Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune-Competent Rat Model of Heart Failure by Ikeotunye Royal Chinyere, Pierce Bradley, Joshua Uhlorn, Joshua Eason, Saffie Mohran, Giuliana G. Repetti, Sherry Daugherty, Jen Watson Koevary, Steven Goldman, Jordan J. Lancaster

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are under preclinical investigation as a cell-based therapy for heart failure post-myocardial infarction. In a previous study, tissue-engineered cardiac grafts were found to improve hosts’ cardiac electrical and mechanical functions. …”
Get full text

Clinical Validation of the Defining Characteristics of the Nursing Diagnosis ‘Activity Intolerance’ in Patients With Acute Coronary Syndrome by Diana Isabel Cáceres Rivera, Luz Mileyde Jaimes Rojas, Luisa Yaneth Cristancho Zambrano, Jennifer Vanesa Acosta Barón, Diana Ivonne Cañon Gómez, Lyda Z. Rojas

Get full text

Residual Dyslipidemia Leads to Unfavorable Outcomes in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention by Bin Que, Chunmei Wang, Hui Ai, Xinyong Zhang, Mei Wang, Shaoping Nie

“…For the follow-up study, major adverse cardiovascular cerebrovascular events (MACCE; including total death, cardiovascular death, myocardial infarction, and revascularization) were documented. …”
Get full text

A Nomogram Model for Predicting Recurrent Coronary Thrombosis in Kawasaki Disease Patients by Zhou X, Peng Y, Yi Q

“…Xue Zhou,1– 4 Yue Peng,1– 4,* Qijian Yi1– 4,* 1Department of Cardiovascular Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 3Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 4Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing,People’s Republic of China*These authors contributed equally to this workCorrespondence: Qijian Yi, Email qjyi@hospital.cqmu.edu.cnBackground: Coronary thrombosis is a serious cardiovascular complication of Kawasaki disease (KD), and recurrence of coronary thrombosis increases the short-term risk of myocardial infarction and the long-term risk of coronary artery disease. …”
Get full text

Disorders of circadian rhythms of heart rate variability in diabetic cardiac autonomic neuropathy: mechanisms and consequences by V.A. Serhiyenko, M.I. Dolynay, V.B. Sehin, Y.V. Lazur, A.A. Serhiyenko

“…Metabolic syndrome, hypertension, myocardial infarction, and DM are characterized by increased SNS activity and decreased PSNS activity. …”
Get full text

Elevated plasma trimethyllysine is associated with incident atrial fibrillation by Mads M Svenningsson, Gard FT Svingen, Per M Ueland, Gerhard Sulo, Espen Ø Bjørnestad, Eva R Pedersen, Indu Dhar, Dennis W. Nilsen, Ottar Nygård

“…TML has recently been linked to atherosclerosis, acute myocardial infarction and prevalent atrial fibrillation (AF). …”
Get full text

Meta-Analysis of Randomized Trials: Efficacy and Safety of Colchicine for Secondary Prevention of Cardiovascular Disease by Elie Akl, Nazanin Sahami, Christopher Labos, Jacques Genest, Ali Zgheib, Nicolo Piazza, Sanjit Jolly

“…The primary outcome was the composite of cardiovascular (CV) death, myocardial infarction (MI), or stroke. Results. A total of 8 RCTs were included with a follow-up duration of ≥1 month, comprising a total of 12,151 patients. …”
Get full text

H₂S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins by Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam

“…Therapeutic strategies aimed at increasing H₂S levels have proven cardioprotective in models of acute myocardial infarction (MI) and heart failure (HF). The present study was undertaken to investigate the effects of a novel H₂S prodrug, SG-1002, on stress induced hypertrophic signaling in murine HL-1 cardiac muscle cells. …”
Get full text

A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation by Xueyang Ren, Wenjie Tang, Yuehui Yuan, Shisheng Chen, Fangzhou Lu, Jinyang Mao, Jidan Fan, Xufeng Wei, Ming Chu, Benhui Hu

“…Neuromodulation experiments demonstrate their potential clinical utility, including vagus nerve stimulation in rats to suppress seizures and alleviation of cardiac remodeling in a canine model of myocardial infarction.…”
Get full text

Clinical and angiographic profile of left main coronary artery disease in patients with chronic coronary syndrome: a retrospective study by Abdulsalam Mahmoud Algamal, Mahmoud Abdelbadie Salem, Ahmed Ibrahim Bedier, Mohammed Salah A. Hussein, Mona Malek Abdelrahim, Shady Hussein Elhusseiny

“…LMD versus non-LMD patients had a significantly higher prevalence of diabetes mellitus, dyslipidemia, and number of stenotic coronary segments and arteries, and nonsignificant differences regarding smoking, hypertension, previous myocardial infarction, and ejection fraction. Ostial LMD had a prevalence of 2%, a mean age of around 58 years and 21% were females. …”
Get full text

Strategies to Lower In-Hospital Mortality in STEMI Patients with Primary PCI: Analysing Two Years Data from a High-Volume Interventional Centre by Alexandru Burlacu, Grigore Tinica, Igor Nedelciuc, Paul Simion, Bogdan Artene, Adrian Covic

“…We aimed to analyse data from our high-volume interventional centre (>1000 primary percutaneous coronary interventions (PCI) per year) searching for predictors of in-hospital mortality in acute myocardial infarction (MI) patients. Moreover, we looked for realistic strategies and interventions for lowering in-hospital mortality under the “5 percent threshold.” …”
Get full text

Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice by Akiyuki Nishimura, Seiryo Ogata, Xiaokang Tang, Kowit Hengphasatporn, Keitaro Umezawa, Makoto Sanbo, Masumi Hirabayashi, Yuri Kato, Yuko Ibuki, Yoshito Kumagai, Kenta Kobayashi, Yasunari Kanda, Yasuteru Urano, Yasuteru Shigeta, Takaaki Akaike, Motohiro Nishida

“…Disruption of Cys644 S-glutathionylation nullifies the cardioprotective effect of GSSG against heart failure after myocardial infarction. Our findings suggest a therapeutic potential of supersulfide-based Cys bulking on Drp1 for ischemic heart disease.…”
Get full text

Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine by Luciano Rezende Vilela, Lindisley Ferreira Gomides, Bruna Araújo David, Maísa Mota Antunes, Ariane Barros Diniz, Fabrício de Araújo Moreira, Gustavo Batista Menezes

“…The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. …”
Get full text

The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) by Øyvind Helgeland, Jens K. Hertel, Anders Molven, Helge Ræder, Carl G. P. Platou, Kristian Midthjell, Kristian Hveem, Ottar Nygård, Pål R. Njølstad, Stefan Johansson

“…By a population based cross-sectional case-control design, we genotyped 18 SNPs upstream of CDKN2B tagging 138 kb in and around two LD-blocks associated with CVD and T2D and investigated associations with T2D, angina pectoris (AP), myocardial infarction (MI), coronary heart disease (CHD; AP or AMI), and stroke using 5,564 subjects from HUNT2. …”
Get full text

Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry by Gyu Chul Oh, Kyung Woo Park, Jeehoon Kang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon Kwon Koo, Hyo-Soo Kim

“…Target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization, was assessed at 3 years. …”
Get full text

The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting by I.V. Shklianka, O.J. Zharinov, К.O. Mikhaliev, O.A. Yepanchintseva, B.M. Todurov

“…In group one there were 4 cases of acute heart failure, one case of acute myocardial infarction, one acute respiratory failure and one significant blockade, which required the implantation of a pacemaker, while in other groups such cases were not recorded. …”
Get full text

Outcomes of coronary artery aneurysms: insights from the Coronary Artery Ectasia and Aneurysm Registry (CAESAR) by Alessandro Candreva, Jessica Huwiler, Diego Gallo, Victor Schweiger, Thomas Gilhofer, Roberta Leone, Michael Würdinger, Maurizio Lodi Rizzini, Claudio Chiastra, Julia Stehli, Jonathan Michel, Alexander Gotschy, Barbara E. Stähli, Frank Ruschitzka, Umberto Morbiducci, Christian Templin

“…Major adverse cardiovascular events included all-cause death, non-fatal myocardial infarction, unplanned ischaemia-driven revascularisation, hospitalisation for heart failure, cerebrovascular events, and clinically overt bleeding. …”
Get full text

The First Harmonic of Radial Pulse as an Early Predictor of Silent Coronary Artery Disease and Adverse Cardiac Events in Type 2 Diabetic Patients by Chi-Wei Chang, Kuo-meng Liao, Yi-Ting Chang, Sheng-Hung Wang, Ying-chun Chen, Gin-Chung Wang

“…By comparing the data of patients with C1 smaller than the first quartile and the patients with C1 greater than the third quartile, the hazard ratios were listed as follows: ACE (hazard ratio, 2.29; 95% CI, 1.55–3.37), heart failure (hazard ratio, 2.22; 95% CI, 1.21–4.09), myocardial infarction (hazard ratio, 2.44; 95% CI, 1.51–3.93), left ventricular dysfunction (Hazard ratio, 2.01; 95% CI, 0.86–4.70), and new symptoms and signs for coronary artery disease (hazard ratio, 2.03; 95% CI, 1.45–2.84). …”
Get full text

Changes in sarcopenia and incident cardiovascular disease in prospective cohorts by Qingyue Zeng, Lijun Zhao, Qian Zhong, Zhenmei An, Shuangqing Li

“…CVD was identified through self-reported physician diagnoses of heart disease, including angina, myocardial infarction, congestive heart failure, and other heart problems, or stroke. …”
Get full text

Association between triglyceride glucose index and adverse cardiovascular prognosis in patients with atrial fibrillation without diabetes: a retrospective cohort study by Aobo Gong, Ying Cao, Zexi Li, Wentao Li, Fanghui Li, Yao Tong, Xianjin Hu, Rui Zeng

“…The primary outcome, major adverse cardiovascular events, included cardiac death, stroke, and myocardial infarction. Kaplan–Meier curve, Cox proportional hazards regression model, and restricted cubic spline were employed to explore the relationship between the Tyg index and outcomes. …”
Get full text