An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp by Tennille K. Marx, Robin Reddeman, Amy E. Clewell, John R. Endres, Erzsébet Béres, Adél Vértesi, Róbert Glávits, Gábor Hirka, Ilona Pasics Szakonyiné

“…No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames), in an in vitro mammalian chromosomal aberration test, or in an in vivo mouse micronucleus study. …”
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Proline isomerization modulates the bacterial IsdB/hemoglobin interaction: an atomic force spectroscopy study by Francesca Pancrazi, Omar De Bei, Francesco Lavecchia di Tocco, Marialaura Marchetti, Barbara Campanini, Salvatore Cannistraro, Stefano Bettati, Anna Rita Bizzarri

“…Here, we show that the single point mutation of Pro173 in the IsdB domain responsible for Hb binding, which weakens the IsdB:Hb interaction without hampering heme extraction, totally abolishes the previously observed behavior. …”
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Adaptation and Molecular Characterization of Two Malaysian Very Virulent Infectious Bursal Disease Virus Isolates Adapted in BGM-70 Cell Line by Nafi’u Lawal, Mohd Hair-Bejo, Siti Suri Arshad, Abdul Rahman Omar, Aini Ideris

“…It appears that a single mutation of UPM190 and UPM0081 IBDV isolates at D279N could facilitate vvIBDV strain adaptability in CEE and BGM-70 cultures.…”
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Genetics of Endometrial Cancers by Tsuyoshi Okuda, Akihiko Sekizawa, Yuditiya Purwosunu, Masaaki Nagatsuka, Miki Morioka, Masaki Hayashi, Takashi Okai

“…A β-catenin mutation was detected in about 20% of endometrioid carcinomas, but is rare in serous carcinoma. …”
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TSC complex decrease the expression of mTOR by regulated miR-199b-3p by Na Zhao, Qiuhong Xiong, Ping Li, Guangxin Chen, Han Xiao, Changxin Wu

“…In this study, besides a reported variation, c.2509_2512del (p.Asn837Valfs*11, p.N837fs) in TSC1, we found a de novo TSC2 variation c.1113delG (p.Gln371Hisfs*18, p.Q371fs), which these two mutation influence the formation of TSC complex. We found that the decrease of TSC complex with the appearance of the decreased miR-199b-3p expression. …”
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The Single-Nucleotide Polymorphism (SNP) Validity to Detect Omicron Variants by Lia Gardenia Partakusuma, Luhung Budiailmiawan, null Budiman, Ida Parwati, null Aryati, Basti Andriyoko, Louisa Markus, Corine Niswara, Cut Nur Cinthia Alamanda

“…Introduction. Mutation of SARS-CoV-2 has generated several variants of concern (VOC) which spread promptly worldwide. …”
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Current views on etiology, diagnosis, epidemiology and gene therapy of maturity onset diabetes in the young by Lilya U. Dzhemileva, Elena N. Zakharova, Anna O. Goncharenko, Maria V. Vorontsova, S. A. Rumyantsev, Natalia G. Mokrysheva, Marina Y. Loguinova, Vladimir P. Chekhonin

“…Mutations in the HNF1A and HNF4A genes result in pancreatic β-cell dysfunction, which in turn causes hyperglycemia. …”
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Rational Primer and Probe Construction in PCR-Based Assays for the Efficient Diagnosis of Drifting Variants of SARS-CoV-2 by Divya RSJB Rana, Nischal Pokhrel, Santosh Dulal

“…In this study, we have utilized in silico-based bioinformatic tools where the alignment for genes, the positions and types of SNPs/mutations of VOCs, and the relative number of SNPs per nucleotide in different genomic regions were investigated. …”
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Associations between an gene polymorphism and ulcerative colitis by ARMS-PCR by Mahsa Sadat Hashemi Doulabi, Reza Goleyjani Moghaddam, Ali Salehzadeh

“…This MDM2 polymorphism was investigated in DNA samples (extracted from biopsy samples) by amplification-refractory mutation system polymerase chain reaction. The mean age of patients with ulcerative colitis was 46.5 years (range, 28 to 69 years) and that of control individuals was 45.3 years (range, 26 to 71 years). …”
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Development of a Novel Prognostic Model for Lung Adenocarcinoma Utilizing Pyroptosis-Associated LncRNAs by Hong-Yan Bai, Tian-Tian Li, Li-Na Sun, Jing-Hong Zhang, Xiu-He Kang, Yi-Qing Qu

“…In addition, we also studied the differences in tumor mutation burden (TMB), tumor immune dysfunction and rejection (TIDE), and immune microenvironment with pRLs risk scores in low-risk and high-risk groups. …”
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Effects of 60Co-γ Ray Irradiation on the Quality of Ponkan Peels by WANG Xue, PAN Zhaoping, LI Wenge, SU Zhipeng, CHEN Jiaxu, HE Shuang, FU Fuhua

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Importance of NAB2-STAT6 Fusion in the Diagnosis of Pancreatic Solitary Fibrous Tumor with Hamartoma-Like Features: A Case Report and Review of the Literature by Kei Tanaka, Takashi Kishimoto, Masayuki Ohtsuka, Yukio Nakatani, Masaru Miyazaki

“…We report a case of pancreatic hamartoma-like solitary fibrous tumor which was differentiated from pancreatic hamartoma with the detection of NAB2-STAT6 fusion, a specific mutation for solitary fibrous tumors. A pancreatic well-demarcated solid nodule, 21×17 mm, of 82-year-old man was surgically enucleated. …”
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Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan by Ünal Metin Tokat, Ashkan Adibi, Ashkan Adibi, Esranur Aydın, Şevval Nur Bilgiç, Eylül Özgü, Onur Tutar, Mutlu Demiray

“…Our case presents GATA3 and NOTCH2 mutations, MCL1 and CKS1B amplifications, as well as ERBB3/KRAS overexpression and ER signaling as potential new mechanisms of resistance to T-DXd. …”
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Role of the Kaiso gene in the development of inflammation in Mucin-2 defcient mice by E. A. Litvinova, K. M. Achasova, M. A. Borisova, S. V. Zhenilo, E. B. Prokhortchouk, E. N. Kozhevnikova

“…One of such models for the study of IBD are mice with a null mutation of the Muc2 gene encoding the Mucin-2 protein, which is involved in the formation of a protective mucin layer in the small and large intestine. …”
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Perancangan Knowledge Management System Berbasis Web pada Tenaga Kependidikan Fakultas Teknik Universitas PGRI Madiun by Sri Anardani, Slamet Riyanto, Dimas Setiawan

“…The PGRI Madiun University routinely carries out mutation, rotation and retirement activities for educational staff. …”
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Optimal Dimensional Synthesis of Ackermann Steering Mechanisms for Three-Axle, Six-Wheeled Vehicles by Yaw-Hong Kang, Da-Chen Pang, Yi-Ching Zeng

“…The employed optimization methods include Particle Swarm Optimization (PSO), Hybrid Particle Swarm Optimization (HPSO), Differential Evolution with golden ratio (DE-gr), and Linearly Ensemble of Parameters and Mutation Strategies in Differential Evolution (L-EPSDE). …”
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Trip route optimization based on bus transit using genetic algorithm with different crossover techniques: a case study in Konya/Türkiye by Akylai Bolotbekova, Huseyin Hakli, Ayse Beskirli

“…In addition, parameter tuning is performed for the values of the algorithm’s parameters such as population size, number of iterations, crossover rate, and mutation rate. As a result of the comparison, PBX is defined as the most suitable method for the problem. …”
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Association of functional variants in miRNA genes with the risk of coronary heart disease by Taqweem Ul Haq, Muhammad Riaz Khan, Sajjad Ali, Tariq Aziz, Thamer H. Albekairi, Aftab Ali Shah

“…Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS-PCR) was used for genotyping, and Sanger sequencing was applied for validation in selected cases. …”
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Analysis of Visual Field Defects Obtained with Semiautomated Kinetic Perimetry in Patients with Leber Hereditary Optic Neuropathy by Katarzyna Nowomiejska, Agnieszka Kiszka, Edyta Koman-Wierdak, Katarzyna Tonska, Ryszard Maciejewski, Anselm G. Jünemann, Robert Rejdak

“…Twenty-two eyes of eleven consecutive LHON male patients with confirmed mitochondrial 11778G>A DNA mutation were prospectively examined with the V4e stimulus of SKP in both eyes. …”
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Complete chloroplast genomes of 13 species of the Impatiens genus for genomic features and phylogenetic relationships studies by Qinqin Yong, Meijun Li, Zhi Li, Chao Luo, Jinling Zhang, Xinxiang Bai

“…The frequency of codon usage was essentially the same, with a total of 31 high-frequency codons detected, the vast majority ending in A/U. Five mutation hotspots were detected: rps16-trnQ-UUG, ndhF, ccsA-ndhD, ycf1, and trnN-GUU, among which ycf1 had the highest Pi value and the greatest potential as a DNA barcode marker. …”
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