Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer by Jeremy L. Pinyon, Georg vonJonquieres, Stephen L. Mow, Amr Al Abed, Keng‐Yin Lai, Mathumathi Manoharan, Edward N. Crawford, Stanley H. Xue, Sarah Smith‐Moore, Lisa J. Caproni, Sarah Milsom, Matthias Klugmann, Nigel H. Lovell, Gary D. Housley

“…Here, this work addresses these challenges through gene electrotransfer (GET) of “naked” polyanionic DNA/mRNA using a single needle form‐factor which supports “electro‐lens” based compression of the local electric field, and local control of tissue conductivity, enabling single capacitive discharge minimal charge gene delivery. Proof‐of‐concept studies for “single capacitive discharge conductivity‐clamped gene electrotransfer” (SCD‐CC‐GET) deep tissue delivery of naked DNA and mRNA in the mouse hindlimb skeletal muscle achieve stable (>18 month) expression of luciferase reporter synthetic DNA, and mRNA encoding the reporter yield rapid onset (<3 h) high transient expression for several weeks. …”
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The Impact of Electronic Reading Devices on Reading Speed and Comfort in Patients with Decreased Vision by Henry L. Feng, Daniel B. Roth, Howard F. Fine, Jonathan L. Prenner, Kunjal K. Modi, William J. Feuer

“…Reading speed was faster on back-illuminated media compared to nonilluminated media. Text magnification minimized losses in reading performance with worsening patient VA. …”
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Toward the Development of the Trojan Female Technique in Pest Insects: Male‐Specific Influence of Mitochondrial Haplotype on Reproductive Output in the Seed Beetle Acanthoscelides... by Lea Vlajnić, Uroš Savković, Jelena Jović, Sanja Budečević, Biljana Stojković, Mirko Đorđević

“…ABSTRACT Biocontrol techniques that impair reproductive capacity of insect pests provide opportunities to control the dynamics of their populations while minimizing collateral damage to non‐target species and the environment. …”
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Machine learning helps reveal key factors affecting tire wear particulate matter emissions by Zhenyu Jia, Jiawei Yin, Tiange Fang, Zhiwen Jiang, Chongzhi Zhong, Zeping Cao, Lin Wu, Ning Wei, Zhengyu Men, Lei Yang, Qijun Zhang, Hongjun Mao

“…Avoiding strenuous driving behaviors (TTF < 400 N, TLF < 400 N), reducing tread temperature (T < 45℃), and minimizing the number of small tread patterns are feasible ways to reduce TWPs.…”
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Preferential flow in soils is key to the development of nebkhas in water limited regions by Weicheng Luo, Wenzhi Zhao, Ning An, Chengpeng Sun, Hong Zhou

“…The degree of preferential flow was highest in LN, intermediate in SN, and minimal in BD, and it decreased with an increase in precipitation. …”
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Cervical heterotopic heart transplantation in mice using a novel suture technique by Hao Dun, MD MSc, Maura Sticco-Ivins, Yuriko Terada, MD PhD, Amber Berning, MD, Kory J. Lavine, MD PhD, Daniel Kreisel, MD PhD, Benjamin J. Kopecky, MD PhD

“…This procedure reconstitutes coronary blood flow in the heart graft with minimal interruption to recipient anatomy and provides an experimental platform to study transplant immunology.…”
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Determining anatomically-safe corridors for placement of lateral mass screws in the first cervical vertebra of the Emirati population – a CT study by Dineshwary Suresh, Nerissa Naidoo, Rashid AlSharhan, Usama Al Bastaki, Jeyaseelan Lakshmanan, Baylis Vivek Joseph, Ivan James Prithishkumar

“…Pre-operative knowledge of the above dimensions would help in greater precision, minimizing the risk of injury to neurovascular structures in the vicinity of C1 lateral mass.…”
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NLOS Dies Twice: Challenges and Solutions of V2X for Cooperative Perception by Lantao Li, Wenqi Zhang, Xiaoxue Wang, Tao Cui, Chen Sun

“…Multi-agent multi-sensor fusion between connected vehicles for cooperative perception has recently been recognized as the best technique for minimizing the occluded zone of individual vehicular perception system and further enhancing the overall safety of autonomous driving system. …”
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Boosting non-oxide interfacial Co/SiO2 hybrid bonding by selective surface activation by Xiaoyun Qi, Shicheng Zhou, Yan Ma, Tadatomo Suga, Chenxi Wang

“…Additionally, the substantial coefficient of thermal expansion mismatch between the robust capping layers (Co and SiO _2 layers) necessitates hybrid bonding with minimal thermal input and compression. In this study, we introduce a ternary plasma activation strategy employing an Ar/NH _3 /H _2 O gas mixture to facilitate Co/SiO _2 hybrid bonding at temperatures as low as ∼200 °C, which is markedly lower than the melting point of Co (∼1500 °C). …”
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Intrusion detection using synaptic intelligent convolutional neural networks for dynamic Internet of Things environments by Hui Chen, Zhendong Wang, Shuxin Yang, Xiao Luo, Daojing He, Sammy Chan

“…Enhancing the deployability of the detection model on resource-limited IoT devices, the model’s structure and parameters are quantized, and the loss associated with model quantization is minimized through quantization-aware training. Ultimately, experiments are conducted on the intrusion detection datasets CIC IDS2017 and CICIoT2023, demonstrating that the proposed detection method outperforms other state-of-the-art intrusion detection approaches. …”
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Molecular Simulation of Graphene Growth Reactions at Various Temperatures Derived from Benzene in Coal Tar Aromatic Hydrocarbons by Shuhan Zhao, Zhongyang Luo, Mengxiang Fang, Qinhui Wang, Jianmeng Cen

“…This approach offers a promising avenue for the cost-effective and large-scale industrial production of graphene while minimizing energy consumption. Nevertheless, there is a paucity of research focused on the low-temperature synthesis mechanisms of graphene derived from aromatic compounds in the context of graphene growth. …”
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Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis by Simeng Zhang, Caiyi Wei, Bo Peng, Lizhi Lv, Fengbo Pei, Jianming Xia, Jun Yan, Jie Liu, Qiang Wang, Yi Shi

“…This emphasized the significance of minimizing CPB exposure for the prognosis of patients with SVAS.…”
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Evaluation of addition of chemical and organic fertilizers to irrigation in the production of Prosopis laevigata (Humb. & Bonpl. ex Willd.) M.C. Johnst. by Víctor M. Martínez-Calderón, Fabián A. Rubalcava-Castillo, Jorge A. Torres-González, Manuel H. Sandoval-Ortega, Araceli G. Mendieta-Vázquez

“…Producers should create their own organic fertilizers to minimize costs. …”
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Survival after Abdominoperineal and Sphincter-Preserving Resection in Nonmetastatic Rectal Cancer: A Population-Based Time-Trend and Propensity Score-Matched SEER Analysis by Rene Warschkow, Sabrina M. Ebinger, Walter Brunner, Bruno M. Schmied, Lukas Marti

“…In 36,488 patients with rectal cancer resection, the APR rate declined from 31.8% in 1998 to 19.2% in 2011, with a significant trend change in 2004 at 21.6% (P<0.001). To minimize a potential time-trend bias, survival analysis was limited to patients diagnosed after 2004. …”
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Optimal Positioning and Sizing of Distributed Energy Sources in Distribution System Using Hunter-Prey Optimizer Algorithm by P. Rajakumar, M. Senthil Kumar, K. Karunanithi, S. Vinoth John Prakash, P. Baburao, S. P. Raja

“…HPO optimizes solar photovoltaic (PV) and wind turbine (WT) DG systems to minimize multi-objective functions (MOFs) including active power loss (APL) and voltage deviation (VD), and to enhance voltage stability (VS). …”
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Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair by Penghui Wang, Zaifeng Chen, Ping Li, Abdullah Al Mamun, Shaoxia Ning, Jinjing Zhang, Chonghui Tang, Tianmiao Sun, Jian Xiao, Xiaojie Wei, Fenzan Wu

“…Our results demonstrate that encapsulating Que in LipTC (QLipTC) enhances solubility, minimizes toxic side effects, facilitates lesion targeting, and aids in crossing the blood-spinal cord barrier. …”
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Offshore Network Development to Foster the Energy Transition by Enrico Maria Carlini, Corrado Gadaleta, Michela Migliori, Francesca Longobardi, Gianfranco Luongo, Stefano Lauria, Marco Maccioni, Jacopo Dell’Olmo

“…Starting from a realistic estimate of the offshore wind power plants (OWPPs) to be realized off the southern coasts in a very long-term scenario, this paper presents a novel optimization procedure for meshed AC offshore network configuration, aiming at minimizing the offshore wind generation curtailment based on the DC optimal power flow approximation, assessing the security condition of the whole onshore and offshore networks. …”
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Description of the New Species <i>Laccaria albifolia</i> (Hydnangiaceae, Basidiomycota) and a Reassessment of <i>Laccaria affinis</i> Based on Morphological and Phylogenetic Analys... by Francesco Dovana, Roberto Para, Gabriel Moreno, Edoardo Scali, Matteo Garbelotto, Bernardo Ernesto Lechner, Luigi Forte

“…Phylogenetic analyses indicate that <i>L. affinis</i> occupies a distinct clade within Northern Hemisphere <i>Laccaria</i> species, although minimal genetic differences challenge its independence from <i>L. macrocystidiata</i>. …”
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Restless Legs Syndrome: A Comprehensive Review of Current Treatment Methods and the Disease's Impact on Quality of Life by Natalie Papachristoforou, Natalia Tekiela, Daria Michałka, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Emilia Bąk, Justyna Głowacka, Aleksandra Kocjan, Radosław Chmiel

“…Pharmacological strategies involve dopaminergic medications, low-potency opioids, and benzodiazepines, with a target on minimizing side effects and dependency. Conclusion: RLS affects approximately 5-10% of the population, severely disrupting sleep and daily functioning. …”
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Comparative analysis of wild and cultivated Lathyrus L. species to assess their content of sugars, polyols, free fatty acids, and phytosterols by A. E. Solovyeva, T. V. Shelenga, A. L. Shavarda, M. O. Burlyaeva

“…The grass pea is one of the most resistant to drought, aterlogging, cold, salinity, diseases and pests among cultivated legumes, and it is grown at minimal cost. The development of new Lathyrus cultivars with an improved composition of nutrients will make it possible to produce high-quality animal feed in areas with extremely unstable weather conditions. …”
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