The Optimal Intervention Time of Bone Marrow Mesenchymal Stem Cells in Ameliorating Cardiac Fibrosis Induced by Viral Myocarditis: A Randomized Controlled Trial in Mice by Tingting Wu, Yuan Xie, Jing Huang, Ping Li, Xuliang Wang, Yaoyao Yan, Tianhe Xia, Lei Li, Feng Zhu, Hao Li, Rongzhou Wu

“…Bone marrow-derived mesenchymal stem cells (BMSCs) have recently been introduced to treat cardiovascular diseases, such as myocardial infarction and dilated cardiomyopathy. Nevertheless, there are few researches focused on the application of BMSCs in treating viral myocarditis, not to mention its optimal intervention timer potential mechanisms. …”
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Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study by Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Cristian Papara, Katja Bieber, David A. De Luca, Jan Philipp Klein, Marlene A. Ludwig, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Artem Vorobyev, Astrid Dempfle, Ralf J. Ludwig

“…Using propensity score matching (PSM) to control for age, sex, ethnicity, and other CID risk factors, we contrasted the risk of developing any or any of the 38 CIDs in 881,192 EHRs from individuals with nicotine dependence to PSM-matched unexposed counterparts.ResultsThe analytical pipeline was validated by demonstrating an increased risk of individuals exposed to nicotine dependence for subsequent diagnosis of myocardial infarction, malignant neoplasm of the lung, and chronic obstructive pulmonary disease. …”
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Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3 by Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Bethan Morgan, Daniela Costa, Yong Li, Anirban Choudhury, Rito Mitra, David Bosanquet, Alex Reed, Iuliia K. Denisenko, Katsuyuki Nagata, Hideo Shindou, Benjamin F. Cravatt, Alastair W. Poole, Takao Shimizu, Zaheer Yousef, Peter W. Collins, Valerie B. O’Donnell

“…Limb or coronary (ST-elevation myocardial infarction, STEMI) thrombi displayed a platelet eoxPL signature while carotid thrombi had a white cell profile. …”
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Clinical Profile and Outcome in Patients with Coronary Slow Flow Phenomenon by Xiaogang Zhu, Hua Shen, Fei Gao, Sijing Wu, Qian Ma, Shuo Jia, Ziwei Zhao, Shan Tong, Zhihao Zhang, Yujie Zhou

“…Two teams (clinical center and core lab) were blind to patient data for the assessment of coronary angiograph using corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC). The study cohort consisted of 429 patients (294 men, 68.5%), aged from 30 to 78 years (mean, 54 years). …”
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Development of a pandemic-related core set of quality indicators for quality and patient safety in University Hospitals in Germany by Janis Evers, Natalie Altschuck, Claudia Mehl, Lilly Rüthrich, Lorenz Harst, Felix Walther, Oliver Steidle, Arnt Suckow, Ruth Hecker, Jochen Schmitt, Max Geraedts

“…Results The comprehensive evaluation identified two primary strands: organizational/management indicators (Strand A, 60 indicators) and disease-specific clinical quality and patient safety indicators (Strand B, 20 indicators for critical conditions like stroke, myocardial infarction, and cancer.) Three additional indicators were added after a final expert panel meeting, resulting in a final set of 83 indicators. …”
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Predictors of long-term symptom burden and quality of life in patients hospitalised with chest pain: a prospective observational study by Tone Merete Norekvål, Jørund Langørgen, Torbjørn Omland, Øyvind Skadberg, Kjell Vikenes, Nasir Saeed, Ole-Thomas Steiro, Hilde Lunde Tjora, Rune Oskar Bjørneklett, Vernon Vijay Singha Bonarjee, Øistein Rønneberg Mjelva, Kristin Moberg Aakre

“…Discharge diagnoses were non-ST elevation myocardial infarction (NSTEMI) (14.2%), UAP (17.1%), non-coronary cardiac disease (6.6%), non-cardiac disease (6.3%) and non-cardiac chest pain (NCCP) (55.6%). …”
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Oxidative Stress, Antioxidant Capacity, and Inflammatory Markers in Patients with Idiopathic Complete Heart Block by Shobhit Shah, Monika Bhandari, Pravesh Vishwakarma, Wahid Ali, Mohammad Kaleem Ahmad, Abhishek Singh, Ayush Shukla, Akhil Kumar Sharma, Gaurav Chaudhary, Akshyaya Pradhan, Sharad Chandra, Rishi Sethi, S. K. Dwivedi

“…Individuals with drug-induced CHB and acute myocardial infarction were not accepted. Results: Out of 60 patients, the gender distribution was 37 men and 23 women, with a mean age of 62.48 ± 7.98 years. …”
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Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p by Li T, Zhao Y, Cao Z, Shen Y, Chen J, Huang X, Shao Z, Zeng Y, Chen Q, Yan X, Li X, Zhang Y, Hu B

“…Our previous study demonstrated that Apelin pretreatment enhanced the therapeutic benefit of MSCs in myocardial infarction by improving their paracrine effects. …”
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Comparison of biodegradable and durable polymer drug-eluting stents in acute coronary syndrome: a meta-analysis by Tingting Wei, Can Huang, Yifan Zeng, Haoyong Yuan, Zhongshi Wu, Ting Lu, Yalin Liu

“…Safety endpoints included all-cause death, cardiac death, target vessel myocardial infarction and stent thrombosis (ST).Methods We searched PubMed, Medline, Embase and the Cochrane Controlled Register of Trials for comparative studies of BP-DES and DP-DES in patients with ACS from January 2000 to July 2021. …”
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Both Low and High Postprocedural hsCRP Associate with Increased Risk of Death in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention by Runzhen Chen, Chen Liu, Peng Zhou, Yu Tan, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Yi Chen, Li Song, Hanjun Zhao, Hongbing Yan

“…Inflammation poses dual effects after myocardial infarction, but robust evidence shows that high-sensitivity C-reactive protein (hsCRP), as an inflammatory marker, is constantly associated with worse outcomes. …”
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Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention by Jianmei Zheng, Cen Chen, Zhongcai Fan, Qiang Ye, Yi Zhong, Jinsong Li, Hao Huang, Jianping Deng, Jinghong Zhao, Tinglin Xiong, Wenjie Tian, Xuemei Zhang

“…MACE was defined as a composite of cardiac death, nonfatal recurrent myocardial infarction, ischemic-driven revascularization, and ischemic stroke. …”
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Cardiovascular outcomes associated with treatment of type 2 diabetes in patients with ischaemic heart failure by Thomas R. Godec, Daniel I. Bromage, Mar Pujades‐Rodriguez, Antonio Cannatà, Arturo Gonzalez‐Izquierdo, Spiros Denaxas, Harry Hemingway, Ajay M. Shah, Derek M. Yellon, Theresa A. McDonagh

“…Abstract Aim The optimal strategy for diabetes control in patients with heart failure (HF) following myocardial infarction (MI) remains unknown. Metformin, a guideline‐recommended therapy for patients with chronic HF and type 2 diabetes mellitus (T2DM), is associated with reduced mortality and HF hospitalizations. …”
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Predictors of late complications after coronary artery bypass grafting in patients with stable coronary heart disease by O.J. Zharinov, К.O. Mikhaliev, O.A. Yepanchintseva, B.M. Todurov

“…In general, 29 late complications (3 cases of heart failure, 3 – first diagnosed atrial fibrillation (AF), 4 – acute coronary syndrome, 11 – left ventricular ejection fraction (LV EF) relative decrease more than 10 %, 2 – formation of atrial fibrillation permanent form, 2 – acute myocardial infarction and 4 deaths) were diagnosed in 24 patients. …”
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Complementary Embryonic and Adult Cell Populations Enhance Myocardial Repair in Rat Myocardial Injury Model by Sergio Li Calzi, Todd Cook, Domenico G. Della Rocca, Juan Zhang, Vinayak Shenoy, Yuanqing Yan, Andrew Espejo, Anandharajan Rathinasabapathy, Max H. Jacobsen, Tatiana Salazar, George E. Sandusky, Lynn C. Shaw, Keith March, Mohan K. Raizada, Carl J. Pepine, Michael J. Katovich, Maria B. Grant

“…We compared the functional outcome of Isl-1+ cardiac progenitors, CD90+ bone marrow-derived progenitor cells, and the combination of the two in a rat myocardial infarction (MI) model. Isl-1+ cells were isolated from embryonic day 12.5 (E12.5) rat hearts and expanded in vitro. …”
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Structural tailoring of etoricoxib: A spectrochemical, medicinal and pharmacological study by Bakul Akter, Silvia Aishee, Abdullah Hridoy, Md. Mehedi Hasan Pulok, Mohammad Ariful Islam, Antu Biswas, Aurna Patwary, Majedul Hoque, MD. Sazidul Islam, Md. Nipatul Hasan Nirob, Faisal Islam Chowdhury, Monir Uzzaman

“…Nevertheless, its therapeutic efficacy is limited by poor aqueous solubility, low bioavailability, and significant cardiovascular risks, including increased blood pressure, thrombosis, and the potential for myocardial infarction. This study aimed to address these limitations through structural modifications of etoricoxib. …”
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Potassium Current Signature of Neuronal/Glial Progenitors in Amniotic Fluid Stem Cells by Paola Sabbatini, Sabrina Cipriani, Andrea Biagini, Luana Sallicandro, Cataldo Arcuri, Rita Romani, Paolo Prontera, Alessandra Mirarchi, Rosaria Gentile, Diletta Del Bianco, Elko Gliozheni, Sandro Gerli, Irene Giardina, Maurizio Arduini, Alessandro Favilli, Antonio Malvasi, Andrea Tinelli, Bernard Fioretti

“…These cells are highly appealing due to their numerous potential applications in the field of regenerative medicine for tissues and organs as well as for treating conditions such as traumatic or ischemic injuries to the nervous system, myocardial infarction, or cancer. AF-SCs, when subcultured in the presence of basic Fibroblast Growth Factor (bFGF), have been shown to survive and migrate when transplanted into the striatum of the rat brain, exhibiting behavior characteristics of neuronal/glial progenitor cells. …”
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Percutaneous Coronary Intervention Complexity and Risk of Adverse Events in relation to High Bleeding Risk among Patients Receiving Drug-Eluting Stents: Insights from a Large Singl... by Hao-Yu Wang, Yang Wang, Dong Yin, Run-Lin Gao, Yue-Jin Yang, Bo Xu, Ke-Fei Dou

“…The primary ischemic endpoint was major adverse cardiovascular events (MACE) (composite of cardiac death, myocardial infarction, definite/probable stent thrombosis, and target lesion revascularization), and primary bleeding endpoint was Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 bleeding. …”
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Development and Validation of a Nomogram for Predicting Long-Term Net Adverse Clinical Events in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention by Junyan Zhang, Zhongxiu Chen, Ran Liu, Yuxiao Li, Hongsen Zhao, Yanning Li, Minggang Zhou, Hua Wang, Chen Li, Li Rao, Yong He

“…The outcome of the NACEs is defined as a composite endpoint that includes death, myocardial infarction, ischemic stroke, and Bleeding Academic Research Consortium (BARC) grade 3–5 major bleeding. …”
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Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness by Stepanka Pruhova, Petra Dusatkova, Pavel J. Kraml, Michal Kulich, Zdena Prochazkova, Jan Broz, Jaroslav Zikmund, Ondrej Cinek, Michal Andel, Oluf Pedersen, Torben Hansen, Jan Lebl

“…The frequency of myocardial infarction and ischemic stroke did not differ between groups. …”
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The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy by Felice Gragnano, Simona Sperlongano, Enrica Golia, Francesco Natale, Renatomaria Bianchi, Mario Crisci, Fabio Fimiani, Ivana Pariggiano, Vincenzo Diana, Andreina Carbone, Arturo Cesaro, Claudia Concilio, Giuseppe Limongelli, Mariagiovanna Russo, Paolo Calabrò

“…Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis. All these features make VWF an attractive therapeutic target in thromboinflammation. …”
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