Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…The specific design and structural features of ISB 1442 enable: 1) enhanced trans binding to adjacent CD38 molecules to increase Fc density at the cancer cell surface; 2) prevention of avid cis binding to monomeric CD38 to minimize blockade by soluble shed CD38; and 3) greater binding avidity, with a slower off-rate at high CD38 density, for increased specificity. …”
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Effects of Bioactive Packaging Films Incorporated with Bifidocin A on Microbial Reduction and Quality Parameters of Chill-Stored Spanish Mackerel (Scomberomorus niphonius) Fillets by Guorong Liu, Xue Li, Xu Hao, Chengtao Wang, Baoguo Sun

“…To evaluate the potential of bifidocin A for preservation of fresh Spanish mackerel fillets, the bioactive packaging films incorporated with bifidocin A (1 × minimal inhibition concentration (MIC), 2 × MIC and 4 × MIC) were developed, and their effects on the microbiological and physicochemical properties and sensory profile of mackerel fillets at refrigerated storage were investigated. …”
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Selective solvothermal extraction of tetrabromobisphenol A to promote plastic recycling by Paavo Auvinen, Ville H. Nissinen, Erno Karjalainen, Kirsi Korpijärvi, Eerika Olkkonen, Krista Grönlund, Ilkka Rytöluoto, Lauri Kuutti, Mika Suvanto, Janne Jänis, Jarkko J. Saarinen

“…Additionally, DIP-MS was found to be a valuable characterization method for assessing the removal and decomposition of various additives from solid plastic samples with minimal sample preparation. Overall, the results presented herein offer a target-selective extraction processes under relatively mild conditions for further advancing the mechanical recycling of plastics.…”
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Questionnaire to Survey Cosmetic Outcomes in Laparoscopic Surgery for Colorectal Cancer by Masaaki Miyo, MD, PhD, Ichiro Takemasa, MD, PhD, Koichi Okuya, MD, PhD, Tatsuya Ito, MD, PhD, Emi Akizuki, MD, PhD, Tadashi Ogawa, MD, PhD, Ai Noda, MD, Masayuki Ishii, MD, PhD, Ryo Miura, MD, Momoko Ichihara, MD, Maho Toyota, MD, Akina Kimura, MD, Mitsugu Sekimoto, MD, PhD

“…There has been a steady increase in the use of minimally invasive surgery, including conventional multiport laparoscopic surgery (MLS) and single-site laparoscopic surgery (SLS) for colorectal cancer. …”
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Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study by Tomohisa Iwai, Mitsuhiro Kida, Kazuya Sugimori, Hiroaki Shigoka, Takaaki Matsumoto, Masashi Ijima, Haruo Miwa, Kosuke Okuwaki, Masafumi Watanabe, Kai Adachi, Akihiro Tamaki, Taro Hanaoka, Junro Ishizaki, Chika Kusano

“…Conclusions A six‐month placement of a modified fully covered self‐expanding metallic stent effectively improved strictures and minimized stent‐induced Adverse events in patients with refractory benign biliary stricture. …”
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Exploring patient preferences for intraocular lenses selection in age-related cataract: a discrete choice experiment study by Qiaolin Zhu, Qiaolin Zhu, Qiaolin Zhu, Qianqian Sun, Qianqian Sun, Qianqian Sun, Yujia Huo, Yujia Huo, Yujia Huo, Xiaoling Yang, Xiaoling Yang, Xiaoling Yang, Hehe Huang, Hehe Huang, Hehe Huang, Shanshan Qian, Shanshan Qian, Shanshan Qian, Wenjing Lin, Wentao Yan, Wentao Yan, Wentao Yan

“…The inclusion of blue-blocking functionality and the surgeon’s recommendation had minimal influence on patient choice. LCA revealed three distinct preference groups: Class 1 (“Aberration Correction Seekers”) preferred aspheric IOLs, Class 2 (“Presbyopia and Blue-Blocking Enthusiasts”) favored multifocal IOLs, and Class 3 (“Astigmatism and Cost-Sensitive Patients”) preferred toric IOLs. …”
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Posterior Urethral Valves and Fertility: Insight on Paternity Rates and Seminal Parameters by Marcello Della Corte, Simona Gerocarni Nappo, Antonio Aversa, Sandro La Vignera, Francesco Porpiglia, Cristian Fiori, Nicola Mondaini

“…Lastly, seminal parameters were assessed in a minimal cohort of patients, therefore, they could not be considered representative. …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…Results Pristine, 200 nm SiNPs induced minimal changes to energy metabolism and proteomic profiles in vitro while treatment with SAD SiNPs resulted in mitochondrial membrane hyperpolarization, inhibited mitochondrial respiration, increased reactive oxygen species generation, and redox proteomic trends suggesting activation of aryl hydrocarbon receptor (AHR) and other signaling pathways with known roles in mitochondrial inhibition and CKD progression. …”
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Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-exp... by Michael A. Deaney, Katherine C. Shihadeh, Alexandra Craig, Margaret M. Cooper, Paul D. Paratore, Timothy C. Jenkins

“…Interventions: Implementation of a GN-BSI clinical care guideline based on a 2021 consensus statement, emphasizing 7-day antibiotic courses, use of highly bioavailable oral antibiotics, and minimizing repeat blood cultures. Results: The study included 147 patients pre-intervention and 169 post-intervention. …”
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Molecular Characterization and Pathogenicity of <i>Colletotrichum</i> on Banana Fruits: Wound Effects on Virulence and Cross-Infection by Maysa C. Santos, Luis O. Viteri, Sabrina H. Araujo, Dalmarcia C. Mourão, Marcos P. Câmara, Ana G. Amaral, Eugênio E. Oliveira, Gil Rodrigues dos Santos

“…Collectively, our findings reinforce the relevance of minimizing post-harvest wounds on banana fruits and highlight the risks of cross-infection when storing bananas alongside other fruit species.…”
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Manifestation of agronomically valuable traits in the progeny of a sorghum mutant carrying the genetic construct for RNA silencing of the γ-kafirin gene by L. A. Elkonin, N. V. Borisenko, T. E. Pylaev, O. A. Kenzhegulov, S. Kh. Sarsenova, N. Yu. Selivanov, V. M. Panin

“…In T3, a line with a high digestibility of endosperm proteins (81 %) and a minimal decrease in agronomically valuable traits (by 5–7 %) was selected.…”
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Chemical Characterization and Differential Lipid-Modulating Effects of Selected Plant Extracts from Côa Valley (Portugal) in a Cell Model for Liver Steatosis by Ricardo Amorim, Mário Pedro Marques, Catarina Melim, Carla Varela, Vilma A. Sardão, José Teixeira, Maria Inês Dias, Lillian Barros, Paulo J. Oliveira, Célia Cabral

“…Results: Chemical analysis revealed diverse phenolic compounds, particularly kaempferol derivatives in <i>E. ramosissimum</i>. All extracts showed minimal cytotoxicity at 25–50 µg/mL. At 100 µg/mL, only <i>E. ramosissimum</i> extracts maintained high cell viability. …”
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Powdery mildew resistance of barley accessions from Dagestan by R. A. Abdullaev, T. V. Lebedeva, N. V. Alpatieva, B. A. Batasheva, I. N. Anisimova, E. E. Radchenko

“…Growing resistant varieties can significantly minimize harmful effects of the pathogen. The specificity in the interaction between the fungus and its host plant requires a continuous search for new donors of the resistance trait. …”
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Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis by Huann-Cheng Horng, Jin-Wei Xu, Yi-Shan Kuo, Yu-Sin Chen, Yu-Hsuan Chiu, Kuan-Hao Tsui, Yu-Tang Tung

“…Histological analysis showed minimal fungal invasion and preserved vaginal epithelial integrity in VAGINNE^®-treated mice compared to untreated controls. …”
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Colorimetric aptasensor coupled with a deep-learning-powered smartphone app for programmed death ligand-1 expressing extracellular vesicles by Adeel Khan, Adeel Khan, Haroon Khan, Nongyue He, Zhiyang Li, Heba Khalil Alyahya, Yousef A. Bin Jardan

“…To transform the qualitative colorimetric approach into a quantitative operation, we developed an intelligent convolutional neural network (CNN)-powered quantitative analyzer for chromaticity in the form of a smartphone app named ExoP, thereby achieving the intelligent analysis of chromaticity with minimal user intervention or additional hardware attachments for the sensitive and specific quantification of PD-L1@EVs. …”
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Assessing Genetic Diversity and Population Structure of Western Honey Bees in the Czech Republic Using 22 Microsatellite Loci by Aleš Knoll, Martin Šotek, Jan Prouza, Lucie Langová, Antonín Přidal, Tomáš Urban

“…The low <i>F_ST</i> and <i>F_IS</i> values (they measured the level of genetic differentiation between populations and the level of inbreeding, respectively) suggest the absence or minimal genetic diversity within and among studied populations. …”
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Secondary neoplasms in survivors of pediatric acute lymphoblastic leukemia and lymphoblastic lymphoma: a single-center, retrospective study by Eri Ushida, Hidemi Toyoda, Atsushi Kohso, Yosuke Okumura, Kaori Niwa, Takahiro Ito, Mari Morimoto, Ryo Hanaki, Keishiro Amano, Shotaro Iwamoto, Takao Deguchi, Hiroki Hori, Masahiro Hirayama

“…Gliomas occurred significantly earlier than meningiomas (p = 0.047), and three patients died of secondary neoplasms (all gliomas).ConclusionsAs secondary gliomas occurred earlier than meningiomas and are associated with poor outcomes, physicians should take great pains to minimize their risk to improve long-term survival and quality of life.…”
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RAS/BRAF Circulating Tumor DNA Mutations as a Predictor of Response to First-Line Chemotherapy in Metastatic Colorectal Cancer Patients by Jiannan Yao, Wanchun Zang, Yang Ge, Nathaniel Weygant, Pan Yu, Lei Li, Guanhua Rao, Zhi Jiang, Rui Yan, Linjia He, Yang Yu, Mulan Jin, Gang Cheng, Guangyu An

“…Since circulating tumor DNA (ctDNA) offers clear advantages as a minimally invasive method for tumor monitoring compared with tumor tissue, we aimed to evaluate genotyping ctDNA using a next-generation sequencing- (NGS-) based panel to identify the prognostic value of mutation status in metastatic colorectal cancer (mCRC) patients with primary tumor resected and with subsequent lines of treatment in this study. …”
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The succession of One Day Surgery with Breast Cancer Home Recovery Program by the National Cancer Institute (ODS BHR NCI) during the COVID-19 pandemic in Thailand by Chayanoot Rattadilok, Napaphat Poprom, Vipavee Niyomnaitham, Oradee Phadhana-anake, Jirawadee Ruamjaroenchai, Napat Saigosoom, Wimonporn Papathe, Suttida Thuranutch, Araya Chanwet

“…In response to the need to hospital stays and minimize waiting time for surgery, particularly during the COVID-19 pandemic, the National Cancer Institute developed the One Day Surgery with Breast cancer Home Recovery program (ODS BHR NCI). …”
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Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences by Pål Møller, Aysel Ahadova, Matthias Kloor, Toni T. Seppälä, John Burn, Saskia Haupt, Finlay Macrae, Mev Dominguez-Valentin, Gabriela Möslein, Annika Lindblom, Lone sunde, Ingrid Winship, Gabriel Capella, Kevin Monahan, Daniel D. Buchanan, D. Gareth Evans, Eivind Hovig, Julian R. Sampson

“…In contrast to other path_ MMR carriers, path_PMS2 carriers who receive colonoscopic surveillance exhibit minimal increase in CRC incidence. This is consistent with a hybrid model: the initial mutation may cause an adenoma, and the second hit in the wild-type PMS2 allele may drive the adenoma towards become cancerous with MSI. …”
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