Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART by Na Li, Hong-Yi Zheng, Wei Li, Xiao-Yan He, Mi Zhang, Xia Li, Ren-Rong Tian, Xing-Qi Dong, Zhi-Qiang Shen, Yong-Tang Zheng

“…Compared with young and middle-aged PLWH, older PLWH presented distinct alterations in their immune profile, including a decline in the Naïve CD4+T and CD8+T cell subsets, an expansion of effector memory cells, and other potential immune risk phenotypes, such as activation, exhaustion, and up-regulation of aging markers. …”
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Xanthogranulomatous Pyelonephritis with Incomplete Double Ureter by Yutaro Hayashi, Takashi Kawahara, Yusuke Hattori, Kota Shimokihara, Sohgo Tsutsumi, Daiji Takamoto, Taku Mochizuki, Jun-ichi Teranishi, Yasushi Yumura, Yasuhide Miyoshi, Masako Otani, Hiroji Uemura

“…Xanthogranulomatous pyelonephritis (XGP) is a type of chronic renal inflammation that usually occurs in immunocompromised middle-aged women with chronic urinary tract infection or ureteral obstruction induced by the formation of ureteral stones. …”
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Multiple Symmetric Lipomatosis: A Review of 3 Cases by Emilio Mevio, Michele Sbrocca, Mauro Mullace, Silvia Viglione, Niccolò Mevio

“…This disease usually affects middle-aged males from the Mediterranean area with a history of alcohol abuse. …”
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Extension of a Coronary Intramural Hematoma as a Complication of Early Percutaneous Coronary Intervention after Thrombolytic Therapy by Mohamed El-Mawardy, Mohamed Abdel-Wahab, Gert Richardt

“…We describe a case of iatrogenic periprocedural dissection of the left anterior descending artery (LAD) with development of an intramural hematoma and the extension of this hematoma to the left main (LM) and left circumflex (LCX) arteries in a middle-aged female, where prior recent thrombolytic therapy may have played a role in its triggering or facilitation of its extension. …”
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Challenges Associated with Negative Pressure Pulmonary Oedema: A Case Report and Review by Wing Hoh Loo, Kay Mint Goh

“…We present a case of NPPO in a middle-aged obese patient with high perioperative cardiac risk who underwent an emergency open appendicectomy. …”
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Dermoscopic Features of CD8-Positive Solitary Pagetoid Reticulosis on the Left Leg by Reiko Suzaki, Ken Kobayashi, Sumiko Ishizaki, Mariko Fujibayashi, Masaru Tanaka

“…It primarily affects middle-aged males. Because the clinical features of pagetoid reticulosis are indistinctive, pagetoid reticulosis may progress for years before accurate diagnosis. …”
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Knee Osteoarthritis Treatment with the KineSpring Knee Implant System: A Report of Two Cases by David A. Hayes, Larry E. Miller, Jon E. Block

“…Osteoarthritis (OA) is a leading cause of disability in middle-aged and older adults with the prevalence expected to increase by 40% by 2025. …”
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Mixed Germ Cell Tumor with Extensive Yolk Sac Tumor Elements in the Frontal Lobe of an Adult by Toshihide Takahashi, Eiichi Ishikawa, Yosuke Masuda, Tetsuya Yamamoto, Taiki Sato, Makoto Shibuya, Akira Matsumura

“…Here, we report a case of a yolk sac tumor in the frontal lobe in a middle-aged patient. A 42-year-old man was admitted to our hospital for headache and nausea. …”
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Oral Verruciform Xanthoma: A Case Report and Literature Review by Akshay Shetty, Kourosh Nakhaei, Yogesh Lakkashetty, Maryam Mohseni, Iman Mohebatzadeh

“…Verruciform xanthoma is a benign mucocutaneous, uncommon, nonsymptomatic lesion of uncertain etiopathology, which occurs mostly on the oral mucosa of middle-aged individuals. Histopathologically, VX is diagnosed by presence of lipid-laden foam cells in papillary region of connective tissue. …”
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Nodular Fasciitis of the Breast Mimicking Breast Cancer by Shinya Yamamoto, Takashi Chishima, Shouko Adachi

“…Nodular fasciitis is a benign proliferative lesion that is usually found in the soft tissue of the upper extremity and trunk in young to middle-aged persons. It has rarely been described in the breast. …”
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Floating Knee Injury Associated with Patellar Tendon Rupture: A Case Report and Review of Literature by Singaravadivelu Vaidyanathan, Jagannath Panchanathan Ganesan, Mugundhan Moongilpatti Sengodan

“…Floating knee injuries are frequently associated with other concomitant injuries to the ipsilateral limb or other parts of body of which injury to the ipsilateral knee ligaments carries significance for various reasons. A middle-aged man sustained a floating knee injury following RTA. …”
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The combined effects of cardiometabolic index and high-sensitivity C-reactive protein on the risk of new onset stroke in a Chinese national prospective longitudinal cohort study by Fangfang Li, Yu He, Ali Yang, Mingrong Xia, Weizhou Zang, Jiewen Zhang

“…Conclusions The combination of CMI and hs-CRP exhibited a significant association with stroke risk among middle-aged and older Chinese adults, highlighting the importance of joint assessments of these biomarkers for refining risk stratification and enhancing primary prevention strategies for stroke.…”
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Correlation and predictive value of novel anthropometric indicators with adult sarcopenia and sarcopenia obesity by Xue Wu, Ziang Chen, Yuanhui Zhao, Hong Ren

“…Sarcopenia and sarcopenic obesity are commonly observed in individuals within the middle-aged and elderly demographics. The prevalence of these conditions is higher among middle-aged men of a given age when contrasted with women at the age of 40. …”
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Reversing the Negative Genomic Effects of Aging with Short-Term Calorie Restriction by Stephen R. Spindler

“…With the baby-boom generation now moving through middle age, the prescription for the U.S. health care system will be disastrous unless we learn how to keep people healthier longer. …”
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Confusion and Hallucination: A Case Report of an Unusual Presentation of COVID-19 by Rawabi Aljumaiah, Wael Alturaiki, Bandar Alosaimi

“…Here, we report the case report of a middle-aged man, with no previous known medical illness, who presented with a 5-day-history of anxiety, fever, confusion, and hallucinations. …”
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Unraveling the Narrative of Orbital Cellulitis as a Sequelae to Trauma by Anilkumar S. Harugop, Aditya Achyut Redkar, Ajay Choondal, E. V. Manishaa

“…Facial trauma is one of the possible causes of orbital cellulitis. A middle-aged man, a mason by occupation, presented to ENT OPD following a facial trauma. …”
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Bilateral adrenal cryptococcosis causing adrenal insufficiency in an immunocompetent patient by Ramneek Kaur, Naveen Mittal, Ankita Soni, Harpreet Kaur

“…We present a case of a middle-aged immunocompetent man with primary adrenal insufficiency and bilateral adrenal lesions, splenomegaly, and miliary mottling in the lungs on imaging. …”
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Iron Deficiency Anaemia Caused by Nonspecific (Idiopathic) Small Bowel Ulceration: An Uncommon Presentation of an Uncommon Disease by Gabriele Capurso, Edith Lahner, Nadia Pallotta, Francesco Panzuto, Gianfranco Delle Fave, Bruno Annibale

“…Such lesions are uncommon, and in most cases present with occlusion. A case of a middle-aged woman with iron deficiency anemia due to occult bleeding, with negative gastroscopy and colonoscopy is presented. …”
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Lateral Subtalar Dislocation with Tarsometatarsal Dislocation: A Case Report of a Rare Injury by Samik Banerjee, Mostafa M. Abousayed, Douglas J. Vanderbrook, Kaushik Bagchi

“…In this report, we describe this atypical presentation in a middle aged, otherwise healthy male who sustained a trivial twisting injury to the ankle when he slipped and fell on ice. …”
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A Rare Case of Primary Bilateral Adrenal Lymphoma by Veeraraghavan Meyyur Aravamudan, Phang Kee Fong, Yang Shiyao Sam, Pavel Singh, Siok-Bian Ng, Gollamudi Satya Pavan Kumar

“…We here present a case of a middle-aged female who presented with persistent fever for three weeks. …”
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