Association of lung health and cardiovascular health (Life’s Essential 8) by Wanjia Zhang, Menglong Zou, Junyao Liang, Dexu Zhang, Man Zhou, Hui Feng, Chusen Tang, Jie Xiao, Zhan Yi, Yin Xu

“…Regarding lung function, each 10-point increase in LE8 was associated with an increase of 50 ml in FEV1 (Beta = 50; 95% CI = 32, 67) and 56 ml in FVC (Beta = 56; 95% CI = 32, 79). Among middle-aged and older adults (age > 40), the high LE8 group had significantly lower odds of respiratory symptoms, including cough (OR = 0.23; 95% CI = 0.12, 0.46), phlegm (OR = 0.42; 95% CI = 0.19, 0.90), and wheezing (OR = 0.29; 95% CI = 0.15, 0.54). …”
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Assessment of genetic conservation units of an endangered glacial relict insular species, Amentotaxus formosana, based on fine-scale genetic structures of multiple fragmented mount... by Ya-Zhu Ko, Huie-Chuan Shih, Chin-Shang Ho, Chaur-Tzuhn Chen, Tsai-Wen Hsu, Meng-Shin Shiao, Yu-Chung Chiang, Yu-Chung Chiang

“…In this study, a substantial sample of over 600 individuals, predominantly middle-aged, was collected, representing a majority of the existing individuals in the Chachayalaishan and Dawu habitats. …”
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Evaluation of the Therapeutic Effect of Traditional Chinese Medicine on Osteoarthritis: A Systematic Review and Meta-Analysis by Lin Wang, Xiao-Fei Zhang, Xue Zhang, Dong-Yan Guo, Yu-Wei Duan, Zhi-Chao Wang, Li-Shan Pei, Han Ru, Jiang-Xue Cheng, Ya-Jun Shi, Jun-Bo Zou

“…Osteoarthritis (OA) is a common degenerative disease of bone and joint characterized by the damage of articular cartilage and hypertonia, which often occurs in the middle-aged and elderly. Traditional Chinese medicine (TCM) therapy, including acupuncture (ACU), oral administration, and external use of traditional Chinese medicines (TCMs), can significantly improve the therapeutic effect on OA and reduce the occurrence of side effects. …”
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Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy by Alireza Azarboo, Mahboobeh Hemmatabadi, Noushin Fahimfar, Zahra Faghihi, SeyedAhmad SeyedAlinaghi, Nooshin Shirzad, Ladan Abbasian

“…There is a lack of information regarding the osteoporosis status of middle-aged patients with HIV in Iran, despite the fact that Antiretroviral Therapy (ART) is widely accessible. …”
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A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults by Zi-yue Liu, Sha Liu, Xue Yao, Chun-yang Wang, Yunhao Song, Yan-ming Bi, Jin-Xiu Wang, Yang Li, Ta-la Shi, Wei Mi, Caiyun Chen, Zhi-Yong Hu

“…Vitamin D deficiency and insufficiency were prevalent among the middle-aged and elderly population (78.24%). Significant differences were found between the two groups in multiple sociodemographic variables, behavioral factors, and metabolic risk factors (p < 0.05). …”
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The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer by Vesna Ćeriman Krstić, Dragana Jovanović, Natalija Samardžić, Milija Gajić, Jelena Kotur Stevuljević, Aleksandra Klisic, Ivan Soldatović, Damir Radončić, Marina Roksandić Milenković, Biljana Šeha, Nikola Čolić, Katarina Lukić, Milan Savić

“…We analyzed sPD-L1 concentrations in 30 healthy middle-aged subjects, as a control population, to determine the reference range. …”
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Short-Term Effect of Air Pollution on Daily Hospital Visits for Anxiety Disorders in Southern China with Low Pollution Concentrations by Xinyuan Zhong, Tingting Guo, Jianghui Zhang, Qiong Wang, Rong Yin, Kunpeng Wu, Qing Zou, Meng Zheng, Brian J. Hall, Andre M. N. Renzaho, Kangning Huang, Wen Chen

“…The effects of NO₂ and CO remained robust across subgroup analyses and sensitivity analyses. Females and middle-aged individuals showed stronger associations than other subgroups. …”
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Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults by Tjard Sattler, Sophie Gottschalk, Hans-Helmut König, Tobias Braun, Gisela Büchele, Michael Denkinger, Tim Fleiner, Corinna Nerz, Kilian Rapp, Martina Schäufele, Christian Werner, Judith Dams

“…The model included potential explanatory pathways through physical activity (German Physical Activity Questionnaire for middle-aged and older adults), physical capacity (Short Physical Performance Battery), physical performance (Late-Life Function and Disability Instrument [LLFDI] function component), disability (LLFDI disability component – short form), and affect (visual analogue scales on ‘happiness’, ‘sadness’, ‘calmness’ and ‘tension’). …”
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Clinical portrait of a patient with acute coronary syndrome and type 2 diabetes mellitus: a novel strategy for the diagnosis, prognosis and treatment by M.I. Shved, I.O. Yastremska, L.V. Levytska, V.Yu. Kuchmiy, O.A. Prokopovych, Ya.M. Kitsak, R.M. Liakhovych

“…ACS with T2DM was substantially more frequent (84 % of cases) in young to middle-aged males (up to 60 years of age) who predominated compared to female patients in a 4.8 : 1 ratio. …”
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Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts by Lewis Steell, Stefanie J. Krauth, Sayem Ahmed, Grace O. Dibben, Emma McIntosh, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair, Bhautesh D. Jani, the PERFORM research team

“…Hypertension was prominent across clusters in all ages, while depression featured in younger groups and painful conditions/arthritis were common in clusters from middle-age onwards. MLTC clusters showed different associations with HRQoL. …”
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Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease by Rui Wang, Yuanyuan Li, Yuting Jiang, Xiaona Liu, Hongqi Feng, Zhe Jiao, Bingyun Li, Chang Liu, Yuncheng Shen, Fang Chu, Chenpeng Zhu, Dianjun Sun, Wei Zhang

“…We assessed the effects of gene polymorphism of inflammatory and immune-active factors and gene-environment interaction on risk of COPD in middle-aged and older Chinese individuals. Methods In this community-based case–control study, 471 patients with COPD and 485 controls aged 40–76 years in Heilongjiang Province, China were included. …”
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Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

“…However, whether dmNPC can be treated with immunochemotherapy alone (without LRRT) remains controversial.Case presentationWe report two cases of dmNPC, both in middle-aged men who mainly presented with epistaxis and systemic pain. …”
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Assessment of Asthma Control and Quality of Life among Asthmatic Patients Attending Armed Forces Referral and Teaching Hospital, Addis Ababa, Ethiopia by Tesfalidet Gebremeskel Zeru, Ephrem Engidawork, Alemseged Beyene Berha

“…Uncontrolled asthma was associated with middle-aged adults (adjusted odds ratio AOR=6.31; 95% CI: 2.06, 19.3; P=0.001), male gender (AOR=0.38; 95% CI: 0.15, 0.98; P=0.044), married (AOR=0.24; 95% CI: 0.08, 0.78; P=0.017), comorbidities (AOR=0.23; 95% CI: 0.09, 0.61; P=0.003), and oral SABA use (AOR=0.22; 95% CI: 0.09, 0.59; P=0.003). …”
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Efficacy of intermittent fasting on improving liver function in individuals with metabolic disorders: a systematic review and meta-analysis by Mousa Khalafi, Sara K Rosenkranz, Faeghe Ghasemi, Shokoufeh Kheradmand, Aref Habibi Maleki, Mallikarjuna Korivi, Jung-Piao Tsao

“…IF significantly decreased liver fibrosis in those with obesity; and decreased AST following 5:2 diets, in middle-aged adults, adults with obesity, and regardless of health status or intervention duration. …”
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Clinicopathological analysis of adrenal intravascular large B-cell lymphoma by LIN Jiaxin, WEI Ran, SHUI Ruohong, LU Hongfen, LI Xiaoqiu, YU Baohua

“…Conclusion: Adrenal IVLBCL is rare and tends to occur in the middle-aged and elderly male. The majority of our patients were non-GCB phenotype, often accompanied by MYC/BCL2 double expression, and MYD88 non-L265P mutation was detected. …”
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Validation Indicator Identification and Customer Ranking in Microloans: A Study at Middle East Bank in Iran by Azadeh Ahmadi Kousha, Faegh Ahmadi, Mohammad Hossein Ranjbar, Hamidreza Kordlouie

“…Fourth, the person's age is above middle age. Fifth, the person's degree is not a bachelor's degree, diploma, or sub-diploma. …”
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Socio-economic assessment of drought impacts in Lesotho: implications for early action by Relebohile Agnes Mojaki, Makoala Vitalis Marake, Evan Easton-Calabria, Joalane Rethabile Marunye, Erin Coughlan de Perez

“…Overall, this paper conducted 48 community consultations where genderized focus group discussions (mixed elderly, mixed youth, middled aged men and women) and nine key informants (local authorities, schoolteachers, wisemen and women in the community) interviews were conducted. …”
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Influencing factors of the participation of patients with severe mental disorders in community health service management by Shiming Li, Yingying Ji, Queping Yang, Ying Jiang, Qitao Yin, Haohao Zhu

“…Special attention should be given to patients with severe mental disorders who exhibit negative factors, such as being middle-aged or young, having a long duration of illness, a history of violent or harmful behavior, higher education levels (college and above), student status, or lack of social welfare benefits. …”
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Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial by Diana Ovejero, Anna Ribes, Judit Villar-García, Marta Trenchs-Rodriguez, Daniel Lopez, Xavier Nogués, Robert Güerri-Fernandez, Natalia Garcia-Giralt

“…The majority of participants were middle-aged women (> 84%; mean age 48 years), and the most prevalent symptoms were fatigue, musculoskeletal pain, and neurocognitive impairment (> 88%). …”
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Bilateral synchronous UBE for unilateral laminotomy and bilateral decompression as a potentially effective minimally Invasive approach for two-level lumbar spinal stenosis by Yulin Zhao, Yingjun Guo, Xin Pan, Hao Li, Xianlei Gao, Haipeng Si, Wanlong Xu

“…It is a common cause of lumbago or lumbago and leg pain, which is common among middle-aged and elderly people1. LSS has become the most common cause of lumbar surgery among patients over 60 years of age2. …”
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