Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

“…Topical drug administration effectively minimizes side effects. We aimed to investigate potential trends of the efficacy of topical delgocitinib administration in a mouse model. …”
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Management of Oro-Antral Communication: A Systemic Review of Diagnostic and Therapeutic Strategies by Gianna Dipalma, Angelo Michele Inchingolo, Irma Trilli, Laura Ferrante, Angela Di Noia, Elisabetta de Ruvo, Francesco Inchingolo, Antonio Mancini, Stefan Cocis, Andrea Palermo, Alessio Danilo Inchingolo

“…Emerging techniques and minimally invasive procedures continue to improve patient outcomes, offering hope for more effective and sustainable solutions in complex cases.…”
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Caspase-11 Modulates Inflammation and Attenuates Toxoplasma gondii Pathogenesis by Sheryl L. Coutermarsh-Ott, John T. Doran, Caroline Campbell, Tere M. Williams, David S. Lindsay, Irving C. Allen

“…Together, our data suggest that caspase-11 functions to protect the host by enhancing inflammation during the early phase of infection in an effort to minimize disease pathogenesis during later stages of toxoplasmosis.…”
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4-Thiobenzoic acid-functionalized nanocomposite probes for surface-enhanced raman spectroscopy-based detection of CA19-9 in colorectal adenocarcinoma by Yinan Hu, Tao Liu, Bo Guo, Miao Ni, Yanrong Li

“…Recovery studies in spiked serum samples yielded results ranging from 94.5 % to 105.2 %, indicating minimal matrix effects. Clinical validation using 70 serum samples (50 colorectal adenocarcinoma patients, 20 healthy volunteers) showed strong agreement with a commercial ELISA kit (Pearson's r = 0.987, p < 0.0001). …”
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Magnetic Integrated Multi-Trap Filters Using Mutual Inductance to Mitigate Current Harmonics in Grid-Connected Power Electronics Converters by Maged Al-Barashi, Aicheng Zou, Yongjun Wang, Wei Luo, Nan Shao, Zeyu Tang, Bing Lu

“…Moreover, a design method is presented to further minimize the size of the output filter components. …”
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Prioritizing multifunctional conservation zones with dominant function based on comprehensive hotspots and bundles of ecosystem service by Liehui Zhi, Xiaowen Li, Junhong Bai, Dongdong Shao

“…This optimized zoning yields minimizing land use in the core priority zone, achieving 79% synergy with just 7% allocated for priority protection, thereby fostering efficient ecological safeguards. …”
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Effect of Time and Temperature on the Detection of PRRSV RNA and Endogenous Internal Sample Control in Porcine Tongue Fluids by Isadora F. Machado, Onyekachukwu H. Osemeke, Kent Doolittle, Cesar A. A. Moura, Lucina Galina Pantoja, Giovani Trevisan, Phillip Gauger, Daniel C. L. Linhares

“…At 4 °C, Ct value variation was minimal (≤1.1) over 14 days (336 h), with no significant changes within 48 h. …”
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Synthesis, Characterization, Semiempirical and Biological Activities of Organotin(IV) Carboxylates with 4-Piperidinecarboxylic Acid by Shabbir Hussain, Saqib Ali, Saira Shahzadi, Saroj K. Sharma, Kushal Qanungo, Muhammad Shahid

“…The organotin(IV) carboxylates displayed powerful antimicrobial activities against various strains of bacteria and fungi and their minimal inhibitory concentration were also evaluated. …”
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Occurrence of macrolides resistance in Legionella pneumophila ST188: Results of the Belgian epidemiology and resistome investigation of clinical isolates by Charlotte Michel, Fedoua Echahidi, Geraldine De Muylder, Max Sewell, Ian Boostrom, Olivier Denis, Owen B. Spiller, Denis Pierard

“…Urinary antigen testing remains the main used test, but polymerase chain reaction and serology allow the diagnostic in 14.8% and 2.4% of cases, respectively. cgMLST showed a good discrimination between sequence typing (ST) and minimal variation for ST47 isolates, whereas ST1s were more diverse. …”
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A lectin produced by a Streptomyces species targets mammalian pancreatic acinar cells in mice and humans by Janine C. Quijano, Honoka Natsuyama, Alonso Tapia, Karine Bagramyan, Jose A. Ortiz, Jacob Mares, Markus Kalkum, Yoko Fujita-Yamaguchi, Hsun Teresa Ku

“…We found that only acinar, but not ductal or endocrine cells were stained positively with mCherry-SHA from embryonic day (E) 18.5 to 35 weeks old mice; in contrast, E12.5 and E15.5 pancreas display minimal mCherry-SHA binding. In adult humans, mCherry-SHA also targeted acinar cells specifically; however, only tissue from blood type B donors, but not type A or O donors, showed positivity. …”
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Mechanical Properties and Shrinkage of Ultrahigh-Performance Concrete Containing Lithium Carbonate and Nano-Calcium Carbonate by Tingyu Wang, Jianqing Gong, Bo Chen, Xiao Gong, Wanli Guo, Yang Zhang, Falei Li

“…The results also indicated that the combined LC-NC dosage had profound effects on the early autogenous shrinkage of UHPC, which could, however, be minimized by adjusting the Li2CO3 and NC dosages. That is, the combined dosage of the two early strength enhancers shortens the hydration induction period of cement whilst concurrently accelerating the hydration rate of the cement. …”
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Low-carbon economic dispatch of integrated energy system with carbon capture power plant and multiple utilization of hydrogen energy by Jiarui Wang, Xiu Ji, Xiangdong Meng, Yang Bai, Meiyue Li

“…It can utilize the potential of collaborative operation with carbon capture power plants; on this basis, consider the transferability and substitutability characteristics of electric heating gas load, and construct an electric heating gas comprehensive demand response model; secondly, consider the mutual recognition relationship between carbon quotas and green certificates, Propose a green certificate-carbon trading mechanism; finally establish an integrated energy system with the optimization goal of minimizing the sum of energy purchase cost, demand response compensation cost, wind curtailment cost, carbon storage cost, carbon purchase cost, carbon trading cost and green certificate trading compensation. …”
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Evaluating the Functionality of Conjunctiva Using a Rabbit Dry Eye Model by Yuan Ning, Dhruva Bhattacharya, Richard E. Jones, Fangkun Zhao, Rongji Chen, Jinsong Zhang, Mingwu Wang

“…Nictitating membrane, lacrimal and Harderian glands were surgically excised from male New Zealand white rabbits using minimally invasive surgery. Fluorescein/rose Bengal staining of ocular surface (OS) and Schirmer test were done before (BE) and after excision (AE). …”
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Detection and safety assessment of bonding defects in architectural decorative surface layer based on the variation of vibration acceleration amplitude by Zhide Wang, Xiaogen Liu, Dake Cao, Detian Wan, Shaoshan Wei

“…Bonding defects in the architectural decorative surface layer can cause the finish layer to detach, posing a significant threat to urban public safety. To minimize the risk of finish layer detachment and ensure its safety, this study presents a novel non-destructive testing technique that detects bonding defects in the decorative surface layer by analyzing variations in vibration acceleration amplitude. …”
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Pharmacokinetics of Transdermal Flunixin Meglumine Following a Single Dose in Marine Toads (Rhinella marina) by Gregory Scott, Meghan M. Louis, Julie A. Balko, Claire M. Bublitz, Brigid V. Troan, Ronald E. Baynes, Dustin Smith, Larry J. Minter

“…Histopathology of skin and major organs revealed one minimal superficial lesion in a single toad potentially attributable to flunixin meglumine administration; otherwise, no other treatment-related lesions were observed in 11 of 12 toads. …”
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Dataset of speech produced with delayed auditory feedbackOpen Science FrameworkOpen Science Framework by Matthias Heyne, Monique C. Tardif, Alexander Ocampo, Ashley P. Petitjean, Emily J. Hacker, Caroline N. Fox, Megan A. Liu, Madeline Fontana, Vincent Pennetti, Jason W. Bohland

“…Auditory feedback latencies were tightly controlled and included a zero / minimal delay (∼12 ms), 150 ms, 200 ms, and 250 ms. …”
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CFD modelling and simulation of anaerobic digestion reactors for energy generation from organic wastes: A comprehensive review by Muhammad Usman Farid, Indiana A. Olbert, Andreas Bück, Abdul Ghafoor, Guangxue Wu

“…This approach contributes to minimize the experimental costs while optimizing the reactor configurations in less time. …”
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Establishing a Surgical Procedure for Rhesus Epiretinal Scaffold Implantation with HiPSC-Derived Retinal Progenitors by Ziming Luo, Kang Li, Kaijing Li, Bikun Xian, Ying Liu, Sijing Yang, Chaochao Xu, Zhigang Fan, Shoutao Lu, Haijun Zhang, Jian Ge

“…Follow-up examination showed that retinal tack fixation was the only method to maintain the scaffolds attached to host retina for at least 3 weeks, which is the minimal time required for cell integration. Histological staining demonstrated slight glial fibrillary acidic protein (GFAP) accumulation in the retinal tack insertion area. …”
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Predicting Traffic Accident Risk in Seoul Metropolitan City: A Dataset Construction Approach by Ji-Woong Yang, Hyeon-Jin Jung, Tae-Wook Kim, Han-Jin Lee, Ellen J. Hong

“…In contemporary society, the rapid progression of urbanization and technological advancements has led to a substantial increase in the number of vehicles, consequently elevating the rate of traffic accidents. To minimize the human and economic losses resulting from these accidents, extensive research has been conducted over the past decades. …”
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Analysis of Spiders’ Joint Kinematics and Driving Modes under Different Ground Conditions by Xin Hao, Wenxing Ma, Chunbao Liu, Yilei Li, Zhihui Qian, Luquan Ren, Lei Ren

“…The duty factor was greater than 60% in all three pavement environments, which was minimal when walking on the sloped soft pavement. …”
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