Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis by Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang

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Exploring the Mechanism of Canmei Formula in Preventing and Treating Recurrence of Colorectal Adenoma Based on Data Mining and Algorithm Prediction by Xiaoling Fu, Yimin Xu, Xinyue Han, Xiangying Lin, Jingnan Wang, Guanhong Li, Xiaochen Fu, Min Zhang

“…In the treatment group, 98 patients completed follow-up examinations, with 16 patients (14.0%) exhibiting shedding, Adenoma recurrence was identified in 24 (24.5%) patients through colonoscopy. In the control group, 99 cases completed the follow-up examination, while 15 cases (13.2%) were lost to follow-up. …”
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Safety, reactogenicity, and immunogenicity of Ad26.COV2.S co-administered with a quadrivalent standard-dose or high-dose seasonal influenza vaccine: a non-inferiority randomised co... by Gabriela Tapia-Calle, Gloria Aguilar, Nathalie Vaissiere, Carla Truyers, Pedro Ylisastigui, Erik Buntinx, Mathieu Le Gars, Frank Struyf, Gert Scheper, Macaya Douoguih, Javier Ruiz-Guiñazú, Robert Patrizi, Wai Ling, Sanne de Ridder, Marit de Groot, Maria Grazia Pau, Gerald Weidinger, Srividya Pradeep, Nadine Salisch, Sophie Cambre

“…Findings: Non-inferiority criteria for concomitant administration in the SD groups were met for SARS-CoV-2 Spike-specific antibodies (ratio 1.11, 95% CI 0.97–1.26) and haemagglutinin inhibition titres for all influenza strains (A/H3N2 1.23, 95% CI 1.05–1.45; B/Victoria 0.99, 95% CI 0.84–1.19; B/Yamagata, 1.03, 95% CI 0.88–1.21) except A/H1N1 (1.28, 95% CI 1.09–1.53) for which the upper limit of the 95% CI was >1.5. …”
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Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs by ARom Cho, Hyeona Bae, Youngju Kim, Yeseul Jeon, Rankyung Jung, Minji Kim, Minjeong Kang, Sumin Cha, Kyu‐Woan Cho, Dong‐In Jung, Jinho Park, DoHyeon Yu

“…Results The median WBC (17.63, interquartile range [IQR]: 11.72‐20.24 × 109/L), neutrophils (12.28, IQR: 7.17‐16.88 × 109/L), band neutrophils (1288.5, IQR: 252.5‐2575 cells/μL), serum IL‐6 (731.80, IQR: 299.79‐5522.05 pg/mL), and plasma C‐reactive protein (4.10, IQR: 1.00‐8.58 mg/L) were significantly higher in nRBC‐positive dogs than negative dogs (11.27, IQR: 7.63‐15.13 × 109/L; 7.57, IQR: 4.96‐11.71 × 109/L; 62.5, IQR: 0‐350.25 cells/μL; 232.30, IQR: 99.33‐447.01 pg/mL; 0.40, IQR: 0.10‐3.00 mg/L, respectively; P < .05). …”
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血浆游离甲氧基肾上腺类物质对嗜铬细胞瘤和副神经节瘤的诊断价值 by 姚瑶, 冯绮玲, 李永洁, 张小云, 唐菊英, 郭颖, 张少玲, 严励

“…血浆MN如以0.395 nmol/L为切点，其灵敏性为60.2%，特异性为97.8%；NMN切点值为1.105 nmol/L，其诊断灵敏性为87.0%，特异性为98.7%，二者联合时灵敏性和特异性分别为91.7%、99.8%。血浆MN、NMN及两者联合诊断PPGL的ROC曲线下面积及95%置信区间分别为0.800（0.743，0.858）、0.959（0.932，0.985）、0.970（0.944，0.996）。…”
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Spatial Changes in Soil Nutrients in Tea Gardens from the Perspective of South-to-North Tea Migration: A Case Study of Shangluo City by Ziqi Shang, Jichang Han, Yonghua Zhao, Ziru Niu, Tingyu Zhang

“…The mean values for total nitrogen (TN), available nitrogen (AN), total phosphorus (TP), available phosphorus (AP), total potassium (TK), available potassium (AK), clay, silt, and sand were 1.53 g/kg, 213 mg/kg, 0.85 g/kg, 49.1 mg/kg, 5.5 g/kg, 110 mg/kg, 3.99, 44.89, and 51.11, respectively. AN and AP displayed higher coefficients of variation at 57% and 120.1%, respectively. …”
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Redefining outcomes of ventricular arrhythmia for SGLT2 inhibitor medication in heart failure patients: a meta-analysis of randomized controlled trials by Miao Lin, Shiyu Zhang, Lu Zhang, Chengying Yang, Yang Luo, Yajin Peng, Xiaoqiu Tan, Qiang Wen, Xinrong Fan, Xianhong Ou

“…Subgroup analyses indicated that longer follow-up (≥ 1 year) taking SGLT2 inhibitors can still reduce the risk of VAs (RR 0.79, 95% CI 0.65–0.96; P = 0.02) and SCD (RR 0.80, 95% CI 0.65–0.99; P = 0.04). Conclusion SGLT2 inhibitors have beneficial effects on lowering risks of VAs and SCD in patients with type 2 diabetes, cardiovascular diseases, heart failure with reduced ejection fraction (HFrEF), heart failure with preserved ejection fraction (HFpEF), and heart failure with mildly reduced ejection fraction (HFmrEF), with longer follow-up duration reinforcing these findings. …”
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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…In vitro release of rhein from RS-SNEDDS showed prolonged release up to 24h with 99.03± 1.04% drug release. Differential scanning calorimetry and powdered X-ray diffraction analysis confirmed the reduction in drug crystallinity and supported the results of the dissolution study. …”
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Вплив антропометричних факторів та даних акушерсько-гінекологічного анамнезу на ризик невдалої імплантації після запліднення in vitro... by V.O. Berestoviy, Yu.O. Bulavchenko, O.G. Sihunov, O.O. Berestoviy, D.O. Govsieiev

“…Успішність імплантації в разі застосування аспірину, низькомолекулярних гепаринів, внутрішньовенних імуноглобулінів у комплексній терапії є вищою порівняно зі стандартним лікуванням безпліддя (р=0,049), ВШ=0,37 (95% ДІ 0,14–0,99). Висновки. У дослідженні виявлено вплив віку, зросту жінки та кількості статевих актів на імплантацію. …”
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Global prevalence of Eimeria species in goats: a systematic review and meta-analysis by Endris A. Ali, Abdul Ghafar, Juan C. Angeles-Hernandez, Muhammad Yaseen, Muhammad Yaseen, Charles G. Gauci, Ian Beveridge, Sandra Baxendell, Abdul Jabbar

“…Our results indicated high inter-study variability (inconsistency index (I2) = 99.7%, p &lt; 0.01). Among the variables analyzed, regions and quality of studies were the most significant predictors of heterogeneity. …”
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The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial by Sewar Khatib, Yuval Palgi, Yoni K Ashar, Natalya Polyvyannaya, Pavel Goldstein

“…MethodsA total of 96 patients aged 65-99 years from a nursing home were randomly assigned to 3 groups: SS, TS, and combined SS+TS interventions, each delivered as four 20-minute sessions. …”
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Supporting and hindering environments for participation of adolescents diagnosed with autism spectrum disorder: A scoping review. by Beate Krieger, Barbara Piškur, Christina Schulze, Uta Jakobs, Anna Beurskens, Albine Moser

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Superior suspensory complex of the shoulder reconstruction for acute and chronic acromioclavicular joint dislocations: the Queensland Unit for Advanced Shoulder Research 3-tunnel t... by Helen Ingoe, MBBS, FRCS Eng, MD, MSc, PGCert, Jashint Maharaj, MBBS, MPHTM, FRSPH, Nagmani Singh, MBBS, MS, Kathir Azhagan Stalin, MBBS, MS, MRCS, DNB, Kristine Italia, MD, FPOA, Roberto Pareyon, MD, Mohammad N. Jomaa, MD, Kenneth Cutbush, MBBS, FRACS, FAOrthA, Ashish Gupta, MBBS, MSc, FRACS

“…Mean postoperative scores with associated 95% confidence interval were Specific Acromioclavicular Score 87.38 (confidence interval 75.38-99.37), American Shoulder and Elbow Surgeons score 94.60 (87.85-101.35), Constant 79.47 (71.87-87.07), simple shoulder test 85.44 (72.34-98.54) and visual analog score 0.50 (−0.15 to 1.15). …”
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Long-term trends and patterns in ultra-processed food consumption among Korean adults from 1998 to 2022 by Hyeseung Lee, Yesol Yim, Yerin Cho, Jiyeon Oh, Soeun Kim, Yejun Son, Hyesu Jo, Seohyun Hong, Masoud Rahmati, Hanseul Cho, Jiyoung Hwang, Dong Keon Yon

“…From 1998 to 2022, the fat content of both ultra-processed and non-ultra-processed foods significantly increased, rising from 26.24 to 28.15% for ultra-processed foods (mean difference: 1.91% [95% CI, 1.33–2.49%]) and from 16.81 to 22.26% for non-ultra-processed foods (mean difference: 5.45% [95% CI, 4.99–5.91%]). This study examined 25-year trends in ultra-processed food consumption among South Koreans, showing a consistent increase in energy intake from ultra-processed foods until the COVID-19 pandemic, during which it declined for the first time. …”
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Degassing at the Volcanic/Geothermal System of Kos (Greece): Geochemical Characterization of the Released Gases and CO2 Output Estimation by Kyriaki Daskalopoulou, Antonina Lisa Gagliano, Sergio Calabrese, Lorenza Li Vigni, Manfredi Longo, Konstantinos Kyriakopoulos, Giovannella Pecoraino, Walter D’Alessandro

“…Carbon dioxide is the prevailing gas species (ranging from 88 to 99%), while minor amounts of N2 (up to 7.5%) and CH4 (up to 2.1%) are also present. …”
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Aurora kinase A promotes hepatic stellate cell activation and liver fibrosis through the Wnt/β-catenin pathway by Guanqi Dai, Guanqi Dai, Junhao Lin, Yuchuan Jiang, Yuchuan Jiang, Xinhui Liu, Peng Chen, Yixiao Zhang, Zhenghui Song, Xuefen Zhuang, Jinge Cong, Yingchun Li, Xuanjia Hong, Yun Liu, Dong Xiao, Dong Xiao, Aimin Li, Yue Luo

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Elevated D-dimer on admission may predict poor prognosis in childhood influenza associated encephalopathy by Huizhen Wang, Lingkong Zeng, Xingfeng Cheng, Hui Li, Hong Zhang, Yuanmei Shi, Yong Zhang, Changjian Li

“…In the univariate analysis, the poor prognosis group compared with the clinically cured group showed a significant increase in the number of days of hospitalization (3.0 vs. 9.5 days, P < 0.001), high-sensitivity C-reactive protein (6.80 vs. 1.88 mg/L, P = 0.003), interleukin-6 (20.26 vs. 8.24 pg/mL, P = 0.001), interleukin-10 (11.75 vs. 4.72 pg/mL, P = 0.003), alanine aminotransferase (104.0 vs. 20.0 U/L, P = 0.011), aspartate azelotransferase (186.5 vs. 37.0 U/L, P = 0.003), serum albumin (37.99 vs. 40.76 g/L, P = 0.042), prothrombin time (13.2 vs. 11.4 s, P = 0.017), D-dimer (4.34 vs. 0.44 mg/L FEU, P < 0.001), peripheral blood CD19 B-cell count (35.11 vs. 32.75 cells/µL, P = 0.018), and cerebrospinal fluid chloride (126.82 vs. 125.50 mmol/L, P = 0.027) were statistically different in the above 11 indicators. …”
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Epidemiological aspects of nephrolithiasis and chronic diseases of the cardiovascular system combination by R. V. Royuk, S. K. Yarovoy, N. A. Guseva, Sh. L. Voskanyan, V. V. Royuk, D. B. Rodin

“…Kidney stones were found in 59,4% of patients, in the ureters – in 30,9% of patients, in kidneys and in the ureters – in 9,9% of patients. Share of the patients with kidney stones in the shape of corals is 3,4% of the whole sample. …”
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Locking compression plate as a sequential external fixator following the distraction phase for the treatment of tibial bone defects caused by fracture-related infection: experience... by Xiriaili Kadier, Kai Liu, Aierbanjiang Shali, Yimurang Hamiti, Sulong Wang, Xin Yang, Alimu Keremu, Aihemaitijiang Yusufu

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Association of TNF-α gene promoter polymorphism with primary open-angle glaucoma by A.V. Shevchenko, V.F. Prokof’ev, V.I. Konenkov, A.V. Eremina, A.N. Trunov, V.V. Chernykh

“…</i> </p> <p> <i><b>Patients and Methods: </b>the study enrolled 401 individuals, i.e., 99 patients with POAG stage 2 and 302 individuals without POAG (randomized control group). …”
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