In-depth characterization of miRNome in papillary thyroid cancer with BRAF V600E mutation by Azliana Mohamad Yusof, Francis Yew Fu Tieng, Rohaizak Muhammad, Shahrun Niza Abdullah Suhaimi, Isa Mohamed Rose, Sazuita Saidin, Rahman Jamal, Imilia Ismail, Nurul-Syakima Ab Mutalib

“…Fifteen miRNAs were significantly differentially expressed only in BRAF V600E-positive PTC, and eight of these were validated in TCGA THCA dataset (hsa-miR-212, -132, -135b-3p/5p, -200b, -200a-3p/5p, -27a-3p/5p, -29a and -1296). …”
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ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats by Mohammed Esawie, Marwa Matboli, Mariam Sameh Bushra, Amany H. Hasanin, Eman Kamal Habib, Reham Hussein Mohamed, Hebatalla Said Ali

“…Inflammation relevant genes have been downregulated regarding CHUK, NFKB1 and miR-611. Therefore, ZBiotics is speculated to operate by modulating the genetic-epigenetic network linked to inflammatory cGAS-STING and autophagy signaling. …”
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Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model by Yang Liu, Chen Chen, Jinbo Liu, Zhenqiang Sun, Bo Shao, Yanxin Xu, Pengyuan Dang, Shengyun Hu, Haifeng Sun, Chaoguan Wang, Junhong Hu

“…In vitro and in vivo experiments showed that tumor-derived exosomal circPOLQ did not directly regulate CRC cell development but promoted CRC metastatic nodule formation by enhancing M2 macrophage polarization. circPOLQ activated the interleukin-10/signal transducer and activator of transcription 3 axis by targeting miR-379–3 p to promote M2 macrophage polarization.Conclusion circPOLQ can enter macrophages via CRC cell-derived exosomes and promote CRC metastatic nodule formation by enhancing M2 macrophage polarization. …”
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Detection of early relapse in multiple myeloma patients by Tereza Růžičková, Monika Vlachová, Lukáš Pečinka, Monika Brychtová, Marek Večeřa, Lenka Radová, Simona Ševčíková, Marie Jarošová, Josef Havel, Luděk Pour, Sabina Ševčíková

“…Independent validation by RT-qPCR confirmed changed levels of miR-598-3p in MM patients with different times to relapse. …”
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肾透明细胞癌差异表达基因的筛选及其核心基因相应miRNA和lncRNA 预测分析 by 朱合欢, 赵虎, 林智文, 王洁, 路君, 谭建明

“…【方法】通过从TCGA数据库和GEO数据库筛选ccRCC差异表达基因并取交集，对差异表达基因进行GO功能分析和KEGG通路富集分析，使用MCODE软件筛选出差异表达基因中的核心基因，并利用mirDIP 数据库和STARBASE 数据库对核心基因上游的miRNA 和lncRNA 进行预测。…”
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CRAT downregulation promotes ovarian cancer progression by facilitating mitochondrial metabolism through decreasing the acetylation of PGC-1α by Zhen Zhang, Shuhua Zhao, Xiaohui Lv, Yan Gao, Qian Guo, Yanjie Ren, Yuanyuan He, Yihua Jin, Hong Yang, Shujuan Liu, Xiaohong Zhang

“…Here, we found a frequent down-regulation of CRAT in OC, which is mainly caused by up-regulation of miR-132-5p. Downregulation of CRAT was significantly associated with shorter survival time for patients with OC. …”
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Genome-Wide Identification of miRNAs in Oily Persimmon (<i>Diospyros oleifera</i> Cheng) and Their Functional Targets Associated with Proanthocyanidin Metabolism by Meng Zhang, Rong Wu, Xinlong Hu, Zhengrong Luo, Qinglin Zhang, Sichao Yang

“…The qRT-PCR assay was performed to elucidate the potential expression patterns of precursor miRNA and their targets during fruit development, and one target gene, <i>DkMYB22</i>, of miR2911 was verified to promote the conversion of soluble tannins into insoluble tannins involved in the deastringency in persimmons. …”
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Exploring RNA cargo in extracellular vesicles for pleural mesothelioma detection by Agnieszka Kraft, Michaela B. Kirschner, Vanessa Orlowski, Manuel Ronner, Caroline Bodmer, Valentina Boeva, Isabelle Opitz, Mayura Meerang

“…RNA isolation from EVs was done using the mirVana PARIS kit. Finally, single-end RNA sequencing was done with Illumina Novaseq 6000. …”
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Gastric cancer incidence, mortality and burden in adolescents and young adults: a time-trend analysis and comparison among China, South Korea, Japan and the USA by Jian Li, Yao Zhang, Si Lin Wu, Yi Fu, Ji Sheng Wang

“…GC ranks fifth, first, fourth and ninth in China, South Korea, Japan and the USA regarding burdens caused by cancer in adolescents and young adults. The MIRs declined constantly in South Korea and China, and the MIR in the USA became the highest in 2019.Conclusions Although not covered by prevention and screening programmes, variations in disease burden and time trends may reflect variations in risk factors, cancer control strategies and treatment accessibility of GC among the four countries. …”
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Endoplasmic reticulum stress-related CLIP4 plays a procarcinogenic role in hepatocellular carcinoma: an integrated analysis by Anqi Wang, Sitong Yan, Weijia Jiang, Xiang Chen, Yuhan Huang, Xiangyu Zu, Xiao Du, Lulu Fan, Jiatao Liu, Guoping Sun

“…In addition, the ERS-RELA-miR-222-5p-CLIP4 transcriptional network was constructed to clarify the role of CLIP4. …”
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Therapeutic effects of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content by Danielle J. Beetler, Danielle J. Beetler, Danielle J. Beetler, Presley Giresi, Damian N. Di Florio, Damian N. Di Florio, Damian N. Di Florio, Jessica J. Fliess, Elizabeth J. McCabe, Molly M. Watkins, Molly M. Watkins, Molly M. Watkins, Vivian Xu, Matthew E. Auda, Katelyn A. Bruno, Katelyn A. Bruno, Emily R. Whelan, Emily R. Whelan, Emily R. Whelan, Stephen P. C. Kocsis, Brandy H. Edenfield, Sierra A. Walker, Sierra A. Walker, Sierra A. Walker, Logan P. Macomb, Kevin C. Keegan, Angita Jain, Angita Jain, Angita Jain, Andrea C. Morales-Lara, Isha Chekuri, Anneliese R. Hill, Houssam Farres, Joy Wolfram, Joy Wolfram, Atta Behfar, Atta Behfar, Paul G. Stalboerger, Andre Terzic, Andre Terzic, Leslie T. Cooper, DeLisa Fairweather, DeLisa Fairweather, DeLisa Fairweather

“…Proteome and miR sequencing of EVs revealed that PEV miRs specifically targeted antiviral, Toll-like receptor (TLR)4, and inflammasome pathways known to contribute to myocarditis while pmPEV contained general immunoregulatory miRs.DiscussionThese differences in EV content corresponded to the differing anti-inflammatory effects of the two types of EVs on viral myocarditis.…”
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Simultaneous Recognition of Species, Quality Grades, and Multivariate Calibration of Antioxidant Activities for 12 Famous Green Teas Using Mid- and Near-Infrared Spectroscopy Coupl... by Haiyan Fu, Ou Hu, Lu Xu, Yao Fan, Qiong Shi, Xiaoming Guo, Wei Lan, Tianming Yang, Shunping Xie, Yuanbin She

“…As a result, 12 famous green teas can be discriminated with a recognition rate of 100% by MIR or NIR data. However, compared with individual instrumental data, data fusion was more adequate for modeling the antioxidant activities of samples with RMSEP of 0.0065. …”
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Genome-Wide Identification and Expression Analysis of the <i>GRF</i> and <i>GIF</i> Gene Families in <i>Prunus avium</i> by Hongxu Chen, Yangang Pei, Wanjia Tang, Hongfen Li, Yidi Huang, Yizhe Chu, Guanqiong Kou, Wenyi Niu, Runmei He, Ronggao Gong

“…However, light stress did not significantly impact the expression of <i>PavGRFs</i> and <i>PavGIFs</i>. Additionally, miR396 could bind to the <i>PavGRFs</i>, thereby regulating the expression level of <i>PavGIF</i> after transcription. …”
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RCE-IFE: recursive cluster elimination with intra-cluster feature elimination by Cihan Kuzudisli, Burcu Bakir-Gungor, Bahjat Qaqish, Malik Yousef

“…The comparability of RCE-IFE is also verified with other biological domain knowledge-based Grouping-Scoring-Modeling (G-S-M) tools, including mirGediNET, 3Mint, and miRcorrNet. Additionally, the biological relevance of the selected features by RCE-IFE is evaluated. …”
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The members of zinc finger-homeodomain (ZF-HD) transcription factors are associated with abiotic stresses in soybean: insights from genomics and expression analysis by Hafiz Muhammad Rizwan, Jiayi He, Muhammad Nawaz, Keyu Lu, Mingfu Wang

“…A total of 94 gma-miRNAs from 41 diverse miRNA families were identified, targeting 40 GmZF-HD genes, with GmZF-HD6 being most targeted by 7 miRNAs, and gma-miR4993 emerging as the dominant miRNA family. Different TFs including ERF, LBD, BBR-BPC and MYB, etc., were predicted in all 51 GmZF-HD genes upstream regions and visualized in the network. …”
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Reduced Presence of SARS-CoV-2 microRNA-like Small RNA in the Serum of Patients with Post-Acute Sequelae SARS-CoV-2 Infection by Maria Alfreda Stincarelli, Isabella Abbate, Giulia Matusali, Michele Tanturli, Marta Camici, Rosaria Arvia, Elisabetta Lazzari, Eleonora Cimini, Alessandra Vergori, Fabrizio Maggi, Simone Giannecchini

“…Initially, it was demonstrated that three previously identified SARS-CoV-2 miRNA-like small RNAs, specifically svRNA 1 and 2 and miR-07a, were significantly expressed in infected cells in vitro and released into the supernatant following infection by different SARS-CoV-2 variants. …”
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Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights by Lingxia Wu, Chenxiaoxiao Liu, Weicai Hu

“…Furthermore, we elucidated potential regulatory pathways involving miR-22-3p, which targets MMP7, MMP11, and MMP14 genes in SKCM. …”
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Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA Sequencing by Xinjian Jia, Hai Lei, Xuemei Jiang, Ying Yi, Xue Luo, Junyan Li, Yu Chen, Sha Liu, Chengcheng Yang

“…In the DElncRNA-DEmRNA coexpression, some hub lncRNAs were identified, including AP001528.2, LINC00968, LINC02202, TRHDE-AS1, LINC01140, AL354707.1, AC097534.1, MIR222HG, and AL662844.4. The mRNA expression result of TFF1, COL10A1, LEP, PLIN1, PGM5-AS1, and TRHDE-AD1 in the GSE98793 was consistent with the RNA sequencing result. …”
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Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

“…Single-cell functional analysis elucidated the involvement of MAP3K genes in shaping the tumor microenvironment. miRNA-mRNA network analysis revealed intricate regulatory mechanisms, with hsa-mir-200b-3p emerging as a key regulator. Finally, the MAP3K1 knockdown has shown significant impacts on the cellular behavior of the BGC823 cells. …”
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Identification of circRNA/miRNA/mRNA regulatory network involving (+)-catechin ameliorates diabetic nephropathy mice by Chao Chen, Dina Zhu, Shuai Zhang, Wensheng Zhang

“…Overall, circRNA.5549 and circRNA.4712 exhibit a promotive function in CE-treated db/db mice, especially in circRNA.5549/miR-29a-5P/Cd36 regulatory network, and this evidence suggest that their ceRNA regulatory network might be a therapeutic target for DN in humans.…”
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