Atypical Radiographic Presentation of Cryptococcus Pneumonia in a Newly Diagnosed HIV Patient by Arthur Cacacho, Umair Ashraf, Arsalan Rehmani, Masooma Niazi, Misbahuddin Khaja

“…Interferon-gamma release assay, Mycobacterium tuberculosis PCR, and acid-fast bacilli staining of the bronchoalveolar lavage were negative for the M. tuberculosis complex. …”
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Identifying skin surface chemicals as potential tuberculosis diagnostic biomarkers using ultra performance liquid chromatography-high resolution mass spectrometry by Madelien Wooding, Kornelis van Pletzen, Yvette Naudé

“…Early and accurate diagnosis of active TB is essential for enhancing patient care, improving outcomes, and interrupting the transmission cycles of Mycobacterium tuberculosis (M.tb). Metabolomics proves to be an emerging area of study for the development of a non-invasive approach to TB diagnostics.. …”
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Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV by Sarah Park, Brian Epling, Morgan Richey, Daniel Lupu, Mona Mughar, Irini Sereti

“…Adding mcfDNA sequencing to UC proportionally increased HHV-8 detection by 38%, while also identifying in 18 (86%) people other microbes of potential interest, including common herpesviruses, Mycobacterium tuberculosis, and Pneumocystis jirovecii. Conclusions: Plasma mcfDNA sequencing may improve UC in detection of HHV-8 infection, especially in immunocompromised outpatients, in whom early detection may facilitate appropriate management to prevent severe KS disease. …”
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Role of GeneXpert MTB/Rif Assay in Diagnosing Tuberculosis in Pregnancy and Puerperium by Zaiyad G. Habib, Farouq M. Dayyab, Abdallah Sanda, Sirajo H. Tambuwal, Mahmood M. Dalhat, Hamza Muhammad, Garba Iliyasu, Ibrahim Nashabaru, Abdulrazaq G. Habib

“…Sputum GeneXpert MTB/Rif (Xpert MTB/RIF) was positive for Mycobacterium tuberculosis. To strengthen maternal and childhood TB control, screening with same-day point-of-care Xpert MTB/RIF is advocated among both HIV positive pregnant women and symptomatic HIV negative pregnant women during antenatal care in pregnancy and at puerperium.…”
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Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? by Laura E. Carreto-Binaghi, Esmeralda Juárez, Silvia Guzmán-Beltrán, María Teresa Herrera, Martha Torres, Alejandro Alejandre, José Arturo Martínez-Orozco, Eduardo Becerril-Vargas, Yolanda Gonzalez

“…Progression of Mycobacterium tuberculosis infection to active disease depends on mycobacterial virulence, environmental diversity, and host susceptibility and immune response. …”
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Additive Effects of Glutathione in Improving Antibiotic Efficacy in HIV–<i>M.tb</i> Co-Infection in the Central Nervous System: A Systematic Review by Leena Nabipur, Michael Mouawad, Vishwanath Venketaraman

“…Results: Preclinical studies showed that GSH improves macrophage antimicrobial function, reduces oxidative stress, and limits <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) growth. Animal models demonstrated reduced bacterial burden in the lungs, liver, and spleen with GSH supplementation, along with enhanced granuloma stability. …”
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Diabetes Mellitus and Increased Tuberculosis Susceptibility: The Role of Short-Chain Fatty Acids by Ekta Lachmandas, Corina N. A. M. van den Heuvel, Michelle S. M. A. Damen, Maartje C. P. Cleophas, Mihai G. Netea, Reinout van Crevel

“…We examined the influence of physiological concentrations of butyrate on cytokine responses to Mycobacterium tuberculosis (Mtb) in human peripheral blood mononuclear cells (PBMCs). …”
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Progress in the role of nanoparticles in the diagnosis and treatment of bone and joint tuberculosis by Yitong Ding, Baiyun Li, Yangfei Yi, Can Liu, Jie Wen, Jie Wen, Xiaohong Jian, Yufei Li

“…Bone and joint tuberculosis (BJTB), caused by Mycobacterium tuberculosis (MTB), is a prevalent form of extrapulmonary tuberculosis that poses significant challenges to global public health due to difficulties in early diagnosis, prolonged treatment cycles, and drug resistance. …”
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Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment by Figen Deveci, H. Handan Akbulut, Teyfik Turgut, M. Hamdi Muz

“…Because the serum IL-12p40, IL-10, TNF-α, and IFN-γ levels were high in APTB, we believe that these cytokines have important roles in the immune response to Mycobacterium tuberculosis (M tuberculosis). These parameters could be used in follow-up as indicators of the success of APTB therapy.…”
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A New Functional Model for Prediction of Chaperone Activity of the Recombinant M. tb Acr (α-Crystallin) Using Insulin as Substrate by Gautam Krishnan, Utpal Roy

“…Mycobacterium tuberculosis Acr is an important protein expressed in latent tuberculosis which is active as an oligomer in preventing misfolding of cellular proteins. …”
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Unveiling Genital Tuberculosis: India’s hidden Infertility Epidemic by Yashvanthan VR, Angeline Grace G, Sujitha P, Ilam Ilaval T, Hariharan S

“…Hematogenous spread of Mycobacterium tuberculosis leads to chronic inflammation, fibrosis, and scarring of reproductive organs, resulting in irreversible damage. …”
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Autologous Cytokine-Induced Killer Cell Immunotherapy Enhances Chemotherapy Efficacy against Multidrug-Resistant Tuberculosis by Peijun Tang, Xingnian Chen, Junchi Xu, Yunlong Hu, Zhijian Ye, Xiafang Wang, Yumei Xiao, Xinghua Shen, Jianping Zhang, Yanjun Feng, Cuilin Shi, Xin Yu, Lixian Yi, Xinchun Chen, Binfeng Lu, Ping Xu, Zhongwen Sun, Meiying Wu

“…T cell-mediated immunity plays a critical role in controlling Mycobacterium tuberculosis (Mtb) infection, and therefore, enhancing Mtb-specific T cell immune responses represents a promising therapeutic strategy against TB. …”
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Two-centers machine learning analysis for predicting acid-fast bacilli results in tuberculosis sputum tests by Jichong Zhu, Yong Zhao, Chengqian Huang, Chenxing Zhou, Shaofeng Wu, Tianyou Chen, Xinli Zhan

“…Background: Tuberculosis (TB) is a chronic respiratory infectious disease caused by Mycobacterium tuberculosis, typically diagnosed through sputum smear microscopy for acid-fast bacilli (AFB) to assess the infectivity of TB. …”
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Profil Kasus Tuberkulosis Paru di Instalasi Rawat Inap Paru RSUP Dr. M. Djamil Padang Periode 1 Januari 2010 - 31 Desember 2011 by Muhammad Gamal Eddin, Oea Khairsyaf, Elly Usman

“…<br />Keywords: Mycobacterium tuberculosis, tuberculosis, pulmonary tuberculosis<br /><br /><br />…”
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Differentially expressed transcript isoforms associate with resistance to tuberculin skin test and interferon gamma release assay conversion. by Jason D Simmons, R Max Segnitz, Kimberly A Dill-McFarland, Catherine M Stein, Glenna J Peterson, Harriet Mayanja-Kizza, W Henry Boom, Thomas R Hawn

“…Using gene level analytic methods, we previously found distinct monocyte transcriptional responses associated with resistance to Mycobacterium tuberculosis (Mtb) infection defined as persistently negative tuberculin skin test (TST) and interferon gamma release assay (IGRA) reactivity among highly exposed contacts (RSTR phenotype).…”
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Developing a priority global research agenda for antimicrobial resistance in the human health sector: protocol for a scoping review by Alessandro Cassini, Raph L Hamers, Koe Stella Asadinia, Silvia Bertagnolio

“…Introduction To accelerate the response to the public health threat by antimicrobial resistance (AMR), the WHO is developing a Global Research Agenda for AMR in the human health sector that aims to provide a global and transparent assessment of priority knowledge gaps related to critical bacteria—including Mycobacterium tuberculosis—and fungi that inform control and response strategies to tackle AMR by 2030. …”
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Sequential testing with Xpert MTB/RIF assay for diagnosis of tuberculous meningitis in Maharaj Nakorn Chiang Mai University Hospital by Poramed Winichakoon, Kanokwan Watcharasaksilp, Sunisa Butphet, Kanlaya Wongworapat, Chansom Pantip, Phadungkiat Khamnoi, Khuanchai Supparatpinyo, Parichat Salee

“…The Xpert MTB/RIF assay is a rapid and valuable tool for detecting Mycobacterium tuberculosis in centrifuged CSF specimens. A diagnostic algorithm incorporating the TBM score enhances performance, balancing sensitivity and specificity, and could improve patient outcomes in resource-limited settings.…”
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Performance of a score to characterise adequate contact among the social network of persons with TB by M.E. Castellanos, S. Zalwango, T.H.T. Quach, R. Kakaire, L. Martínez, M.H. Ebell, K.K. Dobbin, N. Kiwanuka, C.C. Whalen

“…BACKGROUND: Transmission of Mycobacterium tuberculosis requires adequate contact between an infectious case and a susceptible host. …”
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Severe Tuberculosis Requiring Intensive Care: A Descriptive Analysis by Raquel Pacheco Duro, Paulo Figueiredo Dias, Alcina Azevedo Ferreira, Sandra Margarida Xerinda, Carlos Lima Alves, António Carlos Sarmento, Lurdes Campos dos Santos

“…The diagnosis of isolated pulmonary TB, a positive smear for acid-fast-bacilli and a positive PCR for Mycobacterium tuberculosis in patients of pulmonary disease, severe sepsis/septic shock, acute renal failure and Multiple Organ Dysfunction Syndrome on admission, the need for mechanical ventilation or vasopressor support, hospital acquired infection, use of adjunctive corticotherapy, smoking, and alcohol abuse were significantly associated with mortality (p<0.05). …”
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The role of isoniazid dosage and NAT2 gene polymorphism in the treatment of tuberculous meningitis by Yi Jian, Yuhang Bao, Fashuang Yang, Mei Zhu

“…BackgroundTuberculous meningitis (TBM) is a non-purulent inflammatory condition affecting the meninges and spinal membranes, caused by Mycobacterium tuberculosis (MTB) infection. This study seeks to explore the impact of varying INH dosages and NAT2 gene polymorphisms on TBM treatment, contributing new insights to improve clinical management and patient prognosis.MethodsPatients with TBM hospitalized between July 2020 and December 2022 were categorized into two groups based on INH dosage: the standard-dose group (300 mg/day) and the high-dose group (600 mg/day). …”
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