Chronic intermittent fasting impairs β cell maturation and function in adolescent mice by Leonardo Matta, Peter Weber, Suheda Erener, Alina Walth-Hummel, Daniela Hass, Lea K. Bühler, Katarina Klepac, Julia Szendroedi, Joel Guerra, Maria Rohm, Michael Sterr, Heiko Lickert, Alexander Bartelt, Stephan Herzig

“…Here, we investigated the effects of IF on systemic metabolism and β cell function in old, middle-aged, and young mice. Short-term IF improves glucose homeostasis across all age groups without altering islet function and morphology. …”
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An association between average daily sleep duration and gallstones in US adults by Yong Fang, Qiuyuan Xu, Jia Xu, HaiHua Wang

“…Interestingly, the inflection points were observed among middle-aged adults (40–60 years) and individuals with diabetes. …”
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Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin by Nikolaos K. Gatselis, Kalliopi Zachou, George N. Dalekos

“…Our report may suggest that PBC could be kept in mind in EN patients of unknown aetiology and particularly, when middle-aged female patients are affected. In such cases a thorough evaluation for AMA and/or ANA PBC-specific antibodies could be helpful to achieve a correct and timely diagnosis.…”
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Intraosseous Mucoepidermoid Carcinoma in the Mandible by George Borja de Freitas, Arthur José Barbosa de França, Stefanny Torres dos Santos, Miqueias Oliveira de Lima Júnior, Adilis Stepple da Fonte Neto, Paula Bernardon

“…They are more common in middle-aged adults and have a slight female predilection. …”
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Association Between Triglyceride–Glucose Index and Carotid Plaque Stability in Different Glycemic Status: A Single‐Center Retrospective Study by Guijun Huo, Jin Zheng, Junjie Cao, Lili Zhang, Zhichao Yao, Yuqi Zeng, Yao Tang, Zhanao Liu, Ziyi Tan, Dayong Zhou

“…The association between the TyG index and unstable carotid plaque is similar between men and women, and the association in older patients is higher than that in middle‐aged patients. In different glycemic status, the association between the TyG index and unstable carotid plaque is highest in patients with diabetes.…”
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Association between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China by Chaojuan Huang, Hongtao You, Yuyang Zhang, Ligang Fan, Xingliang Feng, Naiyuan Shao

“…Abstract Background Stroke has emerged as an escalating public health challenge among middle-aged and older individuals in China, closely linked to glycolipid metabolic abnormalities. …”
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Research and Application Progress of Dual-energy CT in Prostate Lesions by Yize LI, Ziqi CHEN, Luyao ZHANG, Yingmin CHEN

“…Prostate lesions are common in middle-aged and elderly men. Dual-energy CT (DECT) can capture projection data at high and low X-ray energies in a single scan, significantly enhancing its ability to differentiate substances compared with traditional CT. …”
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Gallbladder Agenesis without Additional Biliary Tracts Abnormality by Seyed Mostafa Meshkati Yazd, Hamidreza Bayati, Sara Sadat Nabavizadeh, Reza Shahriarirad

“…In this case report, we will discuss our experience with an intraoperative accidental diagnosis of GA in a middle-aged woman that was effectively treated. Case Presentation. …”
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"A watering of her desert": Depression and (Dis)consolation in Jenny Diski’s Monkey’s Uncle by Diane GAGNERET

“…Her 1994 novel Monkey’s Uncle, charting a middle-aged woman’s descent into depression following two cataclysmic events, qualifies as a work that seems all about inconsolability, yet invites a reflection on what David James calls “discrepant solace.” …”
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Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection by Gabriela Gonzalez Aleman, George D. Vavougios, George D. Vavougios, Carmela Tartaglia, Carmela Tartaglia, Nalakath A. Uvais, Alla Guekht, Alla Guekht, Akram A. Hosseini, Akram A. Hosseini, Vincenzina Lo Re, Vincenzina Lo Re, Catterina Ferreccio, Catterina Ferreccio, Giovanni D'Avossa, Hernan P. Zamponi, Mariana Figueredo Aguiar, Agustin Yecora, Agustin Yecora, Mohammad Zia Ul Haq Katshu, Vasileios T. Stavrou, Vasileios T. Stavrou, Stylianos Boutlas, Konstantinos I. Gourgoulianis, Camila Botero, Francisco González Insúa, Santiago Perez-Lloret, Mikhail Zinchuk, Anna Gersamija, Sofya Popova, Yulia Bryzgalova, Ekaterina Sviatskaya, Giovanna Russelli, Giovanna Russelli, Federica Avorio, Federica Avorio, Sophia Wang, Sophia Wang, Paul Edison, Paul Edison, Yoshiki Niimi, Hamid R. Sohrabi, Elizabeta B. Mukaetova Ladinska, Elizabeta B. Mukaetova Ladinska, Daria Neidre, Gabriel A. de Erausquin, Gabriel A. de Erausquin, Gabriel A. de Erausquin

“…The profile and severity of cognitive impairment varied by age, with mild attentional impairment observed in young and middle-aged adults, but memory, language, and executive function impairment in older adults. …”
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Oral verrucous hyperplasia – A literature review by R. Santhosh Kumar, Divya Bose, Thayalan Dineshkumar, M. Harinisubasri, Rajkumar Krishnan, Rameshkumar Annasamy

“…It shows a predilection for middle-aged and older adults, with male predominance. …”
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Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm by Jitendra Parmar, Tapan Patel, Sandip Shah, Jay Kothari, Sameer Dani, Sagar Vyas

“…Its widespread manifestations and vascular complications are increasingly being reported even in young and middle-aged patients. Hyperinflammation is a continuum of host’s exaggerated inflammatory response representing cytokine dysregulation/storm which produces coagulopathy and vascular endothelial dysfunction, apart from a prothrombotic state. …”
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Diagnosis and treatment of obstructive sleep apnea by Natalia Myśliwiec, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej, Alicja Kot, Marta Wojtczak, Adrian Różycki

“…Obstructive sleep apnoea (OSA) is a prevalent disorder characterized by repeated episodes of partial or complete upper airway collapse during sleep, resulting in intermittent hypoxia, hypercapnia, and sleep fragmentation. Common in middle-aged and older adults, its pathogenesis is multifactorial, encompassing obesity, craniofacial abnormalities, altered upper airway muscle function, pharyngeal neuropathy, and fluid redistribution to the neck. …”
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A Case of Nonunion Avulsion Fracture of the Anterior Tibial Eminence by Satoru Atsumi, Yuji Arai, Shuji Nakagawa, Hiroaki Inoue, Kazuya Ikoma, Hiroyoshi Fujiwara, Toshikazu Kubo

“…These findings indicate that arthroscopic debridement of an avulsed fragment for nonunion of an avulsion fracture of the anterior tibial eminence is a minimally invasive and effective treatment for middle-aged and elderly patients with a low level of sports activity.…”
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Hypertension, Periodontal Disease, and Potassium Intake in Nonsmoking, Nondrinker African Women on No Medication by Masashi Yamori, Marina Njelekela, Jacob Mtabaji, Yukio Yamori, Kazuhisa Bessho

“…Potassium intake may be an important factor linking periodontitis and hypertension in middle-aged nonsmoking and nonalcoholic women on no medication, although chronic inflammation such as periodontitis may cause hypertension through a more direct mechanism.…”
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Clinical Characteristics of Six Cases of Tracheobronchopathia Osteochondroplastica by Rong Guo, Mingming Zhou, Xiaohui Wei, Ling Niu

“…All six patients with TO were middle-aged males, confirmed by histopathological examination. …”
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Polder Effects on Sediment-to-Soil Conversion: Water Table, Residual Available Water Capacity, and Salt Stress Interdependence by Raymond Tojo Radimy, Patrick Dudoignon, Jean Michel Hillaireau, Elise Deboute

“…The French Atlantic marshlands, reclaimed since the Middle Age, have been successively used for extensive grazing and more recently for cereal cultivation from 1970. …”
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Nomogram for predicting mild cognitive impairment in Chinese elder CSVD patients based on Boruta algorithm by Yanzi Huang, Wendie Huang, Xiaoming Ma, Guoyin Zhao, Jingwen Kang, Huajie Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Shiying Sheng, Fengjuan Qian

“…ROC and calibration curves indicate its high discriminative ability.ConclusionWhile CSVD is prevalent among middle-aged and older individuals, cognitive decline trajectories differ. …”
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Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features by Ya-Qin Tan, Jing Zhang, Ge-Fei Du, Rui Lu, Guan-Ying Chen, Gang Zhou

“…Quantitative real-time RT-PCR results confirmed that IGF1 expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients. In addition, ATG9B mRNA levels were significantly lower in nonerosive OLP patients. …”
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Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes by Jianqing Fang, Zhe Wang, Yu Shen, Xuenong Wu, Hao Fang, Xiaokui Sun, Ting Yu, Qingqing Zhang

“…We discuss experience with them and the shortcomings in their treatment by summarizing their medical history, disease evolution, tests, and diagnostic and therapeutic processes.ResultsIn both patients, the diagnosis of Legionnaires’ disease was confirmed through analysis of the bronchoalveolar lavage fluid (BALF). The middle-aged male patient was cured and discharged due to early detection and diagnosis. …”
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