde Husebø, Hege Wathne, Marianne Storm, Kristin H. Urstad, Ingvild Morken, Bjørg Karlsen

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Jargon and Readability in Plain Language Summaries of Health Research: Cross-Sectional Observational Study by Iain A Lang, Angela King, Kate Boddy, Ken Stein, Lauren Asare, Jo Day, Kristin Liabo

“…ObjectiveWe aimed to assess the readability and level of jargon in the PLSs of research funded by the largest national clinical research funder in Europe, the United Kingdom’s National Institute for Health and Care Research (NIHR). We also aimed to assess whether readability and jargon were influenced by internal and external characteristics of research projects. …”
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