The Effects of Adverse Events and Associated Costs on Value-Based Care for Metastatic Pancreatic Ductal Adenocarcinoma by Prachi Bhatt, Jared Hirsch, Paul Cockrum, George Kim, Gabriela Dieguez

“…**Discussion:** Treatment decisions intended to minimize chemotherapy costs may lead to suboptimal decisions if the goal is to reduce TCOC. …”
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The accuracy of ultrasensitive PSA in predicting disease progression after radical prostatectomy by Heikki Seikkula, Jaakko Hyysalo, Mikael Högerman, Peter J. Boström, Otto Ettala

“…Conclusion In conclusion, a low usPSA predicts minimal BCR risk over the next 2–3 years post‐measurement. …”
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Effect of Microwave Heat Processing on Nutritional Indices, Antinutrients, and Sensory Attributes of Potato Powder-Supplemented Flatbread by Muhammad Waseem, Saeed Akhtar, Nazir Ahmad, Tariq Ismail, Claudia E. Lazarte, Majid Hussain, Muhammad Faisal Manzoor

“…Microwave heating of potato powder was observed to reduce the load of alkaloids, oxalates, tannins, and phytates of the raw potato powder at the rate of 76%, 80%, 84%, and 82%, respectively, thus anticipating a promising response to minimize toxicant load in supplemented flatbread. Supplementing potato powder in SGF elucidated significant (p<0.05) improvement in color values, i.e., a∗ (1.89–2.32) and b∗ (10.95–13.22), and increased product hardness from 3.17 to 7.9 N. …”
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CRISPR/Cas9-mediated genomic insertion of functional genes into Lactiplantibacillus plantarum WCFS1 by Kamilla Wiull, Lisa K. Haugen, Vincent G. H. Eijsink, Geir Mathiesen

“…An obstacle in developing bacterial delivery vehicles is generating a production strain that lacks antibiotic resistance genes and contains minimal foreign DNA. To deal with this obstacle, we have constructed a finetuned, inducible two-plasmid CRISPR/Cas9-system for chromosomal gene insertion in L. plantarum. …”
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Significance of the Powder Metallurgy Approach and Its Processing Parameters on the Mechanical Behavior of Magnesium-Based Materials by Sachin Kumar Sharma, Sandra Gajević, Lokesh Kumar Sharma, Dhanesh G. Mohan, Yogesh Sharma, Mladen Radojković, Blaža Stojanović

“…PM is identified as the most efficient due to its ability to produce near-net shape composites with high precision, cost-effectiveness, and minimal waste. Furthermore, PM enables precise control over critical processing parameters, such as compaction pressure, sintering temperature, and particle size, which directly influence the composite’s microstructure and properties. …”
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Experimental analysis of the exergetic performance of a solar air heater using separate liquid and solid sensible thermal storage media by Harikrishnan M, R Ajith Kumar, Rajesh Baby, Dani Percy, S. Ajith Kumar

“…The designed SAHRR-WPBS and SAHRR-WTH55 can generate hot air in the range between 45- 65°C with minimal temperature variation over extended periods, making it suitable for producing high-quality dried products.…”
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Compressive stress-strain relationship of limestone calcined clay cement-based UHPC matrix by Kunjie Fan, Peng Du, Yao Yao

“…Furthermore, adding an appropriate amount of LC2 (no more than 30 %) to UHPC matrix is found to reduce the nonlinearity of compressive stress-strain relationships, thereby minimizing the plastic deformation of LC3-UHPC matrix. …”
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Optimization of the Offshore Wind Turbines Layout Using Cuckoo Search Algorithm by Ibrahim Abdulwahab, Solomon Andrew Onazi, Gideon Rimamfate, Akande Abdulwasiu, Abubakar Umar, N.A Iliyasu

“…After-which a cuckoo search algorithm technique is employed in the wind farm model to optimize the optimization problem (minimizing the wake effect while improving power output and cost). …”
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Research on Lean Planning and Optimization for Precast Component Production Based on Discrete Event Simulation by Zhenmin Yuan, Yaning Qiao, Yaru Guo, Yaowu Wang, Chen Chen, Wenshun Wang

“…The important findings are as follows: (1) this method can minimize the difference between the processing time of each workstation to avoid bottleneck stations as much as possible; (2) this method can capture the uncertainty during precast component production, and the most likely production time calculated by the method is 12.05 hours instead of the 11.50 hours originally estimated by the component factory; (3) this method can identify some unnecessary waste in the production process of precast components, including less than 50% utilization of workstations and unnecessary equipment purchases; (4) this method also provides some suggestions regarding production optimization. …”
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Organic amendments tighten nitrogen cycling in agricultural soils: a meta-analysis on gross nitrogen flux by Lauren C. Breza, A. Stuart Grandy, A. Stuart Grandy

“…As such, residue amendments encourage soil N recycling between inorganic and organic forms, which is crucial to supporting crop N needs throughout the growing season while minimizing N losses.…”
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Geotechnical investigations of lead-silver ore processing residues at the Auzelles site, Auvergne (France) by Diaka Sidibé, Mamadou Diallo, Ahmed Amara Konaté, Muhammad Zaheer

“…Proactive management, based on these results, requires the implementation of appropriate rehabilitation techniques, such as drainage optimization and incorporation of vegetation covers, to minimize environmental impacts and ensure the long-term sustainability of mining waste structures.…”
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The Obesity Paradox Revisited: Is Obesity Still a Protective Factor for Patients With High Comorbidity Burden or High-Complexity Procedures? by Hyo Jin Son, BSc, Denise W. Gee, MD, David Gomez, MD, PhD, James J. Jung, MD, PhD

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Psychological impact and coping mechanisms among sudanese medical students: a study on anxiety, depression, behavioral, and cognitive changes post COVID-19 lockdown and ongoing con... by Ali Awadallah Saeed, Ahmad Mohammad Al Zamel, Abrar Abdu Abass, Aisha Ahmed Mohammed, Fidaaldeen Adil Abdallh, Hiba Elhadi Ali, Nooralain Mohammed Hassan, Raad Mohammed Osman, Toga Abdelmutaal Mohammed, Azza Osman Yousif, Lamya Bashir Eisa

“…Results Data analysis using SPSS 27 indicated minimal missing data (0.25%) among the 393 participants. …”
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Problems and prospects of grapevine genetic resources preservation at “Magarach” Institute by A. A. Polulyakh, V. A. Volynkin, V. V. Likhovsko

“…To supplement the traditional method of grapevine genetic resources conservation in the field collection, we have developed a method of preserving the gene pool collection in vitro under the minimal growth conditions. At the institute “Magarach” we have formed a vegetative collection of 40 grapevine varieties, hybrids and clones in vitro, and this work is under way. …”
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Immunolipid magnetic bead-based circulating tumor cell sorting: a novel approach for pathological staging of colorectal cancer by Qingyan Deng, Weidong Li, Yueming Huang, Haitao Wang, Xinhao Zhou, Zhifen Guan, Bohao Cheng, Yao Wang

“…This system partially solves the problem of difficult tumor tissue sample collection and provides a reference for gene mutation testing in early diagnosis, therapeutic efficacy evaluation, prognosis assessment, and minimal metastasis detection in CRC patients, showing significant potential for clinical application, especially in targeted therapy gene testing for CRC.…”
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The fate and mobility of chromium, arsenic and zinc in municipal sewage sludge during the co-pyrolysis process with organic and inorganic chlorides by Mahboub Saffari, Masomeh Moazallahi, Rezvan Mashayekhi

“…While FeCl3 demonstrated better performance in Cr stabilization, these findings highlight the importance of selecting appropriate chlorinated additives based on the target heavy metal for optimizing biochar production and minimizing environmental impacts effectively.…”
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The effect of combined thermal and sonication treatment on shelf life extension and quality retention of banana by Mahfujul Alam, Mir Meahadi Hasan, Mohammad Mainuddin Molla, Mrinal Kanti Debnath, Md Shakir Moazzem, Biddut Chandra Dey

“…Based on the findings, combined hot water and ultrasound treatment (HW+US) can be considered promising postharvest treatment of bananas, could extend their shelf life, minimize microbial contamination, and enhance overall quality retention during ambient storage. …”
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Physicochemical Characterization, Storage Stability Behavior, and Intestinal Bioaccessibility of Clove Extract Encapsulated Using Varying Combinations of Gum Arabic and Maltodextri... by Farhad Ahmadi, Hafiz A. R. Suleria, Frank R. Dunshea

“…Encapsulation was effective in protecting bioactive components of clove extract during storage at room (up to 40 days) or high temperature (60 °C for 7 days) and minimized the loss of antioxidant activity during storage, as compared to the clove extract in a non-encapsulated form. …”
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A Systematic Review and Meta-Analysis of Outcomes for Type 1 Diabetes after Bariatric Surgery by Alexandra Chow, Noah J. Switzer, Jerry Dang, Xinzhe Shi, Christopher de Gara, Daniel W. Birch, Richdeep S. Gill, Shahzeer Karmali

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Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway by Sun Kening, Chen Ping, Zhang Liang, Lu Zhidong, Jin Qunhua

“…Deguelin specifically inhibited the multiple myeloma cell growth while the normal plasma cells were minimally affected. Multiple myeloma cells when treated with deguelin exhibited remarkably lower viability and colony-forming ability. …”
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