Insights Into Genetic Variations of the OCT1 Gene in Metformin Poor Responders Among Bangladeshi Type 2 Diabetic Patients by Rokeya Begum, Arindita Das, Md. Jahangir Alam, Gazi Nurun Nahar Sultana

“…This study aims to analyze the complete mutation spectrum of the OCT1 gene in metformin poor responders and to explore the potential pathogenic effects of the identified mutations. …”
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DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer by Rashmi R. Joshi, Sk Imran Ali, Amanda K. Ashley

“…DNA damage is a hallmark of cancer, and mutation and misregulation of proteins that maintain genomic fidelity are associated with the development of multiple cancers. …”
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An Atypical Presentation of a Male with Oral-Facial-Digital Syndrome Type 1 Related Ciliopathy by Sheena Sharma, Jennifer M. Kalish, Ethan M. Goldberg, Francis Jeshira Reynoso, Madhura Pradhan

“…Oral-facial-digital syndrome type 1 (OFD1) is a rare condition with X-linked dominant inheritance caused by mutations in the Cxorf5 (OFD1) gene. This gene encodes the OFD1 protein located within centrosomes and basal bodies of primary cilia. …”
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Genomic assessment of targets implicated in Rhipicephalus microplus acaricide resistance. by Christina Meiring, Michel Labuschagne

“…Novel mutations emerged from the 11 targets, but distinctions between susceptible and resistant isolates were not evident, except for the prevalent kdr mutation in synthetic pyrethroid-resistant isolates. …”
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Virulence and Antimicrobial Resistance in Campylobacter spp. from a Peruvian Pediatric Cohort by Angela Lluque, Maribel Riveros, Ana Prada, Theresa J. Ochoa, Joaquim Ruiz

“…Nalidixic acid, ciprofloxacin, erythromycin, and azithromycin susceptibilities were established in 115 isolates and tetracycline-susceptibility was established in 100 isolates. The presence of mutations in the gyrA, parC, and 23S rRNA genes was determined. …”
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Disseminated Candida lusitaniae: Nosocomial Acquisition Secondary to an Indwelling Urinary Catheter by Ali Raja, Julia Park

“…The ability of this organism to form biofilms, and its rapid mutation rate, makes treating C. lusitaniae very difficult. …”
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Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis... by Spyros I. Papamichos, Dimitrios Margaritis, Ioannis Kotsianidis

“…Throughout the course of Catarrhini evolution MYEOV acquired a gradually elongated translatable open reading frame (ORF), a gradually shortened translation-regulatory upstream ORF, and alternatively spliced mRNA variants. A point mutation introduced in human allowed for the acquisition of MYEOV long-isoform start codon. …”
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Expanded Use of Vorasidenib in Non-Enhancing Recurrent CNS WHO Grade 3 Oligodendroglioma by Alexander S. Himstead, Jefferson W. Chen, Eleanor Chu, Mari A. Perez-Rosendahl, Michelle Zheng, Sherin Mathew, Carlen A. Yuen

“…<b>Background/Objectives</b>: Anaplastic oligodendrogliomas (AOs) are central nervous system (CNS) World Health Organization (WHO) grade 3 gliomas characterized by isocitrate dehydrogenase (IDH) mutation (m)IDH and 1p/19q codeletion. AOs are typically treated with surgery and chemoradiation. …”
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Chronic Granulomatous Disease Presenting as Aseptic Ascites in a 2-Year-Old Child by J. F. Moreau, John A. Ozolek, P. Ling Lin, Todd D. Green, Elaine A. Cassidy, Veena L. Venkat, Andrew R. Buchert

“…Genetic testing revealed a novel mutation in the CYBB gene underlying his condition. …”
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A New Prognostic Indicator of Immune Microenvironment and Therapeutic Response in Lung Adenocarcinoma Based on Peroxisome-Related Genes by Zhen Xiong, Liwen Zhang, Wei Fan

“…However, the prognostic values of peroxisome-related genes (PRGs) were rarely reported. Genomic sequence, mutation, and clinical data of 535 LUAD tissues were obtained from TCGA data sets. …”
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Integration of circulating tumor DNA in biliary tract cancer: the emerging landscape by Joy A Awosika, Cecilia Monge, Tim F Greten

“…The utility of both plasma and bile ctDNA has been explored in several studies demonstrating the high mutation detection rates and the ability to isolate targetable mutations when present. …”
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Genetic Artificial Hummingbird Algorithm-Support Vector Machine for Timely Power Theft Detection by Emmanuel Gbafore, Davies Rene Segera, Cosmas Raymond Mutugi Kiruki

“…The proposed algorithm combines the artificial hummingbird algorithm exploration phase with the genetic algorithm’s mutation and crossover operators, to optimize the support vector machine’s hyperparameters and categorize users as fraudulent or nonfraudulent. …”
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Some limitations in the use of the mitochondrial DNA cytb gene as a molecular marker for phylogenetic and population genetic studies by the example of the Apodemus genus by A. G. Lapinski, M. V. Pavlenko, L. L. Solovenchuk, V. V. Gorbachev

“…The interpretation of a signal sent by the mtDNA cytb gene as a molecular marker in phylogenetic and population genetic research can be complicated by cumulative influence of parallel mutations, i.e., the entropy of nucleotide sequences. …”
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Hematological Parameters in Individuals with Beta Thalassemia Trait in South Sumatra, Indonesia by Dian Puspita Sari, Pustika Amalia Wahidiyat, Iswari Setianingsih, Ina S. Timan, Djajadiman Gatot, Aria Kekalih

“…A total of 203 subjects with thalassemia traits were included from the families of thalassemia patients, consisting of 101 subjects with β0-thalassemia, 82 subjects with β+-thalassemia, and the mutation had not been found in 20 subjects. There was a relationship in the mean/median of hematological parameters, HbA2 and HbF, between β0-thalassemia and β+-thalassemia (P<0.05). …”
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Molecular basis and genetics of hypohidrotic ectodermal dysplasias by V. A. Kovalskaia, T. Cherevatova, A. V. Polyakov, O. P. Ryzhkova

“…Moreover, this article brings up the possibility of recurrent mutations in the EDA and WNT10A genes. The review also presents data on promising approaches for intrauterine ED treatment.…”
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Effects of Colchicine and ⁶⁰Co-γ Radiation Treatments on the Leaf Size and Fruit Quality of Kiwifruit ‘Donghong’ by Limei Wang, Qing Liu, Xishi Li, Guanglian Liao, Xiaobiao Xu

“…Significant changes were observed in both leaf and fruit morphology following the mutation treatments. Most of the mutant materials showed significant increases in fruit weight, flesh firmness, and soluble sugar content, while titratable acidity and ascorbic acid content significantly decreased. …”
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Challenges in Medicine: The Odyssey of a Patient with Isolated IgG4-Related Eosinophilic Angiocentric Fibrosis Presenting as a Locally Destructive Sinonasal Mass by Snigdha Nutalapati, Richard O’Neal, William O’Connor, Brett T. Comer, Gerhard C. Hildebrandt

“…Our case interestingly also had T-cell clonality and isolated isocitrate dehydrogenase 2 enzyme mutation on next-generation sequencing, suggesting a possible role of novel molecular-targeted therapies in this rare disease. …”
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Temporal-Spatial Characteristics and Future Changes of Temperature Extremes in Longtan Watershed Based on Multiple Indices by Chongxun Mo, Shiting Long, Yuli Ruan, Yanping Xie, Xingbi Lei, Shufeng Lai, Guikai Sun, Zhenxiang Xing

“…The Mann-Kendall trend mutation test, Empirical Orthogonal Function, and other methods were used to explore the spatial and temporal distribution characteristics of temperature extremes. …”
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Mowat-Wilson Syndrome: The First Clinical and Molecular Report of an Indonesian Patient by Farmaditya E. P. Mundhofir, Helger G. Yntema, Ineke van der Burgt, Ben C. J. Hamel, Sultana M. H. Faradz, Bregje W. M. van Bon

“…Approximately 80% of mutations are nonsense and frameshift mutations (small insertions or deletions). …”
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Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms by Romina A. Tobares, Román A. Martino, Claudia A. Colque, Gaston L. Castillo Moro, Alejandro J. Moyano, Andrea G. Albarracín Orio, Andrea M. Smania

“…This increased genetic accessibility, driven by higher mutation rates and specific mutational biases, supports sustained cycles of SCV conversion and reversion. …”
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