Unveiling Genital Tuberculosis: India’s hidden Infertility Epidemic by Yashvanthan VR, Angeline Grace G, Sujitha P, Ilam Ilaval T, Hariharan S

“…Hematogenous spread of Mycobacterium tuberculosis leads to chronic inflammation, fibrosis, and scarring of reproductive organs, resulting in irreversible damage. …”
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Autologous Cytokine-Induced Killer Cell Immunotherapy Enhances Chemotherapy Efficacy against Multidrug-Resistant Tuberculosis by Peijun Tang, Xingnian Chen, Junchi Xu, Yunlong Hu, Zhijian Ye, Xiafang Wang, Yumei Xiao, Xinghua Shen, Jianping Zhang, Yanjun Feng, Cuilin Shi, Xin Yu, Lixian Yi, Xinchun Chen, Binfeng Lu, Ping Xu, Zhongwen Sun, Meiying Wu

“…T cell-mediated immunity plays a critical role in controlling Mycobacterium tuberculosis (Mtb) infection, and therefore, enhancing Mtb-specific T cell immune responses represents a promising therapeutic strategy against TB. …”
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Two-centers machine learning analysis for predicting acid-fast bacilli results in tuberculosis sputum tests by Jichong Zhu, Yong Zhao, Chengqian Huang, Chenxing Zhou, Shaofeng Wu, Tianyou Chen, Xinli Zhan

“…Background: Tuberculosis (TB) is a chronic respiratory infectious disease caused by Mycobacterium tuberculosis, typically diagnosed through sputum smear microscopy for acid-fast bacilli (AFB) to assess the infectivity of TB. …”
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Profil Kasus Tuberkulosis Paru di Instalasi Rawat Inap Paru RSUP Dr. M. Djamil Padang Periode 1 Januari 2010 - 31 Desember 2011 by Muhammad Gamal Eddin, Oea Khairsyaf, Elly Usman

“…<br />Keywords: Mycobacterium tuberculosis, tuberculosis, pulmonary tuberculosis<br /><br /><br />…”
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Differentially expressed transcript isoforms associate with resistance to tuberculin skin test and interferon gamma release assay conversion. by Jason D Simmons, R Max Segnitz, Kimberly A Dill-McFarland, Catherine M Stein, Glenna J Peterson, Harriet Mayanja-Kizza, W Henry Boom, Thomas R Hawn

“…Using gene level analytic methods, we previously found distinct monocyte transcriptional responses associated with resistance to Mycobacterium tuberculosis (Mtb) infection defined as persistently negative tuberculin skin test (TST) and interferon gamma release assay (IGRA) reactivity among highly exposed contacts (RSTR phenotype).…”
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Developing a priority global research agenda for antimicrobial resistance in the human health sector: protocol for a scoping review by Alessandro Cassini, Raph L Hamers, Koe Stella Asadinia, Silvia Bertagnolio

“…Introduction To accelerate the response to the public health threat by antimicrobial resistance (AMR), the WHO is developing a Global Research Agenda for AMR in the human health sector that aims to provide a global and transparent assessment of priority knowledge gaps related to critical bacteria—including Mycobacterium tuberculosis—and fungi that inform control and response strategies to tackle AMR by 2030. …”
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Sequential testing with Xpert MTB/RIF assay for diagnosis of tuberculous meningitis in Maharaj Nakorn Chiang Mai University Hospital by Poramed Winichakoon, Kanokwan Watcharasaksilp, Sunisa Butphet, Kanlaya Wongworapat, Chansom Pantip, Phadungkiat Khamnoi, Khuanchai Supparatpinyo, Parichat Salee

“…The Xpert MTB/RIF assay is a rapid and valuable tool for detecting Mycobacterium tuberculosis in centrifuged CSF specimens. A diagnostic algorithm incorporating the TBM score enhances performance, balancing sensitivity and specificity, and could improve patient outcomes in resource-limited settings.…”
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Performance of a score to characterise adequate contact among the social network of persons with TB by M.E. Castellanos, S. Zalwango, T.H.T. Quach, R. Kakaire, L. Martínez, M.H. Ebell, K.K. Dobbin, N. Kiwanuka, C.C. Whalen

“…BACKGROUND: Transmission of Mycobacterium tuberculosis requires adequate contact between an infectious case and a susceptible host. …”
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Hematological profile of pulmonary tuberculosis patients before and after 1 month of taking anti-TB drugs by Ririh Jatmi Wikandari, Surati, Siti Nuryani, Sistoyono

“…Tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis. Indonesia ranks third in the number of global TB cases. …”
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Diagnostic accuracy of cartridge-based nucleic acid amplification test and resistance pattern in new and previously treated tuberculosis cases: A prospective observational study by Ranjit Suva, Gaurang Khadiya, Kinjal D. Rami, Urvashi Modh, Firoz Ghanchi, Yogesh Murugan

“…CBNAAT is a rapid molecular test that detects the genetic material of Mycobacterium tuberculosis (MTB), the bacterium causing TB, in sputum samples. …”
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Severe Tuberculosis Requiring Intensive Care: A Descriptive Analysis by Raquel Pacheco Duro, Paulo Figueiredo Dias, Alcina Azevedo Ferreira, Sandra Margarida Xerinda, Carlos Lima Alves, António Carlos Sarmento, Lurdes Campos dos Santos

“…The diagnosis of isolated pulmonary TB, a positive smear for acid-fast-bacilli and a positive PCR for Mycobacterium tuberculosis in patients of pulmonary disease, severe sepsis/septic shock, acute renal failure and Multiple Organ Dysfunction Syndrome on admission, the need for mechanical ventilation or vasopressor support, hospital acquired infection, use of adjunctive corticotherapy, smoking, and alcohol abuse were significantly associated with mortality (p<0.05). …”
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The role of isoniazid dosage and NAT2 gene polymorphism in the treatment of tuberculous meningitis by Yi Jian, Yuhang Bao, Fashuang Yang, Mei Zhu

“…BackgroundTuberculous meningitis (TBM) is a non-purulent inflammatory condition affecting the meninges and spinal membranes, caused by Mycobacterium tuberculosis (MTB) infection. This study seeks to explore the impact of varying INH dosages and NAT2 gene polymorphisms on TBM treatment, contributing new insights to improve clinical management and patient prognosis.MethodsPatients with TBM hospitalized between July 2020 and December 2022 were categorized into two groups based on INH dosage: the standard-dose group (300 mg/day) and the high-dose group (600 mg/day). …”
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Interferon (IFN)-gamma (γ) inducible protein 10 (IP-10) in the diagnosis of latent and active tuberculosis in Bacille Calmette Guerin (BCG)-vaccinated pediatric population. by Magdalena Druszczynska, Michał Seweryn, Sebastian Wawrocki, Anna Pankowska, Anastasiia Kulbachko, Magdalena Jurczak, Magdalena Kowalewska-Pietrzak

“…Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.tb) infection (LTBI) that have a high risk of progressing to active TB disease remains a significant diagnostic hurdle.…”
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Prevalence and predictors of NTM in presumed/confirmed drug-resistant TB by E.T. Abbew, R. Laryea, F. Sorvor, Y.A. Poku, N. Lorent, D. Obiri-Yeboah, L. Lynen, L. Rigouts

“…The MPT64 assay was performed on positive cultures to distinguish between Mycobacterium tuberculosis complex MTBc and NTM. NTM isolates were re-cultured for species identification using GenoType® Mycobacterium CM/AS line-probe assay, polymerase chain reaction, and Sanger sequencing targeting 16S rRNA and rpoB genes. …”
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Rifampicin-induced Stevens-Johnson Syndrome: A Rare Case Report by Bhaveshkumar Manilal Patel, Mugdha Manaji Kadam, Arti Dhawal Shah, Chirag Chakravarti, Virenkumar Jayendrakumar Patel

“…These drugs are essential for the treatment of TB, a contagious bacterial infection caused by Mycobacterium tuberculosis. However, antitubercular drugs can lead to various skin reactions, which may range from mild to severe. …”
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Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis by Yone Vila Nova Cavalcanti, Maria Carolina Accioly Brelaz, Juliana Kelle de Andrade Lemoine Neves, José Candido Ferraz, Valéria Rêgo Alves Pereira

“…Host immune response against Mycobacterium tuberculosis is mediated by cellular immunity, in which cytokines and Th1 cells play a critical role. …”
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Development of a Highly Biocompatible Antituberculosis Nanodelivery Formulation Based on Para-Aminosalicylic Acid—Zinc Layered Hydroxide Nanocomposites by Bullo Saifullah, Palanisamy Arulselvan, Mohamed Ezzat El Zowalaty, Sharida Fakurazi, Thomas J. Webster, Benjamin Geilich, Mohd Zobir Hussein

“…The developed formulation has a fourfold higher efficacy of PAS against mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) found to be at 1.40 μg/mL compared to the free drug PAS with a MIC of 5.0 μg/mL. …”
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Synthesis and Antitubercular Activity of Heteroaromatic Isonicotinoyl and 7-Chloro-4-Quinolinyl Hydrazone Derivatives by Marcelle de L. Ferreira, Raoni S.B. Gonçalves, Laura N. de F. Cardoso, Carlos R. Kaiser, Andre L.P. Candéa, Maria das Graças M. de O. Henriques, Maria C.S. Lourenço, Flávio A.F.M. Bezerra, Marcus V. N. de Souza

“…Two series of N’(E)-heteroaromatic-isonicotinohydrazide derivatives (3a-f and 4a-b) and 1-(7-chloroquinolin-4-yl)-2-[(heteroaromatic)methylene]hydrazone derivatives (5a-f and 6a-b) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Several compounds were noncytotoxic and exhibited significant minimum inhibitory concentration (MIC) activity (3.12, 2.50, 1.25, or 0.60 μg/mL), which can be compared to that of the first-line drugs ethambutol (3.12 μg/mL) and rifampicin (2.0 μg/ml). …”
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Risk factors of multidrug resistant tuberculosis among patients with tuberculosis at selected multidrug resistance treatment initiative centres in southern Ethiopia: a case-control... by Fantahun Admassu, Ermias Abera, Addisalem Gizachew, Tagesse Sedoro, Taye Gari

“…Cases were all patients with TB with culture proven or line probe assay confirmed Mycobacterium tuberculosis resistant to at least both isoniazid and rifampicin and registered on second-line TB treatment. …”
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Dissociação clinicorradiológica em lactente com tuberculose pulmonar: relato de caso by Débora Elisabeth Sales Vieira, Rafael José Souza Filho, Rebecca da Silva Sales Vieira, Ana Carolina Gonçalves Galeano Arco, Juliènne Martins Araújo, Clarissa Netto dos Reys Laia Franco Prillwitz, Christiane Mello Schmidt, Claudete Araújo Cardoso

“…Pulmonary tuberculosis (TB) is a preventable treatable and infectious disease caused by Mycobacterium tuberculosis (Mtb). The infection occurs through the inhalation of droplets expelled by an individual with the active disease. …”
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