Obesity in pregnancy: infant health service utilisation and costs on the NHS by Ronan A Lyons, Ashrafunnesa Khanom, Sinead T Brophy, Kelly L Morgan, Muhammad A Rahman, Rebecca A Hill

“…Objective To estimate the direct healthcare cost of infants born to overweight or obese mothers to the National Health Service in the UK.Design Retrospective prevalence-based study.Setting Combined linked anonymised electronic data sets on a cohort of mother–child pairs enrolled on the Growing Up in Wales: Environments for Healthy Living (EHL) study. …”
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Autism Spectrum Social Stories In Schools Trial (ASSSIST): study protocol for a feasibility randomised controlled trial analysing clinical and cost-effectiveness of Social Stories... by Dean McMillan, Victoria Allgar, Barry Wright, David Marshall, Shehzad Ali, Joy Adamson, Chris Williams, Elizabeth Littlewood, Dominic Trépel, Lisa Dyson, Hannah Ainsworth, Liz Cook, Lisa Hackney, Danielle Collingridge Moore, Rebecca Hargate, Anne McLaren, Jo Whitehead

“…Qualitative analysis will ascertain information on perceptions about the feasibility and acceptability of the intervention.Ethics and dissemination National Health Service Ethics Approval (NHS; ref 11/YH/0340) for the trial protocol has been obtained along with NHS Research and Development permission from Leeds and York Partnership NHS Foundation Trust. …”
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Exercise-based cardiac rehabilitation for patients with atrial fibrillation receiving catheter ablation: protocol for a feasibility randomised controlled trial (RCT) with embedded... by Gregory Y H Lip, Helen Jones, Mark T Mills, Dhiraj Gupta, Lawrence Foweather, Benjamin JR Buckley, Charlotte Fitzhugh

“…The trial (n=60) will involve one National Health Service (NHS) research site enrolling patients to assess intervention and study design processes. …”
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Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality by Chris P Gale, Jonathan Weir-McCall, James H F Rudd, Mamas Mamas, Ramesh Nadarajah, Ben Gibbison, Louise Sun, Christian Philip Stickels, Houyuan Jiang, Kieran J Sharkey, Nick Holliman, Sara Lombardo, Lars Schewe, Matteo Sommacal, Katherine Cheema, Feryal Erhun

“…Objectives To provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect National Health Service (NHS) England waiting list duration and associated mortality.Design We constructed a mathematical model of the excess waiting list and found the closed-form analytic solution to that model. …”
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A model based cost-utility analysis of Embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 d... by Melanie J Davies, Alan Brennan, Danielle H Bodicoat, Daniel John Pollard, Anju Keetharuth, Michelle Hadjiconstantinou, Agnieszka Glab, Joesph P Mensa, Alison Northern

“…With costs and effectiveness parameters coming from analyses of data from a cluster randomised control trial.Setting English National Health Service.Participants People with T2DM from 64 GP practices in England.Interventions Embedding SSME implementation package Usual care.Primary and secondary outcome measures The primary outcome measure was the incremental cost-effectiveness ratio. …”
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Impact of pandemic service changes on ethnic inequalities in maternal and perinatal outcomes in England: a population-based study by Andrew Judge, Erik Lenguerrand, Tim Draycott, Stamatina Iliodromiti, Asma Khalil, Buthaina Ibrahim, Jennifer Elizabeth Jardine

“…We aim to assess the impact of the unprecedented change in care provision during the COVID-19 pandemic on inequalities in adverse maternity outcomes.Design Retrospective cohort study using structured electronic health record data.Setting English hospital trusts providing maternity care.Participants Women giving birth and babies born in the National Health Service (NHS) in England between 1 April 2018 and 31 March 2021, in three time groups: prepandemic, the first pandemic wave (26 March 2020 to 30 June 2020) and second pandemic wave (1 July 2020 to 31 March 2021). …”
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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study by Helen Blackshaw, Anne GM Schilder, Rishi Mandavia, Gerjon Hannink, Muhammad Nayeem Ahmed, Yaami Premakumar, Timothy Shun Man Chu, Tanjinah Ferdous, Nishchay Mehta, Joseph Manjaly, Maha Khan

“…This study will collect these data in a nationwide cohort study of patients presenting with SSNHL across 97 National Health Service (NHS) trusts. The study will be delivered through ear, nose and throat (ENT) trainee networks, the NIHR Clinical Research Network (CRN) Audiology Champions and the NIHR CRN. …”
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Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

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Quantitative examination of video-recorded NHS Health Checks: comparison of the use of QRISK2 versus JBS3 cardiovascular risk calculators by Christopher J Gidlow, Sarah Grogan, Lisa Cowap, Elizabeth Cottrell, Ruth Chambers, Naomi J Ellis, Victoria A Riley, Diane Crone, David Clark-Carter

“…Objectives Quantitatively examine the content of National Health Service Health Check (NHSHC), patient–practitioner communication balance and differences when using QRISK2 versus JBS3 cardiovascular disease (CVD) risk calculators.Design RIsk COmmunication in NHSHC was a qualitative study with quantitative process evaluation, comparing NHSHC using QRISK2 or JBS3. …”
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Cohort profile: Oxford Pain, Activity and Lifestyle (OPAL) Study, a prospective cohort study of older adults in England by Sarah E Lamb, Christian D Mallen, M Watson, Julie Bruce, S Dutton, S Petrou, Lesley Ward, Maria T Sanchez Santos, Esther Williamson, Angela Garrett, Alana Morris, O Conway, F Darton, D Hagan, D Haywood, A Hewitt, I Marian, L Nevay, P Nicolson, M Slark, K Vadher, E Williamson, N Arden, K Barker, G Collins, J Fairbank, J Fitch, D French, F Griffiths, Z Hanson, C Hutchinson

“…The majority of participants (n=5367) also consented for research team to access their UK National Health Service (NHS) Digital and primary healthcare records.Findings to date Mean participant age was 74.9 years (range 65–100); 51.5% (n=2784/5409) were women. 94.9% of participants were white, and 28.8% lived alone. …”
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Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…Objectives To assess the feasibility of delivering and evaluating a lifestyle programme for patients with colorectal cancer undergoing potentially curative treatments.Study design Non-randomised feasibility trial.Setting National Health Service (NHS) Tayside.Participants Adults with stage I–III colorectal cancer.Intervention The programme targeted smoking, alcohol, physical activity, diet and weight management. …”
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TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK by Rebekah Webb, Mohammed Al-Zubaidi, Mark A Baxter, Karin Purshouse, James Robertson, Helen Creedon, Katherine Fair, Asma Sarwar, Laura Hannington, Adam L Peters, Samuel Mcinerney, Karen E Mactier, Georgina E Wood, Mai K Bishr, Leonie Eastlake, Katharine Lankester, Alison L Stillie

“…Routine clinical data, including general patient demographics, diagnosis, treatment and outcomes, were collated and pseudonymised.Setting Patients diagnosed with uterine sarcoma in the UK National Health Service between 1 January 2008 and 31 December 2017 were identified from electronic records.Participants A total of 406 patients from eight centres were eligible for inclusion.Results The median age at diagnosis was 56 years, with leiomyosarcoma the most common diagnosis (54.4%). …”
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Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review by Anisha Panesar, Palma Gharanei, Natasha Khovanova, Lawrence Young, Dimitris Grammatopoulos, Dimitris Grammatopoulos

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Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial by Mohamed Abdelrahman, Neil Cowan, Meera Ramcharn, Bassel H Al Wattar, William Parry-Smith, Sarah McRobbie, Michael Rimmer, Nagla Elfaki, Cheryl Dunlop, Damien Coleburt, Olivia Raglan, Jhia Jiat Teh, Maria Fisher, Nilaani Murugesu, Yazid Jibrel, Matthew Wood

“…The Web-Ed trial aims to evaluate the educational benefits, feasibility and acceptability of web-based virtual JCs compared with traditional face-to-face ones.Methods and analysis Web-Ed is a multicentre pragmatic parallel-group randomised trial across teaching hospitals within the UK National Health Service (NHS). We will enrol qualified doctors or medical students who are >18 years old, proficient in English and able to use online videoconferencing software. …”
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Barriers and facilitators to implementation of a home-based cardiac rehabilitation programme for patients with heart failure in the NHS: a mixed-methods study by Rod S Taylor, Paulina Daw, Samantha B van Beurden, Jet J C S Veldhuijzen van Zanten, Alexander Harrison, Sinead T J McDonagh, Patrick J Doherty, Colin J Greaves, Hasnain M Dalal, Grace E R Wood

“…In 2020, 5 online REACH-HF training events were attended by 85 healthcare professionals from 45 National Health Service (NHS) teams across the UK and Ireland.Design Our mixed-methods study used in-depth semi-structured interviews and an online survey. …”
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Improving the experience of health services for trans and gender-diverse young people and their families: an exploratory qualitative study by Melissa Stepney, Samantha Martin, Magdalena Mikulak, Sara Ryan, Jay Stewart, Richard Ma, Adam Barnett

“…Finally, the National Health Service needs to positively influence current debates and challenge false and misleading information about transgender people. …”
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Which patients received a ReSPECT form, what was documented and what were the patient outcomes? A protocol for a retrospective observational study investigating the impact of the C... by Lucy Selman, Charlotte Chamberlain, Adam McDermott, Claire A Woodall, Lucy Victoria Pocock

“…These include emergency department attendances, emergency hospital admissions, community nurse home visits, hospice referrals, anticipatory medication prescribing, place of death and if the patient died in preferred place of death.Ethics and dissemination Approval has been obtained from a National Health Service Research Ethics Committee (20/YH/0185). …”
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Mixed methods evaluation of the Getting it Right First Time programme in elective orthopaedic surgery in England: an analysis from the National Joint Registry and Hospital Episode... by Stephen Morris, James Mason, Rosalind Raine, Peter Martin, Naomi J Fulop, Elena Pizzo, Andrew Hutchings, Helen Barratt, Jean Ledger, Raj Mehta, Sarah Jasim, Fiona Aspinal, Rafael Gafoor

“…Objective To evaluate the impact of the ‘Getting it Right First Time’ (GIRFT) national improvement programme in orthopaedics, which started in 2012.Design Mixed-methods study comprising statistical analysis of linked national datasets (National Joint Registry; Hospital Episode Statistics; Patient-Reported Outcomes); economic analysis and qualitative case studies in six National Health Service (NHS) Trusts.Setting NHS elective orthopaedic surgery in England.Participants 736 088 patients who underwent primary hip or knee replacement at 126 NHS Trusts between 1 April 2009 and 31 March 2018, plus 50 NHS staff.Intervention Improvement bundle including ‘deep dive’ visits by senior clinician to NHS Trusts, informed by bespoke set of routine performance data, to discuss how improvements could be made locally.Main outcome measures Number of procedures conducted by low volume surgeons; use of uncemented hip implants in patients >65; arthroscopy in year prior to knee replacement; hospital length of stay; emergency readmissions within 30 days; revision surgery within 1 year; health-related quality of life and functional status.Results National trends demonstrated substantial improvements beginning prior to GIRFT. …”
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Task-shifted approaches to postdiagnostic dementia support: a qualitative study exploring professional views and experiences by Louise Robinson, Greta Rait, Claire Bamford, Jill Manthorpe, Rachael Frost, Jane Wilcock, Karen Harrison Dening, Martin Knapp, Sube Banerjee, Joy Adamson, Alistair Burns, Raphael Wittenberg, Kate Walters, Alison Wheatley, Greta Brunskill, Louise Allan, Lynne Corner, Donna Buxton, Katherine Jacques, Doug Lewins, Sue Tucker

“…Objectives To explore the views of commissioners, service development leads, service managers and senior staff in selected dementia services on increasing the role of primary care in postdiagnostic support for people with dementia.Design Qualitative semi-structured telephone interviews and a focus group.Setting Participants were drawn from National Health Service (NHS) Clinical Commissioning Groups, social care commissioning and a range of dementia services across primary care, secondary mental healthcare, social care and the third sector. …”
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Estimating the global cost of vision impairment and its major causes: protocol for a systematic review by Nathan Congdon, Thomas Butt, Peng Tee Khaw, Andrew Bastawrous, Tasanee Braithwaite, Rupert R A Bourne, Matthew J Burton, Serge Resnikoff, Jacqueline Ramke, Kevin Frick, Hugh Taylor, Iris Gordon, Ana Patricia Marques, John Cairns, Justine H Zhang, Hannah B Faal, Iain Jones, Marty Jovic, Allyala Nandakumar

“…Here we outline the protocol for a systematic review to describe and summarise the costs associated with VI and its major causes.Methods and analysis We will systematically search in Medline (Ovid) and the Centre for Reviews and Dissemination database which includes the National Health Service Economics Evaluation Database. No language or geographical restriction will be applied. …”
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