Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease by Vincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

“…For other antivirals where resistance has been a challenge, we have demonstrated that the likelihood of resistance can be minimized by designing inhibitors that leverage the evolutionary constraints of the target. …”
Get full text

Hemolysis, Elevated Liver Enzymes, and Low Platelets, Severe Fetal Growth Restriction, Postpartum Subarachnoid Hemorrhage, and Craniotomy: A Rare Case Report and Systematic Review by Shadi Rezai, Justin Faye, Alexander Hughes, Mon-Lai Cheung, Joel R. Cohen, Judy A. Kaia, Paul N. Fuller, Cassandra E. Henderson

“…The syndrome itself is manifested by hemolytic anemia, increased liver enzymes, and decreasing platelet counts with a majority of neurological defects resulting from hemorrhagic stroke or subarachnoid hemorrhage (SAH). To minimize adverse perinatal outcomes, obstetric management of this medical complication must include rapid clinical assessment, diagnostic examination, and neurosurgery consultation.…”
Get full text

The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Tria... by Tanyong Pipanmekaporn, Yodying Punjasawadwong, Somrat Charuluxananan, Worawut Lapisatepun, Pavena Bunburaphong

“…Prophylactic dexmedetomidine can attenuate the hemodynamic responses to laryngoscopy and DLT intubation with minimal adverse effects. This trial is registered with ClinicalTrials.gov NCT01289769.…”
Get full text

ElectroCom61: A multiclass dataset for detection of electronic componentsMendeley Data by Md. Faiyaz Abdullah Sayeedi, Anas Mohammad Ishfaqul Muktadir Osmani, Taimur Rahman, Jannatul Ferdous Deepti, Raiyan Rahman, Salekul Islam

“…Additionally, we conducted minimal pre-processing to optimise model training and performance. …”
Get full text

Process Optimization in Sea Ports: Integrating Sustainability and Efficiency Through a Novel Mathematical Model by Maria Teresa Pereira, Nuno Rocha, Francisco Gomes Silva, Miguel Ângelo Lellis Moreira, Yusuf Ozden Altinkaya, Marisa João Pereira

“…Key findings demonstrate the model’s potential to streamline operations and minimize environmental impacts. These advancements align economic efficiency with environmental sustainability, addressing global emissions regulations. …”
Get full text

α-Copaene is a potent repellent against the Asian Citrus Psyllid Diaphorina citri by Rodrigo Facchini Magnani, Haroldo Xavier Linhares Volpe, Rejane Angélica Grigio Luvizotto, Tatiana Aparecida Mulinari, Thiago Trevisoli Agostini, Jairo Kenupp Bastos, Victor Pena Ribeiro, Michele Carmo-Sousa, Nelson Arno Wulff, Leandro Peña, Walter S. Leal

“…There is growing evidence that the push-pull strategy is suitable to partially mitigate HLB by repelling ACP with transgenic plants engineered to produce repellents and attracting the vector to plants with a minimal disease transmission rate. Species that pull ACP away from commercial citrus plants have been identified, and transgenic plants that repel ACP have been developed. …”
Get full text

Strength training in pregnancy. Systematic review of benefits and risks by Karol Demel, Antoni Kantor, Jakub Król, Łukasz Bialic, Monika Dziedzic, Sebastian Polok, Adriana Potoczek, Justyna Talaska, Marta Godyń, Dorota Zatłoka-Mazur

“…Conclusions Individualized assessment and tailored programs are essential to maximize benefits and minimize risks. Safe practices, including professional consultation, appropriate exercise selection, and monitoring of intensity, are crucial. …”
Get full text

Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies by Fang-Yuan Liu, Xin Liu, Dan-Ni Ding, Shao-Xuan Liu, Jing Xu, Yu-Xin Zhao, Yan-Hong Wang, Feng-Juan Han

“…Conclusions From a game theory perspective, doctors can devise strategies to minimize drug toxicity and improve tumor treatment outcomes by coordinating the use of chemotherapy drugs with appropriate adjustments to Chinese medicine therapy methods.…”
Get full text

Strain Rockbursts Simulated by Low-Strength Brittle Equivalent Materials by Lang Li, Mingyang Wang, Pengxian Fan, Haiming Jiang, Yihao Cheng, Derong Wang

“…To begin with, the boundary conditions for excavation in deep underground engineering were analysed and elastic adaptive boundary is an effective way to minimize the boundary effect of geomechanical model test. …”
Get full text

Effects of Cover-Plate Geometry on the Mechanical Behavior of Steel Frame Joints with Middle-Flange and Wide-Flange H-Beams by Osama Zaid Yahya Al-Ansi, Linfeng Lu, Saleem Mohammed Ali Ahmed AL-Saeedi, Bingyou Liu

“…The shape of the top cover plate had minimal impact on mechanical behavior. The cover-plate length and thickness significantly influenced seismic ductility and load-bearing capacity. …”
Get full text

<i>Broussonetia papyrifera</i> Extract Can Be Used as a Raw Material Source for a Sterility Agent for <i>Microtus fortis</i> by Shuangye Wang, Tian Lan, Yunlin Zhao, Wanfu Liu, Tian Huang, Meiwen Zhang, Zhiyuan Hu, Zhenggang Xu

“…Plant sterilants are used to control rodent populations due to their minimal environmental risk and other ethical considerations. …”
Get full text

Retroperitoneal Soft Tissue Sarcoma and Kidney Autotransplantation: A Case Report by S. N. Hakkesteegt, C. A. J. Oudmaijer, L. J. Jeletich, J. Sprakel, H. J. A. N. Kimenai, D. J. Grünhagen

“…RPS often presents late due to minimal early symptoms, typically requiring complete en‐bloc resection for optimal survival outcomes. …”
Get full text

Reusable Biosensor for Easy RNA Detection from Unfiltered Saliva by Paweł Wityk, Agata Terebieniec, Robert Nowak, Jacek Łubiński, Martyna Mroczyńska-Szeląg, Tomasz Wityk, Dorota Kostrzewa-Nowak

“…This reusable, easy-to-use biosensor offers significant potential for point-of-care applications in various healthcare settings, providing a fast, efficient, and cost-effective method for detecting viral infections such as COVID-19. Its robust design, minimal sample preparation requirements, and multiple-use capability mark a significant advancement in biosensing technology.…”
Get full text

Analysis of Predictors for Lymph Node Metastasis in Patients with Superficial Esophageal Carcinoma by Ruzhen Jia, Qinsong Luan, Jing Wang, Dongsheng Hou, Shulei Zhao

“…In order to predict related risk factors for lymph node metastasis (LNM) in patients with superficial esophageal carcinoma (SEC) and provide reference for endoscopic minimally invasive treatment, we included a total of 93 patients with superficial esophageal carcinoma who have underwent esophagectomy and lymph node dissection from 2010 to 2015. …”
Get full text

Contact patches of radial tires with different length-to-width ratiosunder static loads by Fengliang Qiao, Zhaojie Shen, Yuxia Kang

“…The findings reveal that as the aspect ratio increases, the contact length along the tire's axial direction decreases, while the contact width along the rolling direction increases. Minimal differences in contact area were observed among tires with different aspect ratios under the same static load. …”
Get full text

Integrating Energy and Time Efficiency in Robotic Manufacturing Cell Design: A Methodology for Optimizing Workplace Layout by Roman Ruzarovsky, Tibor Horak, Robert Bocak, Martin Csekei, Roman Zelník

“…This paper presents a novel methodology for optimizing the deployment of industrial robots and their peripherals, focusing on minimizing energy and time costs to enhance the sustainability of industrial processes. …”
Get full text

Clinical Application of CT-Guided Percutaneous Microwave Ablation for the Treatment of Lung Metastasis from Colorectal Cancer by Lin Li, Ketong Wu, Haiyang Lai, Bo Zhang

“…Our results demonstrate that CT-guided percutaneous MWA appears to be an effective, reliable, and minimally invasive method for the treatment of lung metastasis from colorectal cancer. …”
Get full text

Development of a Cost-effective Adsorption Dryer for High-quality Aerosol Sampling by Simonas Kecorius, Leizel Madueño, Susanne Sues, Josef Cyrys, Mario Lovrić, Mira Pöhlker, Kristina Plauškaitė, Lina Davulienė, Agnė Minderytė, Steigvilė Byčenkienė

“…Aerosol drying below 40% RH is recommended to minimize measurement artifacts, increase data quality, and make results from different environments comparable. …”
Get full text

Correlation and heritability estimation for agronomic traits in rice (Oryza sativa L.) genotypes by Nadir Ali Bhangar, Farah Arain, Mohammad Iqbal Pandrani, Naila Khan, Ghazala Soomro, Faiza Rao, Nimra Rao, Irshad Ali Pandrani, Abdul Hakeem Jamro

“…All the traits showed high heritability showing minimal environmental effect, however, panicle length and fertility% showed medium heritability showing some environmental effect on them. …”
Get full text

A Robust Metatranscriptomic Technology for Population-Scale Studies of Diet, Gut Microbiome, and Human Health by Andrew Hatch, James Horne, Ryan Toma, Brittany L. Twibell, Kalie M. Somerville, Benjamin Pelle, Kinga P. Canfield, Matvey Genkin, Guruduth Banavar, Ally Perlina, Helen Messier, Niels Klitgord, Momchilo Vuyisich

“…A functional readout of the gut microbiome is necessary to enable precise control of the gut microbiome’s functions, which support human health and prevent or minimize a wide range of chronic diseases. Stool metatranscriptomic analysis offers a comprehensive functional view of the gut microbiome, but despite its usefulness, it has rarely been used in clinical studies due to its complexity, cost, and bioinformatic challenges. …”
Get full text