Metagenomic next-generation sequencing for the clinical identification of spinal infection-associated pathogens by Tengfei Shi, Yuhan Lin, Xuexin Zheng, Hongliang Ruan, Rui Zhang, Yinhuan Liu, Shaohan Xu, Shaohan Xu, Huafeng Wang

“…Staphylococcus aureus (22.22%, n=30) and Mycobacterium tuberculosis (22.22%, n=30) were the major pathogens, while various rare pathogens such as anaerobes, Brucella, and Coxiella burnetii were also detected. …”
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Global prevalence, treatment and outcome of tuberculosis and COVID-19 coinfection: a systematic review and meta-analysis (from November 2019 to March 2021) by Qiang Sun, Hui Li, Jie Zhao, Xiaolin Wei, Quan Wang, Shasha Guo, Quanfang Dong, Ning Xu

“…TB and COVID-19 (TB–COVID) coinfection means the disease caused by both Mycobacterium tuberculosis and SARS-CoV-2 infection. Currently, the prevalence status, treatment and outcomes of the coinfection are poorly characterised. …”
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Assessing the effects of diabetes mellitus on the monocyte-to-lymphocyte ratio and the QuantiFERON-TB gold plus assays for tuberculosis treatment monitoring: a prospective cohort s... by Paulo Ranaivomanana, Arimanitra Razafimahefa, Mame Ndiaye, Crisca Razafimahatratra, Haja Ramamonjisoa, Perlinot Herindrainy, Mamy Raherison, Antso Hasina Raherinandrasana, Julio Rakotonirina, Jonathan Hoffmann, Rila Ratovoson, Niaina Rakotosamimanana

“…The TBDM patients were characterized by an elevated Mycobacterium tuberculosis-specific QFT-P IFN-γ response after TB treatment compared to the TBP group (p<0.001 and p<0.05, respectively, after TB1 and TB2 antigens stimulation). …”
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Pengembangan Automated Image Analysis untuk Menentukan Jumlah Bakteri Tahan Asam (BTA) pada Kasus Tubercolosis by Safri Adam, Puji Astuti, Puspa Amalia, Fadli Sukandiarsyah

“…The general diagnosis used in TK 1 Health Facilities (Faskes) is carried out by revealing a patient's sputum specimen using the Ziehl-Neelsen method to detect the presence of acid-fast bacteria such as Mycobacterium tuberculosis, which causes TB. However, in practice, manual calculations with a limited field of view on a microscope require a fairly long processing time. …”
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Le lymphosarcome fausse les résultats du test de la tuberculose effectué sur le sang by Cheick Coulibaly, Julia Seidl, Bettina Bernhard, Roland Plesker

“…La législation européenne (directive 92/65/CEE, article 14 et annexe B) impose, pour les primates non humains, un dépistage annuel de la tuberculose (Mycobacterium tuberculosis). Les institutions dont les colonies sont testées positives risquent la suspension ou la perte de l’autorisation de détenir des primates. …”
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Prevalence of pulmonary tuberculosis and associated factors among adults living with HIV/AIDS in Ethiopia, systematic review and meta-analysis by Amlaku Nigusie Yirsaw, Berihun Agegn Mengistie, Eyob Getachew, Gebrehiwot Berie Mekonnen, Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Gemeda Wakgari Kitil, Wubet Tazeb Wondie, Gebeyehu Lakew

“…Abstract Background Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a global health crisis, especially in sub-Saharan Africa, where high human immune virus (HIV) prevalence exacerbates the problem. …”
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Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery by Thomas Smytheman, Tiffany Pecor, Dana E. Miller, Debora Ferede, Suhavi Kaur, Matthew H. Harband, Hazem F. M. Abdelaal, Carlos A. Guerrero-Bustamante, Krista G. Freeman, Whitney E. Harrington, Lisa M. Frenkel, Graham F. Hatfull, Rhea N. Coler, Sasha E. Larsen

“…Abstract For much of the last decade, tuberculosis (TB) was the leading cause of mortality due to an infectious pathogen (Mycobacterium tuberculosis, M.tb). Approximately 1.3 million deaths in 2023 worldwide were attributed to TB disease. …”
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Evaluation of twin-arginine translocation substrate proteins as potential antigen candidates for serodiagnosis of brucellosis by Yao Wu, Yao Wu, Xin Yan, Mingjun Sun, Xiaohan Guo, Jiaqi Li, Xiangxiang Sun, Xiangxiang Sun, Mengda Liu, Mengda Liu, Haobo Zhang, Haobo Zhang, Wenlong Nan, Weixing Shao, Fangkun Wang, Xiaoxu Fan, Xiaoxu Fan, Shufang Sun

“…Both the combined protein group and YxeI displayed no cross-reactivity with rabbit serum immunized against Yersinia enterocolitica O9, Escherichia coli O157:H7, Mycobacterium tuberculosis, Vibrio cholerae, Legionella, and Salmonella, indicating relatively good specificity.ConclusionThe findings of this study suggest that Tat substrate proteins serve as promising candidate antigens with significant potential value for the clinical diagnosis of brucellosis.…”
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Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…This study aimed to assess the efficacy of an IL17A peptide-based vaccine on SpA manifestations in model rats.Methods HLA-B27/human β2-microglobulin (hβ2M) transgenic rats were immunised with heat-inactivated Mycobacterium tuberculosis (MT) to develop spondylitis and arthritis as an experimental SpA model after immunisation with a keyhole limpet hemocyanin-conjugated IL17A peptide-based vaccine with an alum adjuvant three times. …”
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Accuracy of ESAT6-CFP10 skin test compared with tuberculin skin test in a healthy population: a randomized, blind, parallel controlled phase III clinical study by Xiaoyan Ding, Weixin Du, Qiao Liu, Lifeng Tao, Yan Shao, Peng Lu, Huaiyu Yang, Xiaoxue Teng, Cheng Chen, Zhongqi Li, Jinbiao Lu, Aihua Zhao, Guozhi Wang, Miao Xu, Limei Zhu

“…Clinical trials Registration NCT02795260, Clinical Study of Recombinant Mycobacterium Tuberculosis Allergen ESAT6-CFP10 on Healthy People Aged 18–65(III-healthy), Registration Date: June 10, 2016.…”
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Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assays by Sandra Schwarzlose-Schwarck, Mark Reinwald, Torsten Bauer, Florian Hentschel, Til Kiderlen, Dorinja Zapf, Victor Herbst, Stefan Lüth, David Krieger, Werner Dammermann

“…Abstract Background Mycobacterium tuberculosis (MT) infections represent a global health problem and latent tuberculosis infection (LTBI) affects an estimated 25% of the world population. 10.6 million people fell ill with tuberculosis (TB) worldwide in 2021 and a total of 1.6 million TB-associated deaths were reported. …”
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ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway by Xiaofei Huang, Xiaofei Huang, Yuqun Zeng, Jingru Lin, Huazhen Liu, Huazhen Liu, Chun-Ling Liang, Chun-Ling Liang, Yuchao Chen, Yuchao Chen, Feifei Qiu, Feifei Qiu, Jonathan S. Bromberg, Zhenhua Dai, Zhenhua Dai

“…The early secreted antigenic target of 6 kDa (ESAT-6) is a virulence factor and immunoregulatory protein of mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development or activation of various immune cells. …”
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«Green-Ligand» in Metallodrugs Design—Cu(II) Complex with Phytic Acid: Synthetic Approach, EPR-Spectroscopy, and Antimycobacterial Activity by Kseniya A. Koshenskova, Natalia V. Makarenko, Fedor M. Dolgushin, Dmitriy S. Yambulatov, Olga B. Bekker, Matvey V. Fedin, Sergei A. Dementev, Olesya A. Krumkacheva, Igor L. Eremenko, Irina A. Lutsenko

“…The biological activity of <b>1</b> in vitro against the non-pathogenic (model for <i>Mycobacterium tuberculosis</i>) strain of <i>Mycolicibacterium smegmatis</i> is comparable to the first-line drug for tuberculosis treatment, rifampicin.…”
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Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa by Richard Hayes, Sarah Fidler, Sian Floyd, María Rupérez, Helen Ayles, Redwaan Vermaak, Kwame Shanaube, Albertus Schaap, Eveline Klinkenberg, Petra de Haas, Barry Kosloff, Thomas Gachie, Pete J Dodd, Chali Wapamesa, Michael J Burnett, Nico Kalisvaart, Tila Mainga, Linda Mureithi

“…Clinicians reviewed screening and test results; in Zambia, participants with Mycobacterium tuberculosis-positive results were followed up 6–13 months later. …”
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Candidiasis mucocutánea crónica, infecciones micobacterianas y rosácea en un adulto mexicano con aumento de la función en STAT1 by Valeria Valerio-Gómez, Uriel Pérez-Blanco, Guillermo Velázquez-Sámano, Andrea Aída Velasco-Medina, Antonio Albarrán, Itzel Yoselín Sánchez, Laura Berrón-Ruiz, Sara Espinosa-Padilla, Lizbeth Blancas-Galicia

“…Actualmente, tiene 27 años, ha presentado infección por el bacilo de Calmette-Guérin y Mycobacterium tuberculosis, candidiasis mucocutánea crónica, tiña de la cabeza (tinea capitis), y rosácea facial y ocular. …”
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The role of mNGS in the diagnosis of talaromycosis and case series by Jing Zhao, Hui-Ting Su, Dong Zhang, Xue-Tong Li, Min-Ya Lu, Juan Du, Jia-Yu Guo, Yi Gao, Xin-Fei Chen, Dong-Hua Wen, Shi-Yu Jia, Yao Wang, Qi-Wen Yang

“…One of them was mix infected by fungi, bacteria, Mycobacterium tuberculosis and virus, improved by voriconzole and followed by introconaole. …”
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Impact of heteroresistance on treatment outcomes of people with drug-resistant TB by R. Crowder, M. Kato-Maeda, B. Schwem, A. dela Tonga, D.M. Geocaniga-Gaviola, E. Lopez, C.L. Valdez, A.R. Lim, N. Hunat, A.G. Sedusta, C.A. Sacopon, G.A.M. Atienza, E. Bulag, D. Lim, J. Bascuña, K. Shah, R.P. Basillio, C.A. Berger, M.C.D.P. Lopez, S. Sen, C. Allender, M. Folkerts, U. Karaoz, E. Brodie, S. Mitarai, A.M.C. Garfin, M.C. Ama, D.M. Engelthaler, A. Cattamanchi, R. Destura

“…Heteroresistance (presence of susceptible and resistant Mycobacterium tuberculosis in the same sample) has been identified in some people with TB, but its impact on treatment outcomes is unknown. …”
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Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer by Kurt VerCauteren, Abigail Feuka, Michael Lavelle, Michael Glow, Keely Kohen, Patrick Ryan, Tony Aderman, Anthony Duffiney, Mitchell Palmer, Paola M. Boggiatto, Carly Kanipe, Hayden Hamby, Emily Ruell, Melinda Cosgrove, Michael Vanderklok, Nathan Snow, Kim M. Pepin, Henry Campa

“…With apparent prevalence in deer being low (1–2%) but constant, vaccination could be an additional tool to aid in addressing the problem and merits investigation. Mycobacterium tuberculosis Bacillus Calmette-Guérin (BCG) vaccine is a widely used human vaccine for tuberculosis that has also been well studied in domestic livestock and wildlife. …”
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Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens by Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Cristian Melgarejo, Cristian Melgarejo, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Gareth J. Jones, Bernat Pérez de Val, Bernat Pérez de Val

“…Tuberculosis (TB) in goats is a chronic infectious disease caused by Mycobacterium tuberculosis complex (MTBC) organisms that pose a great health and economic challenge for the caprine industry in some European and developing countries. …”
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Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis by José Alberto Choreño-Parra, Luis Armando Jiménez-Álvarez, Ellis Daniela Maldonado-Díaz, Graciela Cárdenas, Luis Alejandro Fernández-Lopez, José Luis Soto-Hernandez, Marcela Muñoz-Torrico, Gustavo Ramírez-Martínez, Alfredo Cruz-Lagunas, Armando Vega-López, María Lilia Domínguez-López, Carlos Sánchez-Garibay, Parménides Guadarrama-Ortíz, Silvia Giono, Luis Antonio Jiménez-Zamudio, Shabaana A. Khader, Ethel A. García-Latorre, Citlaltepetl Salinas-Lara, Joaquín Zúñiga

“…It is currently believed that the spread of Mycobacterium tuberculosis (Mtb) from the lung is an early event that occurs before the establishment of adaptive immunity. …”
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