Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

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Differentiating Pulmonary Nodule Malignancy Using Exhaled Volatile Organic Compounds: A Prospective Observational Study by Guangyu Lu, Zhixia Su, Xiaoping Yu, Yuhang He, Taining Sha, Kai Yan, Hong Guo, Yujian Tao, Liting Liao, Yanyan Zhang, Guotao Lu, Weijuan Gong

“…The logistic regression model integrating lifestyle and health data achieved an AUC of 0.91 (95% CI: 0.8611–0.9658), while the random forest model incorporating exhaled VOCs achieved an AUC of 0.99 (95% CI: 0.974–1.00). Calibration curves indicated strong concordance between predicted and observed risks. …”
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Retinoblastoma. Part 1. Clinical presentations and diagnostic tools by S.V. Ivanova, S.A. Kuleva, N.N. Sadovnikova, M.I. Komissarov, M.N. Chistyakova, A.V. Khokhlova, N.A. Shchegoleva

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Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury by Nils Becker, Philipp Störmann, Andrea Janicova, Kernt Köhler, Klemens Horst, Ildiko Rita Dunay, Claudia Neunaber, Ingo Marzi, Jan Tilmann Vollrath, Borna Relja

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Differential impact of TyG and TyG-BMI indices on short- and long-term mortality in critically ill ischemic stroke patients by Yufan Pu, Na Xing, Ying Wang, Huihuang Wang, Jiang Xu, Xuejing Li

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Longitudinal impact of cross-clamp duration on postoperative sleep disturbance and quality of life in elderly cardiac surgery patients: a secondary analysis of the MINDDS trial by Grace E. Namirembe, Jamie Sparling, Alexis Novak, Ariel Mueller, Julia Bertsch, Kwame Wiredu, Jason Z. Qu, M. Brandon Westover, Timothy T. Houle, Oluwaseun Akeju

“…Sleep quality, measured by PROMIS scores, showed improvement over time, and did not differ based on cross-clamp duration (MD 0.74 points, 95% CI: −0.57, 2.07), procedure type (MD 2.14 points, 95% CI: 0.29, 3.99), or dexmedetomidine (MD 0.9 points, 95% CI: −1.33, 1.5). …”
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Proficiency, Clarity, and Objectivity of Large Language Models Versus Specialists’ Knowledge on COVID-19's Impacts in Pregnancy: Cross-Sectional Pilot Study by Nicola Luigi Bragazzi, Michèle Buchinger, Hisham Atwan, Ruba Tuma, Francesco Chirico, Lukasz Szarpak, Raymond Farah, Rola Khamisy-Farah

“…Finally, concerning the readability analysis, Flesch-Kincaid Grade Level and Flesch Reading Ease Score showed that Microsoft Copilot was the most accessible at 9.9 and 49, followed by ChatGPT-4 at 12.4 and 37.1, while ChatGPT-3.5 (12.9 and 35.6) and Google Bard (12.9 and 35.8) generated particularly complex responses. …”
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Evaluating Different Crown Reconstruction Approaches from Airborne LiDAR for Quantifying APAR Distribution Using a 3D Radiative Transfer Model by Xun Zhao, Can Liu, Jianbo Qi, Lijuan Yuan, Zhexiu Yu, Siying He, Huaguo Huang

“…In the branchless scenario, HET09′s metrics are 10.65 kW, 10.22 kW, and 9.79%, and for HET51, they are 2.99 kW, 2.65 kW, and 2.11%. However, differences remain between the branched and branchless scenarios, with the extent of these differences being dependent on the canopy structure. …”
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Comparative Genomics Reveals Evidence of the Genome Reduction and Metabolic Potentials of <i>Aliineobacillus hadale</i> Isolated from Challenger Deep Sediment of the Mariana Trench by Shaofeng Yang, Jie Liu, Yang Liu, Weichao Wu, Jiahua Wang, Yuli Wei

“…Strain Lsc_1132^T contains heterogenous 16S rRNA genes, exhibiting the highest sequence similarities to the type strains of <i>Neobacillus drentensis</i> LMG 21831^T, <i>Neobacillus dielmonensis</i>, <i>Neobacillus drentensis</i> NBRC 102427^T, <i>Neobacillus rhizosphaerae</i>, and <i>Neobacillus soli</i> NBRC 102451^T, with a range of 98.60–99.10% identity. The highest average nucleotide identity (ANI), the highest digital DNA-DNA hybridization (DDH) values, and the average amino acid identity (AAI) with <i>Neobacillus</i> sp. …”
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Correlations among hope, fertility quality of life and negative emotions for couples undergoing their first in vitro fertilization–embryo transfer: a cross-sectional analysis by Hui Ye, Jing Zhao, Yujie Zou, Xiaorun Song, Mi Xu, Yu Zhang, Lili Zhang, Gaohua Wang

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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…These results were robust in 99% of probabilistic simulations. CONCLUSION: Sotorasib did not demonstrate cost-effectiveness at the full dosage nor when reduced to a quarter of the dose. …”
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Behavior Changes in Quinpirole Obsessive-Compulsive Disorder Rats Treated with 6-Hydroxydopamine and the Corresponding Dopaminergic Compulsive Loop Mechanism by Haowen Zheng, Rui He, Yang Ming, Haiping He, Wei Wang, Ligang Chen, Feilong Gong

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High-Performance Carbon Nanotube Optoelectronic Transistor With Optimized Process for 3D Communication Circuit Applications by Shuang Liu, Heyi Huang, Yanqing Li, Yadong Zhang, Feixiong Wang, Zhaohao Zhang, Qingzhu Zhang, Jiali Huo, Jiaxin Yao, Jing Wen, Huaxiang Yin

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Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis by Suriyan Sukati, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Ching-Ping Tseng, Aongart Mahittikorn, Nsoh Godwin Anabire, Polrat Wilairatana, Kinley Wangdi, Hideyuki J Majima, Apiporn Thinkhamrop Suwannatrai, Wiyada Kwanhian Klangbud, Wanida Mala, Rujikorn Rattanatham, Manas Kotepui

“…However, no significant alterations in D-dimer levels were observed following the comparison between patients with severe and uncomplicated malaria, also with high heterogeneity (SMD = 2.54, 95% CI = -1.60; 6.68, P = 0.23, I² = 99%, 3 studies, 595 participants). The findings suggested that malaria patients have significantly higher D-dimer levels compared to non-malarial individuals. …”
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Sex differences in the associations of water, coffee and tea consumption with cardiovascular diseases: a prospective cohort study by Dandan Ke, Dandan Ke, Yueqing Wang, Yabing Hou, Weihao Shao, Jiawen Ke, Xiaoxuan Zhang, Hongxi Yang, Zhong He, Zuolin Lu

“…In contrast, heavy coffee consumption (particularly ≥6 cups/day) was associated with a greater risk of HF [1.16 (1.03–1.31) in men vs. 1.25 (1.12–1.40) in women], a greater risk of CHD [1.27 (1.18–1.36) in men vs. 1.21 (1.14–1.29) in women] and a greater risk of stroke [1.13 (0.99–1.29) in men vs. 1.20 (1.03–1.31) in women]. …”
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Impact of Mobile Health (mHealth) Use by Community Health Workers on the Utilization of Maternity Care in Rural Malawi: A Time Series Analysis by Kachimanga C, Ng’ambi WF, Kazinga D, Ndarama E, Amulele MA, Munyaneza F, Abejirinde IOO, van den Akker T, Kulinkina AV

“…For long-term effect, YendaNafe was associated with an increase in new ANC visits (aIRR 1.04, 95% CI 1.01– 1.07, p < 0.01) and ANC in the first trimester (aIRR 1.03,95% CI 1.00– 1.07 p=0.046), but not facility-based births (aIRR 1.01, 95% CI 0.99– 1.03, p=0.46) or PNC (aIRR 0.97 95% CI 0.93– 1.01, p=0.14).Conclusion: mHealth shows potential of increasing utilization of new ANC visits, ANC in the first trimester and facility-based births. …”
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Evaluating Impact of Surgical Myocardial Revascularization on Global Left Ventricular Systolic Function and Immediate Postoperative Outcome using Transesophageal Echocardiography by Abhijeet Shitole, Veerappa Kothiwale, Sharanagouda Patil, Preeti Lamba, Anand Vagarali, Jabbar Momin, Sweta Sooragonda, Anushri Patil

“…Results: In 96 subjects analyzed, there was a significant improvement in TEE derived LV-FS (38.60 ± 16.38 vs. 31.31 ± 13.14) (P = 0.002), FAC (51.94 ± 16.06 vs. 43.99 ± 16.02) (P ≤ 0.001), EF (53.08 ± 9.97 vs. 46.71 ± 7.53) (P < 0.00001), LV end diastolic volume index (34.84 ± 13.43 vs. 40.08 ± 17.22) (P = 0.0188) and ‘Tei’ index (0.47 ± 0.13 vs. 0.53 ± 0.13) (P = 0.0007). …”
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WATER versus WATER II 5‐year update: Comparing Aquablation therapy for benign prostatic hyperplasia in 30–80‐cm3 and 80–150‐cm3 prostates by Mohamad Baker Berjaoui, David‐Dan Nguyen, Saud Almousa, Karim Daher, Neil Barber, Mo Bidair, Peter Gilling, Paul Anderson, Kevin C. Zorn, Gopal Badlani, Mitch Humphreys, Steven Kaplan, Ronald P. Kaufman Jr, Dean Elterman, Mihir Desai, Claus Roehrborn, Naeem Bhojani

“…At 5 years, a notable percentage of patients in both groups were BPH medication‐free (WATER: 99%; WATER II: 94%) (P = 0.0517) and free from surgical retreatment (WATER: 95%; WATER II: 97%) (P = 0.508). …”
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Time-series analysis on relationship between short-term exposure to atmospheric ozone and the risk of non-accidental deaths in Hefei during 2017−2020 by Linling YU, Yu ZHU, Changchun XIAO

“…The effects of O3-8 h concentration on total NAD were also examined by stratification of age and sex.ResultsDuring the period of 2017 to 2020, the average concentration of O3-8 h in Hefei City was 99.12 μg·m−3, and the total number of non-accidental deaths was 45787. …”
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Gender difference in domain-specific quality of life measured by modified WHOQoL-BREF questionnaire and their associated factors among older adults in a rural district in Banglades... by Fakir M Amirul Islam

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