Eficacia y seguridad clínica del itolizumab en fase de inducción, en pacientes con psoriasis grave by Maritza Batista Romagosa, Olaine Regla Gray Lovio, Leopoldina Falcón Lincheta, Teresita Pérez Alonso, Beatriz Mantecón Fernández, Aleida Urquiza Rodríguez, Liliana Almenares Soria, Yaimarelis Saumell Nápoles, Ana Rosa Valls Hung, Isabel Vicente Gómez

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Cardio-renal effect of dapagliflozin and dapagliflozin- saxagliptin combination on CD34 + ve hematopoietic stem cells (HSCs) and podocyte specific markers in type 2 diabetes (T2DM)... by Seshagiri Rao Nandula, Arad Jain, Sabyasachi Sen

“…Dapagliflozin alone reduced lipid parameters significantly particularly triglyceride (TG) when compared to placebo, with resultant visit 3 values at 99.5 ± 7.2 vs. 129 ± 12.3 and LDL/HDL ratio values were similar at 2.18 ± 0.08 vs. 2.13 ± 0.15. …”
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Bronchiectasis Exacerbation Increases the Risk of Adverse Renal Outcomes—Results From a Large Territory‐Wide Cohort Study by Wang Chun Kwok, Chung Ki Tsui, Leung Sze Him Isaac, Chun Ka Emmanuel Wong, Terence Chi Chun Tam, James Chung Man Ho, Desmond Yat Hin Yap

“…. −3.03 [−1.56 to −5.12] mL/min/1.73 m2/year, p = 0.004) and AKI (aOR 1.99; 95% CI 1.44–2.73, p < 0.001) than the “Non‐exacerbators.” …”
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Cross-cultural validation and reference norms for the DCDDaily-Q questionnaire Chinese version (DCDDaily-Q-CN): evaluating children’s motor performance in activities of daily livin... by Meihuan Huang, Yujun Zhan, Haishan Zhou, Ping Song, Yanping Fan, Yang Lu, Yijing Chen, Zhen Lv, Qing Liu, Guojun Yun, Jianguo Cao

“…The total performance score effectively differentiated between children with DCD and controls (U = 9.0, p &lt; 0.001), with a cutoff score of 45, demonstrating a sensitivity of 93% (95%CI: 77–99%) and specificity of 90% (95%CI: 74–98%).ConclusionThe findings support that the DCDDaily-Q-CN is a reliable and valid measure to assess participation and performance in motor-based ADLs and fulfill criterion B of the diagnostic criteria for DCD.…”
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Corrosion behavior of Fe amorphous/Al-12Si piston composites with core-shell structure by Yingdong Wang, Zuxiang Lin, Chengzhou Liu, Deyong Zhao, Chunqiong Li, Yuan Wang

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Non Linear Thermal Radiation Analysis of Electromagnetic Chemically Reacting Ternary Nanofluid Flow over a Bilinear Stretching Surface by Shobha V, Hasan Mulki, Baskar P, S. Suresh Kumar Raju, Saleh Mahmoud, Mostafa Abdrabboh, S.V.K. Varma

“…Residual analysis confirms model reliability, with Model-1 at 98.73 % and Model-2 at 99.15%. These findings inform parameter optimization in heat transfer applications, particularly in thermal management systems and heat exchangers.…”
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Comparison of Placental Doppler Ultrasound indices in Pregnant Women with Iron Deficiency Anemia, Minor Beta-Thalassemia and Healthy Pregnant in first half of pregnancy by Zahra Rahmani, Maryam Abdi Valikchali, Tahere Gelini Moghaddam, Shahabodin Gharahveysi

“…This index was higher in pregnant women with iron deficiency anemia compared to the other two groups (2.34 in the iron deficiency anemia group, 0.7 in the beta-thalassemia minor group, and 0.99 in the healthy group; P=0.03). Additionally, the mean pulsatility index of the placental spiral artery (PIP) was significantly lower in patients with beta-thalassemia minor compared to the healthy group (1.44 vs. 2.02, P=0.02). …”
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Automated quantification of anterior chamber cells using swept-source anterior segment optical coherence tomography by Shani Pillar, Shin Kadomoto, Keren Chen, Saitiel Sandoval Gonzalez, Nina Cherian, Joseph K. Privratsky, Nicolette Zargari, Nicholas J. Jackson, Giulia Corradetti, Judy L. Chen, SriniVas R. Sadda, Gary N. Holland, Edmund Tsui

“…ICC comparing automated to manual counts was 0.99 and the Pearson correlation coefficient was 0.98. …”
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Deep Learning for Identification and Characterization of Ca ii Absorption Lines: A Multitask Convolutional Neural Network Approach by Yang Liu, Jie Li, Linqing Gao, Haotong Zhang, Zhenghua Xu, Yu Wang, Wenbin Lin

“…The results show that the ResNet-CBAM model achieves an accuracy of 99.7% in detecting Ca ii absorbers and excels in predicting critical parameters such as equivalent width and full width at half-maximum, with average correlation coefficients of 0.98 and 0.85, respectively. …”
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Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL) by Fateme Arjmand, Samaneh Shojaei, Mitra Khalili, Hossein Dinmohammadi, Behzad Poopak, Samira Mohammadi-Yeganeh, Yousef Mortazavi

“…Results: Six miRNAs (miR-3143, miR-3182, miR-99a/100, miR-155, miR-576-5p, and miR-501- 3p) were predicted as inhibitors of PI3K/AKT/mTOR pathway. …”
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In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis by Eva A. Krijnen, Hansol Lee, Samantha Noteboom, Florence L. Chiang, Martijn D. Steenwijk, Menno M. Schoonheim, Eric C. Klawiter, Susie Y. Huang

“…The soma radius varied significantly across cortices, becoming smaller when moving outward from cortical lesions (cortical lesions: 10.38 ± 0.209 μm, “inner” layer: 10.19 ± 0.140 μm, “outer” layer: 10.07 ± 0.149 μm, normal‐appearing cortex: 9.99 ± 0.127 μm). Interpretation Cortical cell body loss in multiple sclerosis is most pronounced in cortical lesions and also present in normal‐appearing cortex. …”
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Patients’ loyalty to primary care institutions and associated factors in China: a cross-sectional study by Liqing Li, Qi Zhang, Liyong Zhu, Guohua Zeng, Hongwei Huang, Zhensheng Chen, Xiaogang Zhou, Xiaofang Wang, Zisheng Xu, Chunmei Wu, Di Yang, Xiaoting Zhai, Sule Yang, Zuxun Lu, Yong Gan, Zuxun Lu

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Karakteristik Penderita Penyakit Jantung Bawaan pada Anak di RSUP Dr. M. Djamil Padang Periode Januari 2010 – Mei 2012 by Nur Ain, Didik Hariyanto, Sovina Rusdan

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Prognostic value of body adipose tissue parameters in cancer patients treated with immune checkpoint inhibitors by Yan Li, Yean Yu, Kun Lv, Rongjuan Ge, Xie Xie

“…Additionally, increased subcutaneous adipose tissue (SAT) levels were associated with significantly better OS (HR: 0.69, 95% CI: 0.58–0.82, p &lt; 0.001) and PFS (HR: 0.82, 95% CI: 0.68–1.00, p = 0.049), and a higher DCR (OR: 1.99, 95% CI: 1.15–3.44, p = 0.014). Elevated total adipose tissue (TAT) levels were also linked to longer OS (HR: 0.73, 95% CI: 0.55–0.97, p = 0.028). …”
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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

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Seroprevalence of brucellosis in camels and humans in the Al-Qassim region of Saudi Arabia and its implications for public health by Abdulaziz M. Almuzaini, Abdullah S. M. Aljohani, Ahmed I. Alajaji, Ayman Elbehiry, Adil Abalkhail, Abdulrahman Almujaidel, Sahar N. Aljarallah, Hazem R. Sherif, Eman Marzouk, Abdelmaged A. Draz

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An ecological, environmental, and economic indicators-based approach towards enhancing sustainability in water and nutrient use for passion fruit cultivation in Colombia by Sonia Mercedes Polo-Murcia, Nesrine Chaali, Camilo Ignacio Jaramillo-Barrios, Sofiane Ouazaa, Victor Javier Polo, John Edisson Calderon Carvajal

“…Fertilization with F2 under I2 maximized nutrient use efficiency (PFPN: 223.88 ± 11.75 kg kg⁻1, PFPK: 675.97 ± 35.48 kg kg⁻1).In HP2, I2F3 achieved the highest NEEB (27.42 ± 0.70 thousand USD ha⁻1) and yield (16.55 ± 0.39 t ha⁻1), while I2F2 exhibited high IWUE (2.02 ± 0.12 kg m⁻³) and consistent nutrient use efficiency (PFPN: 566.06 ± 33.85 kg kg⁻1; PFPK: 1658.65 ± 99.19 kg kg⁻1). F2 demonstrated strong economic performance, supported by a PCA, explaining over 83% of the variance in both periods. …”
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Regulation of LPS-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells via TLR4-Mediated NF-κB and MAPK Signaling Pathways by Lactoferrin by Kai Zhang, Ruizhen Zhang, Yuanyuan Zhang, Min Zhang, Hong Su, Feifei Zhao, Daqing Wang, Guifang Cao, Yong Zhang

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Serum 25‐Hydroxyvitamin D Levels and Survival Outcomes in Advanced Biliary Tract Cancer: Results From the NIFTY Trial by So Heun Lee, Jaekyung Cheon, Ilhwan Kim, Kyu‐pyo Kim, Baek‐Yeol Ryoo, Jae Ho Jeong, Myoung Joo Kang, Byung Woog Kang, Hyewon Ryu, Ji Sung Lee, Changhoon Yoo

“…Methods From the 174 patients in the NIFTY trial, a total of 173 patients (99.4%) were included in this analysis comparing a liposomal irinotecan plus 5‐FU/leucovorin group (n = 87) and a 5‐FU/leucovorin alone group (n = 86). …”
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Admission outcomes and their associated factors among children admitted to the paediatric emergency unit within 24 hours of Dilla University Referral Hospital, Ethiopia, 2023: a cr... by Binyam Tariku Seboka, Tomas Yeheyis, Yihenew Ayehu Dessie, Samuel Jigso Dube, Abel Desalegn Demeke, Mekdes Mekonnen Feleke, Abdo Hajo Jarso, Asresu Feleke Bati, Etaferaw Udo, Selam Tadele Markos, Chalachew Kassaw, Amdehiwot Aynalem Debebe, Ephrem Geja Gechere

“…Children presented with diarrhoea (adjusted OR (AOR) =2.92, 95% CI 1.46 to 5.84), severe respiratory distress (AOR=5.08, 95% CI 2.49 to 10.35), coma (AOR=3.71, 95% CI 1.24 to 11.13), comorbidity (AOR=3.33, 95% CI 1.49 to 7.41) and delay to seek healthcare (AOR=1.99, 95% CI 1.03 to 3.83) were significantly associated factors with emergency unit mortality, whereas pneumonia (AOR=1.76, 95% CI 1.16 to 2.65) and severe acute malnutrition (AOR=3.46, 95% CI 2.06 to 5.81) were significantly associated factors with intrahospital unit/ward transfer.Conclusion The magnitude of mortality, transfer to the ward and discharge against medical advice were relatively higher. …”
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