Poor efficacy of the combination of clarithromycin, amikacin, and cefoxitin against Mycobacterium abscessus in the hollow fiber infection model by Etienne Vignaud, Sylvain Goutelle, Charlotte Genestet, Jérôme Guitton, Sabine Cohen, Chloé Bourg, Aurore Durand, Laura Lebouteiller, Albin Bernard, Caroline Richet, Oana Dumitrescu, Elisabeth Hodille

“…Moreover, increasing clarithromycin concentrations stabilized the amikacin-tolerance level: amikacin minimal inhibitory concentration of amikacin-tolerant strains increased over time using blood concentrations while it remained stable using lung concentrations. …”
Get full text

NIR‐II AIEgens nanosystem for fluorescence and chemiluminescence synergistic imaging‐guided precise resection in osteosarcoma surgery by Ruotong Li, Kaiyuan Liu, Qian Hu, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Xingjun Zhu, Wei Sun

“…Precise and tumor‐specific resection guidance to minimize recurrence remains a significant challenge. …”
Get full text

Association of ERCC2/XPD polymorphisms and the risk of head and neck carcinoma: a systematic review, meta-analysis, trial sequential analysis, network analysis, and functional effe... by Mohammad Moslem Imani, Ali Ashabi, Farzad Rezaei, Atefe Saffar Shahroudi, Sadegh Kashkouli, Edris Sadeghi, Masoud Sadeghi

“…Future studies should also aim to minimize the impact of confounding factors and heterogeneity to ensure more accurate results.…”
Get full text

Effects of Breast-Conserving Surgery Combined with Sentinel Lymph Node Biopsy on Breast Cosmetic Appearance and Systemic Stress of Patients with Breast Cancer by Jing Ji, Junfeng Shi, Xia Da, Guozhu Wang, Jin Xu

“…Propensity score matching was performed to minimize selection bias based on baseline characteristics, resulting in two matched groups of 55 patients each. …”
Get full text

Influence of SARS-CoV2 Pandemic on Colorectal Cancer Diagnosis, Presentation, and Surgical Management in a Tertiary Center: A Retrospective Study by Roman Taulean, Roxana Zaharie, Dan Valean, Lia Usatiuc, Mohammad Dib, Emil Moiș, Calin Popa, Andra Ciocan, Alin Fetti, Nadim Al-Hajjar, Florin Zaharie

“…<b>Results</b>: Statistically significant differences regarding environment, type of admission, and ASA score, as well as a more advanced tumoral stage, increased number of important postoperative complications, and a lower minimally invasive surgical approach, were highlighted within the pandemic group. …”
Get full text

Structures and strategies for retaining an international pediatric cohort from birth: Lessons from The Environmental Determinants of Diabetes in the Young (TEDDY) study by Patricia Gesualdo, Jessica Melin, Rachel Karban, Claire Crouch, Michael Killian, Diane Hopkins, Annika Adamsson, Joanna Stock, Suzanne Bennett Johnson, Judith Baxter

“…Background: Retention of study participants in observational studies is essential to maintaining the representativeness of the population, minimizing selection bias, and assuring sufficient statistical power. …”
Get full text

Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints by Fatemeh Nosrat, Cem Dede, Lucas B. McCullum, Raul Garcia, Abdallah S.R. Mohamed, Jacob G. Scott, James E. Bates, Brigid A. McDonald, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Aysenur Karagoz, Amy C. Moreno, Lisanne V. van Dijk, Kristy K. Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J. Schaefer, Clifton D. Fuller

“…Conclusion: In limited-resource settings that impeded high-frequency adaptations, ΔNTCP thresholds obtained from an MDP model could derive optimal timing of re-planning to minimize the likelihood of treatment toxicities.…”
Get full text

Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors by Andreas Hermann, Jeong Beom Kim, Sumitra Srimasorn, Holm Zaehres, Peter Reinhardt, Hans R. Schöler, Alexander Storch

“…Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of the transcription factors OCT4, SOX2, KLF4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an attempt to minimize the risk of chromosomal disruption and to simplify reprogramming, several studies demonstrated that a reduced set of reprogramming factors is sufficient to generate iPSC. …”
Get full text

Modified CD15/CD16-CLL1 inhibitory CAR-T cells for mitigating granulocytopenia toxicities in the treatment of acute myeloid leukemia by Rui Zhang, Yifan Zhao, Xiao Chai, Yingshuai Wang, Mohan Zhao, Shujing Guo, Yu Zhang, Mingfeng Zhao

“…These modified cells demonstrate enhanced cytotoxicity against blasts while minimizing neutrophil elimination. Furthermore, their functionality has been effectively validated through both in vitro and in vivo experiments. …”
Get full text

Predictive modeling and optimization of noise emissions in a palm oil methyl ester-fueled diesel engine using response surface methodology and artificial neural network integrated... by J.M. Zikri, M.S.M. Sani, M.F.F.A. Rashid, J. Muriban, G.S. Prayogo

“…Specific components, such as the radiator, crankshaft, and crankcase, exhibited minimal prediction errors under ANN-GA, suggesting that this model is particularly adept at capturing the complex noise emission patterns associated with POME-fueled engines. …”
Get full text

Ageing response of Ni-rich NiTi shape memory alloy additively manufactured by electron beam freeform fabrication by R.P.M. Guimarães, B. Rauchdobler, F. Pixner, F.M.B. Ferraz, A. Mahdi, N. Enzinger, C. Poletti, S.T. Amancio-Filho

“…The solubilised sample aged at 350 °C for 12 h showed optimal superelastic behaviour, with nearly complete strain recovery and minimal permanent strain (1.3%) after ten compression cycles under 860 MPa. …”
Get full text

Diffused Multi-scale Generative Adversarial Network for low-dose PET images reconstruction by Xiang Yu, Daoyan Hu, Qiong Yao, Yu Fu, Yan Zhong, Jing Wang, Mei Tian, Hong Zhang

“…This method offers a potential balance between minimizing radiation exposure and preserving diagnostic performance.…”
Get full text

Anatomical and physiological features of the right heart affecting the effectiveness of balloon valvuloplasty and increase the risk of repeated interventions in children with valvu... by Yu.L. Kuzmenko, A.A. Dovhaliuk, M.P. Radchenko, O.О. Motrechko

“…This procedure was associated with no cases of lethality and with a minimal risk of complications (1.6 %). During 5 years of follow-up, 87.8 % of newborns and 88.5 % of children between 29 days and 1 year did not require repeat surgery. …”
Get full text

A backwater technology for enhancing pollutants discharge from aquaculture tanks in a Litopenaeus vannamei recirculating aquaculture system: Performance and control models by Jianping Xu, Yishuai Du, Jiawei Zhang, Fudi Chen, Li Zhou, Tianlong Qiu, Jianming Sun

“…This improvement is due to the IEB device's capability to enhance the removal of SSN, thereby minimizing its dissolution, decomposition, and mineralization. …”
Get full text

Deciphering the potential of plant metabolites as insecticides against melon fly (Zeugodacus cucurbitae): Exposing control alternatives to assure food security by Zinat Jahan Chowdhury, Anik Banik, Tanjin Barketullah Robin, Mohammed Rashed Chowdhury

“…This study identified 59 phytocompounds with potential insecticidal properties against the melon fly, exhibiting minimal environmental impact. Key protein targets—hedgehog protein, spastin protein, and ABC-type heme transporter ABCB6 protein—were selected for binding affinity analysis. …”
Get full text

Guest-Host Interactions in Symmetrical Carboxy Heptamethine Cyanine Dyes-Titanium Dioxide Systems: Synthesis, Theoretical Calculations, Aggregation Properties, and Application in D... by Rodrigo da Costa Duarte, Matheus Costa de Oliveira, Josene Maria Toldo, Paulo Fernando Bruno Gonçalves, Marcos José Leite Santos, Fabiano Severo Rodembusch

“…Different approaches have been tested, aimed at reducing the H-aggregation and minimizing the competition between cyanine molecules and DCA for active sites of the host, thus improving solar cell efficiency. …”
Get full text

Advanced KNN-based cost-efficient algorithm for precision localization and energy optimization in dynamic underwater sensor networks by Nadia Shamshad, Lei Wang, Kiran Saleem, Danish Sarwr, Salil Bharany, Ahmad Almogren, Jaeyoung Choi, Ateeq Ur Rehman, Ayman Altameem

“…By addressing existing localization challenges, the algorithm minimizes localization errors, energy consumption and Time costs while significantly enhancing localization accuracy to 99.98%. …”
Get full text

OSAD: Open-Set Aircraft Detection in SAR Images by Xiayang Xiao, Zhuoxuan Li, Xiaolin Mi, Dandan Gu, Haipeng Wang

“…PCL employs prototype-based contrastive encoding loss to promote instance-level intraclass compactness and interclass variance, aiming to minimize the overlap between known and unknown distributions and reduce the empirical classification risk of known categories. …”
Get full text

Isolation and Characterisation of Mesenchymal Stem Cells from Rat Bone Marrow and the Endosteal Niche: A Comparative Study by Norhayati Yusop, Paul Battersby, Amr Alraies, Alastair J. Sloan, Ryan Moseley, Rachel J. Waddington

“…Both populations exhibited consistent telomere lengths (12–17 kb), minimal senescence, and positive telomerase expression. …”
Get full text

Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury by Linzhong Yang, Yuanchen Liu, Cheng Tao, Zichen Cao, Shilin Guo, Zheng Wei, Yanyi Wang, Tao Liu, Lin Chen, Ke Xiong, Xingyu Luo, Jianchuan Ran, Wei Han

“…This approach is designed to minimize the likelihood of thrombus formation and to clear the intravascular inflammatory microenvironment, with the aim of preventing and salvaging ischemic flaps. …”
Get full text