Intracellular Cytokine Flow Cytometry to Differentiate between Active and Latent Tuberculosis through Assessment of Tuberculosis-specific Cytokines by Sindhura Lakshmi Koulmane Laxminarayana, Sushma Belurkar, Kavitha Saravu, Shilna Muttickal Swaminathan

“…We studied the role of ICCFC in differentiating active pulmonary TB (Mycobacterium tuberculosis [MTB]) from LTBI in comparison with QFT. …”
Get full text

Mycoketide: A CD1c-Presented Antigen with Important Implications in Mycobacterial Infection by Isamu Matsunaga, Masahiko Sugita

“…Mycobacterium tuberculosis and related mycobacteria species are unique in that the acid-fast bacilli possess a highly lipid-rich cell wall that not simply confers resistance to treatment with acid alcohol, but also controls their survival and virulence. …”
Get full text

Inflammasomes, Autophagy, and Cell Death: The Trinity of Innate Host Defense against Intracellular Bacteria by Teresa Krakauer

“…Contrasting evasion strategies used by B. pseudomallei, Mycobacterium tuberculosis, and Legionella pneumophila to avoid and dampen these innate immune responses will be discussed.…”
Get full text

Viability Reagent, PrestoBlue, in Comparison with Other Available Reagents, Utilized in Cytotoxicity and Antimicrobial Assays by Namrita Lall, Cynthia Joan Henley-Smith, Marco Nuno De Canha, Carel Basson Oosthuizen, Danielle Berrington

“…The growth indicator reagents include p-iodonitrotetrazolium violet (INT), PrestoBlue, and Alamar Blue which were used for antimicrobial analysis against Streptococcus mutans, Prevotella intermedia, Propionibacterium acnes, and Mycobacterium tuberculosis. PrestoBlue and Alamar Blue are resazurin based reagents that resulted in a quick and easily distinguishable colour change that allowed for visual readings. …”
Get full text

The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis by Nazar Trotsko, Agnieszka Głogowska, Barbara Kaproń, Katarzyna Kozieł, Ewa Augustynowicz-Kopeć, Agata Paneth

“…The TZD-based hybrids with the thiosemicarbazone or the pyridinecarbohydrazone moiety were synthesised and their antimycobacterial activity was investigated against the reference H37Rv and two wild Mycobacterium tuberculosis (Mtb) strains. In further studies, a two-drug interaction analysis was also performed for assessing their synergism with the current first-line drugs used for the treatment of TB. …”
Get full text

Perbandingan Profil Penderita Tuberkulosis Paru antara Perokok dan Non Perokok di Poliklinik Paru RSUP. Dr. M. Djamil Padang by Cantika Dinia Zulda, Rizanda Machmud, Irvan Medison

“…Salah satu faktor risiko yang dapat menurunkan daya tahan tubuh terhadap bakteri Mycobacterium tuberculosis adalah faktor merokok. Menurut Public Health Agency of Canada terdapat hubungan yang erat antara merokok dengan TB. …”
Get full text

Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV by Anna K. Coussens, Adrian R. Martineau, Robert J. Wilkinson

“…Vitamin D metabolites can increase antimicrobial activity in innate immune cells, which, in the context of HIV-1 coinfection, have insufficient T cell-mediated help to combat Mycobacterium tuberculosis (MTB) infection. Moreover, maintaining vitamin D sufficiency prior to MTB infection enhances the innate antimicrobial response to T cell-mediated interferon-γ. …”
Get full text

Spatial epidemiological analysis based on township scale and analysis of influencing factors of pulmonary tuberculosis cure of Changshu city from 2015 to 2022. by Xiao-Yan Xu, Zheng-Yuan Zhou, Li-Qiang Gong, Li-Qiang Xu, Xiao-Kang Jiao, Bian Yin, Tian-Hong Jiang

“…Shorter diagnosis delay days and mycobacterium tuberculosis (MTB) promote the cure of tuberculosis, while drug sensitivity was a risk factor for its cure.…”
Get full text

Tuberculosis of the thyroid gland: A rare case report by Manisha Kamlesh Galani, Kamlesh Jamnadas Galani, Swati Nileshkumar Lakhani

“…Confirmation typically involves detecting acid-fast bacilli through staining techniques like Ziehl Neelsen (ZN), molecular diagnostic methods such as TB Gene Expert or polymerase chain reaction for Mycobacterium tuberculosis (TB PCR), and histopathological examination of excised specimens. …”
Get full text

Spatial Spread of Tuberculosis through Neighborhoods Segregated by Socioeconomic Position: A Stochastic Automata Model by David Rehkopf, Alice Furumoto-Dawson, Anthony Kiszewski, Tamara Awerbuch-Friedlander

“…Transmission of the agent of tuberculosis, Mycobacterium tuberculosis, is dependent on social context. …”
Get full text

Immune Vulnerability of Infants to Tuberculosis by Koen Vanden Driessche, Alexander Persson, Ben J. Marais, Pamela J. Fink, Kevin B. Urdahl

“…A downside of this bias is that several factors critical for controlling Mycobacterium tuberculosis infection are significantly restricted in infants, including TNF, IL-1, and IL-12. …”
Get full text

Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting by Iukary Takenami, Brook Finkmoore, Almério Machado, Krisztina Emodi, Lee W. Riley, Sérgio Arruda

“…The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. …”
Get full text

Exploration of Lipid Metabolism Alterations in Children with Active Tuberculosis Using UHPLC-MS/MS by Baixu Sun, Fang Liu, Qingqin Yin, Tingting Jiang, Min Fang, Li Duan, Shuting Quan, Xue Tian, Adong Shen, Kaixia Mi, Lin Sun

“…Therefore, the study was performed to explore lipid metabolic changes caused by Mycobacterium tuberculosis infection and identify specific lipids as diagnostic biomarkers in children with TB using UHPLC-MS/MS. …”
Get full text

The impact of tuberculosis-induced hyperglycemia on pulmonary microbiota and airway mucus secretion in individuals not previously diabetic: A systematic review and meta-analysis pr... by Victor Moses Musyoki, Marianne Mureithi, Annamari Heikinheimo, Elizabeth Maleche-Obimbo, Kariuki Njaanake, Omu Anzala

“…Infection with Mycobacterium tuberculosis, psychological stress associated with the tuberculosis (TB) disease, and the metabolites from the rifampicin treatment regimen have been reported to induce hyperglycemia and consequently type 2 diabetes mellitus (T2DM) in individuals not previously diabetic. …”
Get full text

The Value of Routine Polymerase Chain Reaction Analysis of Intraocular Fluid Specimens in the Diagnosis of Infectious Posterior Uveitis by Marius A. Scheepers, Karin A. Lecuona, Graeme Rogers, Catey Bunce, Craig Corcoran, Michel Michaelides

“…PCR analysis was performed for cytomegalovirus, varicella zoster virus, herpes simplex virus types 1 and 2, Toxoplasma gondii, and Mycobacterium tuberculosis. Results. PCR analysis confirmed the initial clinical diagnosis in 55 patients (35%) and altered the initial clinical diagnosis in 36 patients (23%). …”
Get full text

Disseminated tuberculosis masquerading as a psychiatric illness—A case report by Shalini Bhaskar, Mimi N. M. Noh

“…Pus drained from the collection showed mycobacterium tuberculosis bacteria on staining with ZN stain. …”
Get full text

Immune Response to Mycobacterial Infection: Lessons from Flow Cytometry by Nikoletta Rovina, Marios Panagiotou, Konstantinos Pontikis, Magdalini Kyriakopoulou, Nikolaos G. Koulouris, Antonia Koutsoukou

“…This paper reviews the current diagnostic tools for mycobacterial infection and focuses on the application of flow cytometry as a promising method for rapid and reliable diagnosis of mycobacterial infection as well as discrimination between active and latent TB: it summarizes diagnostic biomarkers distinguishing the two states of infection and also features of the distinct immune response against Mycobacterium tuberculosis (Mtb) at certain stages of infection as revealed by flow cytometry to date.…”
Get full text

Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes by Martin Krátký, Eva Novotná, Shalini Saxena, Perumal Yogeeswari, Dharmarajan Sriram, Markéta Švarcová, Jarmila Vinšová

“…The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicylanilide diethyl phosphates represent new candidates with significant inhibitory activity especially against L-alanine dehydrogenase. …”
Get full text

Peritoneal Tuberculosis in an Immunocompetent, Unknown Risk Patient by Yutaka Tomizawa, Emmanuelle B. Yecies, Fiona E. Craig, Adam Sohnen

“…Mesenteric lymph node tissue culture subsequently grew Mycobacterium tuberculosis complex and the diagnosis of peritoneal tuberculosis was confirmed. …”
Get full text

Tuberculous cardiac tamponade presenting as severe hypoxic hepatitis by Valdes Roberto Bollela, Fernanda Guioti Puga, Rodrigo Carvalho Santana

“…A total of 640 ml of hemorrhagic fluid was drained, with significant clinical improvement after the procedure. Mycobacterium tuberculosis was isolated from the gastric lavage and pericardial fluid cultures. …”
Get full text