An Apparent Achilles Heel of the NFL: Have Achilles Tendon Injuries Significantly Increased to Unacceptably High Incidence Levels in the NFL and if so, why?... by Timothy E Hewett, Chad D Lavender, Andrew L Schaver

“…That first week of the NFL season the NFL Players Association, the NFLPA, put out a statement to this effect that demanded removal of rubberized turf surfaces throughout the NFL! …”
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Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures studyResearch in context by Deborah R. Gustafson, Xuantao Li, Alison E. Baird, Henrik Zetterberg, Kaj Blennow, Jinbing Zhang, Amanda Blair Spence, Pauline Maki, Anjali Sharma, Kathleen Weber, Recai Yucel

“…Summary: Background: Blood-based biomarkers of Alzheimer's disease (AD) and stroke, including serum neurofilament light chain (sNFL), are understudied in women living with and without HIV. …”
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Evaluating NfL and NTproBNP as predictive biomarkers of intracranial injuries after mild traumatic brain injury in children presenting to emergency departments by Anne-Cécile Chiollaz, Virginie Pouillard, Michelle Seiler, Céline Habre, Fabrizio Romano, Céline Ritter Schenck, Fabian Spigariol, Christian Korff, Fabienne Maréchal, Verena Wyss, Lyssia Gruaz, Joan Montaner, Jean-Charles Sanchez, Sergio Manzano

“…We aim to assess the performances of two routinely used biomarkers in other fields: the neurofilament light chain protein (NfL), and the N-terminal prohormone of brain natriuretic peptide (NTproBNP), to safely discharge children without intracranial injuries (ICIs).MethodsA prospective multicenter cohort study was conducted, enrolling children suffering from mTBI, both with and without imaging during their acute management in the PED. …”
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Head in the game: the impact of cognitive abilities on performance of National Football League quarterbacks by R. Thomas Boone, Nicholas S. Zambrotta, Andrew M. Manocchio, James K. Bowman

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Short-term variability of Alzheimer’s disease plasma biomarkers in a mixed memory clinic cohort by Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Anja Hviid Simonsen, Nicholas J. Ashton, Hanna Huber, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen

Subjects: “…Intra- and Inter-individual variability, Reference change value (RCV), Plasma Aβ42/Aβ40 ratio, Phosphorylated tau (p-tau), Neurofilament light (NfL), Glial fibrillary acidic protein (GFAP)…”
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Association of serum neurofilament light chain with cognitive impairment: findings from the National Health and Nutrition Examination Survey by Tianjiao Meng, Qinwen Fei, Tian Lv, Shiqin Chen

“…This article aims to determine whether serum NfL associated with cognitive level.MethodsUsing NHANES data, we conducted an analysis of cognitive test results for 450 adults aged 60 years and older and examined their correlation with serum NfL levels. …”
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The role of neurofilament light chain in the context of neurological disorders by V. Taluntienė, R. Motiekaitytė, R. Kizlaitienė, N. Giedraitienė, G. Kaubrys

“… Neurofilament light chain (NFL) is a structural neuronal protein highly expressed in large myelinated axons. …”
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Shared prognostic information in amyotrophic lateral sclerosis – systematic assessment of the patients’ perception of neurofilament light chain and the ALS functional rating scale... by Lukas Maximilian Möhwald, André Maier, Torsten Grehl, Ute Weyen, Patrick Weydt, René Günther, Paul Lingor, Bettina Göricke, Susanne Petri, Julian Grosskreutz, Matthias Boentert, Isabell Cordts, Jochen H. Weishaupt, Johannes Dorst, Christoph Münch, Thomas Meyer, Petra Baum

“…Abstract Background In amyotrophic lateral sclerosis (ALS), neurofilament light chain (NfL) was introduced as a prognostic biomarker. More recently, NfL values can be shared on the patient’s ALS app. …”
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Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study by Karel Pavelka, Marta Olejárova, Veronika Balajková, Aneta Prokopcová, Martin Elisak, Hana Mojžišová

“…The serum and CSF levels of NfL were determined using ELISA.Results Patients with NPSLE demonstrated significantly higher levels of serum NfL compared with the non-NPSLE group (mean 31.68±36.63 pg/mL vs mean 16.75±12.48 pg/mL, respectively, p<0.05) and with controls (mean 10.74±4.36 pg/mL, p<0.01). …”
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Neurofilament light chain levels in neuronal surface antibody-associated autoimmune encephalitis: a systematic review and meta-analysis by Qi-Lun Lai, Meng-Ting Cai, Er-Chuang Li, Gao-Li Fang, Chun-Hong Shen, Yong-Feng Xu, Song Qiao, Jia-Jia Wang, Qin-Jie Weng, Yin-Xi Zhang

“…Studies have explored the role of neurofilament light chain (NfL) in NSAE and provided inconsistent data. We performed a systematic review and meta-analysis to evaluate the NfL levels in the serum and cerebrospinal fluid (CSF) of patients with NSAE. …”
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Plastic harmful ingredients reduce the level of neurofilament light chain protein by Long Li, Xiaoxiu Ma, Junwei Liu, Yongli Wu

“…Generalized linear model revealed a positive correlation between Mono-isononyl phthalate and Mono (2-Ethyl- 5-Hydroxyhexyl) Phthalate (MEHHP) with NFL. Furthermore, a significant dose-response relationship was observed between MEHHP and NFL, while Butyl paraben and Mono (Hydroxy-Isononyl) Ester exhibited a distinct ''inverted U-shaped'' nonlinear pattern with NFL. …”
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Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis by Cédric Hirzel, Annina Grütter, Denis Grandgirard, Robert Hoepner, Franziska Suter-Riniker, Stephen L. Leib

“…Methods: We compared serum and CSF NfL levels in LNB patients and age-matched controls. …”
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Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury by Andrew R. Mayer, Tracey V. Wick, Jessica R. McQuaid, Masen L. Boucher, Andrew B. Dodd, Cidney R. Robertson-Benta, Harm J. van der Horn, Erik B. Erhardt, Robert E. Sapien, Rawan Tarawneh, Rebekah Mannix

“…Samples were analyzed for GFAP, NFL, Tau, pTau181 and UCH-L1 protein concentrations in conjunction with a clinical battery. …”
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Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels by Zhikui Zhou, Baiyun Fan, Qiang Chen, Xuezhong Li, Xianjin Ke

“…The association between vitamin K intake and cognitive function may be mediated by serum NfL concentration.…”
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Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults by Farwa Ali, Jeremy A. Syrjanen, Dan J. Figdore, Walter K. Kremers, Michelle M. Mielke, Clifford R. Jack, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, B. Gwen Windham, Leland R. Barnard, Ronald C. Petersen, Alicia Algeciras-Schimnich

“…Overall, NfL has the strongest associations with poor gait performance. …”
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Sex differences in the association between repetitive negative thinking and neurofilament light by Yolanda Lau, Amit Bansal, Cassandre Palix, Harriet Demnitz-King, Miranka Wirth, Olga Klimecki, Gael Chetelat, Géraldine Poisnel, Natalie L. Marchant, The Medit-Ageing Research Group

“…We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. …”
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Retinal Microperimetry as a Novel Tool for Early Detection of Subclinical Cognitive Dysfunction and Brain Damage in Type 1 Diabetes: A Pilot Study by Manel Mateu‐Salat, Nicole Stanton‐Yonge, Frederic Sampedro Santaló, José Ignacio Vela, Jesús Díaz Cascajosa, Eva Safont Pérez, Daniela Rego‐Lorca, Ana Chico

“…Our group described subclinical cognitive alterations, structural brain differences, and increased levels of light chain neurofilament (NfL) in people with T1D and impaired awareness of hypoglycaemia. …”
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Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome by Valerie Lohner, Laura Perna, Ben Schöttker, Robert Perneczky, Hermann Brenner, Ute Mons

“…Conclusions: In persons with CSS, NfL and the Aβ40/Aβ42-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by ApoE genotype. …”
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Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema by LakshmiPriya Rangaraju, Xuejuan Jiang, J. Jason McAnany, Michael R. Tan, Justin Wanek, Norman P. Blair, Jennifer I. Lim, Mahnaz Shahidi

“…Furthermore, increased NFL reflectance and decreased OSL reflectance were associated with reduced VA. …”
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Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study by Siqi Dong, Xiaoni Liu, Yanni Zhou, Jiatong Li, Zihan Qi, Zihan Wang, Wenbo Yang, Xiangjun Chen

“…Additional serum samples were collected from 51 other ALS patients. NfL concentrations were quantified using the single molecule array (Simoa) technique. …”
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