The Concentration of Micronutrients and Heavy Metals in Maternal Serum, Placenta, and Cord Blood: A Cross-Sectional Study in Preterm Birth by Rima Irwinda, Noroyono Wibowo, Atikah Sayogo Putri

“…Term group had higher concentration of maternal serum AtRA (0.22 ± 0.07 ng/mL versus 0.12 ± 0.03 ng/mL, p <0.001), higher placental concentration of manganese {0.99 (0.38 – 1.78) μg/g versus 0.42 ± 0.18 μg/g, p <0.001}, iron (252.16 ± 170.61 μg/g versus 78.45 ± 51.73 μg/g, p <0.001), copper {2.96 ± 1.80 μg/g versus 1.62 (0.70 – 3.88) μg/g, p 0.019}, zinc {58.34 (27.88 – 124.05) μg/g versus 28.41 (1.46 – 137.69) μg/g, p 0.011}, selenium (0.31 ± 0.31 ng/g versus 0.14 ± 0.20 ng/g, p 0.024), AtRA {21.7 ± 10.69 ng/g versus 0.7 (0.42 – 5.10) ng/g, p <0.001}, and 25(OH)D {75.84 ± 45.12 ng/g versus 18.00 (5 – 88) ng/g, p <0.001}, lower placental concentration of mercury (0.20 ± 0.17 ng/g versus 20.47 ± 41.35 ng/g, p 0.019) and lead (0.02 ± 0.01 ng/g versus 0.81 ± 1.43 ng/g, p 0.009), and higher cord blood concentration of copper {32.20 (16.30 – 69.60) μg/dL versus 20.60 (5.80 – 53.30) μg/dL, p 0.006} and AtRA (0.16 ± 0.04 versus 0.07 ± 0.01, p <0.001). …”
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Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study by Ana Molina, Nagore Ambrosio, María Molina, Eduardo Montero, Leire Virto, David Herrera, Elena Figuero, Mariano Sanz

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Fluid Inclusion and H–O–S–Pb Isotope Geochemistry of the Yuka Orogenic Gold Deposit, Northern Qaidam, China by Pengjie Cai, Rongke Xu, Youye Zheng, Yueming Yin, Xin Chen, Xianbin Fan, Chao Ma

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Knowledge, attitudes and behaviour towards ticks and tick-borne diseases—A survey among Lyme borreliosis cases in Bavaria in 2019 by Stefanie Böhm, Volker Fingerle, Andreas Beyerlein, Manfred Wildner, Merle M. Böhmer

“…Even though a majority perceived checking for ticks after spending time outdoors, wearing long clothes, wearing closed shoes and tucking pants in socks as effective protection measures against tick bites, a much lower proportion applied those measures frequently (proportions perceived vs. applied: 99.2 % vs. 72.1%; 93.8 % vs. 40.2 %, 88.8 % vs. 51.1 % and 85.4 % vs. 16.8 %, respectively).Identified lack of knowledge or misconception regarding risk factors, availability of protection measures and tick behaviour may hamper application of recommended protection measures. …”
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The method and practice of clinical teaching for nursing students in the endocrinology department of Traditional Chinese Medicine hospital (中医院内分泌科实习护生临床带教方法研究与实践)... by YUAN Zheng (袁铮), CHEN Yuanyuan (陈媛媛), LI Wei (李伟)

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Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia by Olga Plisko, Jana Žodžika, Irina Jermakova, Inta Liepniece-Karele, Jeļena Eglīte, Dace Rezeberga

“…CIN2+ was more often associated with DQA1*0401 (OR 6.68, 95% CI 1.47-30.29, p=0.014), DRB*15 (OR 2.99, 95% CI 1.22-7.39, p=0.017), DQB1*0401 (OR 2.91, 95%CI 1.11-7.68, p=0.03), DQA1*0103 (OR 2.72, 95% CI 1.02-7.21, p=0.045), DRB1*11 (OR 2.42, 95% CI 1.10-5.33, p=0.029) and DQB1*0301 (OR 1.94, 95% CI 1.12-3.38, p=0.018). …”
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Clinical benefits of modifying the evening light environment in an acute psychiatric unit: A single-centre, two-arm, parallel-group, pragmatic effectiveness randomised controlled t... by Håvard Kallestad, Knut Langsrud, Melanie Rae Simpson, Cecilie Lund Vestergaard, Daniel Vethe, Kaia Kjørstad, Patrick Faaland, Stian Lydersen, Gunnar Morken, Ingvild Ulsaker-Janke, Simen Berg Saksvik, Jan Scott

“…Inpatients exposed to the blue-depleted evening light showed higher improvement during admission (CGI-I difference 0.28 (95% CI [0.02, 0.54]; p = 0.035), Number Needed to Treat for clinically meaningful improvement (NNT): 12); lower illness severity at discharge (CGI-S difference -0.18 (95% CI [-0.34, -0.02]; p = 0.029), NNT for mild severity at discharge: 7); and lower levels of aggressive behaviour (difference in BVC predicted serious events per 100 days: -2.98 (95% CI [-4.98, -0.99]; p = 0.003), NNT: 9). There were no differences in other secondary outcomes. …”
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Relationship of the gene pool of the Khants with the peoples of Western Siberia, Cis-Urals and the Altai-Sayan Region according to the data on the polymorphism of autosomic locus a... by V. N. Kharkov, N. A. Kolesnikov, L. V. Valikhova, A. A. Zarubin, M. G. Svarovskaya, A. V. Marusin, I. Yu. Khitrinskaya, V. A. Stepanov

“…When analyzing autosomal SNPs, the Ugrian genetic component completely dominates in both samples (up to 99–100 %). The samples of the Khanty showed the maximum match in IBD blocks with each other, with a sample of the Kets, Chulyms, Tuvans, Tomsk Tatars, Khakas, Kachins, and Southern Altaians. …”
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硬膜外腔注射硬脂酸纳米吗啡的药代动力学和镇痛研究

“…【目的】 观察并探讨硬脂酸纳米吗啡(SLN-M)单次注入大鼠硬膜外腔后的镇痛效应及用药后的药代动力学特点65377; 【方法】 SD雄性大鼠40只,随机分为4组,每组10只65377;A组(对照组):经硬膜外腔给予SLN;B组:给予0.5 mg普通吗啡;C1组与C2组:分别给予含0.5及2 mg吗啡的SLN-M,上述药品均用生理盐水溶解至50 μL65377;用药后测定热痛阈值评价镇痛效果(以最大镇痛效应MPE表示),并在不同时点测量脑脊液(CSF)和血浆内的吗啡浓度以进行药代动力学研究,同时观察药物副作用65377; 【结果】 C1及C2组单次使用SLN-M后最大镇痛强度(MPE)与B组相比差异无统计学意义(97.5 ± 28.465380;99.9 ± 20.5 VS 98.2 ± 30.5; P > 0.05),但达到最大镇痛强度的时间比B组显著延长[(1.24 ± 0.29)h, (0.93 ± 0.26)h VS (0.54 ± 0.21)h; P < 0.05)],镇痛持续时间也显著延长[(68.6 ± 9.7)h65380;(83.3 ± 11.6)h VS (9.3 ± 2.3)h; P < 0.05]65377;C1与C2组动物CSF吗啡浓度达峰时间明显长于B组[(6.0 ± 1.2)h65380;(3.0 ± 0.4)h VS (5.0 ± 0.9)min; P < 0.05],其峰值浓度也显著低于B组[(2768 ± 1005)ng/mL65380; (3274 ± 1095)ng/mL VS (8612 ± 3129)ng/mL; P < 0.05],B组动物CSF内药物储留时间明显缩短[(3.84 ± 0.55)h VS (88 ± 10)h65380;(101 ± 15)h; P < 0.05]65377;B组动物呼吸抑制和僵直症及角膜反射消失的发生率要高于C1与C2组(P < 0.05)65377; 【结论】 药物动力学证据表明:硬膜外腔单次给予SLN-M后通过持续缓慢释放吗啡发挥长时效镇痛作用,而且副作用比普通吗啡明显降低65377;…”
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Semen Analysis of Covid-19 Survivors and Uninfected Men: Examining the Motility, Concentration, Vitality, and Morphology Parameters of Spermatozoa by Sri Musta'ina, Eko Budi Siswidiyanto, Pety Narulita, Agustinus, Aucky Hinting, Atika, Zakiyatul Faizah

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Population Dynamics of Bullet Tuna (Auxis rochei Risso 1881) from the Indian Ocean, West Nusa Tenggara, Indonesia by Evron Asrial, Ruly Isfatul Khasanah, Fathurriadi Fathrurriadi, Yasir Arapat, Usma Kurniawan Hadi, Lalu Achmad Tan Tilar Wangsajati Sukmaring Kalih, Lalu Samsul Rizal, Mita Ayu Liliyanti, Erwin Rosadi, Daduk Setyohadi, Muhammad Junaidi, Ishani Nelunika Rathnayake

“…Meanwhile, the composition of BLT is worth selling (Condition Factor > 1.00), fit for catch (FLc / FLm > 1.00) and worthy of maturity (FLc > FLm), respectively 99.92%, 0.82% and 0.00%. The BLT fish composition indicates that the stocks of resources and populations do not support current sustainable fisheries management.…”
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Antimicrobial prescribing quality in Australian emergency departments: an analysis of the Hospital NAPS data set by Lenna Zosky-Shiller, Karin Thursky, Sarah Park, Rodney James, Lisa Hall, Caroline Chen, Courtney Ierano

“…Amoxicillin-clavulanic acid (53.2%, n = 99), and acute exacerbation of chronic obstructive pulmonary disease (54.3%, n = 57), were the antimicrobial and indication with the lowest rates of appropriateness respectively. …”
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Enhancement of densification and mechanical property of (Hf0.2Zr0.2Ti0.2Nb0.2Ta0.2)N high-entropy bulk ceramic via silicon carbide addition by Wuyang Song, Youjun Lu, Lutong Yang, Maohui Li, Xiao Zhang, Bo Ma, Chuyun Wang, Yanmin Wang, Jinfeng Li, Xiang Liu

“…The results show that the relative density of the composite bulk ceramics with increasing SiC particle content from 0 to 10.0 wt% increases from 93.08%±0.13% to 99.12%±0.12%. The high-entropy composite bulk ceramic with SiC particle content of 10.0 wt% exhibits the optimum mechanical properties (i.e., Vickers hardness of 23.34±0.67 GPa, fracture toughness of 4.35±0.13 MPa·m1/2, and bending strength of 409±11 MPa) compared with the ceramic without SiC particles (i.e., Vickers hardness of 19.16±0.56 GPa, fracture toughness of 3.78±0.09 MPa·m1/2, and bending strength of 335±11 MPa). …”
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Enterobacter-inoculation altered the C, N contents and regulated biomass allocation in Reaumuria soongorica to promote plant growth and improve salt stress tolerance by Xin-Guang Bao, Xin-Guang Bao, Pei-Fang Chong, Pei-Fang Chong, Cai He, Xue-Mei Lu, Xue-Ying Wang, Feng Zhang, Bing-Bing Tan, Jia-Li Yang, Li-Li Gao

“…Compared to NaCl treatment alone, co-treatment with these strains significantly increases the biomass of roots, stems, and leaves, particularly root biomass, which increases by 99.88%, 85.55%, and 141.76%, respectively (P&lt;0.05). …”
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Dietary intake of tomato and lycopene, blood levels of lycopene, and risk of total and specific cancers in adults: a systematic review and dose–response meta-analysis of prospectiv... by Arghavan Balali, Kimia Fathzadeh, Gholamreza Askari, Omid Sadeghi, Omid Sadeghi

“…Moreover, we found a linear inverse association between dietary lycopene intake and prostate cancer risk (Pooled RR 0.99, 95% CI 0.97–1.00, I2 = 0, p = 0.045). Regarding cancer mortality, negative relationships were found with total tomato intake (Pooled RR: 0.89, 95% CI: 0.85–0.93, I2 = 65.7%, p &lt; 0.001), lycopene intake (Pooled RR: 0.84, 95% CI: 0.81–0.86, I2 = 86.5%, p &lt; 0.001) and lycopene levels (Pooled RR 0.76, 95% CI: 0.60–0.98, I2 = 70.9%, p = 0.031). …”
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Effectiveness and Safety of Treatments for Early‐Stage Merkel Cell Carcinoma: A Systematic Review and Meta‐Analysis of Randomized and Non‐Randomized Studies by Yves Paul Vincent Mbous, Rowida Mohamed, Usha Sambamoorthi, Murtuza Bharmal, Khalid M. Kamal, Traci LeMasters, Joanna Kolodney, George A. Kelley

“…A statistically significant improvement in OS was observed for groups administered adjuvant RTx (SRx + RTx) compared to SRx only (HR = 0.78, 95% CI, 0.62–0.99), albeit with statistically significant heterogeneity (Q = 532.30, p < 0.001) and a large amount of inconsistency (I2 = 94%, 95% CI, 93.0–95.5). …”
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Circulating levels of adiponectin and AdipoR expression in peripheral blood mononuclear cells are associated with lower respiratory tract Infection by Qian Wang, Xuemei Wang, Danning Xu, Mengjie Jiang, Yidan Gao, Lijuan Jiang, Meilian Liu, Haoneng Tang, Lingli Tang

“…We aimed to measure APN and its signaling receptors, adiponectin receptor (AdipoR), in peripheral blood mononuclear cells (PBMCs) from LRTI patients to explore their potential roles in the LRTI process.MethodsA total of 99 LRTI patients from the Second Xiangya Hospital of Central South University were categorized into acute (n=35) and non-acute (n=64), and non-severe (n=62) and severe (n=37) groups. …”
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Replication of European hypertension associations in a case-control study of 9,534 African Americans. by Harpreet Kaur, Dana C Crawford, Jingjing Liang, Penelope Benchek, COGENT BP Consortium, Xiaofeng Zhu, Asha R Kallianpur, William S Bush

“…Variant rs17080093 associated with lower SBP and DBP (β = -2.99, p = 0.0352 and - β = 1.69, p = 0.0184) among younger individuals, particularly in younger women (β = -3.92, p = 0.0025 and β = -1.87, p = 0.0241 for SBP and DBP respectively). …”
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Care Complexity Factors and Discharge Destination in an Emergency Department: A Retrospective Cohort Study by Andrea Urbina, Jordi Adamuz, Maria-Eulàlia Juvé-Udina, Judith Peñafiel-Muñoz, Virginia Munoa-Urruticoechea, Maribel González-Samartino, Pilar Delgado-Hito, Javier Jacob, Marta Romero-García

“…The presence of CCIFs was a risk factor of ED mortality (odds ratio (OR): 13.49 [95% confidence interval (CI): 4.99;36.46]), intensive care unit admission (OR:1.26 [95%CI:1.08;1.47]), and hospitalization (OR: 1.62 [95%CI:1.53;1.71]), whilst the presence of care complexity factors was a protective factor of discharge against medical advice (OR:0.64 [95%CI:0.55;0.74]). …”
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Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke by Chenchen Liu, Dai Shi, Xiaoqiong Ni, Shoujiang You, Shoujiang You, Xiaofen Wu, Sheng Zhuang, Sheng Zhuang, Wu Cai, Liang Xu, Liang Xu

“…After adjustment for potential covariates, the highest quartiles of lymphocyte counts were significantly associated with lower risk of WMH (adjusted odds ratio [aOR] 0.57, 95% confidence intervals [CI] 0.32–0.99), PVH (aOR 0.52, 95% CI 0.31–0.87), DWMH (aOR 0.53 95% CI 0.32–0.90) as well as brain atrophy (aOR 0.46, 95% CI 0.23–0.92) compared with the lowest quartiles of lymphocyte counts, respectively. …”
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