Polymers for the treatment of Alzheimer’s disease by Yunfeng Zhu, Haibin Xu, Chaoyan Yu, Wenting Jiang, Xiaowen Hou, Mingyue Ma, Ji Wu

“…Alzheimer’s disease (AD) is one of the most common diseases of the central nervous system in the middle-aged and elderly population. It is a neurodegenerative disorder, and its main clinical symptoms include the loss of established memories, a decline in learning capacity, and the buildup of β-amyloid peptides. …”
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Outdoor activity time and depression risk among adults aged 40 years and older: a cross-sectional analysis of NHANES 2011–2018 data by Kai Liu, Cheng Guo, Juan Xie, Liming Cheng

“…Subgroup analysis revealed that this association was particularly pronounced among adults aged 40 and older, as well as non-Hispanic whites and non-Hispanic blacks.ConclusionEncouraging outdoor activities may represent an effective public health strategy to reduce depression risk, particularly among middle-aged and older adults and specific ethnic populations. …”
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Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study by Kazuma Ohshima, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Jun Ouchida, Yasuhiko Takegami, Shinya Ishizuka, Ippei Yamauchi, Yukiharu Hasegawa, Kenta Murotani, Shiro Imagama

“…Thus, we aimed to evaluate the DISH effect on QOL and LS in community-dwelling middle-aged and older adults. Data of community volunteers who attended a health checkup in 2018–2019 were assessed. …”
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Effects of forest age and stand density on the growth, soil moisture content, and soil carbon content of Populus simoni plantations in the sandy area of western Liaoning, Northeast... by Hao Chen, Zhaowei Zhang, Xiangyu Yang, Xin Ai, Yutao Wang, Ping Liu

“…We found that DBH and TH increase with increasing stand density in young and middle-aged forests, but the opposite is true at near-maturity, maturity, and over-maturity, where DBH and TH decrease with increasing stand density. …”
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Low Serum Magnesium Level Is Associated with Microalbuminuria in Chinese Diabetic Patients by Baihui Xu, Jichao Sun, Xinru Deng, Xiaolin Huang, Wanwan Sun, Yu Xu, Min Xu, Jieli Lu, Yufang Bi

“…We concluded that low serum magnesium level was significantly associated with the prevalence of microalbuminuria in middle-aged and elderly Chinese.…”
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Parchment Glutamine Index (PQI): A novel method to estimate glutamine deamidation levels in parchment collagen obtained from low-quality MALDI-TOF data by Nair, Bharath, Palomo, Ismael Rodríguez, Markussen, Bo, Wiuf, Carsten, Fiddyment, Sarah, Collins, Matthew James

“…Parchment was used as a writing material in the Middle Ages and was made using animal skins by liming them with Ca(OH)2. …”
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ENDOCRINE DISORDERS IN DOGS: EPIDEMIOLOGY, CLINICAL PRESENTATION, AND DIAGNOSTIC METHODS by Daniela Neagu, Vlad-Emil Luca, Răzvan Codea, Cristian Popovici, Anca Bărbos, Ștefania Dandea, Dragoș Hodor, Alexandra Biriș

“…Diabetes mellitus (55%) and hyperadrenocorticism (22%) were the most common, with seasonal trends noted for diabetes in spring and hyperadrenocorticism in winter. Middle-aged or geriatric dogs showed higher incidences, and overweight dogs frequently had Cushing's syndrome. …”
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Literature review of spontaneous subarachnoid haemorrhage: risk factors, diagnostic features, and complications (Part I) by J. Grigaitė, G. Rutkauskaitė, L. Piliponis, J. Ščerbak, D. Jatužis, J. Valaikienė

“… Ruptured cerebral aneurysm-induced subarachnoid haemorrhage (SAH) is a common cause of disability and death in middle-aged people. SAH is more common in females than males, among non-white ethnicity, and is most commonly diagnosed in Finland and Japan. …”
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An Immunocompetent HIV-Negative Elderly Patient with Low-Grade Fever, Generalized Lymphadenopathy, Splenomegaly, and Acute Phase Response: Do Not Forget Castleman Disease by Kalliopi Azariadis, Maria Ioannou, Kalliopi Zachou, George N. Dalekos

“…Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder that mainly affects middle-aged patients with human immunodeficiency virus (HIV) infection. …”
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Entre peste et famine : caractérisation d’une crise de mortalité par l’étude de trois sépultures multiples du site de Kutná Hora – Sedlec (République tchèque, XIVe siècle)... by Auxane de Lépinau, Dominique Castex, Hana Brzobohatá, Jan Frolík, Filip Velímský, Jaroslav Brůžek, Petr Velemínský, Sacha Kacki

“…The later centuries of the Middle Ages were a time of recurrent epidemics and famines, some of which caused such huge mortality that mass graves and emergency burial grounds had to be created. …”
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The Piesberg: A NW-German site of international importance for the Pennsylvanian (Late Carboniferous) by Angelika Leipner, Tobias Fischer, Patrick Chellouche

“…The importance of the Piesberg for international geosciences has been enabled through its very rich mining history beginning in the Middle Ages and its long scientific history beginning at the end of the 18th century. …”
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Archaeological heritage and problems of its preservation in Ghor province, Afghanistan by Aleksiejus Luchtanas

“…Ghor province is full of easily recognizable objects of archaeological heritage: • Ancient settlements (tapa), which have chronology from Eneolithic and Bronze Age to the Islamic period of the Middle Ages; • Remains of castles and fortresses from the 1st millennium A.D.; • Monuments from Buddhistic period - monastery of Vayguna Sange Bar (first half of the 15th millennium); • Remains of settlements and cult objects of Kabre Zabok; • Monuments of technology and engineering - mills, brickyards, ruins of bridges, caravanserais - still exist in many places. …”
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Association of anti-phospholipid antibodies and hepatitis B virus infection in Najaf Governorate by Ameer Mohammed Kadhim, Hawraa Ameer Mubark, Dhefaf Hameed Al-Mudhafar, Zainab Hayder Abdulmajeed

“…Conclusion: HBV may lead to the production of APLA in some patients without any other risk factors, especially in middle-aged patients.…”
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Driving Fatigue Prediction Model considering Schedule and Circadian Rhythm by Qi Zhang, Chaozhong Wu, Hui Zhang

“…With the cooperation of one commercial transportation company, a Naturalistic Driving Study (NDS) was conducted, and NDS data from thirty-four middle-aged drivers were selected for analysis. With regard to the circadian rhythms, commercial drivers operated the vehicle and started driving at around 09:00, 14:00, and 21:00, respectively. …”
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Transformation of Space Discourse: from Traditional Society to Postmodern Era by V. A. Shchipkov

“…The author refers the archaic society, the Antiquity and the Middle Ages to the traditional stage, the Renaissance, the Modernity and the Postmodernity to the post-traditional. …”
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A cross-sectional study exploring the positive aspects of caregiving in opioid dependence and its relation with quality of life, social support, and caregivers’ burden by Priyanka Saha, Sayan Saha, Gauri Shanker Kaloiya, Siddharth Sarkar

“…Results: Of the 199 caregivers recruited, a majority of the caregivers were middle-aged women. About two-thirds of the patients were currently using opioids (n = 135, 67.8%), while the remaining were abstinent. …”
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Enhanced Hepatocarcinogenicity Due to Agonists of Peroxisome Proliferator-Activated Receptors in Senescent Rats: Role of Peroxisome Proliferation, Cell Proliferation, and Apoptosis by Jihan Youssef, Mostafa Badr

“…In addition, aged livers showed remarkably higher levels of the antiapoptotic protein Bcl-2 than livers of young, adult, and middle-aged animals. Interestingly, the PPARa agonist Wy-14,643 significantly diminished elements of the proapoptotic machinery (e.g., Bax, caspases, and fas) in the aged liver, while remarkably increasing elements of this machinery in younger animals. …”
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Civic participation digitalisation: limitations in the digital divides field by M. A. Gruzdeva

“…The online citizenship format is most likely to be attractive to young and middle-aged people, working and living in cities, with secondary vocational or higher education. …”
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Wpływ nowożytnego antropocentryzmu na relację człowieka do przyrody. Część pierwsza by Anita Ganowicz-Bączyk

“…One can distinguish at least several stages of the process, which led to this crisis, namely: stage of Magic and Myth, Ancient Times, Middle Ages, and Modern Times. The aim of this article is to show the process of development of an anthropocentric thought in Modern European culture when the culmination of this process is observed. …”
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Starożytne źródła antropocentryzmu by Anita Ganowicz-Bączyk

“…One can distinguish at least several stages of the process, which led to this crisis, namely: stage of Magic and Myth, Ancient Times, Middle Ages, and Modern Times. The aim of this article is to show the process of development of an anthropocentric thought in Ancient European culture. …”
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