Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA by Stephanie He, Davindra Singh, Brandon Helfield

“…Here, we explore the influence of flow rate on the microbubble-assisted delivery of miR-126, a potent pro-angiogenic biologic, using a custom acoustically coupled pressurized mesenteric artery model. …”
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Geographical origin discrimination of Chenpi using machine learning and enhanced mid-level data fusion by Xin Kang Li, Li Jun Tang, Ze Ying Li, Dian Qiu, Zhuo Ling Yang, Xiao Yi Zhang, Xiang-Zhi Zhang, Jing Jing Guo, Bao Qiong Li

“…Thirty-nine samples from eight regions in Xinhui district (Guangdong, China) are analyzed by gas chromatography (GC) and mid-infrared (MIR) technique. Four machine learning methods are employed to establish discrimination models based on GC and MIR data, with two mid-level data fusion strategies to combine the data. …”
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Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy by Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi

“…It is shown the TaRiboTAC targets tumor tissue and degrades pre-miR-21. The degradation of pre-miR-21 by TaRiboTACs significantly increases the radiotherapeutic susceptibility of cancer cells achieving efficient suppression of human lung adenocarcinoma A549 tumors in living mice.…”
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Deciphering the role of miRNA-mRNA interactions in cerebral vasospasm post intracranial hemorrhage by Xiang Chu, Xiang Chu, Xiyan Zhu, Honghao Xu, Wenbing Zhao, Debin Guo, Xing Chen, Jinze Wu, Lei Li, Hao Wang, Jun Fei

“…Experimental validation confirmed the significant regulatory roles of four miRNAs (Let-7a-5p, miR-24-3p, miR-29-3p, and miR-132-3p) and two mRNAs (CDK6 and SLC2A1) in the pathogenesis of CVS. …”
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Eurasian Integration in light of the Euro’s History by I. N. Platonova

“…Moscow: zdatel’stvo “VesMir” . 576 р.…”
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The mechanisms of fiber flax adaptation to high soil acidity (a review) by N. V. Kishlyan, N. V. Melnikova, T. A. Rozhmina

“…Also, the differences in the change of miR390 and miR393 expression between resistant and sensitive genotypes were revealed under the toxic effects of aluminum ions. …”
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Rapid Detection of Pesticide Residues in Chinese Herbal Medicines by Fourier Transform Infrared Spectroscopy Coupled with Partial Least Squares Regression by Tianming Yang, Rong Zhou, Du Jiang, Haiyan Fu, Rui Su, Yangxi Liu, Hanbo Su

“…It was found that both models could give accurate results and only the performance of MIR-PLSR was slightly better than that of NIR-PLSR in the cases suffering from herbal matrix interferences. …”
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Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b by Shuang Liang, Yu-Shuang Sun, Lu Li, Yao Long, Meng Wang, Hou-Zhi Yang, Chun-Di Li, Yan Wang, Shan-Shan Li, Xu Chen, Xin Jin

“…Kv2.1, as well as miR-29b, might be used as potential therapeutic targets for adaptations of the maternal cardiovascular system or evaluation of progesterone medication during pregnancy.…”
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Plant MicroRNA Prediction by Supervised Machine Learning Using C5.0 Decision Trees by Philip H. Williams, Rod Eyles, Georg Weiller

“…A variety of machine learning methods have successfully predicted miRNA precursors, mature miRNAs, and other nonprotein coding sequences. MirTools, mirDeep2, and miRanalyzer require “read count” to be included with the input sequences, which restricts their use to deep-sequencing data. …”
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Comparison of Proangiogenic Effects of Adipose-Derived Stem Cells and Foreskin Fibroblast Exosomes on Artificial Dermis Prefabricated Flaps by Jiachao Xiong, Zhixiao Liu, Minliang Wu, Mengyan Sun, Yu Xia, Yuchong Wang

“…Bioinformatics analysis suggested that significantly upregulated hsa-miR-760 and significantly downregulated hsa-miR-423-3p in ADSC-Exo could regulate the expression of the ITGA5 and HDAC5 genes, respectively, to promote the vascularization of skin flaps. …”
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MicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity. by Hailey Johnson, Stephanie Banakis, Matthew Chung, Elodie Ghedin, Denis Voronin

“…While one is Brugia-specific (bma-miR-5864) and the other nematode-specific (bma-miR-86), both miRNAs are secreted in high abundance. …”
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Comparative analysis of fuel wood consumption of improved mud stove and three stone fire stove: a case study by Junejo, Awais, Kumar, Sanjay, Harijan, Khanji, Jeguirim, Mejdi

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circRNA CDR1as Regulated the Proliferation of Human Periodontal Ligament Stem Cells under a Lipopolysaccharide-Induced Inflammatory Condition by Fang Wang, Xi Chen, Ying Han, Shuang Xi, Guofeng Wu

“…Mechanistically, CDR1as functioned as an miR-7 sponge to activate the ERK signal pathway to mediate the inhibition effect of LPS on cell proliferation. …”
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林麝<i>FASN</i>基因CDS区克隆及序列分析 by 谌颖莲 竭 航 赵贵军 封孝兰 张承露 吴佳勇 曾德军

“…获取了林麝<i>FASN</i>基因的mRNA序列(GenBank ID:MW570770),其具有一定的物种保守性,筛选出16个关键位点,其中第307、602、657和1 334位氨基酸能够改变蛋白羟基活性,预测出10个蛋白磷酸化位点,miR-1307-5p和miR-669与3’-UTR亲和能力较强。林麝<i>FASN</i>基因序列与其他物种之间的差异信息可为解析麝香生物合成机制提供参考。…”
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Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a by YANG Hongyan, LIAO Qirong, HOU Mingliang

“…In starBase database, there are complementary sequences observed between circ-Olfm1 and miR-330-5p. Western blotting showed that the addition of Aβ42 significantly increased the expression of AMPK and FOXO3a in the neuronal cells (P<0.01). …”
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Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy by Jūratė Savickienė, Sandra Baronaitė, Aistė Zentelytė, Gražina Treigytė, Rūta Navakauskienė

“…Within passages 4 and 8, senescent cultures exhibited typical morphological features, senescence-associated β-galactosidase activity, increased levels of p16, and decreased levels of miR-17 and miR-21 but showed differential expression of p21, p53, and ATM dependently on the onset of cell senescence. …”
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Comprehensive analysis of ceRNA Networks in UCEC: Prognostic and therapeutic implications. by Li Fan, Mengqiu Lan, Xiaohua Wei, Lili Wei, Liuhong Yang, Liuying Nong, Jiajia Wei, Jingjing Li, Wenjie Huang

“…These findings suggest that the CDKN2B-AS1-hsa-miR-497-5p-IGF2BP3 axis is a key regulatory element in UCEC and a potential therapeutic target.…”
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The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity by Lynda Bourebaba, Anna Serwotka-Suszczak, Nabila Bourebaba, Magdalena Zyzak, Krzysztof Marycz

“…PTP1B inhibition using trodusquemine resulted in decreased proinflammatory cytokines (IL-1β, TNF-α, and IL-6) release from liver and PBMC affected by EMS and regulated expression of major proinflammatory microRNAs such as miR-802 and miR-211. Moreover, MSI-1436 enhanced the anti-inflammatory profile of livers by elevating the expression of IL-10 and IL-4 and activating CD4+CD25+Foxp3+ regulatory T cells in treated PBMC. …”
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Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures by Zhuo Cheng, Xuanmei Luo, Wenzheng Liu, Xiaofang Lu, Hong Chang, Yingchun Wang, Wei Zheng, Xiue Yan, Yonghui Huang

“…Bcf-eccDNAs carried cancer-related mutations, which could guide treatment. EccDNA carrying miR-106a/363 cluster or miR-374b/421 cluster were proven to regulate cancer gene expression, accelerate tumor proliferation, and inhibit tumor apoptosis. …”
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Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology by Jessica Ramirez, Pincas Bitterman, Sanjib Basu, Animesh Barua

“…Similar patterns were also observed for macrophages. Expression of miR-125a-5p decreased significantly (P<0.001) with the increase in IL-16 expression during aging. …”
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