The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment by Tao Huang, Gang Zhu, Fan Chen

“…This included analyzing the association of HNRNPA2B1 expression with prognosis, tumor mutation burden (TMB), microsatellite instability (MSI), immune response, and immune cell infiltration of individual tumors. …”
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Consensus guidelines for the management of treatment-naïve chronic lymphocytic leukaemia in Singapore (2024) by Yeow Tee Goh, Yvonne Loh, Esther Chan, Yuh Shan Lee, Venkata Sreekanth Sampath, Daryl Tan, Shin Yeu Ong, Chandramouli Nagarajan

“…Due to the superior efficacy of targeted agents (Bruton's tyrosine kinase inhibitors [BTKis] and B-cell lymphoma 2 inhibitors [BCL2is]), sthese are favoured over standard chemotherapy or chemotherapy-immunotherapy, especially for patients with del(17p) or TP53 mutation, and less fit patients. Conclusion: These consensus statements provide practical recommendations for the current management of TN CLL patients in Singapore and similar healthcare systems based on up-to-date evidence. …”
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Comparison of natural and artificial vasopressin deficiency: why the latter is lethal? by D. Zelena

“…The transgenic mouse technology is widespread, however, untill now 22.0 % of tested null mutations was found to be lethal. The complete lack of vasopressin (AVP) resulted also in preweaning lethality. …”
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Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy by Sadhak Sengupta, Jaclyn Marrinan, Caroline Frishman, Prakash Sampath

“…Deletion of O6-methylguanine-DNA-methyltransferase (MGMT) activity, a DNA repair enzyme, by temozolomide has been determined to be the cause of lymphopenia. Drug-resistant mutation of the MGMT protein has been shown to render chemoprotection against TMZ. …”
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Detection and Validation of A2 Milk Suitable for Consumers Having Milk Intolerance by ELISA Method by Mediha Esra Yayla

“…Casein proteins, which make up 80% of the total proteins in cow's milk, consist of mainly A1 and A2 genetic types which differ by a mutation that causes conversion from proline to histidine. …”
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SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development. by Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R Pineiro, Alexandra N McKillop, Jun Liu

“…Detailed analyses of mutant animals harboring this point mutation uncovered new functions of SEM-2 in the M lineage. …”
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An Adverse Reaction in the Pediatric Sleep Laboratory by Diana Reppucci, Debra Medin, Suhail Al-Saleh, Mary Jane Smith, Jill Barter, Reshma Amin

“…We present a case of a 15-month-old boy with Cornelia de Lange Syndrome (NIPBL gene mutation). On a PSG, central sleep apnea (central apnea-hypopnea index of 19/hour) and nocturnal hypoventilation (transcutaneous CO2 > 50 mmHg for 53% of the night) were found. …”
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Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition by Sun Ah Kim, Yun Joo Yoo

“…The location and distribution of haplotype blocks can be seen as a population property influenced by population genetic events such as selection, mutation, recombination and population structure. In this study, we investigate the effects of the density of markers relative to the full set of all polymorphisms in the region on the results of haplotype partitioning for five popular haplotype block partition methods: three methods in Haploview (confidence interval, four gamete test, and solid spine), MIG++ implemented in PLINK 1.9 and S-MIG++. …”
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A Stepwise Discrimination Method of Multi-Index in Landslide Stability Monitoring by Hao Chen, Honggang Wu

“…Relied on the monitoring data on deep displacement of borehole of a landslide in Wushan County, Chongqing, China, this study finds that a single index is easily disturbed by external factors, causing the abnormal mutation in curve which affects analysis of landslide deformation. …”
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Rare skin adverse reactions induced by osimertinib: a case report and literature review by Ye Zhang, Mingzhu Ling, Min Wang, Ye Chen, Liting Zhang

“…Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in the treatment of EGFR mutation-positive advanced non-small cell lung cancer. …”
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A novel topology optimization of coverage-oriented strategy for wireless sensor networks by Shuxin Wang, Hairong You, Yinggao Yue, Li Cao

“…Combining the characteristics of topology structure of wireless sensor networks and the optimization idea of the wolf pack algorithm redefines the group’s wandering and surprise behavior. A novel head wolf mutation strategy is proposed, which increases the neighborhood search range of the optimal solution, enhances the uniformity of wolf pack distribution and the ergodicity ability of the wolf pack search, and greatly improves the calculation speed and the accuracy of the wolf pack algorithm. …”
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A Boy With KIF11-Associated Disorder Along With ADHD and ASD: Collaboration Between Paediatrics and Child Psychiatry by Annelien Marcelis, Evelyne Van Reet

“…Kinesin family member 11 (KIF11)-associated disorder, a rare condition caused by autosomal dominant mutations in the KIF11 gene, presents with microcephaly, chorioretinal dysplasia, lymphoedema, and varying degrees of intellectual disability. …”
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Modeling and Solving Multi-Objective Path Planning Problem for Cooperative Cable-Suspended Load Transportation Considering the Time Variable Risk by Amir Arslan Haghrah, Sehraneh Ghaemi, Mohammad Ali Badamchizadeh

“…Furthermore, a chaotic mutation operator prevents premature convergence in the PSO algorithm. …”
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Idiopathic CRMO and MEFV Gene Variant Alleles: Is There Any Relationship? by Farhad Salehzadeh, Hassan Anari, Sepehr Sarkhanloo

“…This study evaluates MEFV gene mutations as background pathology of idiopathic CRMO. …”
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The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis. by Qiuling Li, Kayla Y Lim, Raad Altawell, Faith Verderose, Xiling Li, Wanying Dong, Joshua Martinez, Dion Dickman, Nicholas Stavropoulos

“…Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. …”
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Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma by Richard A. Peterson, Bhavani Kashyap, Pamala A. Pawloski, Anna C. Forsberg, Leah R. Hanson

“…Genetic testing revealed no pathogenic mutation in the TP53 gene. Ultimately, treatment was unsuccessful and the patient succumbed to glioma and sarcoma within 2 years of initial diagnosis. …”
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A Modified Wolf Pack Algorithm for Multiconstrained Sparse Linear Array Synthesis by Ting Wang, Ke-Wen Xia, Hai-Lin Tang, Su-Wei Zhang, Mukase Sandrine

“…Selective mutation enhances the robustness of the algorithm and improves the search speed. …”
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Fuzzy Mixed Assembly Line Sequencing and Scheduling Optimization Model Using Multiobjective Dynamic Fuzzy GA by Farzad Tahriri, Siti Zawiah Md Dawal, Zahari Taha

“…The enhanced algorithm dynamically adjusts the population size, number of generations, tournament candidate, crossover rate, and mutation rate compared with using fixed control parameters. …”
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The JN.1 variant of COVID-19: immune evasion, transmissibility, and implications for global health by Araj Naveed Siddiqui, Imshaal Musharaf, Bashar Haruna Gulumbe

“…Findings reveal that JN.1 exhibits higher infectivity and immune evasion than previous variants, largely due to the L4555 mutation. From November 2023 to March 2024, JN.1 showed an increasing trend in transmission. …”
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Bilateral Jugular Vein and Sigmoid Sinus Thrombosis Related to an Inherited Coagulopathy: An Unusual Presentation by Özge Altıntaş, Azize Esra Gürsoy, Gözde Baran, Elnur Mehdi, Talip Asil

“…According to the etiological workup, she had a mutation in the homozygous methylene tetrahydrofolate reductase (MTHFR) gene and reduced protein C levels and activity. …”
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