Controlled Non-Dominated Sorting Genetic Algorithms for Multi-Objective Optimal Design of Standalone and Grid-Connected Renewable Energy Systems in Integrated Energy Sectors by Hamza El Hafdaoui, Ahmed Khallaayoun, Salah Al-Majeed

“…However, inefficiencies due to random initial populations and mutations can impact processing times and error rates. …”
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Association of β-Catenin, APC, SMAD3/4, Tp53, and Cyclin D1 Genes in Colorectal Cancer: A Systematic Review and Meta-Analysis by Hongfeng Yan, Fuquan Jiang, Jianwu Yang

“…Pooled results showed that β-catenin overexpression, APC mutation, SMAD-3 or 4 loss of expression, TP53 mutations, and Cyclin D1 expression were associated with shorter OS. β-Catenin overexpression (HR: 0.137 (95% CI: 0.131–0.406)), loss of expression of SMAD3 or 4 (HR: 0.449 (95% CI: 0.146–0.753)), the mutations of TP53 (HR: 0.179 (95% CI: 0.126–0.485)), and Cyclin D1 expression (HR: 0.485 (95% CI: 0.772–0.198)) also presented risk for shorter DFS. …”
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Testing convolutional neural network based deep learning systems: a statistical metamorphic approach by Faqeer ur Rehman, Clemente Izurieta

“…We propose seven MRs combined with different statistical methods to statistically verify whether the program under test adheres to the relation(s) specified in the MR(s). We further use mutation testing techniques to show the usefulness of the proposed approach in the healthcare space and test two CNN-based deep learning models (used for pneumonia detection among patients). …”
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Anti-Abortion Mobilization in Latin America: Signs of a Field in Transformation by Marta Rodriguez de Assis Machado, María Angélica Peñas-Defago, Camila Gianella Malca

“…The anti-abortion mobilization shows important signs of adaptation and mutation on different fronts – networks, alliances, strategies, and frameworks. …”
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Integrated intraoperative predictive model for malignancy risk assessment of thyroid nodules with atypia of undetermined significance cytology by Cheng Li, Yong Luo, Yan Jiang, Qi Li

“…A retrospective cohort study was conducted on patients with AUS/FLUS cytology and negative BRAF V600E mutation who underwent thyroid surgery. The cohort was randomly divided into training and validation sets. …”
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Dynamics of Salmonella Dublin infection and antimicrobial resistance in a dairy herd endemic to salmonellosis. by Victor Santos do Amarante, Joelma Kellen de Castro Pereira, Matheus Ferreira Serafini, Carolina Pantuzza Ramos, Isabela Pádua Zanon, Thayanne Gabryelle Viana de Souza, Tiago Facury Moreira, Antônio Ultimo de Carvalho, Rodrigo Melo Meneses, Flavia Figueira Aburjaile, Vasco Azevedo, Elias Jorge Facury Filho, Rodrigo Otávio Silveira Silva

“…Among the resistance determinants identified, a mutation in the gyrA gene, present in all sequenced isolates, was notable. …”
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Assessing the Roles of Molecular Markers of Antimalarial Drug Resistance and the Host Pharmacogenetics in Drug-Resistant Malaria by Peter Hodoameda, Nancy Odurowah Duah-Quashie, Neils Ben Quashie

“…The parasite genetic factors involve undergoing mutation in the drug target sites or increasing the drug target gene copy number to prevent the intended action of the antimalarial drugs. …”
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Influenza A Virus and Influenza B Virus Can Induce Apoptosis via Intrinsic or Extrinsic Pathways and Also via NF-κB in a Time and Dose Dependent Manner by Ibrahim El-Sayed, Khalid Bassiouny, Aziz Nokaly, Ahmed S. Abdelghani, Wael Roshdy

“…Influenza viruses are able to cause annual epidemics and pandemics due to their mutation rates and reassortment capabilities leading to antigenic shifts and drifts. …”
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Improved Laplacian Biogeography-Based Optimization Algorithm and Its Application to QAP by Xinming Zhang, Doudou Wang, Haiyan Chen, Wentao Mao, Shangwang Liu, Guoqi Liu, Zhi Dou

“…Finally, some measures such as example learning, mutation operation removing, and greedy selection are adopted mostly to reduce the computation complexity of LxBBO. …”
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Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients by R. P. Pölönen, K. Penttinen, H. Swan, K. Aalto-Setälä

“…Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for catecholaminergic polymorphic ventricular tachycardia (CPVT). …”
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Treatment failure and drug resistance among the newly reported HIV-infected patients in Taizhou City from 2020 to 2022 by LI Yan, WU Xuanhe, SHI Lu, LI Guixia, WANG Shanling, WANG Yating, CHEN Tailin, WANG Tingting, XIE Yali, SHEN Weiwei, LIN Haijiang, CHEN Xiaoxiao, HE Na

“…K103N and M184V were the most common mutation sites, but PIs mutations occured less frequently. …”
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Identification of PANoptosis associated lncRNAs associated with clinical prognosis and immune infiltration microenvironment in colon adenocarcinoma by Yangyang Wang, Shihui Zhao, Songtao Du, Tianyi Xia, Liqiang Song, Mingyu Xia, Bomiao Zhang

“…Pathway enrichment analysis, somatic mutation profiling, and drug sensitivity analysis were employed to comprehensively assess the clinical value of the PAL score. …”
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Two Unrelated Iranian Patients with Adenosine Deaminase 2 Deficiency: A Case Report and Review of Treatment by Parvaneh Karimzade, Aziz Eghbali, Mohammad Keramatipour, Reza Shiari, Zahra Golchehre, Mahdieh Taghizadeh, Mazdak Fallahi, Shahrzad Fallah, Nasrin Khakbazan Fard, Narges Eslami, Narges Bazgir, Mahnaz Jamee, Zahra Chavoshzadeh

“…Adenosine deaminase deficiency 2 (DADA2) is an autoinflammatory disorder, caused by the CECR1 gene mutation. The major clinical manifestations include recurrent vasculitis, neurological disorders such as stroke, hematologic abnormalities, and immunodeficiency. …”
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Two-Echelon Multidepot Logistics Network Design with Resource Sharing by Siyu Luo, Yong Wang, Jinjun Tang, Xiangyang Guan, Maozeng Xu

“…The Im-NSGA-II combines the order crossover operation and the polynomial mutation process to find the optimal solution of the 2E-CMDPDTW. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…Today‘s methods of NAFLD modelling can be divided into two extensive groups: induction of liver disease by genetic mutation, and phenotypic development of NAFLD due to alimentary factor. …”
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Transcriptome analysis of liver injury of fatty liver disease induced by ALDH2 deficiency by Ziying Xu, Yagang Gao, Zihui Yu, Rui Zhang, Ruikun Wang, Shang Li, Shuowen Wang, Bing Du, Ziyan Tian, Lijuan Huang, Zanbo Ding, Jing Yuan

“…Abstract Aldehyde dehydrogenase 2 (Aldh2) Glu504Lys mutation, common in East Asians, is linked to various alcohol-related pathologies, notably fatty liver disease. …”
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Molecular Age-Related Changes in the Anterior Segment of the Eye by Luis Fernando Hernandez-Zimbron, Rosario Gulias-Cañizo, María F. Golzarri, Blanca Elizabeth Martínez-Báez, Hugo Quiroz-Mercado, Roberto Gonzalez-Salinas

“…Among the principal causes of age-dependent alterations in the anterior segment of the eye, we found the mutation of the TGF-β gene and loss of autophagy in addition to oxidative stress, which contributes to the pathogenesis of degenerative diseases. …”
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Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach by Debojyoti Halder, Shreya Mukherjee, R. S. Jeyaprakash

“…The significant development is hindered by the multi-drug resistance and poor patient compliance. PIK3CA gene mutation is one of the important causes of TNBC, which causes dysregulation of the cell cycle and cell proliferation. …”
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An Improved Human Evolution Optimization Algorithm for Unmanned Aerial Vehicle 3D Trajectory Planning by Xue Wang, Shiyuan Zhou, Zijia Wang, Xiaoyun Xia, Yaolong Duan

“…Furthermore, in the loser update strategy, an adaptive <i>t</i>-distribution perturbation strategy is utilized for its small mutation amplitude, which enhances the local search capability and robustness of the algorithm. …”
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Clinical Characteristics in Patients with Triple Negative Breast Cancer by Janet Yeh, Jennifer Chun, Shira Schwartz, Annie Wang, Elizabeth Kern, Amber A. Guth, Deborah Axelrod, Richard Shapiro, Freya Schnabel

“…We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC. …”
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