Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies by Ravi Kumar Madireddy, Krishnaraju Venkata Alluri, Venkateswarlu Somepalli, Trimurtulu Golakoti, Krishanu Sengupta

“…The observations from the bacterial reverse mutation test, in vitro chromosomal aberration assay, micronucleus assay in mouse bone marrow erythrocytes, and in vitro mouse lymphoma TK+/− gene mutation assay suggest that LN18178 is neither mutagenic nor clastogenic. …”
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Utility of MYD88 in the Differential Diagnosis and Choice of Second-Line Therapy in a Case of Nonsecretory Lymphoplasmacytic Lymphoma versus Free Light Chain Waldenstrom’s Macroglo... by D. Kazmierski, M. L. Palomba, C. Barsigian

“…This diagnosis was called into question 3 years later following relapse, and MZL was favored based on the lack of MYD88 mutation. One year later, however, repeat bone marrow biopsy detected the MYD88 mutation and therapy with ibrutinib yielded a favorable response. …”
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Reentry Trajectory Optimization for a Hypersonic Vehicle Based on an Improved Adaptive Fireworks Algorithm by Xing Wei, Lei Liu, Yongji Wang, Ye Yang

“…To solve the problem, an improved AFWA with a new mutation strategy is developed, where the fireworks can learn from more individuals by the new mutation operator. …”
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p53 dosage can impede KrasG12D- and KrasQ61R-mediated tumorigenesis. by Özgün Le Roux, Jeffery I Everitt, Christopher M Counter

“…Mice engineered with a G12D versus Q61R mutation in Kras exhibited differences in tumorigenesis. …”
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Performance and limitations of linkage-disequilibrium-based methods for inferring the genomic landscape of recombination and detecting hotspots: a simulation study by Raynaud, Marie, Gagnaire, Pierre-Alexandre, Galtier, Nicolas

“…Using simulations, we specifically assessed the impact of methodological (sample size, phasing errors, block penalty) and evolutionary parameters (effective population size (Ne),  demographic history, mutation to recombination rate ratio) on inferred map quality. …”
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NLRP3 Is Expressed in the Spiral Ganglion Neurons and Associated with Both Syndromic and Nonsyndromic Sensorineural Deafness by Penghui Chen, Longxia He, Xiuhong Pang, Xiaowen Wang, Tao Yang, Hao Wu

“…Whole exome sequencing, however, identified a p.E313K mutation in NLRP3, a gene reported to cause syndromic deafness Muckle-Wells Syndrome (MWS) but not included in any targeted NGS panels for deafness in previous reports. …”
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Explore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension by Xiuwen Liang, Tingting He, Lihong Gao, Libo Wei, Di Rong, Yu Zhang, Yu Liu

“…Both rs1801133 mutation on Methylenetetrahydrofolate reductase (MTHFR) gene and transcription factor peroxisome proliferator-activated gamma (PPARG) have been associated with plasma homocysteine (Hcy) levels and hypertension. …”
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Role of the Mucin-2 and Kaiso genes in the social behavior of mice by E. N. Kozhevnikova, K. M. Achasova, V. S. Korostina, E. B. Prokhortchouk, E. A. Litvinova

“…The animals used were knock-out mice with double mutations in the Kaiso and Mucin-2 genes. The Kaiso gene encodes a transcription factor that is expressed both in the brain and in the intestine. …”
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A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish. by Ugo Coppola, Bitan Saha, Jennifer Kenney, Joshua S Waxman

“…Similarly, mutation of the Foxf binding sites in the 3'reg1 reporter, coupled with gain- and loss-of-function analysis supported that Foxf1 promotes expression of the enhancer and AC differentiation. …”
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Effects of Social Structure on Effective Population Size Change Estimates by Bárbara Ribeiro Parreira, Shyam Gopalakrishnan, Lounès Chikhi

“…The first approach, BOTTLENECK, tests whether the samples are at mutation–drift equilibrium and thus whether a single Ne can be estimated. …”
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Xanthomonas citri subsp. citri requires a polyketide cyclase to activate the type III secretion system for virulence by Shuying Zhu, Siyu Wu, Yanmin Liu, Zaibao Zhang, Huasong Zou

“…An in-frame deletion mutation resulted in a loss of virulence on the citrus hosts, which was restored by the SRPBCC domain. …”
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An Analysis of the Catastrophe Model and Catastrophe Characteristics of Traffic Flow Based on Cusp Catastrophe Theory by Yanguo Huang, Huimin Zhang, Hongjun Liu, Shengsheng Zhang

“…Through the data analysis, it was found that the traffic flow state had the characteristics of multimode, mutation, inaccessibility, divergence and hysteresis, which were similar to the mutation characteristics of the basic model of catastrophe theory when the system state changed. …”
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Spatial-Temporal Variations and Influencing Factors of Water-related Ecosystem Services in Southwest China Under Complex Terrain by TANG Shuang, ZHU Chongjing, GAO Jie, BIAN Hongyan

“…[Results] (1) From 1992 to 2020, water yield in Southwest China showed a downward trend, with a notable mutation occurring in 2002; soil erosion showed an increasing trend, with a mutation observed in 1997. (2) The water yield decreased and soil erosion increased with rising altitude. (3) The relative contribution rate of precipitation to both water yield and soil erosion in karst areas was found to be greater than that in non-karst areas. …”
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Cardiac Tamponade: A Rare Manifestation of Familial Mediterranean Fever by Abdolreza Malek, Tina Zeraati, Ariane Sadr-Nabavi, Niloofar Vakili, Mohammad Reza Abbaszadegan

“…The patients typically have biallelic mutations in the MEFV gene, located on chromosome 16. …”
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Changes to Intermediary Metabolites in Sporadic and LRRK2 Parkinson’s Disease Demonstrated by Proton Magnetic Resonance Spectroscopy by Jan O. Aasly, Oddbjørn Sæther, Krisztina K. Johansen, Tone F. Bathen, Guro F. Giskeødegård, Linda R. White

“…To study the levels of intermediary metabolites in cerebrospinal fluid (CSF) from patients with PD, either of sporadic type or in carriers of the LRRK2 p.G2019S mutation. Methods. Results from patients with sporadic PD or LRRK2-PD were compared with asymptomatic LRRK2 mutation carriers and healthy control individuals. …”
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Case report: Novel multi-exon homozygous deletion of ZBTB24 causes immunodeficiency, centromeric instability, and facial anomalies syndrome 2 by Yan Long, Chenghan Wang, Jie Xiao, Yunhua Huang, Xiaoting Ling, Chaoyu Huang, Ying Chen, Jiaqi Luo, Rongheng Tang, Faquan Lin, Yifang Huang

“…The discovery of this novel mutation expands the mutation spectrum of the ZBTB24 gene and improves our understanding of the molecular mechanisms underlying ICF.…”
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Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis by Guo-zhong Yi, Hua-yang Zhang, Tian-shi Que, Shan-qiang Qu, Zhi-yong Li, Song-tao Qi, Wen-yan Feng, Guang-long Huang

“…In addition, this study also conducted a comparison of the genetic characteristics, tumor microenvironment, mutation burden and survival between glioma patients with or without gene fusions. …”
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Mondes de l’écrit et société de l’information à l’époque moderne by Jérôme Lamy, Johann Petitjean

“…New publics, reading situations and media (like the press) support and give substance to this deep mutation of early modern information.…”
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Stability of equilibria of a predator-prey model of phenotype evolution by Sílvia Cuadrado

“…We consider a selection mutation predator-prey model for the distribution of individuals with respect to an evolutionary trait. …”
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Theoretical issues in the conservation of contemporary art by Rosario Llamas-Pacheco

“…Thanks to the artist it is possible to document the current production in relation to the mutation and inevitable transformation of matter, determining when the degradation will affect the quiddity of the works of art.…”
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