Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes by Jianqing Fang, Zhe Wang, Yu Shen, Xuenong Wu, Hao Fang, Xiaokui Sun, Ting Yu, Qingqing Zhang

“…We discuss experience with them and the shortcomings in their treatment by summarizing their medical history, disease evolution, tests, and diagnostic and therapeutic processes.ResultsIn both patients, the diagnosis of Legionnaires’ disease was confirmed through analysis of the bronchoalveolar lavage fluid (BALF). The middle-aged male patient was cured and discharged due to early detection and diagnosis. …”
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Woman with Pregnancy and Lactation-Associated Osteoporosis (PLO) by Nasrin Bazgir, Elham Shafiei, Neda Hashemi, Hassan Nourmohamadi

“…Osteoporosis is one of the most common diseases among the middle aged and elderly people that impose high costs on the community. …”
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The Relation of Coffee Consumption to Serum Uric Acid in Japanese Men and Women Aged 49–76 Years by Ngoc Minh Pham, Daigo Yoshida, Makiko Morita, Guang Yin, Kengo Toyomura, Keizo Ohnaka, Ryoichi Takayanagi, Suminori Kono

“…We examined the relation between coffee intake and serum UA levels in free-living middle-aged and elderly men and women in Fukuoka, Japan. …”
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Aging disrupts the link between network centrality and functional properties of prefrontal neurons during memory-guided behavior by Yadollah Ranjbar-Slamloo, Huee Ru Chong, Tsukasa Kamigaki

“…This relationship, however, deteriorates in middle-aged and older mice. A computational model simulating age-related declines in synaptic plasticity reproduces these results. …”
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Unexpected Tension Pneumothorax-Hemothorax during Induction of General Anaesthesia by Ekaterini Amaniti, Chrysoula Provitsaki, Panagiota Papakonstantinou, George Tagarakis, Konstantinos Sapalidis, Ioannis Dalakakis, Dimitrios Gkinas, Vasilios Grosomanidis

“…We describe a case of a healthy middle-aged woman, who was planned to receive general anaesthesia for total thyroidectomy. …”
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Pulmonary Thromboembolism Complicating Amebic Liver Abscess: First Reported Case in the United States—Case Report and Literature Review by Devon McKenzie, Michael Gale, Sunny Patel, Grazyna Kaluta

“…In the USA, it is most prevalent in middle aged immigrant males from endemic countries such as Africa, Mexico, and India. …”
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Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity by Suzhen Chen, Yanping Wang, Qian Zhou, Qiqi Qian, Quanxin Jiang, Chuchu Liu, Yan Liu, Peihui Zhou, Jie Xiong, Yao Zhang, Ning Wang, Yang Emma Li, Limin Yin, Hongyuan Yang, Junli Liu

“…Abstract Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. …”
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Lymphoma of the Urinary Bladder by Anthony Kodzo-Grey Venyo

“…The tumour has female predominance; most cases occur in middle-age women. Secondary LUB occurs in 10% to 25% of leukemias/lymphomas and in advanced-stage systemic lymphoma. …”
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Imagens da Arte by Maria Filomena Borja de Melo

“…What is the discourse about art and aesthetic in late Middle Age? Before Kant, before contemporary art critics, before a systematic reflexion about art, how was it to talk about art subjects, about beauty, about the art works that were done around? …”
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Les agglomérations de Nyon, Lausanne et Yverdon (Suisse) : trois exemples de l’ouest du plateau suisse entre Antiquité tardive et haut Moyen Âge by Clément Hervé

“…This contribution gives a first review of archaeological data on Late Antiquity and Early Middle Age of Nyon, Lausanne and Yverdon — three urban areas which illustrate different urban and territorial mutations which occured during those periods in the Western part of the “Plateau suisse”. …”
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Becoming a Caregiver: The Role of the Environment in the Process of Children Becoming Responsible for Others by Carolina Remorini

“…The concept of “mutual raising” is employed to examine the daily interactions between middle-aged children and their domestic animals. To gain an insight into how children develop sophisticated and ecologically relevant skills to become autonomous and responsible for the care of others within the context of environmental interdependence, we present and analyze a cultural practice that is salient to the identity and way of life in rural communities of the Andean region in South America: becoming a shepherd. …”
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Evaluating the effects of guide plans on the mental health of villagers (Case study: Central district of Darab County) by Hamid Heidary mokarrar, Hamid reza Nasimi, Zohreh Ramezanpour

“…Other results of the research confirm that there is a significant difference between mental health status in all three age groups of men But among women, there is a significant difference between the two age groups of the elderly with young people and middle aged people.…”
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Targeting TRPM3 as a potential therapeutic approach for autosomal dominant polycystic kidney disease by Hüseyin Gül, Jamie A. Davies

“…Abstract Cystic diseases, especially autosomal dominant polycystic kidney disease (ADPKD; incidence approx. 1/1000), are a leading cause of renal failure, caused by appearance and growth of renal cysts that can lead to renal failure in middle age. Most ADPKD cases are caused by mutations in PKD1 or PKD2, encoding polycystin-1 (PC1) and polycystin-2 (PC2). …”
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Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction by Jingyi Tan, Anna Dai, Lai Pan, Lan Zhang, Zhongxiu Wang, Ting Ke, Weilian Sun, Yanmin Wu, Pei-Hui Ding, Lili Chen

“…Periodontal disease (PD), as an age-related disease, prevalent in middle-aged and elderly population, is characterized as inflammatory periodontal tissue loss, including gingival inflammation and alveolar bone resorption. …”
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Immunoglobulin G4 Sclerosing Cholangitis: An Unusual Cause of Obstructive Jaundice—Case Report and Literature Review by Pragya Shrestha, Brian Le, Brent Wagner, William Pompella, Paras Karmacharya

“…IgG4-RD is an increasingly recognized immune-mediated fibroinflammatory systemic disease, mostly affecting middle-aged and older male populations that can affect multiple organs. …”
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The Diagnosis and Treatment of Branch Retinal Vein Occlusions: An Update by Diana-Maria Darabuş, Rodica Georgiana Dărăbuş, Mihnea Munteanu

“…Branch retinal vein occlusion (BRVO) is a common retinal vascular condition and a significant contributor to vision loss worldwide, particularly in middle-aged and elderly populations. This review synthesizes current knowledge on the epidemiology, pathogenesis, and clinical features of BRVO, alongside recent advancements in diagnostic and therapeutic strategies. …”
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Distal muscle weakness as the main onset symptom in thymoma-associated myasthenia gravis: a case report and literature review by Xuan Wu, Xiao-tian Xu, Lin Zhou, Kai Qiao, Chong-bo Zhao, Su-shan Luo

“…This report presents a case of a middle-aged woman with a chronic onset of asymmetric upper limb weakness accompanied by difficulty in finger extension, without ptosis or fluctuation for 4 years. …”
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COVID-19 Vaccination Associated Bilateral Pulmonary Embolism: Cause or Coincidence by John Omotola Ogunkoya, Marion Itohan Ogunmola, Akinwale Folarin Ogunlade, Akindele Emmanuel Ladele

“…These cases were seen and described in middle-aged men. Case Summary. A 59-year-old man presented with a 2 week history of sudden onset dyspnea and a week history of productive cough. …”
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Spiradenoma: A Case Report and Review of the Literature by Jia-Ying Chang, Yen-Chang Chen, Dah-Ching Ding

“…<b>Background and Clinical Significance:</b> Spiradenoma is a rare benign skin adnexal tumor with unknown incidence and prevalence, typically affecting young to middle-aged adults without a sexual predilection. <b>Case Presentation:</b> A 59-year-old woman presented with a palpable lesion in the suprapubic region that had been there for 20 years and had become enlarged over the past 2 months. …”
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Perception of modern technologies by the older generation: comparative analysis by T. A. Aimaletdinov, M. V. Tsimbal

“…Firstly, it is the older generation that assumes the role of “technological optimists”, unlike younger and middle-aged people who have more concerns about the development of information technology. …”
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