Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

Get full text

CWPO mechanism for toxic dye degradation in the presence of Cu@FbHAp catalyst: DFT study, performance analysis, response surface methodology, regeneration, and cost estimation by Youssef Miyah, Mohammed Benjelloun, Fatiha Mejbar, Salma Ssouni, Mohamed El-Habacha, Soulaiman Iaich, Noureddine El Messaoudi, Marouane Zerrouq, Mohammed Souilah, Anissa Lahrichi, Farid Zerrouq

“…These decolorization rates were further improved by Box Behnken response surface methodology applied to 1 %Cu@FbHAp to achieve 98.56 % and 99.28 % for BG and MeO respectively at 60 mg/L dye concentration, 0.0735 M H2O2 concentration, and 2 g/L catalyst dose. …”
Get full text

Long-term outcome in people who use drugs successfully treated for hepatitis C infection with glecaprevir/pibrentasvir by Shana Yi, David Truong, Brian Conway

“…Among the cured individuals, 104 (96.3 %) remained alive, while 4 individuals died of opioid overdoses. Out of the 104 , 99 (95.2 %) remained HCV-free, while 5 (4.8 %) were re-infected. …”
Get full text

ANEMIA EN EL EMBARAZO by Enrique Guevara Ríos, Investigación Materno Perinatal

“…La clasificación de la anemia se basa en los valores de su concentración sérica: anemia leve 100 a 109 g/L, anemia moderada 70 a 99 g/L y anemia severa menos de 70 g/L 2,4. A nivel mundial en las gestantes hay una prevalencia de anemia en gestantes del 41.8% afectándose a 56 millones de gestantes5. …”
Get full text

Land use variation impacts on trace elements in the tissues and health risks of a commercial fish by N.D. Takarina, O.M. Chuan, T.G. Pin, I. Femnisya, A. Fathinah, A.N.B. Ramadhan, R. Hermawan, A. Adiwibowo

Get full text

Construct validity and responsiveness of ASAS Health Index assessed in two longitudinal studies of tumour necrosis factor alpha inhibitor initiation and dose reduction in patients... by Merete Lund Hetland, Inge Juul Sørensen, Mikkel Østergaard, Mikael Boesen, Susanne Juhl Pedersen, Sara Nysom Christiansen, Ole Rintek Madsen, Mette Klarlund, Marie Wetterslev, Mate Lorincz, Mads Bakkegaard, Anne Duer, Kasper Kjærulf Gosvig

“…In the DOBIS study, 105 (99%) patients flared after mean (SD; min–max) 31 (17; 2.7–81) weeks. …”
Get full text

Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study. by Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J Gordijn, Kimberley Kavanagh, Paul Murray, Laura A Magee, Henk Groen, Peter von Dadelszen

“…When categorizing women into multiple risk groups, the PIERS-ML model generally showed good rule-in capacity for the "very high" risk group, with positive likelihood ratio values ranging from 70.99 to infinity, and good rule-out capacity for the "very low" risk group where most negative likelihood ratio values were 0. …”
Get full text

TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders by Nincy Debeuf, Sahine Lameire, Manon Vanheerswynghels, Julie Deckers, Caroline De Wolf, Wendy Toussaint, Rein Verbeke, Kevin Verstaen, Hamida Hammad, Stijn Vanhee, Bart N Lambrecht

Get full text

Cost–Benefit Analysis of in vivo Reflectance Confocal Microscopy for Melanoma Diagnosis in a Real-World Clinical Setting by Bruno GM, Di Matteo S, Longo C, Stanganelli I, Farnetani F, Borsari S, Mazzoni L, Ciardo S, Raucci M, Magi S, Bassoli S, Spadafora M, Mandel VD, Casari A, Chester J, Kaleci S, Colombo GL, Pellacani G

Get full text

Why do patients with isolated PCL rupture experience no subjective knee joint instability during walking? An in vivo biomechanical study by Mingfeng Lu, Mingfeng Lu, Wei Chen, Jinpeng Lin, Jinpeng Lin, Wenhan Huang, Junqing Gao, Junqing Gao, Lilian Zhao, Shilin Li, Lilei He, Yu Zhang

“…Statistical Parametric Mapping (SPM) was employed, using independent and paired t-tests to evaluate differences between the healthy control group and the PCLD group, as well as between the involved and uninvolved sides, respectively.ResultsCompared with the healthy control group, posterior tibial displacement (the main indicator for anterior-posterior instability) of the involved limb was significantly decreased during 79%–94%. additionally, knee flexion angles of the involved limb were significantly increased compared with healthy control group during 0%–5% and 95%–99% of the gait cycle and significantly decreased during 66%–87%; In the uninvolved side, adaptive gait changes were observed, with knee flexion angles significantly reduced during 20%–50% and 64%–89% of the gait cycle and posterior tibial displacement significantly reduced during 60%–94% compared with the healthy control group; Compared to the uninvolved limb, the involved limb showed increased internal rotation during 62%–71% of the gait cycle and increased knee flexion during 8%–53%, with no significant differences in other dimensions.ConclusionFrom a biomechanical perspective, patients with PCL rupture exhibit no joint instability during walking. …”
Get full text

Comparison of safety and effectiveness of medical adhesive and metal spring coil in preoperative localization of peripheral pulmonary nodules by Yifei Wang, Zhenhua Yue, Xiaoqian Shi, Guozhan Xia, Linlin Qin, Qi Sun, Yiling Huang, Rong Chen, Xuewei Zhao, Mingdong Wang

“…After the positioning was completed, record the positioning time of each group of patients and the immediate pain score 15 min after the positioning was completed, the complications located in each group of patients, and whether there was positioning failure or not.ResultsThe localization success rate of the medicine adhesive positioning group [99.5% (204/205)] was higher than that of the metal spring coil positioning group [91.6% (76/83)] (P = 0.001). …”
Get full text

Severity Assessment of COVID-19 Using a CT-Based Radiomics Model by Zhigao Xu, Lili Zhao, Guoqiang Yang, Ying Ren, Jinlong Wu, Yuwei Xia, Xuhong Yang, Milan Cao, Guojiang Zhang, Taisong Peng, Jiafeng Zhao, Hui Yang, Jinfeng Hu, Jiangfeng Du

“…The AUCs for groups 0, 1, 2, and 3 on the training dataset were 0.99, 0.97, 0.96, and 0.93, and the microaverage AUC was 0.97 with a macroaverage AUC of 0.97. …”
Get full text

Retrospective analysis of the occurrence, potential risk factors and medical significance of pulmonary complications after total shoulder arthroplasty from the National Inpatient S... by Mengning Dong, Huitong Liang, Jinlang Fu, Zeying Guo, Hao Xie, Qinfeng Yang, Qingmei Yu, Xiaomin Hou

“…The ailments at this period that were most likely to result in pulmonary problems were ulcer (adjusted odds ratio [AOR] = 9.43; 95% CI, 4.99–46.91), pulmonary circulation disorders (AOR = 9.01; 95% CI, 4.56– 31.92), weight loss (AOR = 4.84; 95% CI, 2.15–10.88), fluid and electrolyte disorders (AOR = 3.55; 95% CI, 2.55–4.95), alcohol abuse (AOR = 1.56; 95% CI, 1.08–2.26), congestive heart failure (AOR = 3.09; 95% CI, 1.83–5.24), chronic pulmonary disease (AOR = 2.45; 95% CI, 1.60–3.75), deficiency anaemia (AOR = 1.56; 95% CI, 1.08–2.26), depression (AOR = 1.47; 95% CI, 1.03–2.11) and obesity (AOR = 1.46; 95% CI, 1.01–2.11). …”
Get full text

Assessment of the southern polar and subpolar warming in the PMIP4 last interglacial simulations using paleoclimate data syntheses by Q. Gao, Q. Gao, Q. Gao, E. Capron, L. C. Sime, R. H. Rhodes, R. Sivankutty, X. Zhang, B. L. Otto-Bliesner, M. Werner

“…The four syntheses include 99 reconstructions, and all syntheses support the presence of a warmer Southern Ocean, with reduced sea ice and a warmer Antarctica at 127 ka compared to the preindustrial. …”
Get full text

Genome-wide association mapping of biochemical traits and its correlation with MYMIV resistance in mungbean (Vigna radiata L. Wilczek) by Manju Kohli, Hina Bansal, Muraleedhar Aski, Gyan P. Mishra, B. R. Shashidhar, Anirban Roy, Soma Gupta, Subodh K. Sinha, Brijesh Kumar Mishra, Nikki Kumari, Atul Kumar, Ranjeet Ranjan Kumar, Ramakrishnan M. Nair, Harsh Kumar Dikshit

“…In YMD susceptible genotypes, significant variations were observed for TPC [2001.27-2834.13 mgGAE/100 g dry weight (DW)], TFC (252.65–341.30 mg/100 g DW), AA (40.33–64.69 mg/100 g DW), DPPH (32.11–53.47% scavenging effect DW), and FRAP (48.99-101.22 µmol Fe2+/g DW). Similarly, in resistant genotypes also wide range was recorded for TPC (1788.50-2286.38 mgGAE/100 g DW), TFC (206.12–337.32 mg/100 gDAS samples varied from 384. 6.46–47.64% scavenging effect DW), and FRAP (53.68-114.24 µmol Fe2+/g DW). …”
Get full text

A new phase of China-ASEAN health cooperation: the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies by Jie Qiao, Siyan Zhan, Minghui Ren, Haijun Wang, Yangmu Huang, Zhenyu Zhang, Yanan Luo, Hui Yin, Zhongwei Jia, Wei Huang, Hong Zhou, Jue Liu, Xiaoyun Liu, Qiudan Sun, Xiaojia Li, Jing Bai, Fangjing Liu, Yihong Liu, Yinzi Jin, Ming Xu, on behalf of China-ASEAN Science and Technology Cooperation Center for Public Health

Get full text

Association of T3/T4 ratio with inflammatory indicators and all-cause mortality in stroke survivors by Sheng Zhang, Zhongzhou Su, Xianqiang Wen

“…Multivariate regression analysis showed that age ≥ 60 years, race of non-Hispanic black, low T3/T4 ratio (p = 0.014, HR = 0.92, 95% CI = 0.87~0.98) and high NPAR (p = 0.009, HR = 2.50, 95% CI = 1.26~4.99) were independent risk factors for all-cause mortality. …”
Get full text

Establishing a baseline for surgical care in Mongolia: a situational analysis using the six indicators from the Lancet Commission on Global Surgery by Raymond R Price, Ali Jalali, Anudari Zorigtbaatar, Sarnai Erdene, Sergelen Orgoi, Andrea Davis, Jonathan Nellermoe, Jade M Nunez, Simon Ruhnke, Battsetseg Gonchigjav, Nomindari Bat-Erdene, Kevin Bagley, Micah Katz, Hannah Pioli, Batsaikhan Bat-Erdene, Ganbold Lundeg

“…All households were financially protected from caesarean section. Appendectomy carried 99.4% and 98.4% protection, external femur fixation carried 75.4% and 50.7% protection from impoverishing and catastrophic expenditures, respectively. …”
Get full text

Entomological Investigations, Seasonal Fluctuations and Impact of Bioclimate Factors of Phlebotomines Sand Flies (Diptera: Psychodidae) of an Emerging Focus of Cutaneous Leishmania... by Fatima Zahra Talbi, Abdelhakim El Ouali Lalami, Mouhcine Fadil, Mohamed Najy, Hassan Ech-Chafay, Mohamed Lachhab, Said Lotfi, Nordine Nouayti, Khadija Lahouiti, Chafika Faraj, Abdellatif Janati Idrissi

“…During a one-year study, 4472 specimens of sand fly were caught (72.56% male/22.44% female) that were composed of seven species divided into two genera: Phlebotomus (99.46%) and Sergentomyia (0.53%). Ph. sergenti was the most prevalent species (46.64%), followed by Ph. perniciosus (38.19%), Ph. longicuspis (9.32%), Ph. papatasi (5.23%), and Ph. ariasi (0.06%). …”
Get full text

Changes in the Advertisement of Goods and Services in the Lithuanian Periodic Press during 1918-1940 by Giedrė Polkaitė

Get full text