Two Small Peptides from <i>Buthus martensii</i> Hydrolysates Exhibit Antitumor Activity Through Inhibition of TNF-α-Mediated Signal Transduction Pathways by Mengshuang Zhu, Shanshan Zhang, Jiyang Tang, Hairong Hou, Lizhen Wang, Houwen Lin, Xuanming Zhang, Meng Jin

“…Mechanistically, AK and GK inactivated the TNF-α/EGFR/STAT3-signaling pathway, decreased c-myc protein expression levels, and upregulated p53 and PTEN expression, thereby preventing TNF-α-induced tumor growth. …”
Get full text

Spermine Enhances the Peroxidase Activities of Multimeric Antiparallel G-quadruplex DNAzymes by Raphael I. Adeoye, Theresia K. Ralebitso-Senior, Amanda Boddis, Amanda J. Reid, Francesca Giuntini, Amos A. Fatokun, Andrew K. Powell, Adaoha Ihekwaba-Ndibe, Sylvia O. Malomo, Femi J. Olorunniji

“…In this study, we examined the effects of spermine on the catalytic activities of multivalent constructs of Bcl2, c-MYC, PS2.M, and PS5.M. Our findings show that spermine significantly improved the peroxidase activity of PS2.M, an antiparallel G4 DNAzyme, while there was no significant effect on c-MYC, which already exists in a parallel conformation. …”
Get full text

Migration of primordial germline cells is negatively regulated by surrounding somatic cells during early embryogenesis in Drosophila melanogaster by N. V. Dorogova, A. S. Khruscheva, Iu. A. Galimova, D. Yu. Oshchepkov, D. E. Maslov, E. D. Shvedkina, K. A. Akhmetova, S. A. Fedorova

“…These genes can be divided into two groups: 1) modulators of JAK/STAT pathway activity inducing PGC migration (stat92E, Tre-1, hop), and 2) myc and Hph involved in epithelial morphogenesis and polarization, i.e. modifying the permeability of the epithelial barrier. …”
Get full text

ERF114/115/109 are essential for jasmonate-repressed non-canonical JAZ8 activity in JA signaling by Jiaxuan Sui, Qianlan Yin, Yiying Chen, Min Sun, Xianzheng Yuan, Zhaojun Ding, Xiangpei Kong

“…This interaction disrupts the formation of the MYC2/3/4-JAZ8 and root hair defective 6 (RHD6)-JAZ8 complexes. …”
Get full text

Pharmacological Mechanism of Zuojin Pill for Gastroesophageal Reflux Disease: A Network Pharmacology Study by Mi Lv, Jinke Huang, Jiayan Hu, Wenxi Yu, Ping Liu, Kunli Zhang, Fengyun Wang

“…Furthermore, quercetin, kaempferol, and coptisine, the three key components of ZJP were shown to stably bond with the 14 core target genes, including AKT1, MMP2, TP53, EGFR, JUN, CASP3, CXCL8, HIF1α, IL-1β, MYC, PPARG, MMP9, PTGS2, and FOS. Results from MDS showed that PPARG-quercetin and MMP2-quercetin bound more stably. …”
Get full text

The m6A Methylation-Regulated AFF4 Promotes Self-Renewal of Bladder Cancer Stem Cells by Qian Gao, Jin Zheng, Zegui Ni, Pengli Sun, Congcong Yang, Maosheng Cheng, Mingqing Wu, Xiuhong Zhang, Lin Yuan, Yingyin Zhang, Yang Li

“…AFF4 binds to the promoter regions and sustains the transcription of SOX2 and MYC which have critical biological functions in BCSCs. …”
Get full text

Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments by Beihui He, Zheng Chen, Yunmeng Nie, Minmin Luo, Sumei Xu, Junbin Yan, Zhiyun Chen

“…The results of WB and qRT–PCR showed that the expression of PTGS2, JUN, MYC, and CDKN1A was higher in NASH rats than in normal rats and decreased after SQP treatment. …”
Get full text

Mechanism of Spica Prunellae in Suppressing Proliferation and Stem Cell Properties of Colorectal Cancer Cells Based on Notch Signaling Pathway by TIAN Haoyuan, XIE Yi, FANG Yi, CHENG Ying, LIN Yan, SU Daifeng, WEI Lihui

“…Western blot method was used to detect the relative expression of c-Myc, CD44, CD133, SOX2 and Notch pathway-related proteins Notch1 and Hes1 in colorectal cancer cells.ResultsCompared with the control group, the proliferation and viability of colorectal cancer SW480 cells in the 0.1, 0.2, and 0.4 mg/mL groups were significantly inhibited with the increase of Spica Prunellae concentration (<italic>P</italic>&lt;0.05). …”
Get full text

Mechanism of <italic>Hedyotis Diffusa</italic> in Treatment of Osteosarcoma based on Network Pharmacology and Molecular Docking by Qin LIU, Xinwei DUAN, Xihai LI

“…After topology analysis to PPI, the eight core genes that indicate a close interaction were estrogen receptor 1(ESR1), JUN, and RAC-alpha serine/threonine-protein kinase(AKT1), G1/S-specific cyclin-D1(CCND1), FOS, mitogen-activated protein kinase 1(MAPK1), cellular tumor antigen p53(TP53)and MYC. The 2, 037 results of biological process(BP), 39 results of cellular components(CC)and 129 results of molecular function(MF)together constituted 2, 205 results of GO enrichment analysis with <italic>P</italic>&lt;0.05. …”
Get full text

白茅苷缓解STZ诱导的I型糖尿病幼龄鼠肝损伤 by 丁艳琴, 汤兴萍, 徐奎, 李萍, 李玲

“…糖耐量实验检测各组小鼠空腹血糖、血清胰岛素和肥胖指数，自动生化分析仪测定血清中高密度脂蛋白、低密度脂蛋白、甘油三酯、总胆固醇含量，苏木精-伊红染色观察肝损伤程度，末端标记染色观察细胞凋亡情况，试剂盒检测超氧化物歧化酶（SOD）和丙二醛（MDA）含量水平，免疫印迹法检测线粒体中Bax/Bcl-2、cleaved cas3/cas3、c-Myc表达水平，酶联免疫吸附试验（ELISA）检测血清中白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白介素-1β（IL-1β）含量。…”
Get full text

Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming by Androniki Kretsovali, Christiana Hadjimichael, Nikolaos Charmpilas

“…In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. …”
Get full text

STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration by Shuichiro Takashima, Roshan Sharma, Winston Chang, Marco Calafiore, Ya-Yuan Fu, Suze A. Jansen, Takahiro Ito, Anastasiya Egorova, Jason Kuttiyara, Viktor Arnhold, Jessica Sharrock, Endi Santosa, Ojasvi Chaudhary, Heather Geiger, Hiromi Iwasaki, Chen Liu, Joseph Sun, Nicolas Robine, Linas Mazutis, Caroline A. Lindemans, Alan M. Hanash

“…Investigating the mechanistic basis underlying this epithelial response, ISC STAT1 expression in GVHD has been found to correlate with upregulation of ISC c-Myc. Furthermore, activated T cells have stimulated Interferon-γ-dependent epithelial regeneration in co-cultured organoids, and Interferon-γ has directly induced STAT1-dependent c-Myc expression and ISC proliferation. …”
Get full text

Clinicopathological analysis of adrenal intravascular large B-cell lymphoma by LIN Jiaxin, WEI Ran, SHUI Ruohong, LU Hongfen, LI Xiaoqiu, YU Baohua

“…The majority of our patients were non-GCB phenotype, often accompanied by MYC/BCL2 double expression, and MYD88 non-L265P mutation was detected. …”
Get full text

NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling by Mikael S. Lindström

“…In addition, NPM1 plays an important role in the Myc-ARF-p53 pathway as well as in SUMO regulation. …”
Get full text

GENES DETERMINING COLORATION OF DIFFERENT ORGANS IN WHEAT by E. K. Khlestkina

“…The data on comparative mapping together with the results of recent studies dedicated to cloning and functions of genes determining coloration in wheat suggest that these genes belong to the Myb- and Myc-like families of genes, encoding transcriptional activators for structural genes involved in plant flavonoid pigments biosynthesis.…”
Get full text

miR-130b-5p下调胰岛素样生长因子-1抑制人绒毛膜滋养层细胞迁移及侵袭的作用及机制 by 相萌, 张旭东

“…结果双荧光素酶报告基因结果显示，<italic>IGF-1</italic>是miR-130b-5p的潜在靶基因；相较于miR-NC组，miR-130b-5pmimics组中miR-130b-5p表达水平、细胞增殖抑制率、钙粘附蛋白E（E-cadherin）表达水平显著增加，IGF-1、c-Myc、细胞周期蛋白D1（CyclinD1）表达水平、迁移距离、侵袭细胞数、基质金属蛋白酶9（MMP9）、基质金属蛋白酶2（MMP2）、神经型钙粘附蛋白（N-cadherin）和波形蛋白（Vimentin）表达水平显著降低（<italic>P</italic>＜0.05）；相较于miR-130b-5pmimics+pcDNA3.1组，miR-130b-5pmimics+pcDNA3.1-IGF-1组中细胞增殖抑制率、E-cadherin表达水平显著降低，c-Myc、CyclinD1表达水平、迁移距离、侵袭细胞数、MMP9、MMP2、Vimentin和N-cadherin表达水平显著增加（<italic>P</italic>＜0.05）。…”
Get full text

MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment by Di Cao, Shi-Juan Mai, Hui-yun Wang, Ge Ren, Yue-Ning Wang, Chao-Yue Sun, Haojiang Li, Yu-Feng Zhou, Mei-Yin Zhang, Shuo-Cheng Wang

“…Understanding the underlying mechanisms by which MAF1 enhances anti-tumor immunity in HCC is crucial for developing novel immunotherapy strategies and enhancing clinical responses to treatment for patients with HCC.Methods Mice were subjected to hydrodynamic tail vein injections of transposon vectors to overexpress AKT/NRas, or c-Myc, with or without wild-type (WT) or mutant-activated (−4A) MAF1, or short-hairpin MAF1 (shMAF1). …”
Get full text

N-Acetylglucosamine Functions in Cell Signaling by James B. Konopka

“…O-linked attachment of GlcNAc to Ser and Thr residues regulates a variety of intracellular proteins, including transcription factors such as NFκB, c-myc, and p53. In addition, the specificity of Notch family receptors for different ligands is altered by GlcNAc attachment to fucose residues in the extracellular domain. …”
Get full text

The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. by Patrick A Carroll, Brian W Freie, Pei Feng Cheng, Sivakanthan Kasinathan, Haiwei Gu, Theresa Hedrich, James A Dowdle, Vivek Venkataramani, Vijay Ramani, Xiaoying Wu, Daniel Raftery, Jay Shendure, Donald E Ayer, Charles H Muller, Robert N Eisenman

“…These in vivo and in vitro studies implicate MLX and other members of the proximal MYC network, such as MNT, in regulation of metabolism and differentiation, as well as in suppression of intrinsic and extrinsic death signaling pathways in both spermatogenesis and male germ cell tumors (MGCTs).…”
Get full text

Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature by Carlos Zagalo, Francesca Pierdomenico, José Cabeçadas, Pedro David Santos

“…The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. …”
Get full text