A Synthetic Voice for an Assistive Conversational Agent: A Survey to Discover Italian Preferences regarding Synthetic Voice’s Gender and Quality Level by Marialucia Cuciniello, Terry Amorese, Claudia Greco, Zoraida Callejas Carrión, Carl Vogel, Gennaro Cordasco, Anna Esposito

“…The voices administered to participants were developed considering two main aspects: the voice quality (high/low) and their gender (male/female). 182 unpaid participants were recruited for the study, divided in four groups according to their age, and therefore classified as adolescents, young adults, middle-aged, and seniors. To collect data regarding each voice, randomly audited by participants, the shortened version of the Virtual Agent Voice Acceptance Questionnaire (VAVAQ) was exploited. …”
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Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss by Ning Zhao, Ana’am Alkharabsheh, Fei Xu, Wei Sun

“…Increased acoustic startle responses (ASR), which represent reduced uncomfortable loudness level in humans, have been reported in middle-aged C57BL/6J mice with sensorineural hearing loss. …”
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The Effect of P-Cymene on Glucose, Insulin, Antioxidant Power, and the Level of AKT Gene mRNA in Streptozotocin-Induced Diabetes Model in Male Wistar Rats by Maryam Arabloei Sani, Zahra Hajebrahimi, Parichehreh Yaghmaei, Nasim Hayati Roodbari

“…Background and Aim: Diabetes is a main metabolic disorder in middle-aged and older people. Oxidative stress can interfere with insulin signaling and are directly relevant to the incidence of diabetes. …”
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Female Farmers’ Agricultural Information Needs and Food Production: A Case Study of Imbulpe ds Division in Sri Lanka by S.D. Dilini Rathnachandra, S.H. Pushpa Malkanthi

“…The result revealed that the majority (62.6%) of respondents were middle aged (40-59 years), married, and belonged to families with 4-5 members. …”
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Epidemiological Profile of Hearing Deficiency in a Tertiary Care Hospital (2019-2022) by Indranil Sen, Anup Kumar Das, Arijit Das

“…Mild hearing loss (25-40dB) accounted for maximum bulk of the patients.The bulk of the population comprised of people in their middle age (30-60) and elderly (>60 years).   …”
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Health economics assessment of statin therapy initiation thresholds for atherosclerosis prevention in China: a cost-effectiveness analysis by Tianyu Feng, Xiaolin Zhang, Jiaying Xu, Shang Gao, Xihe Yu

“…The model utilized the China-PAR prediction tool for ASCVD risk and incorporated data from a nationally representative survey and published meta-analyses of middle-aged and elderly Chinese populations. Four strategies were evaluated: a 7.5% 10-year risk threshold, the current guideline strategy, and a 15% threshold. …”
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SOCIO-ECONOMIC CONSEQUENCES OF IMMIGRATION IN ITALY by E. J. Tsareva

“…The increasing number of migrants has created a certain imbalance in different spheres of life and society. The middle-aged population in Italy is ever growing, thus migrants play an important role in filling the workforce depletion as well as flooding the labor market. …”
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Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review by Ikhwan Rinaldi, Findy Prasetyawaty, Siti Fazlines, Kevin Winston, Yusuf Aji Samudera Nurrobi, Jessica Leoni, Ilham Hidayat Restu Tulus Maha, Satrio Wicaksono, Abdillah Yasir Wicaksono, Averina Octaxena Aslani, Rizkania Ikhsani

“…The first patient was a young female, while the second and third patients were middle-aged and elderly males, respectively. All patients presented with a chief complaint of bruises without hemarthrosis and a history of bleeding. …”
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Auditory steady state response can predict declining EF in healthy elderly individuals by Xiaopeng Mao, Xiaopeng Mao, Nelly Shenton, Sadasivan Puthusserypady, Martin Johannes Lauritzen, Krisztina Benedek

“…The ViTs trained and cross-validated on time-frequency-transformed Electroencephalograms (EEGs) achieved an average cross-subject accuracy of 51.8% in identifying cognitive decline.ConclusionGamma-band ASSR characteristics are linked to early cognitive decline in middle-aged individuals, offering potential as biomarkers. …”
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Impact of Mediterranean Diet Adherence on the Incidence of New‐Onset Hypertension in Adults With Obesity in Korea: A Nationwide Cohort Study by Jung‐Hwan Kim, Ji‐Won Lee, Yaeji Lee, Chung‐Mo Nam, Yu‐Jin Kwon

“…ABSTRACT This study investigated the association between adherence to the Mediterranean diet (MD) and new‐onset hypertension (HTN) in a cohort of community‐dwelling, middle‐aged, older Korean individuals with obesity. …”
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Long-Term Intracranial Progression-Free Survival in Lung Cancer Brain Metastases Extended Beyond 50 Months with Gubenxiaoyi Formula (GBXY): A Groundbreaking Case Study by Zhengzheng Yang, Haiming Li, Lei Chen, Shujiao Li, Dong Chen, Taicheng Lu, Tongjing Ding, Ruiyang Han, Peiyu Cheng, Xiaomin Wang

“…Case presentation Here, we present a case of a middle-aged female with lung cancer BM, whose condition was assessed as progressive post-standard treatment including two local surgeries (both involving resection of cerebellar space-occupying lesions), stereotactic radiotherapy, chemotherapy and EGFR-TKIs. …”
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What a women desire: Application of conjoint analysis for analysing the choice of menstrual hygiene products and factors influencing their consummatory behaviour by Tiwari Abhay Kumar, Patel Vaishali, Saroj Chitra

“…Background/Aim: Middle-aged adolescent girls and women experience menstruation, a normal and physiologic occurrence. …”
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Satisfaction with Nighttime Outdoor Activity Environment Among Elderly Residents in Old Gated Communities by Fang Wen, Liang Peng, Bo Zhang, Yan Zhang, Yuyang Zhang

“…“Aging in place” is the most popular choice for older people in China, with more than 90% of urban older people living in the same residential areas they did in middle age. Nighttime outdoor activity (NOA) is popular among the elderly and has a positive impact on both their physical and mental health. …”
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A Multimodal Approach to Analgesia in Anorectal Surgery by T. N. Garmanova, D. R. Markaryan, E. A. Kazachenko, A. M. Lukianov, M. A. Kazachenko, M. A. Agapov

“…Mainly anorectal disorders affect middle-aged people reducing their life quality. At the same time many articles aimed at studying only postoperative anesthesia. 2 researchers independently searched for articles published in Medline, Scopus, Cochrane, Web of Science, E-library databases using keywords. …”
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Efficacy of Neoadjuvant Chemotherapy DOX and XELOX Regimens for Patients with Resectable Gastric or Gastroesophageal Junction Adenocarcinoma by Yuan Tian, Qun Zhao, Yong Li, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Bibo Tan, Dong Wang, Peigang Yang

“…Neoadjuvant DOX is an effective and feasible regimen and might represent an option for young and middle-aged patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma.…”
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Cardiometabolic deaths in black and white men: Tracing the risks from early- to mid-adulthood by Rebecca Arden Harris, Sameed Ahmed M. Khatana, Judith A. Long

“…Black and White men during the transition from early adulthood to middle age. Methods: Using 2022 National Vital Statistics System data and standard period life table methods, we estimated the risk of CMD death in hypothetical cohorts of Black and White men from age 25 to 45 years. …”
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Diverse clinical manifestations and prognosis in a couple’s mercury poisoning caused by skin-lightening creams: two case reports and literature review by Huixia Ji, Ye Chen, Dandan Liu, Tongzhou Zhou, Yuhua Tang

“…Skin exposure to mercury-containing creams occurs most commonly in young and middle-aged women and, in a few cases, in men. This article presents the symptoms and prognosis of a couple who developed mercury poisoning after cosmetic use of similar duration and dosage. …”
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The Unforeseen Diagnosis: Hyperparathyroidism-Jaw Tumour Syndrome Case Report and Review of the Literature by Maxim Barnett, Farhan Ahmed, Radu Mihai, Asha Rattan, Malik Asif Humayun

“…Primary hyperparathyroidism, a frequent cause of hypercalcaemia, is often seen among middle-aged female patients, typically resulting from an underlying single-gland adenoma. …”
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Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS): study design and me... by Maciej Banach, Martyna Fronczek, Tadeusz Osadnik, Agnieszka Gach, Dominik Strapagiel, Marcin Słomka, Mateusz Lejawa, Anna Goc, Ewa Boniewska-Bernacka, Anna Pańczyszyn, Gregory Y.H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Peter E. Penson, Jacek Jóźwiak

“…Polygenic risk scores (PRS) can be effective in predicting adverse coronary events in younger and middle-aged patients. Our main aim is to assess the utility of a new PRS created for the Polish population in predicting mortality during an 8-year follow-up in the nationwide LIPIDOGEN2015 population. …”
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Clinical Characteristics and Visual Outcomes of Patients Hospitalized for Ocular Trauma in Shandong Province, China by Fangnan Duan, Xiunian Chen, Sai Zhang, Xiaolin Qi, Weiyun Shi, Hua Gao

“…Ocular trauma usually occurs in young and middle-aged men and in the workplace in Shandong Province. …”
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