Rare renal proximal tubular dysfunctions in primary biliary cholangitis by Xiaoxiao Shi, Tianchen Guo, Yubing Wen, Wei Ye, Wenling Ye, Ke Zheng, Yan Qin, Xuemei Li, Fengchun Zhang, Limeng Chen

“…Their medical document, kidney pathology, and follow-up data were retrospectively reviewed and analyzed.Results The 11 PBC-PT patients were mainly middle-aged (57.8 ± 5.2 years) females (81.8%). Most of them were asymptomatic PBC (7, 63.6%) with a high prevalence of elevated serum immunoglobulin M (IgM, 81.8%) and G (IgG, 54.5%) levels. …”
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Analysis and prediction of subarachnoid hemorrhage burden in global, China, and Japan by Peng-Fei Ding, Chen-Jie Xing, Yong-Yue Gao, Chun-Hua Hang, Zong Zhuang, Wei Li

“…In 1990–2019, the incidence of SAH decreased in China, while it increased in Japan, especially among middle-aged and elderly women. Projections suggest that the global incidence of SAH will decrease by 2.06% in 2030, with an increase of 6.24% in China and 13.82% in Japan, with the highest increase among Japanese women being 16.19%. …”
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Assessing the Relationship Between the Type of Internet Use and Internet Addiction in Early and Middle Adolescents: Cross-Sectional Study From Qatar by Khansa Chemnad, Maryam Aziz, Sanaa Al- Harahsheh, Azza Abdelmoneium, Ahmed Baghdady, Diana Alsayed Hassan, Raian Ali

“…To explore age-specific associations, participants were categorized into early (age 11-13 years) and middle (age 14-17 years) adolescents. Factorial analysis, multiple regression, and logistic regression were used for statistical analysis. …”
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Global, regional, and national esophageal cancer deaths and DALYs attributable to diet low in vegetables and fruits, 1990–2019: analysis for the global burden of disease study by Bing Cui, Aqin Chen, Chengcheng Xu

“…The burden was greater in males than females, peaking in middle-aged groups. Substantial regional differences were observed, with low-SDI regions bearing the highest burden. …”
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Choosing a starting professional trajectory: job-education mismatch effect by A. D. Melnik, A. E. Sudakova, N. L. Antonova

“…This information was further supplemented by semi-structured interviews with middle-aged workers conducted 7 to 10 years after graduation (n = 10) and by monitoring the effectiveness of Russian universities based on the number of enterprises serving as practical training bases under agreements established with universities from 2020 to 2022. …”
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A comparative analysis of global and Chinese trends in the burden of kidney cancer from 1990 to 2021 by Zhongli Qiao, Jun Xiong, Shenyu Zhang, Lin Chen, Jialin Wang, Runze Chen

“…Additionally, the age-standardized rate of kidney cancer in males was notably higher than in females, particularly among middle-aged males. The (1-MIR) of renal cancer increased from 0.36 to 0.62 in China and from 0.49 to 0.58 globally. …”
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Systemic nitric oxide metabolites and the chance of pre-diabetes regression to normoglycemia: A 9-year cohort study by Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi, Asghar Ghasemi

“…Methods: This cohort study included 541 middle-aged Iranian men and women with Pre-DM, recruited in 2006-2008 and followed up to 2015-2017. …”
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Global, regional, and national burden of ischemic heart disease attributable to secondhand smoke from 1990 to 2019 by Xinyue Yang, Zhiqiang Zhang, Jiayi Sun, Wenjuan Zhang

“…Despite a declining trend in ASMR and ASDR, regional disparities persist. The elderly and middle-aged populations bore the most significant burden. …”
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A Rare Case of Arteriovenous Hemangioma Clinically Mimicking Pigmented Nevus by Sri Lestari, Tofrizal ., Yenny Raflis

“…Arteriovenous hemangioma is a tumor of middle-age to elderly adults with a peak incidence in the fourth and fifth decades of life. …”
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Sarcomatous tumor with external iliac vein aneurysm: a rare entity by Tushar Kalekar, Neeha Amit Jhala, Reetika Kapoor, Eshan Chetan Durgi, Karishma Krishnani

“…Case presentation A middle-aged male in his fifties presented to the emergency department with continuous bleeding from a wound over a right inguinal swelling that had been ongoing for four hours. …”
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Association between spasticity and neuropathic pain in patients with multiple sclerosis by B. Afanasjeva, R. Balnytė

“…The examined patients were diagnosed with MS at the middle age, the majority of subjects had the relapsing-remitting disease, and disability was higher in the patients with progressive forms. …”
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Atherogenic index of plasma and cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome stage 1 to 3: a longitudinal study by Yu Zhang, Yue Song, Yinfei Lu, Tao Liu, Ping Yin

“…Restricted cubic spline regression indicated the relationship between cumulative AIP and CVD risk is linear (P for nonlinear = 0.3377).ConclusionsIn middle-aged and elderly individuals with CKM syndrome, higher cumulative AIP and poorer AIP control were associated with an elevated incidence of CVD. …”
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Gender characteristics, social determinants, and seasonal patterns of malaria incidence, relapse, and mortality in Sistan and Baluchistan province and other province of Iran: A sys... by Maryam Khazaee-Pool, Mahmood Moosazadeh, Mehran Asadi-Aliabadi, Fereshteh Yazdani, Koen Ponnet

“…The findings highlight the need for health care and the importance of targeted malaria control interventions, especially for men, rural areas, hot weather conditions, and young to middle-aged age groups, particularly in the S&B province.…”
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Body weight gain and development of reproductive tract in crossbred Murrah × Mediterranean water buffalo heifers by Oswaldo J. González, Amílcar Acuña, Solaine Bradley, Ysis Cañizalez, Jorge Espinoza, Cindy Paniagua, María Virginia Suárez, Mónica Fuentes

“…The buffalo heifers (middle age: 710 days old and middleweight: 237 Kg) were randomly assigned to one of two treatments for 174 days. …”
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A preliminary study on the reference intervals of vitamin K in some areas of Beijing with normal physical examination population by Lin Chen, Meiqi Chen, Shi Cheng, Jiaxin Fei, Dan Xu, Xueyun Hou, Nannan Li, Yuliang Yuan, Guijian Liu, Cheng An

“…Finally, preliminary clinical validation was conducted on 60 apparent healthy individuals undergoing physical examination. In the young, middle-aged, and elderly groups, the reference intervals of VK1 were 0.180 ng/mL ∼ 1.494 ng/mL, 0.247 ng/mL ∼ 1.446 ng/mL, and 0.167 ng/mL ∼ 1.445 ng/mL, respectively. …”
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Associations between oxidation balance score and abdominal aortic calcification, and the mediating role of glycohemoglobin: a nationally representative cross-sectional study from N... by Heqian Liu, Yifei Wu, Zhenyu Liu, Hongzhi Ren, Ya Wu, Ya Wu, Yong Liu, Yong Liu, Yong Liu

“…BackgroundAbdominal aortic calcification (AAC) is prevalent among middle-aged and elderly populations, elevating the risk of cardiovascular and cerebrovascular events. …”
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The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers by Patrick D. Gajewski, Peter Bröde, Maren Claus, Klaus Golka, Jan G. Hengstler, Carsten Watzl, Edmund Wascher, Stephan Getzmann

“…These interactions were moderated by age showing the largest impact in middle-aged to older individuals. Conclusions: The present findings shed light on the complex interaction between burnout symptoms and work ability, chronic stress, personality, and the endocrinological and immunological responses across the working lifespan. …”
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Analysis of the risk of oncological adverse events associated with infliximab in combination with azathioprine compared to monotherapy: insights from the FAERS database by Qian Qiao, Qian Qiao, Qian Qiao, Jiachen Sun, Jiachen Sun, Jiachen Sun, Ya Zheng, Ya Zheng, Yingying Mi, Yingying Mi, Yingying Mi, Yanan Gong, Yanan Gong, Jiahui Liu, Jiahui Liu, Jiahui Liu, Wenyue Rui, Wenyue Rui, Wenyue Rui, Yumei Ma, Yumei Ma, Yumei Ma, Yongning Zhou, Yongning Zhou, Min Liu, Min Liu

“…Regarding age, we noted an increasing incidence of adverse tumor events in middle-aged and elderly individuals compared to minors, except in the azathioprine group, where age was not identified as an independent risk factor. …”
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POSSIBILITIES OF DIAGNOSIS OF RADIATION INJURIES AND REHABILITATION OF PATIENTS AFTER COMBINED TREATMENT OF MALIGNANT TUMORS OF THE BREAST by A. V. Kondakov, M. E. Borodina, O. V. Andrianov, N. I. Rozhkova

“…The main contingent of the test (82.4%) were middle-aged women from 33 to 59 years old. For an objective diagnosis of the state of post-radiation fibrosis and scarring using modern methods of instrumental diagnostics: Sonoelastography, infrared thermography and thermal imaging diagnostics. …”
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Changes in Alcohol Consumption During and After the Covid-19 Pandemic From 2020 to 2023 in a Prospective Cohort of Italian Adults by Sonia Cerrai, Giulia Carreras, Filippo Monti, Chiara Stival, Alessandra Lugo, Cristina Bosetti, Silvia Biagioni, Tiziana Fanucchi, Giuseppe Gorini, Andrea Amerio, Luisa Mastrobattista, Claudia Mortali, Anna Odone, Sabrina Molinaro, Luc Smits, Silvano Gallus, the “Lost in Italy” and “Lost in Toscana” Study Investigators

“…Being at-risk alcohol consumers decreased with decreasing economic status (P for trend <0.001), was less frequent among middle-aged compared to younger (OR 0.73; 95% CI, 0.60–0.89) and among divorced/separated (OR 0.77; 95% CI, 0.60–0.99) or single (OR 0.75; 95% CI, 0.64–0.89) compared to married individuals. …”
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