Transmembrane Amino Acid Transporters in Shaping the Metabolic Profile of Breast Cancer Cell Lines: The Focus on Molecular Biological Subtype by Elena I. Dyachenko, Lyudmila V. Bel’skaya

“…In addition to the main signaling pathway PI3K/Akt/mTOR, the activity of the oncogene c-Myc, HIF, p53, GATA2, NF-kB and MAT2A have a direct effect on the amino acid metabolism of cancer cells, their growth and proliferation, as well as the maintenance of homeostatic equilibrium. …”
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Development of submerged cultivation method for vaccine Mycoplasma mycoides subsp. mycoides strain by O. G. Lapteva

“…Membersof Mycоplasmagenusare widely spreadin nature (soil, water, manure, cereals, foodproducts), andthereareonespathogenic for humans, animals andbirds. …”
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Downregulation of TET1 Promotes Glioma Cell Proliferation and Invasion by Targeting Wnt/β-Catenin Pathway by Jianwen Ji, Qiuxiang You, Jidong Zhang, Yutao Wang, Jing Cheng, Xiangyun Huang, Yundong Zhang

“…It was found that downregulation of TET1 could promote the proliferation migration and invasion of glioma cells and the concomitant upregulation of β-catenin, and its downstream targets like cyclinD1 and c-myc were observed. The further rescue experiments were performed, wherein downregulation of β-catenin markedly decreases glioma cell proliferation in vitro and in vivo. …”
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Mechanistic Insights into the Inhibition of Colorectal Cancer by BuShenFang through Adenomatous Polyposis Coli Expression and Wnt/β-catenin Pathway Regulation by Khang Wen Goh, Jie Ji, Hiu Ching Phang, Xian Gu, Rajesh Sreedharan Nair, Xiaohui Wei, Mohammed Tahir Ansari, Kai Bin Liew

“…Furthermore, Western blot results revealed that BSF enhanced adenomatous polyposis coli (APC) expression and inhibited β-catenin, c-Myc, and Cyclin D1, key proteins in the Wnt/β-catenin pathway. …”
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Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas by Rolf Aamodt, Kristin Jonsdottir, Solveig Norheim Andersen, Johan Bondi, Geir Bukholm, Ida R. K. Bukholm

“…There were highly significant differences between the rectal and the colon cancers in the protein expression of cyclin D1, cyclin D3, cyclin E, nuclear β-catenin, and c-Myc and in gene amplification of cyclin A2, cyclin B1, cyclin D1, and cyclin E. …”
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The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…Crucially, PERs modulate cancer cell behaviors including proliferation, apoptosis, and migration by influencing the levels of cell cycle proteins and stimulating the expression of oncogenes c-Myc and MDM2. PER2/3, as antagonists in cancer stem cell biology, play important roles in differentiating cancer stem cells and in maintaining their stemness. …”
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GENES DETERMINING THE SYNTHESIS OF LAVONOID AND MELANIN PIGMENTS IN BARLEY by O. Yu. Shoeva, K. V. Strygina, E. K. Khlestkina

“…The Ant1 and Ant2 genes, determining the accumulation of anthocyanins in grain pericarp, the Ant28 gene controlling the biosynthesis of proanthocyanidins (condensed tannins) in seed coat, as well as the HvMpc2, HvMyc2 and HvWD40 genes responsible for the accumulation of anthocyanins in the aleurone layer of barley grain have been determined. …”
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The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming by Bharathi Suresh, Junwon Lee, Kye-Seong Kim, Suresh Ramakrishna

“…In this review, we have summarized the importance of the ubiquitination of core stem cell transcription factors, such as Oct3/4, c-Myc, Sox2, Klf4, Nanog, and LIN28, during cellular reprogramming. …”
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Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling In Vitro by Reto Eggenschwiler, Komal Loya, Malte Sgodda, Francoise André, Tobias Cantz

“…Direct reprogramming of somatic cells into pluripotent cells by retrovirus-mediated expression of OCT4, SOX2, KLF4, and C-MYC is a promising approach to derive disease-specific induced pluripotent stem cells (iPSCs). …”
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Effect of Codonopsis pilosula Polysaccharides on the Growth and Motility of Hepatocellular Carcinoma HepG2 Cells by Regulating β-Catenin/TCF4 Pathway by Yuan-yuan Zhang, Ying-mei Zhang, Hai-yan Xu

“…Other than that, downregulation of β-catenin, TCF4, and c-Myc protein expression (P<0.05) was observed as well. …”
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Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells by Yinxiang Wang, Jessica Aijia Liu, Keith K. H. Leung, Mai Har Sham, Danny Chan, Kathryn S. E. Cheah, Martin Cheung

“…Following retroviral transduction of Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc), enriched population of osteoblasts underwent silencing of Osx1-GFP::Cre expression at early stage of reprogramming followed by late activation of Oct4-EGFP expression in the resulting iPS cells. …”
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Genetic advancements in breast cancer treatment: a review by Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

“…CRISPR/Cas9 enables precise gene editing to correct mutations in oncogenes like HER2 and MYC, directly addressing tumor growth and immune evasion. …”
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The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s by Lilin Gan, Wenzheng Luo, Qian Cheng, Shanke Wan, Min Wu, Mingqi Wang, Enming Luo, Xianjin Luo, Shuo Li

“…The human C-MYC promoter and telomere G4 DNA structures were widely recognized as promising targets for cancer therapy. …”
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Enitociclib, a selective CDK9 inhibitor: in vitro and in vivo preclinical studies in multiple myeloma by Son Tran, Patrick Sipila, Melanie M. Frigault, Beatrix Stelte-Ludwig, Amy J. Johnson, Joseph Birkett, Raquel Izumi, Ahmed Hamdy, Ranjan Maity, Nizar J. Bahlis, Paola Neri, Aru Narendran

“…Enitociclib inhibited the phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II at Ser2/Ser5 and repressed the protein expression of oncogenes c-Myc, myeloid cell leukemia-1 (Mcl-1), and proliferating cell nuclear antigen (PCNA) in MM cells. …”
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Expression evaluation of exogenous and endogenous alcohol dehydrogenase genes in transgenic Arabidopsis by Haoqiang Yu, Hong Lv, Fengzhong Lu, Qingqing Yang, Huaming Duan, Wanchen Li, Fengling Fu

“…To detect the differences in expression, protein accumulation, and enzyme activity between transformed exogenous and endogenous genes, the coding sequences (CDSs) of the alcohol dehydrogenase (ADH) genes were cloned from dicotyledonous Arabidopsis, monocotyledonous maize, and prokaryotic Escherichia coli, constructed into expression vector pBI121-cMycNY, and used to transform wild-type Arabidopsis, respectively. …”
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Wnt1 Accelerates an Ex Vivo Expansion of Human Cord Blood CD34+CD38− Cells by Kamonnaree Chotinantakul, Patcharee Prasajak, Wilairat Leeanansaksiri

“…The expanded cells exhibited CD34+ CD38− CD133+ CD71low CD33low CD3− CD19− markers, expressed nanog, oct3/4, c-myc, and sox2 genes, and maintained differentiation potential into lymphoid, erythroid and myeloid lineages. …”
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Myeloma cell-derived CXCL7 facilitates proliferation of tumor cells and occurrence of osteolytic lesions through JAK/STAT3 pathway by Yue Wang, Tianwei Lan, Qiongyan Zhang, Chi Zhou, Peng Liu

“…Concurrently, it was discovered that CXCL7 could activate the JAK/STAT3 pathway via CXCR2 and upregulate the expression levels of MMP13 and C-myc, facilitating MM cell proliferation and activation of the osteoclast signaling pathway. …”
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Establishment of Novel Limbus-Derived, Highly Proliferative ABCG2+/ABCB5+ Limbal Epithelial Stem Cell Cultures by Eung Kweon Kim, Ga-Hyun Lee, Boram Lee, Yong-Sun Maeng

“…In addition, cultured LESCs expressed high levels of the stem cell markers Sox2, Oct4, c-Myc, and Klf4, had high telomerase activity, and had stable, normal genomes. …”
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EBV-Negative Monomorphic B-Cell Posttransplant Lymphoproliferative Disorder with Marked Morphologic Pleomorphism and Pathogenic Mutations in ASXL1, BCOR, CDKN2A, NF1, and TP53 by Agata M. Bogusz

“…Fluorescence in situ hybridization studies (FISH) were negative for cMYC, BCL2, and BCL6 rearrangements but showed deletion of TP53 and monosomy of chromosome 17. …”
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Hypoxia-driven mobilization of altruistic cancer stem cells in platinum-treated head and neck cancer by Lekhika Pathak, Lekhika Pathak, Lekhika Pathak, Bidisha Pal, Bidisha Pal, Joyeeta Talukdar, Partha Jyoti Saikia, Sorra Sandhya, Wale Tasabehji, Wale Tasabehji, Hong Li, Jyotirmoy Phukan, Jyotirmoy Phukan, Anjan Bhuyan, Sanjukta Patra, Bikul Das, Bikul Das, Bikul Das, Bikul Das, Bikul Das

“…This TSD phenotype involves the activation of the MYC-HIF2α pathway and, importantly, is linked to a hypoxic tumor microenvironment. …”
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