Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties by Madiha Kanwal, Humaira Nadeem, Sumra Malik, Saima Maqsood

“…The selected derivatives exhibited no toxicity profile with 99 % and 98 % cell survival rate using compound 4a and 4b. …”
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Real-World Efficacy and Safety of Avelumab Plus Axitinib in Metastatic Renal Cell Carcinoma: Results from the Ambispective RAVE-Renal Study by Ilya Tsimafeyeu, Vyacheslav Chubenko, Olga Baklanova, Alexey Kalpinskiy, Sufia Safina, Andrei Lebedinets, Vladislav Petkau, Elvira Parsadanova, Maria Turganova, Aleksei Shkurat, Natalia Tovbik, Elena Tkacheva, Yulia Anzhiganova, Olga Novikova, Varvara Bragina, Ruslan Zukov, Rashida Orlova

“…Any-grade treatment-related adverse events (TRAEs) occurred in 99 (79.2%) cases, including grade ≥3 TRAEs in 24 (19.2%). …”
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Precisión de la prueba de riesgo del ADA y la prueba de riesgo peruana como cribado para prediabetes by Felipe Lepage, Jesús Enrique Talavera, Jenny Raquel Torres-Malca, Fiorella E. Zuzunaga-Montoya, Liliana Cruz-Ausejo, Jhony A. De La Cruz-Vargas, Víctor Juan Vera-Ponce

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Agronomic characteristics, mineral nutrient content, antioxidant capacity, biochemical composition, and fatty acid profile of Iranian pistachio (Pistacia vera L.) cultivars by Ali Khadivi, Mohammadali Nikoogoftar-Sedghi, Yazgan Tunç

“…Total phenolic content varied from 99.9 (‘Rezaei’) to 184.30 mg/g (‘Fandoghi’), and antioxidant activity ranged from 39.14 (‘Shahpasand’) to 82.89% (‘Sefied’). …”
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Perfil antropométrico, aeróbico y de potencia muscular de jugadores juveniles de baloncesto costarricenses by Randall Gutiérrez-Vargas, José Alexis Ugalde-Ramírez, José Pino-Ortega, José Andrés Trejos-Moya, Luis Blanco-Romero, Braulio Sánchez-Ureña, Juan Carlos Gutiérrez-Vargas, Daniel Rojas-Valverde

“…El objetivo de este estudio fue describir un perfil antropométrico, aeróbico y de potencia muscular de basquetbolistas juveniles costarricenses según sexo, posiciones de juego y categoría de edad. Se evaluaron 99 jugadores juveniles (43 mujeres y 56 hombres; 18 bases, 51 aleros y 30 pívots; 42 categoría U16 y 57 categoría U18) de ocho equipos diferentes. …”
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Impact of school salad bars on fruit and vegetable selection, intake, and waste in Mid-Atlantic elementary schools by Melanie K. Bean, Suzanne E. Mazzeo, Lilian de Jonge, Laura Thornton, Hollie Raynor, Ashley Mendoza, Sarah Farthing, Bonnie Moore

“…Images were rated in the laboratory (ICCs = .94-.99) to determine FV selection, intake, and waste (servings [1 NSLP serving = ½c]). …”
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Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis by Spyridon N. Karkavitsas, Marianne Göger-Neff, Maria Kawula, Kemal Sumser, Benjamin Zilles, Martin Wadepohl, Guillaume Landry, Christopher Kurz, Wolfgang G. Kunz, Olaf Dietrich, Lars H. Lindner, Margarethus M. Paulides

“…The Jaccard coefficient quantified pretreatment motion; receiver operating characteristic analysis assessed its predictability for acceptable precision (<1 °C) during HT.Results Compared to the built-in dual-echo approach, single-echo thermometry improved the mean temporal precision from 1.32 ± 0.40 °C to 1.07 ± 0.34 °C (pelvis) and from 0.99 ± 0.28 °C to 0.76 ± 0.23 °C (lower extremities). …”
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Що потрібно змінити для підвищення ефективності знеболювання після кесаревого розтину? Аналіз результатів опитування анестезіологів Вінницької області... by N.V. Tytarenko, A.V. Voznyuk, A.V. Kostiuchenko, O.I. Datsiuk, I.L. Kukuruza, O.P. Zasadnyuk, G.V. Bevz

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Presence of liver metastasis correlated with high tumor abundance and indicated adverse prognostic feature in EGFR mutation non-small-cell lung cancer patients by Piyada Sitthideatphaiboon, Pronwasun Simseekeaw, Chinachote Teerapakpinyo, Nicha Zungsontiporn, Wariya Chintanapakdee, Itthi Itthisawatpan, Shanop Shuangshoti, Virote Sriuranpong, Thanisa Tongbai, Chanida Vinayanuwattikun

“…Median PFS was 13.4 months [95% CI 12.0-14.8] in undetectable ctEGFR, 10.4 months [95% CI 9.9–10.9] in ctEGFR CqMut-high, and 5.9 months [95% CI 3.8–7.4] in ctEGFR CqMut-low. …”
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Revealing the effects of environmental and spatio-temporal variables on changes in Japanese sardine (Sardinops melanostictus) high abundance fishing grounds based on interpretable... by Yongchuang Shi, Lei Yan, Shengmao Zhang, Fenghua Tang, Shenglong Yang, Wei Fan, Haibin Han, Yang Dai

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Характеристика яловичини, отриманої від бугайців української чорно-рябої молочної породи за різного покриву туш жировою тканиною... by Крук О.П., Угнівенко А.М.

“…Встановлено, що за покращення розвитку жирового покриву на туші статистично значуще покращуються їх конформація (м’ясистість) на 37,9 % (Р>0,99), товщина підшкірного жиру у 1,5 раза (Р>0,95), вміст м’язової тканини другого сорту на 13,9 % (Р>0,95), погіршуються кількість м’язової тканини вищого сорту на 2,7 пунктів (Р>0,95) та площа «м’язового вічка» на 23,2% (Р>0,95). …”
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Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis by Erika Kapp, Jacques Joubert, Samantha L. Sampson, Digby F. Warner, Ronnett Seldon, Audrey Jordaan, Margaretha de Vos, Rajan Sharma, Sarel F. Malan

“…The most potent antimycobacterial demonstrated a minimum inhibitory concentration (MIC99) of 9.6 μM against Mycobacterium tuberculosis H37Rv. …”
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Temporal segmentation method for 30-meter long-term mapping of abandoned and reclaimed croplands in Inner Mongolia, China by Deji Wuyun, Liang Sun, Zhongxin Chen, Luís Guilherme Teixeira Crusiol, Jinwei Dong, Nitu Wu, Junwei Bao, Ruiqing Chen, Zheng Sun, Hasituya, Hongwei Zhao

“…Cropland status maps were successfully generated for Inner Mongolia from 2000 to 2022 with annual accuracy between 97% and 99%. The Temporal Segmentation of Abandoned and Reclaimed Cropland (TSARC) method created time series maps of abandoned and reclaimed cropland at a 30-meter resolution, achieving an overall accuracy of 87.61%. …”
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The Relationship Between Serum 25 hydroxy Vitamin D Deficiency and Dietary Pattern in Baxshin Hospital, Sulaimani City by Mohammed I M Gubari, Jeza Muhamad Abdul Aziz, Fadhil Ahmed Mohialdeen, Khalid Anwar Hama-Ghareeb, Bakhtyar Kamal Muhamed, Hemn Abdalla Omer

“…The percentage of obese (99.8%) was significantly higher than normal weight and overweight among severe deficiency Vitamin D. …”
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Assessing Prevention Protocols by a Brief Questionnaire in the Infectious Respiratory Diseases Pandemics: An Application in Pedestrian Population in COVID-19 Pandemic by Ali Jafari-Khounigh, Alireza Razzaghi, Hamid Sharifi, Shahram Habibzadeh, Seyed Taghi Heydari, Rasool Entezarmahdi, Mostafa Farahbakhsh, Alireza Ansari Moghaddam, Mahdi Rezaei, Mohammad Saadati, Ehsan Sarbazi, Morteza Haghighi, Mina Golestani, Homayoun Sadeghi-Bazargani

“…One factor with five items emerged from principal component factor analysis accounting for 51.99% of the variance. Cronbach’s alpha coefficient equal to 0.76 indicated an acceptable internal consistency and the Spearman-Brown correlation coefficient of 0.939 depicted stability of the questionnaire. …”
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The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population by Neda K. Dezfuli, Ian M. Adcock, Shamila D. Alipoor, Sharareh Seyfi, Babak Salimi, Maryam Mafi Golchin, Neda Dalil Roofchayee, Mohammad Varhram, Esmaeil Mortaz

“…The AT genotype (OR = 0.57, 95% CI = 0.33–0.99, p=0.048) and the A allele frequency (OR = 0.58, 95% CI = 0.35–0.98, p=0.043) in rs767649 were lower in NSCLC patients in comparison with the control group. …”
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切口疝腹腔镜与开放修补术的疗效及安全性的Ｍｅｔａ分析

“…【结果】 最终纳入１３篇ＲＣＴ文献（最终纳入１２２０例），Ｍｅｔａ分析结果显示，与开放手术相比，腹腔镜下切口疝修补术可降低术后血清肿发生率（ＲＲ＝ ０．１８，９５％ＣＩ：０．１０ ～ ０．３３，Ｐ ＜ ０．０００１）和术后感染率（ＲＲ ＝ ０．２４，９５％ＣＩ：０．１３ ～ ０．４２，Ｐ ＜ ０．００００１），但不能减少术后肠梗阻发生率（ＲＲ＝ １．０２，９５％ＣＩ：０．４１ ～ ２．５５，Ｐ ＝ ０．９６）、术后出血发生率（ＲＲ＝１．８８，９５％ＣＩ：０．４１ ～ ８．７１，Ｐ ＝ ０．４２）、术后血肿发生率（ＲＲ＝０．９２，９５％ＣＩ：０．５５～１．５６，Ｐ＝０．７７）、术后皮肤坏死发生率（ＲＲ＝０．６６，９５％ＣＩ：０．２６～ １．６６， Ｐ ＝ ０．３７），不能降低复发率（ＲＲ＝１．２０，９５％ＣＩ：０．８２～ １．７５，Ｐ ＝ ０．３５），且术中肠损伤发生率高于开放组（ＲＲ＝３．９５，９５％ＣＩ：０．９９～ １５．７４，Ｐ ＝ ０．０５）。手术时间、住院时间，以及术中出血量由于异质性较大，未进行合并分析。…”
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Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data by Luyang Su, Ren Xu, Yanan Ren, Shixia Zhao, Weilan Liu, Zeqing Du

“…Unforeseen significant AEs such as unintended pregnancy (n = 623; ROR, 6.65; ROR025, 6.1; χ2, 2,482.38; PRR, 6.41; EBGM, 5.69; EBGM05, 5.29), bone pain (n = 35; ROR, 13.78; ROR025, 9.4; χ2, 311.2; PRR, 13.75; EBGM, 10.59; EBGM05, 7.69), gait disturbance (n = 34; ROR, 2.82; ROR025, 1.99; χ2, 37.31; PRR, 2.88; EBGM, 2.7; EBGM05, 2.02), dental caries (n = 15; ROR, 23.16; ROR025, 12.32; χ2, 204.26; PRR, 23.14; EBGM, 15.23; EBGM05, 8.98), decrease in blood pressure (n = 15; ROR, 3.88; ROR025, 2.29; χ2, 29.35; PRR, 3.88; EBGM, 3.63; EBGM05, 2.33), and osteonecrosis (n = 9; ROR, 23.44; ROR025, 10.36; χ2, 123.67; PRR, 23.43; EBGM, 15.35; EBGM05, 7.75) were identified as AEs that were not previously outlined in the prescribing information of the medication.ConclusionOur findings align with clinical observations, highlighting the emergence of previously unreported AE signals associated with MPA and their demographic and TTO characteristics. …”
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Immune Dysfunction in Rett Syndrome Patients Revealed by High Levels of Serum Anti-N(Glc) IgM Antibody Fraction by Anna Maria Papini, Francesca Nuti, Feliciana Real-Fernandez, Giada Rossi, Caterina Tiberi, Giuseppina Sabatino, Shashank Pandey, Silvia Leoncini, Cinzia Signorini, Alessandra Pecorelli, Roberto Guerranti, Solange Lavielle, Lucia Ciccoli, Paolo Rovero, Claudio De Felice, Joussef Hayek

“…Rett syndrome (RTT), a neurodevelopmental disorder affecting exclusively (99%) female infants, is associated with loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2) and, more rarely, cyclin-dependent kinase-like 5 (CDKL5) and forkhead box protein G1 (FOXG1). …”
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Impacts of drought on respiratory mortality in the upper midwest United States: a population subgroup assessment by Yeongjin Gwon, Yuanyuan Ji, Jesse D Berman, Azar M Abadi, Ronald D Leeper, Jared Rennie, Jesse E Bell

“…Our study suggests that the risks differs by subgroups: elevated risks in elderly (higher 14.4% and 9.8% for 6 and 12 month), White (15.1% and 9.0% higher for 6 and 12 month), males (12.7% and 5.1% higher for 6 and 12 month), females (15.8% and 11.1% higher for 6 and 12 month), urban 15.8% and 8.8% higher for 6 and 12 month), and rural (13.6% and 9.9% higher for 6 and 12 month) communities. Iowa showed the greatest increase (23.1%) in the 6 month severe drought, while Minnesota had the highest 20.3% in the 12 month severe drought. …”
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