Influence of Mesalazine on Ferroptosis-Related Gene Expression in In Vitro Colorectal Cancer Culture by Joanna Słoka, Barbara Strzałka-Mrozik, Sebastian Kubica, Ilona Nowak, Celina Kruszniewska-Rajs

“…<b>Results:</b> MES effectively reduces the viability of DLD-1 cells while minimally affecting normal intestinal cells. Subsequent oligonucleotide microarray analysis revealed that MES significantly alters the expression of 56 genes associated with ferroptosis. …”
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Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials by Zubair Hussain, Yueteng Zhang, Lu Qiu, Shanshan Gou, Kangdong Liu

“…In summary, this review presents compelling evidence positioning Clec9a as a promising target for DC-based tumor immunotherapy, capable of enhancing the efficacy of vaccines and immune responses while minimizing adverse effects.…”
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Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial by Cesare Ariasi, Carola Romanò, Cesare Tomasi, Simone Soglia, Gaetano Licata, Luca Rubelli, Piergiacomo Calzavara Pinton, Marina Venturini, Mariachiara Arisi

“…Conclusion: The addition of a prebiotic DC significantly reduced healing time, improved cosmetic outcomes, and minimized LSR post-cryotherapy. No adverse events were reported with this treatment. …”
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Refractive Status in Eyes Implanted with Toric and Nontoric Intraocular Lenses during Combined Cataract Surgery and Microhook Ab Interno Trabeculotomy by Yasuyuki Takai, Kazunobu Sugihara, Mihoko Mochiji, Kaoru Manabe, Aika Tsutsui, Masaki Tanito

“…To compare the refractive status between eyes implanted with toric and nontoric intraocular lenses (IOLs) during combined cataract surgery and microhook ab interno trabeculotomy (μLOT), a minimally invasive glaucoma surgery (MIGS). Methods. …”
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Artificial Intelligence (AI) Competency and Educational Needs: Results of an AI Survey of Members of the European Society of Pediatric Endoscopic Surgeons (ESPES) by Holger Till, Hesham Elsayed, Maria Escolino, Ciro Esposito, Sameh Shehata, Georg Singer

“…Half of respondents (51%) expect AI/ML to play a significant role in advancing robotic surgery, oncology, and minimally invasive techniques. A strong majority (84%) felt that the ESPES should lead AI education in pediatric surgery. …”
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Extent of Farm Mechanization in North Bank Plains Zone of Assam, India by Suhail Alam, Haridra Sharma, Ridip Ranjan Saharia, Arunjyoti Sonowal, Amvrin Baruah

“…These centers would enable farmers to access high-quality machinery at affordable rates, minimizing delays and operational costs. Furthermore, training programs for operators and regular maintenance support at CHCs could alleviate technical difficulties. …”
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A Comparative Study of 0.25% Levobupivacaine, 0.25% Ropivacaine, and 0.25% Bupivacaine in Paediatric Single Shot Caudal Block by Jagdeep Sharma, Ruchi Gupta, Anita Kumari, Lakshmi Mahajan, Jasveer Singh

“…We conclude that levobupivacaine and ropivacaine provide similar intraoperative quality with minimal haemodynamic variability and shorter duration of postoperative analgesia without any significant complications when compared with racemic bupivacaine. …”
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Combined Use of Excimer Laser and High-Speed Rotational Atherectomy to Overcome a Severely Calcified Lesion in Endovascular Therapy by Keisuke Nakabayashi, Shinya Hata, Nobuhito Kaneko, Akihiro Matsui, Kazuhiko Tanaka, Hiroshi Ando, Minoru Shimizu

“…However, no devices (minimal balloon, microcatheter, or Crosser system) were able to pass the lesion in antegrade or retrograde manner, even though the child catheter support or needle cracking technique from outside/inside was applied. …”
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The Effect of Bariatric Surgery Volume on General Surgery Outcomes for Morbidly Obese Patients by Katheryn Hope Wilkinson, Ruizhe Wu, Aniko Szabo, Rana Higgins, Jon Gould, Tammy Kindel

“…HVBH may have a volume-outcomes relationship where the hospital and staff familiarity with the management principles required to minimize the postoperative risk associated with morbid obesity and improve patient outcomes.…”
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Continuous Improvements and Future Challenges of Air Pollution Control at an Advanced Semiconductor Fab by Hsueh-Hsing Lu, Ming-Chun Lu, Thi-Cuc Le, Zhiping An, David Y. H. Pui, Chuen-Jinn Tsai

“…Finally, the by-product NOx can be minimized by using low-NOx burners or de-NOx control technologies in the future.…”
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Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort by Chanakya Kodishala, Vineeta Shobha, S Chandrashekara, Sharath Kumar, Vikram Haridas, Vijay K R Rao, Ramesh Jois, Manisha Daware, Yogesh Preet Singh, Shweta Singhai, B G Dharmanand, Pramod Chebbi, R Subramanian, Ashwini Kamath, Uma Karjiigi, Vikram Raj K Jain, Chethana Dharmapalaiah, Shiva Prasad, C Srinivasa, Ramya Janardana, Benzeeta Pinto, Beenish Nazir, A S Harshini, K M Mahendranath

“…Conclusions: We report high articular disease activity in half while cutaneous disease activity was minimal in majority.…”
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Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1... by Mahmoud A. El Hassab, Wagdy M. Eldehna, Ghaneya S. Hassan, Sahar M. Abou-Seri

“…In an attempt to provide a future guide for developing selective inhibitors for PARP-1 over PARP-2 to minimize the resulting side effects from PARP-2 inhibitors, we constructed a structure-based virtual screening approach (SBVS). …”
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Issues of diagnostics and treatment of abdominal pain at irritable bowel syndrome at outpatient stage of the healthcare by Yu. A. Kucheryavy, T. L. Lapina, M. A. Livzan, M. F. Osipenko

“…In the case of visceral pain the minimal range of laboratory and instrumental tests is indicated. …”
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Efficacy and safety of anti-CD38 monoclonal antibodies-based therapy versus standard therapy in newly diagnosed multiple myeloma patients: a systematic review and meta-analysis by Muhammad Osama, Muhammad Haris Khan, Safeena Khan, Amna Hussain, Ammara Tahir, Mehran Ullah, Abdullah Afridi, Ubaid Ullah, Wajeeh Ur Rehman

“…The primary outcomes were progression-free survival (PFS) and minimal residual disease (MRD) status. Dichotomous outcomes were pooled using risk ratio (RR) along with the 95% confidence interval (CI) in RevMan 5.4. …”
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Urinary Calculi: A Microbiological and Biochemical Analysis at a Tertiary Care Hospital in Eastern Nepal by Pratima Shah, Ratna Baral, C. S. Agrawal, Madhab Lamsal, Dharanidhar Baral, Basudha Khanal

“…This study emphasizes the use of appropriate antimicrobial agents to prevent the regrowth of residual stones and minimize the risk of infectious complications after surgical removal of stones.…”
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Aplicación del modelo &#34;Antecedente-Comportamiento-Consecuencia&#34; en la construcción de lumbreras y túneles Application of an &#34;Antecedent-Behavior-Consequence&#34; model... by Victor Jiménez Arguelles, Jesús A Bustamante, Luis A Rocha Chiu

“…Considering that the construction of the project will require three more years, the second part of the research aims to develop and implement a plan of labor risks prevention (LRP) based on the behavioral intervention of workers, in order to minimize the presence of accidents at work.…”
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A Panel of Three MicroRNA Signatures as a Potential Biomarker for CRC Screening Based on Stages and Functional Prediction Using Bioinformatic Analysis by Syarah Syamimi Mohamed, Azmir Ahmad, Nurul Syakima Ab Mutalib, Tengku Ahmad Damitri Al-Astani Tengku Din, Md Salzihan Md Salleh, Andee Dzulkarnaen Zakaria, Zaidi Zakaria

“…The reflective circulating miRNAs can be contributed to by minimal invasive screening tools. …”
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Participatory research towards the control of snakebite envenoming and other illnesses in a riverine community of the Western Brazilian Amazon. by Alícia Patrine Cacau Santos, Evellyn Antonieta Rondon Tomé Silva, Hiran Sátiro Souza da Gama, Jady Shayenne Mota Cordeiro, Ana Paula Silva Oliveira, Jéssica Albuquerque Araújo, Rafaela Nunes Dávila, Hélio Afonso Amazonas Júnior, Altair Seabra Farias, Jacqueline Almeida Gonçalves Sachett, Vinícius Azevedo Machado, Wuelton Marcelo Monteiro, Felipe Leão Gomes Murta

“…In this scenario, the significant burden of snakebite envenoming (SBE) highlights the need for participatory research to address ways to minimize this situation. Thus, this study aimed to describe the priority health problems identified by this population and the ranking of SBEs in that context, mapping solutions according to the local reality.…”
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UK policymaker and expert perspectives on the smoke-free generation policy: a qualitative study by Rachael L Murray, Joanne Morling, Nathan Davies, Tessa Langley, Manpreet Bains

“…Opinions on enforcement varied. Some believed minimal enforcement would suffice due to anticipated compliance, while others stressed the need for strong enforcement. …”
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Evaluation of Bias in the Measurement of Condensable Particulate Matter with Method 202 by Yu-Mei Huang, Sheng-Hsiu Huang, Chih-Wei Lin, Hsi-Hsien Yang, Chih-Chieh Chen

“…We measured a 4% loss in particles due to the gap between the filter paper and the filter paper holder provided by the original manufacturer; therefore, a gasket to minimize leakage is recommended. Finally, the organic fraction required only 1.5–2.5 h of drying time when it was placed in the forced ventilation chamber, and a sample recovery rate of > 98.5% was subsequently achieved. …”
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