Spermine Enhances the Peroxidase Activities of Multimeric Antiparallel G-quadruplex DNAzymes by Raphael I. Adeoye, Theresia K. Ralebitso-Senior, Amanda Boddis, Amanda J. Reid, Francesca Giuntini, Amos A. Fatokun, Andrew K. Powell, Adaoha Ihekwaba-Ndibe, Sylvia O. Malomo, Femi J. Olorunniji

“…In this study, we examined the effects of spermine on the catalytic activities of multivalent constructs of Bcl2, c-MYC, PS2.M, and PS5.M. Our findings show that spermine significantly improved the peroxidase activity of PS2.M, an antiparallel G4 DNAzyme, while there was no significant effect on c-MYC, which already exists in a parallel conformation. …”
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Migration of primordial germline cells is negatively regulated by surrounding somatic cells during early embryogenesis in Drosophila melanogaster by N. V. Dorogova, A. S. Khruscheva, Iu. A. Galimova, D. Yu. Oshchepkov, D. E. Maslov, E. D. Shvedkina, K. A. Akhmetova, S. A. Fedorova

“…These genes can be divided into two groups: 1) modulators of JAK/STAT pathway activity inducing PGC migration (stat92E, Tre-1, hop), and 2) myc and Hph involved in epithelial morphogenesis and polarization, i.e. modifying the permeability of the epithelial barrier. …”
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ERF114/115/109 are essential for jasmonate-repressed non-canonical JAZ8 activity in JA signaling by Jiaxuan Sui, Qianlan Yin, Yiying Chen, Min Sun, Xianzheng Yuan, Zhaojun Ding, Xiangpei Kong

“…This interaction disrupts the formation of the MYC2/3/4-JAZ8 and root hair defective 6 (RHD6)-JAZ8 complexes. …”
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Pharmacological Mechanism of Zuojin Pill for Gastroesophageal Reflux Disease: A Network Pharmacology Study by Mi Lv, Jinke Huang, Jiayan Hu, Wenxi Yu, Ping Liu, Kunli Zhang, Fengyun Wang

“…Furthermore, quercetin, kaempferol, and coptisine, the three key components of ZJP were shown to stably bond with the 14 core target genes, including AKT1, MMP2, TP53, EGFR, JUN, CASP3, CXCL8, HIF1α, IL-1β, MYC, PPARG, MMP9, PTGS2, and FOS. Results from MDS showed that PPARG-quercetin and MMP2-quercetin bound more stably. …”
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The m6A Methylation-Regulated AFF4 Promotes Self-Renewal of Bladder Cancer Stem Cells by Qian Gao, Jin Zheng, Zegui Ni, Pengli Sun, Congcong Yang, Maosheng Cheng, Mingqing Wu, Xiuhong Zhang, Lin Yuan, Yingyin Zhang, Yang Li

“…AFF4 binds to the promoter regions and sustains the transcription of SOX2 and MYC which have critical biological functions in BCSCs. …”
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Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments by Beihui He, Zheng Chen, Yunmeng Nie, Minmin Luo, Sumei Xu, Junbin Yan, Zhiyun Chen

“…The results of WB and qRT–PCR showed that the expression of PTGS2, JUN, MYC, and CDKN1A was higher in NASH rats than in normal rats and decreased after SQP treatment. …”
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Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming by Androniki Kretsovali, Christiana Hadjimichael, Nikolaos Charmpilas

“…In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. …”
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NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling by Mikael S. Lindström

“…In addition, NPM1 plays an important role in the Myc-ARF-p53 pathway as well as in SUMO regulation. …”
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GENES DETERMINING COLORATION OF DIFFERENT ORGANS IN WHEAT by E. K. Khlestkina

“…The data on comparative mapping together with the results of recent studies dedicated to cloning and functions of genes determining coloration in wheat suggest that these genes belong to the Myb- and Myc-like families of genes, encoding transcriptional activators for structural genes involved in plant flavonoid pigments biosynthesis.…”
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N-Acetylglucosamine Functions in Cell Signaling by James B. Konopka

“…O-linked attachment of GlcNAc to Ser and Thr residues regulates a variety of intracellular proteins, including transcription factors such as NFκB, c-myc, and p53. In addition, the specificity of Notch family receptors for different ligands is altered by GlcNAc attachment to fucose residues in the extracellular domain. …”
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The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. by Patrick A Carroll, Brian W Freie, Pei Feng Cheng, Sivakanthan Kasinathan, Haiwei Gu, Theresa Hedrich, James A Dowdle, Vivek Venkataramani, Vijay Ramani, Xiaoying Wu, Daniel Raftery, Jay Shendure, Donald E Ayer, Charles H Muller, Robert N Eisenman

“…These in vivo and in vitro studies implicate MLX and other members of the proximal MYC network, such as MNT, in regulation of metabolism and differentiation, as well as in suppression of intrinsic and extrinsic death signaling pathways in both spermatogenesis and male germ cell tumors (MGCTs).…”
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Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature by Carlos Zagalo, Francesca Pierdomenico, José Cabeçadas, Pedro David Santos

“…The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. …”
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Untargeted metabolomics and functional analyses reveal that the secondary metabolite quinic acid associates with Angelica sinensis flowering by Pei Liu, Weimeng Feng, He Yang, Guang Yu, Erxin Shang, Sen Zhang, Hui Yan, Jin-ao Duan

“…Quinic acid also significantly changed the expression of genes such as LOX, JAZ1, MYC2 and MYC3 in the jasmonic acid pathway. The trends of GID1, DELLA (GAI) and LOX2 protein expression were essentially consistent with those at the transcription level. …”
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Alpha/beta values in pediatric medulloblastoma: implications for tailored approaches in radiation oncology by Danny Jazmati, Dennis Sohn, Juliane Hörner-Rieber, Nan Qin, Edwin Bölke, Jan Haussmann, Rudolf Schwarz, Niklas David Niggemeier, Arndt Borkhardt, Florian Babor, Triantafyllia Brozou, Melissa Felek, Balint Tamaskovics, Patrick Melchior, Thomas Beez, Beate Timmermann, Marc Remke, Stefanie Corradini, Rémi Till Schulz, Ronja-Linda Preugschas, Wilfried Budach, Christiane Matuschek

“…Neither TP53 status nor the levels of MYC expression influenced fractionated radiosensitivity. …”
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The PPAR Gamma Agonist Troglitazone Regulates Erk 1/2 Phosphorylation via a PPARγ-Independent, MEK-Dependent Pathway in Human Prostate Cancer Cells by Adrienne Bolden, Lynikka Bernard, Danielle Jones, Tunde Akinyeke, LaMonica V. Stewart

“…Pretreatment with U0126 did not alter the ability of troglitazone to regulate expression of two proteins that control cell cycle, p21, and c-Myc. Troglitazone was also still effective at reducing PC-3 proliferation in the presence of U0126. …”
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Transformation of Follicular Lymphoma to Double Hit B-Cell Lymphoma Causing Hypercalcemia in a 69-Year-Old Female: A Case Report and Review of the Literature by Sakshi Kapur, Miles B. Levin

“…Double hit B-cell lymphomas are rare tumors that are defined by a chromosomal breakpoint affecting the MYC/8q24 locus in combination with another recurrent breakpoint, mainly a t(14;18)(q32;q21) involving BCL2. …”
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Interactions between key genes and pathways in prostate cancer progression and therapy resistance by Fan Wu, Hengsen Zhang, Miaomiao Hao

“…Key genetic and pathway alterations include the amplification and/or mutation of the androgen receptor, the loss of Rb, PTEN, and p53, the activation of the WNT signaling pathway, and the amplification of the MYC oncogene. This review summarizes the mechanisms by which these genes influence the progression of prostate cancer and highlights the interactions between multiple genes and their relationship with prostate cancer. …”
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Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature by Clara Bertuzzi, Elena Sabattini, Francesco Bacci, Claudio Agostinelli, Gian Gaetano Ferri

“…The two lymphomas also showed peculiar features: PCTCL are rarely described in HIV+ setting and particularly at such a low clinical stage, and the DLBCL showed uncommon cytology, non-GCB phenotype, EBER negativity, and absence of c-MYC translocation, all atypical features in this clinical context. …”
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S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function by Ying Xiong, Yefim Manevich, Kenneth D. Tew, Danyelle M. Townsend

“…Such drug treatment also reverses estradiol-induced upregulation of c-Myc, cyclinD1, and P21Cip, gene products involved in cell proliferation. …”
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SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling by Jiaoyun Zheng, Jian Gong

“…Mechanically, silencing SLC1A4 inhibited the phosphorylation activation of AKT by suppressing the ubiquitin modification of AKT at lysine 63 and amino acid influx represented by D-serine, decreasing the protein level of β-catenin in the cell nucleus and suppressing the transcriptional activity of c-Myc and EpCAM promoters. As a result, silencing SLC1A4 inhibited the proliferation, migration, and stemness of hepatic cancer cells, which was successfully reversed by the introduction of exogenous AKT. …”
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