PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma by Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet

Get full text

Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging by Weiping Xu, Shujuan Yi, Jie Liu, Yuyan Jiang, Jiaguo Huang

“…Abstract Bioorthogonal chemistry-mediated self-assembly holds great promise for dynamic molecular imaging in living organisms. However, existing approaches are limited to nanoaggregates with ‘always-on’ signals, suffering from high signal-to-background ratio (SBR) and compromised detection sensitivity. …”
Get full text

Noninvasive Optical Imaging and In Vivo Cell Tracking of Indocyanine Green Labeled Human Stem Cells Transplanted at Superficial or In-Depth Tissue of SCID Mice by Vikram Sabapathy, Jyothsna Mentam, Paul Mazhuvanchary Jacob, Sanjay Kumar

“…Recent studies have shown how real-time in vivo molecular imaging has helped in identifying hurdles towards clinical translation and designing potential strategies that may contribute to successful transplantation of stem cells and improved outcomes. …”
Get full text

Feasibility study of PET/CT for the detection and localization of nervous system damage caused by trimethyltin chloride by Anqing Liu, Qingqiang Tu, Ming Huang

“…Micro-positron emission tomography/computed tomography (Micro-PET/CT) and molecular imaging quantitative analysis tools were employed to calculate the uptake rate of 18 F-2-fluoro-D-deoxy-glucose in each functional region of brain tissue. …”
Get full text

Innovative laboratory techniques shaping cancer diagnosis and treatment in developing countries by Azeez Okikiola Lawal, Tolutope Joseph Ogunniyi, Oriire Idunnuoluwa Oludele, Oluwaloseyi Ayomipo Olorunfemi, Olalekan John Okesanya, Jerico Bautista Ogaya, Emery Manirambona, Mohamed Mustaf Ahmed, Don Eliseo Lucero-Prisno

“…Tumor histology, single-cell technology, flow cytometry, molecular imaging, liquid biopsy, immunoassays, and molecular diagnostics have emerged as pivotal tools for cancer detection. …”
Get full text

MPAR-RCNN: a multi-task network for multiple person detection with attribute recognition by S. Raghavendra, S. K. Abhilash, Venu Madhav Nookala, Jayashree Shetty, Praveen Gurunath Bharathi

Get full text

Recent Advances in Indocyanine Green-Based Probes for Second Near-Infrared Fluorescence Imaging and Therapy by Dehong Hu, Menglei Zha, Hairong Zheng, Duyang Gao, Zonghai Sheng

“…Fluorescence imaging, a highly sensitive molecular imaging modality, is being increasingly integrated into clinical practice. …”
Get full text

Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging by Yves Bérubé-Lauzière, Matteo Crotti, Simon Boucher, Seyedrohollah Ettehadi, Julien Pichette, Ivan Rech

“…This paper discusses instrumentation based on multiview parallel high temporal resolution (<50 ps) time-domain (TD) measurements for diffuse optical tomography (DOT) and a prospective view on the steps to undertake as regards such instrumentation to make TD-DOT a viable technology for small animal molecular imaging. TD measurements provide information-richest data, and we briefly review the interaction of light with biological tissues to provide an understanding of this. …”
Get full text

Altered Brain Glucose Consumption in Cogan’s Syndrome by Paolo Mora, Livia Ruffini, Caterina Ghetti, Stella Ghirardini, Maura Scarlattei, Giorgio Baldari, Carla Cidda, Pierangela Rubino, Stefano A. Gandolfi, Jelka G. Orsoni

“…Functional mapping of the CMRglc was obtained by quantitative molecular imaging positron emission tomography, combined with computed tomography (FDG-PET/CT). …”
Get full text

Fluorescence In Situ Hybridization (FISH) Signal Analysis Using Automated Generated Projection Images by Xingwei Wang, Xiaodong Chen, Yuhua Li, Hong Liu, Shibo Li, Roy R. Zhang, Bin Zheng

“…Fluorescence in situ hybridization (FISH) tests provide promising molecular imaging biomarkers to more accurately and reliably detect and diagnose cancers and genetic disorders. …”
Get full text

Investigating the significance of SPECT/CT-SUV for monitoring 177Lu-PSMA-targeted radionuclide therapy: a systematic review by Tahani O. Alkahtani

“…Abstract Background Quantitative molecular imaging via single-photon emission computed tomography-derived standardised uptake value (SPECT/CT-SUV) is used to assess the response of metastatic castration-resistant prostate cancer (mCRPC) patients to targeted radionuclide therapy (TRT) with [177Lu]Lu-PSMA. …”
Get full text

Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice by Meng Li, Min Xu, Jichang Li, Lili Chen, Dongwei Xu, Ying Tong, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia

Get full text

Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy by Jay Chadokiya, Kai Chang, Saurabh Sharma, Jack Hu, Jennie R. Lill, Jennifer Dionne, Jennifer Dionne, Jennifer Dionne, Amanda Kirane

Get full text

Deep learning solutions for inverse problems in advanced biomedical image analysis on disease detection by Amal Alshardan, Hany Mahgoub, Nuha Alruwais, Abdulbasit A. Darem, Wafa Sulaiman Almukadi, Abdullah Mohamed

“…Regarding disease detection, this technique has played a critical role in optimizing diagnostic efficiency by extracting meaningful insights from different imaging modalities like molecular imaging, MRI, and CT scans. Inverse problems contribute to uncovering subtle abnormalities by employing iterative optimization techniques and sophisticated algorithms, enabling precise and early disease detection. …”
Get full text

Notch Signaling Pathway Is Involved in bFGF-Induced Corneal Lymphangiogenesis and Hemangiogenesis by Fang Xie, Xue Zhang, Wenting Luo, Hongyan Ge, Dawei Sun, Ping Liu

“…The notch signaling pathway plays a role in regulating VEGF expression, affecting corneal lymphangiogenesis and hemangiogenesis in mice. The molecular imaging probe technique can visualize the changes in the VEGF-A expression level of corneal limbus hemangiogenesis.…”
Get full text

Association of Septic Shock with Mortality in Hospitalized COVID-19 Patients in Wuhan, China by Shaoqiu Chen, Zitong Gao, Ling Hu, Yi Zuo, Yuanyuan Fu, Meilin Wei, Emory Zitello, Gang Huang, Youping Deng

Get full text

Up-to-Date Imaging for Parathyroid Tumor Localization in MEN1 Patients with Primary Hyperparathyroidism: When and Which Ones (A Narrative Pictorial Review) by Valentina Berti, Francesco Mungai, Paolo Lucibello, Maria Luisa Brandi, Carlo Biagini, Alessio Imperiale

Get full text

A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer by Wei Lv, Yamei Shen, Hengli Yang, Rui Yang, Wenbin Cai, Jian Zhang, Lijun Yuan, Yunyou Duan, Li Zhang

“…Nanobubble (NB), a newly developed nanoscaled ultrasound contrast agent (UCA) for molecular imaging, has been widely researched for these years. …”
Get full text

Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury by Susan Bengs, Alexia Rossi, Martina Haberecker, Nidaa Mikail, Alexander Meisel, Achi Haider, Muriel Grämer, Angela Portmann, Atanas Todorov, Christof Schönenberger, Caroline E. Gebhard, Gabriela M. Kuster, Vera Regitz-Zagrosek, Catherine Gebhard

Get full text

Cryo-Imaging and Software Platform for Analysis of Molecular MR Imaging of Micrometastases by Mohammed Q. Qutaish, Zhuxian Zhou, David Prabhu, Yiqiao Liu, Mallory R. Busso, Donna Izadnegahdar, Madhusudhana Gargesha, Hong Lu, Zheng-Rong Lu, David L. Wilson

“…We created and evaluated a preclinical, multimodality imaging, and software platform to assess molecular imaging of small metastases. This included experimental methods (e.g., GFP-labeled tumor and high resolution multispectral cryo-imaging), nonrigid image registration, and interactive visualization of imaging agent targeting. …”
Get full text