Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy by Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi

“…It is shown the TaRiboTAC targets tumor tissue and degrades pre-miR-21. The degradation of pre-miR-21 by TaRiboTACs significantly increases the radiotherapeutic susceptibility of cancer cells achieving efficient suppression of human lung adenocarcinoma A549 tumors in living mice.…”
Get full text

Deciphering the role of miRNA-mRNA interactions in cerebral vasospasm post intracranial hemorrhage by Xiang Chu, Xiang Chu, Xiyan Zhu, Honghao Xu, Wenbing Zhao, Debin Guo, Xing Chen, Jinze Wu, Lei Li, Hao Wang, Jun Fei

“…Experimental validation confirmed the significant regulatory roles of four miRNAs (Let-7a-5p, miR-24-3p, miR-29-3p, and miR-132-3p) and two mRNAs (CDK6 and SLC2A1) in the pathogenesis of CVS. …”
Get full text

Eurasian Integration in light of the Euro’s History by I. N. Platonova

“…Moscow: zdatel’stvo “VesMir” . 576 р.…”
Get full text

The mechanisms of fiber flax adaptation to high soil acidity (a review) by N. V. Kishlyan, N. V. Melnikova, T. A. Rozhmina

“…Also, the differences in the change of miR390 and miR393 expression between resistant and sensitive genotypes were revealed under the toxic effects of aluminum ions. …”
Get full text

Rapid Detection of Pesticide Residues in Chinese Herbal Medicines by Fourier Transform Infrared Spectroscopy Coupled with Partial Least Squares Regression by Tianming Yang, Rong Zhou, Du Jiang, Haiyan Fu, Rui Su, Yangxi Liu, Hanbo Su

“…It was found that both models could give accurate results and only the performance of MIR-PLSR was slightly better than that of NIR-PLSR in the cases suffering from herbal matrix interferences. …”
Get full text

Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b by Shuang Liang, Yu-Shuang Sun, Lu Li, Yao Long, Meng Wang, Hou-Zhi Yang, Chun-Di Li, Yan Wang, Shan-Shan Li, Xu Chen, Xin Jin

“…Kv2.1, as well as miR-29b, might be used as potential therapeutic targets for adaptations of the maternal cardiovascular system or evaluation of progesterone medication during pregnancy.…”
Get full text

Plant MicroRNA Prediction by Supervised Machine Learning Using C5.0 Decision Trees by Philip H. Williams, Rod Eyles, Georg Weiller

“…A variety of machine learning methods have successfully predicted miRNA precursors, mature miRNAs, and other nonprotein coding sequences. MirTools, mirDeep2, and miRanalyzer require “read count” to be included with the input sequences, which restricts their use to deep-sequencing data. …”
Get full text

Comparison of Proangiogenic Effects of Adipose-Derived Stem Cells and Foreskin Fibroblast Exosomes on Artificial Dermis Prefabricated Flaps by Jiachao Xiong, Zhixiao Liu, Minliang Wu, Mengyan Sun, Yu Xia, Yuchong Wang

“…Bioinformatics analysis suggested that significantly upregulated hsa-miR-760 and significantly downregulated hsa-miR-423-3p in ADSC-Exo could regulate the expression of the ITGA5 and HDAC5 genes, respectively, to promote the vascularization of skin flaps. …”
Get full text

Comparative analysis of fuel wood consumption of improved mud stove and three stone fire stove: a case study by Junejo, Awais, Kumar, Sanjay, Harijan, Khanji, Jeguirim, Mejdi

Get full text

circRNA CDR1as Regulated the Proliferation of Human Periodontal Ligament Stem Cells under a Lipopolysaccharide-Induced Inflammatory Condition by Fang Wang, Xi Chen, Ying Han, Shuang Xi, Guofeng Wu

“…Mechanistically, CDR1as functioned as an miR-7 sponge to activate the ERK signal pathway to mediate the inhibition effect of LPS on cell proliferation. …”
Get full text

Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy by Jūratė Savickienė, Sandra Baronaitė, Aistė Zentelytė, Gražina Treigytė, Rūta Navakauskienė

“…Within passages 4 and 8, senescent cultures exhibited typical morphological features, senescence-associated β-galactosidase activity, increased levels of p16, and decreased levels of miR-17 and miR-21 but showed differential expression of p21, p53, and ATM dependently on the onset of cell senescence. …”
Get full text

Comprehensive analysis of ceRNA Networks in UCEC: Prognostic and therapeutic implications. by Li Fan, Mengqiu Lan, Xiaohua Wei, Lili Wei, Liuhong Yang, Liuying Nong, Jiajia Wei, Jingjing Li, Wenjie Huang

“…These findings suggest that the CDKN2B-AS1-hsa-miR-497-5p-IGF2BP3 axis is a key regulatory element in UCEC and a potential therapeutic target.…”
Get full text

The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity by Lynda Bourebaba, Anna Serwotka-Suszczak, Nabila Bourebaba, Magdalena Zyzak, Krzysztof Marycz

“…PTP1B inhibition using trodusquemine resulted in decreased proinflammatory cytokines (IL-1β, TNF-α, and IL-6) release from liver and PBMC affected by EMS and regulated expression of major proinflammatory microRNAs such as miR-802 and miR-211. Moreover, MSI-1436 enhanced the anti-inflammatory profile of livers by elevating the expression of IL-10 and IL-4 and activating CD4+CD25+Foxp3+ regulatory T cells in treated PBMC. …”
Get full text

Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures by Zhuo Cheng, Xuanmei Luo, Wenzheng Liu, Xiaofang Lu, Hong Chang, Yingchun Wang, Wei Zheng, Xiue Yan, Yonghui Huang

“…Bcf-eccDNAs carried cancer-related mutations, which could guide treatment. EccDNA carrying miR-106a/363 cluster or miR-374b/421 cluster were proven to regulate cancer gene expression, accelerate tumor proliferation, and inhibit tumor apoptosis. …”
Get full text

Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology by Jessica Ramirez, Pincas Bitterman, Sanjib Basu, Animesh Barua

“…Similar patterns were also observed for macrophages. Expression of miR-125a-5p decreased significantly (P<0.001) with the increase in IL-16 expression during aging. …”
Get full text

Folliculin Interacting Protein 1 (FNIP-1) expression and capillary density in gastrocnemius muscle tissue of mice after biological maturation period by Sinta Ayu Choiriyah, Bambang Purwanto, Viskasari Pintoko Kalanjati, Raden Argarini, Anisah Rosydiyah

“…The transition of muscle fibers from type 2 to type 1 requires miR-499 activity from the expression of the Myh7b gene. …”
Get full text

The Application of FT-IR Spectroscopy for Quality Control of Flours Obtained from Polish Producers by Katarzyna Sujka, Piotr Koczoń, Alicja Ceglińska, Magdalena Reder, Hanna Ciemniewska-Żytkiewicz

“…Samples of wheat, spelt, rye, and triticale flours produced by different Polish mills were studied by both classic chemical methods and FT-IR MIR spectroscopy. An attempt was made to statistically correlate FT-IR spectral data with reference data with regard to content of various components, for example, proteins, fats, ash, and fatty acids as well as properties such as moisture, falling number, and energetic value. …”
Get full text

MicroRNA155 in non-small cell lung cancer: a potential therapeutic target by Xiangju Wei, Xiangju Wei, Xianmin Xiong, Xianmin Xiong, Ze Chen, Bi Chen, Cantang Zhang, Wenhui Zhang

“…Among these, microRNA155(miR-155) is one of the most conserved and versatile miRNAs, predominantly overexpressed in various diseases, including malignant tumors. …”
Get full text

Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration by Bysani Chandrasekar, Srinivas Mummidi, Vincent G. DeMarco, Yusuke Higashi

“…Further, treatment with empagliflozin reversed OxLDL-induced miR-30b induction, RECK suppression, MMP activation, SMC migration, proliferation, and proinflammatory phenotype changes. …”
Get full text

Oral probiotic extracellular vesicle therapy mitigates Influenza A Virus infection via blunting IL-17 signaling by Hongxia Zhou, Wenbo Huang, Jieting Li, Peier Chen, Lihan Shen, Wenjing Huang, Kailin Mai, Heyan Zou, Xueqin Shi, Yunceng Weng, Yuhua Liu, Zifeng Yang, Caiwen Ou

“…We confirmed that miR-4239 directly targets IL-17a. Our findings paved the ground for future application of LrEVs in influenza treatment and offered new mechanistic insights regarding the anti-inflammatory role of miR-4239.…”
Get full text