Spatial change analysis, Analysis of Spatial patterns changes in rainy season over Iran by Maryam Sanaei, Gholamreza Barati, Alireza Shakiba

“…In addition, the results of Alexandersonchr('39')s statistics to identify mutations in the long-term series of the rainy season showed that the time series of 13 stations out of 108 stations studied experienced a sudden jump that these mutations are more in the southern stations in the country and in later years. …”
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A Successful Treatment of Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization for Hydrocephalus in Walker-Warburg Syndrome by Tomoko Tanaka, Catharine J. Harris, Sarah S. Barnett, N. Scott Litofsky

“…Mutations in these genes result in a broad phenotypic spectrum ranging from the severe WWS to a mild congenital muscular dystrophy with no brain involvement. …”
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Improved Clonal Selection Algorithm Based on Biological Forgetting Mechanism by Chao Yang, Bing-qiu Chen, Lin Jia, Hai-yang Wen

“…The antibody candidate set generated by the clonal selection algorithm has only a small number of antibodies with high antigen affinity to obtain high-frequency mutations. Among other antibodies, some low-affinity antibodies are replaced by new antibodies to participate in the next clonal selection. …”
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Lung Cancer Prediction Using Neural Network Ensemble with Histogram of Oriented Gradient Genomic Features by Emmanuel Adetiba, Oludayo O. Olugbara

“…The Voss DNA encoding was used to map the nucleotide sequences of mutated and normal genomes to obtain the equivalent numerical genomic sequences for training the selected classifiers. …”
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«The Mechanism of Mendelian Heredity» (The 100th anniversary of the first publication of the book by the group of T.H. Morgan) by E. B. Muzrukova

“…By studying mutations in Drosophila, Morgan obtained an experimental proof of linkage of individual genes in a chromosome. …”
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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Huanyu Z. Li, Ashley C. W. Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C. Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin McKinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M. Kessler, Nicola A. Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L. Dürr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B. Sauer

“…Abstract Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects. …”
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Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer by Yanbo Pan, Olena Berkovska, Soumitra Marathe, Georgios Mermelekas, Greta Gudoityte, Amare D. Wolide, Taner Arslan, Brinton Seashore-Ludlow, Janne Lehtiö, Lukas M. Orre

“…Key findings include the potential therapeutic value of FTIs for NRAS-mutated melanoma and GNAQ/GNA11-mutated uveal melanoma by inhibiting INPP5A farnesylation. …”
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Virological Aspects of COVID-19 in Patients with Hematological Malignancies: Duration of Viral Shedding and Genetic Analysis by Asma Themlaoui, Massimo Ancora, Kais Ghedira, Yosra Mhalla, Manel Hamdoun, Maroua Bahri, Lamia Aissaoui, Raihane Ben Lakhal, Adriano Di Pasquale, Cesare Camma, Olfa Bahri

“…Three types of mutations were detected; the most frequent were nucleotide substitutions in the spike (S) gene. …”
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Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment by Tingwang Shi, Qiong Wu, Zesong Ruan, Zhiyuan Luo, Wenbo Wang, Zhao Guo, Yihong Ma, Xin Wang, Guangyu Chu, Han Lin, Min Ge, Yunfeng Chen

“…Multi‐omics analysis revealed that the acquired high drug resistance is associated with altered flux in the purine metabolism pathway, attributable to mutations in the hypoxanthine phosphoribosyltransferase (hpt) gene. …”
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Genomic landscape and comparative analysis of tissue and liquid-based NGS in Taiwanese anaplastic thyroid carcinoma by Chun-Nan Yeh, Shu-Fu Lin, Chia-Ling Wu, Miaw-Jene Liou, I-Wen Chen, Chiao-Ping Chen, Ching-Fu Chang, Qi‑An Wang, Chiao-En Wu

“…TP53 (65.4%) and BRAF (30.8%) were the most frequently mutated genes in tissue NGS. In paired samples, the concordance rates were 69.2% for TP53 and 84.6% for BRAF. …”
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Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer by Anita Thyagarajan, Zaid Sirhan, Ravi P. Sahu

“…Along similar lines, overactivation or mutations in epidermal growth factor receptor (EGFR) signaling are detected in various human malignancies and associated with poor prognosis. …”
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Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin by Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee, Hyunju Cho

“…The mutated hydrophobic residue in the α4 helix of hsPEX19 variants binds to the N17 domain of mHttex1, thereby inhibiting the initial aggregation process. …”
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Analysis of five cases showing false-high Hemoglobin A1c due to reduced catalase activity by Kenji Hara, Atsushi Ujiie, Shiori Suzuki, Takenori Okumura, Mio Kubo, Hiroyuki Shinozaki, Mototaka Yamauchi, Takafumi Tsuchiya, Kohzo Takebayashi, Nobuyuki Shimozawa, Masafumi Koga, Koshi Hashimoto

“…Catalase activity and gene mutations were examined in the five cases and an immunohistological analysis was performed to assess the expression of catalase. …”
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Correlating disordered activation domain ensembles with gene expression levels by Eduardo Flores, Aleah R. Camacho, Estefania Cuevas-Zepeda, Mary B. McCoy, Feng Yu, Max V. Staller, Shahar Sukenik

“…To test this, we measured the ensemble dimensions of two ADs, HIF-1α and CITED2, in live cells using fluorescence resonance energy transfer microscopy and correlated this structural information with their transcriptional activity. We find that mutations that expanded the ensemble of HIF-1α increased transcriptional activity, while compacting mutations reduced it, highlighting the critical role of structural plasticity in regulating HIF-1α function. …”
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The Polymorphisms with Cataract Susceptibility Impair the EPHA2 Receptor Stability and Its Cytoprotective Function by Jin Yang, Dan Li, Qi Fan, Lei Cai, Xiaodi Qiu, Peng Zhou, Yi Lu

“…The cataract-associated missense mutations resulted in the destabilization of EPHA2 receptor without altering the mRNA transcription. …”
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Allelic diversity of the <i>Vrn</i> genes and the control of growth habit and earliness in wheat by S. E. Smolenskaya, N. P. Goncharov

“…The effects of mutations (polymorphisms) in the recessive vrn genes on vernalization requirement in winter wheats are considered, and this trait was formalized. …”
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Mining-Induced Damage Characteristics of Floors during Fully Mechanized Caving Mining: A Case Study by Yulong Jiang, Dongfeng Zhang, Kai Wang, Xiaoqiang Zhang

“…The failures of the damaged floor rocks can be divided into two types: pull-pressure strain mutations and abnormal mutations. With the advancement of the mining face, the strain increments of floor rocks at different buried depths showed obvious advanced and lagged responses. …”
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Fitness landscapes of human microsatellites. by Ryan J Haasl, Bret A Payseur

“…To meet this challenge, we focus on microsatellites, repetitive variants that mutate orders of magnitude faster than single nucleotide variants, can harbor substantial variation, and are known to influence biological function in some cases. …”
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Neurophysiology of Drosophila Models of Parkinson’s Disease by Ryan J. H. West, Rebecca Furmston, Charles A. C. Williams, Christopher J. H. Elliott

“…Given the neurological impact of disease causing mutations within these same genes in humans the phenotypes observed in fly are of significant interest. …”
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Forme solide et École solide : comment penser une nouvelle grammaire (architecturale) scolaire ? by Béatrice Mabilon-Bonfils, Virginie Martin

“…The scholastic form is questioned on all sides by mutations which affect as much the way of thinking, organizing and dispensing knowledge as the social and political function a verticality of the solid school form answers to a liquid trans-modernity. …”
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