A cross-sectional study exploring the positive aspects of caregiving in opioid dependence and its relation with quality of life, social support, and caregivers’ burden by Priyanka Saha, Sayan Saha, Gauri Shanker Kaloiya, Siddharth Sarkar

“…Results: Of the 199 caregivers recruited, a majority of the caregivers were middle-aged women. About two-thirds of the patients were currently using opioids (n = 135, 67.8%), while the remaining were abstinent. …”
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Enhanced Hepatocarcinogenicity Due to Agonists of Peroxisome Proliferator-Activated Receptors in Senescent Rats: Role of Peroxisome Proliferation, Cell Proliferation, and Apoptosis by Jihan Youssef, Mostafa Badr

“…In addition, aged livers showed remarkably higher levels of the antiapoptotic protein Bcl-2 than livers of young, adult, and middle-aged animals. Interestingly, the PPARa agonist Wy-14,643 significantly diminished elements of the proapoptotic machinery (e.g., Bax, caspases, and fas) in the aged liver, while remarkably increasing elements of this machinery in younger animals. …”
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Civic participation digitalisation: limitations in the digital divides field by M. A. Gruzdeva

“…The online citizenship format is most likely to be attractive to young and middle-aged people, working and living in cities, with secondary vocational or higher education. …”
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Improving myocardial infarction diagnosis with Siamese network-based ECG analysis. by Vaibhav Gadag, Simrat Singh, Anshul Harish Khatri, Shruti Mishra, Sandeep Kumar Satapathy, Sung-Bae Cho, Abishi Chowdhury, Amrit Pal, Sachi Nandan Mohanty

“…The leading cause of death for middle-aged and older people worldwide is myocardial infarction (MI), which is difficult to diagnose because it has no symptoms. …”
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Epidemiological characteristics: traumatic cervical spinal cord injury in Wuhan-China by Ruba Altahla, Jamal Alshorman, Xu Tao

“…The epidemiological characteristics of TCSCI in Wuhan are distinct, highlighting the need for preventive measures targeted at middle-aged individuals. There is a higher incidence of TCSCI in males than females, the most frequently affected level is C4, and ASIA grade B represents the highest prevalence. …”
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Poor control of oxidative stress index is associated with increased DNA methylation in retinopathy patients of a sample from babylonian population by Farah A. Al-Hassan, Hawraa Sabah Al-Musawi

“…Abstract Background: Retinopathy is one of almost insidious advanced neuron-vascular complications of diabetes, oneof the most common complications that lead to permanent visual impairment in the middle-aged population. Objectives: The study investigated the association between poor oxidative stress index and DNA methylation. …”
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The impact of digital literacy in enhancing individuals’ health in China by Jing Yang, Qianyu Shen, Xi Tong, Pundarik Mukhopadhaya

“…The heterogeneity analysis shows that digital literacy is more effective in enhancing the health of middle-aged and older groups as well as rural individuals in China. …”
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Resident Case Series: Blood Flow Restriction as an Adjunct to Strengthening Exercises in Two Patients with Subacromial Impingement and High Irritability by Angel Ceballos, Giorgio Zeppieri Jr., Joel Bialosky

“… # Case descriptions Two middle aged, non-operative patients with signs and symptoms consistent with SAIS and high levels of irritability were included. …”
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Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis by Zahraa S. Hassan, Layla O. Farhan

“…Conclusion: Serum HBD-3 can be a valuable indicator of OP in middle-aged individuals, and may be a helpful biological marker for OP diagnosis. …”
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Prevalence of HDV, HCV, and HIV Infection in the Population of Patients Infected with HBV in a Romanian Cohort by Antoanela Curici, Olivia Mioara Ilie, Dana Elena Mindru

“…The findings from our study highlight the need for targeted interventions, particularly for high-risk groups such as older adults and middle-aged individuals, to reduce the burden of chronic HBV and its complications.…”
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The Old Woman’s Farcical Rejuvenation in The Rejuvenation of Miss Semaphore (1897) by Somi Ahn

“…Charlotte O’Conor Eccles’s The Rejuvenation of Miss Semaphore (1897) is a comedic New Woman narrative in which a lonely, middle-aged, single woman gets rejuvenated after drinking an elixir. …”
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Exploring the enigma of low prevalence of post-traumatic stress disorder in India by Ateev S. Chandna, Satish Suhas, Rahul Patley, Damodharan Dinakaran, Narayana Manjunatha, Girish N. Rao, Gopalkrishna Gururaj, Mathew Varghese, Vivek Benegal, NMHS National Collaborators Group

“…Factors associated with PTSD included female gender, middle age (40-49 years), and urban residence. The study also highlighted a high rate of comorbid mood and anxiety disorders, substantial disability, poor treatment-seeking behavior, and significant suicidal risk among individuals with PTSD. …”
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A Case Study on Strategic Multi-Objective Optimization of Influenza Vaccine Allocation: Age-Specific Approaches in Saudi Arabia by Asma K. Alkhamis, Manar I. Hosny

“…The research divides the population into five age categories—infants and children, adolescents, young adults, middle-aged adults, and seniors—across five regions: Eastern, Central, Northern, Western, and Southern Saudi Arabia. …”
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Folie à Deux in the Setting of COVID-19 Quarantine by Maxsaya Baez Nuñez, Ezequiel Rodriguez, Matthew DeLuca, Krishan Chirimunj, Monica Dhingra

“…We relay the case of a middle-aged male and his mother, an elderly female, who presented with folie à deux in the context of shared delusions of persecution and somatization during the COVID-19 quarantine period. …”
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The Effects of Six Weeks of Patella Taping on Function, Proprioception, and Balance in Women with Knee Osteoarthritis by Maryam Alikhani, Hamid Tabatabai

“…Methods This applied, semi-experimental study involved middle-aged women aged 30 to 50 years. Using convenience sampling, 30 women with knee osteoarthritis from an orthopedic clinic in Tehran were selected. …”
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Effect of traditional Chinese exercise on abnormal lipid metabolism in patients with atherosclerosis: a protocol for meta-analysis of randomised controlled trials by Chen Wang, Peizhen Zhang, Yuting Yang

“…However, these studies focused only on middle-aged and older populations over 50 years of age and had short intervention periods, poor quality control and patient compliance, and no stratification by age and gender to observe the effects of traditional Chinese exercise (TCE) on patients with AS. …”
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Association between sanitary toilets and health poverty vulnerability among rural western Chinese adults aged 45 years and older: A cross-sectional study. by Ximin Ma, Qi Hu, Jiahui He, Chunsheng Li, Kexin Chen, Wenlong Wang, Hui Qiao

“…The provision of sanitary toilets has been instrumental in mitigating health-related poverty among middle-aged and elderly people residing in rural areas. …”
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The Effect of Six Weeks of Patella Taping on Pain in Women with Knee Osteoarthritis by Maryam Alikhani, Hamid Tabatabai

“…The study population consisted of middle-aged women aged 30 to 50 years. Using convenience sampling, 30 women with knee osteoarthritis, referred to an orthopedic clinic in Tehran, were selected as the study sample. …”
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Service users’ perception and attitude toward telemedicine-based treatment for substance use disorders: A qualitative study from India by Abhishek Ghosh, Tathagata Mahintamani, P. V. Aswathy, Debasish Basu, Surendra K. Mattoo, B. N. Subodh, Renjith R. Pillai, Manpreet Kaur

“…Results: Most participants were middle-aged men (40.5 years, 86.7%), dependent on two or more substances (86.7%), and had a history of chronic, heavy substance use (use ~16 years, dependence ~11.5 years). …”
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Elusive Gains of Cognitive Training: Limited Effects on Neural Activity Across Sessions by Luka Juras, Andrea Vranic, Ivana Hromatko

“…Methods: A group of 20 middle-aged participants completed 20 training sessions over 10 weeks. …”
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