Disrupting EDEM3‐induced M2‐like macrophage trafficking by glucose restriction overcomes resistance to PD‐1/PD‐L1 blockade by Shaoyong Peng, Minshan Wu, Qian Yan, Gaopo Xu, Yumo Xie, Guannan Tang, Jinxin Lin, Zixu Yuan, Xiaoxia Liang, Ze Yuan, Jingrong Weng, Liangliang Bai, Xiaolin Wang, Huichuan Yu, Meijin Huang, Yanxin Luo, Xiaoxia Liu

“…Cancer‐associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need for new treatment strategies. Methods Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T cell coculture, crystal violetstaining, ELISA, metabonomic and clinical tumour samples were conducted to assess the role of EDEM3 in immune escape and itsmolecular mechanisms. …”
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Artificial intelligence contouring in radiotherapy for organs-at-risk and lymph node areas by Céline Meyer, Sandrine Huger, Marie Bruand, Thomas Leroy, Jérémy Palisson, Paul Rétif, Thomas Sarrade, Anais Barateau, Sophie Renard, Maria Jolnerovski, Nicolas Demogeot, Johann Marcel, Nicolas Martz, Anaïs Stefani, Selima Sellami, Juliette Jacques, Emma Agnoux, William Gehin, Ida Trampetti, Agathe Margulies, Constance Golfier, Yassir Khattabi, Olivier Cravéreau, Alizée Renan, Jean-François Py, Jean-Christophe Faivre

“…The objective of this study is to compare eight available AI software programs in terms of technical aspects and accuracy for contouring organs-at-risk and lymph node areas with current international contouring recommendations. Material and methods From January–July 2023, we performed a blinded study of the contour scoring of the organs-at-risk and lymph node areas by eight self-contouring AI programs by 20 radiation oncologists. …”
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Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l... by Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir

“…However, there is a lack of longitudinal studies to quantify the concentrations of maternal apolipoproteins from preconception to postpartum and their associations with maternal metabolic health and offspring birth outcomes. Methods: Quantification of apolipoproteins was performed on maternal plasma samples (N = 243 trios) collected at preconception, 26–28 weeks’ pregnancy, and three months postpartum in the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO) cohort study. …”
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Evaluation of long‐acting cabotegravir safety and pharmacokinetics in pregnant women in eastern and southern Africa: a secondary analysis of HPTN 084 by Sinead Delany‐Moretlwe, Brett Hanscom, Xu Guo, Clemensia Nkabiito, Patricia Mandima, Patricia Ntege Nahirya, Juliet Mpendo, Muchaneta Bhondai‐Mhuri, Nyaradzo Mgodi, Rebecca Berhanu, Jennifer Farrior, Estelle Piwowar‐Manning, Susan L. Ford, Craig W. Hendrix, Alex R. Rinehart, James F. Rooney, Adeola Adeyeye, Raphael J. Landovitz, Myron S. Cohen, Mina C. Hosseinipour, Mark A. Marzinke, the HPTN 084 Study Team

“…We report on the safety and CAB‐LA pharmacokinetics in pregnant women during the blinded period of HPTN 084. Methods Participants were randomized 1:1 to either active cabotegravir (CAB) plus tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) placebo or active TDF/FTC plus CAB placebo. …”
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Application of platelet-rich plasma therapy combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis (富血小板血浆联合5E康复护理模式在膝骨性关节炎患者中的应用)... by AN Linjing (安林静), ZHAO Chen (赵晨), CHANG Yueyuan (常月圆), PAN Yaying (潘亚英), CHEN Yanqi (程艳琪), ZHANG Bing (张兵), CHEN Weinan (陈炜楠), GAO Bei (高蓓), NIU Jing (牛静), ZHANG Ting (张婷)

“…Objective To explore the clinical effect of platelet-rich plasma therapy (PRP) combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis. Methods Totally 80 patients with knee osteoarthritis admitted to the orthopedics department of the hospital from March 2021 to March 2023 were selected as subjects. …”
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Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging by Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Guglielmo Genovese, Edward J. Auerbach, Andrea Grant, Matt Waks, Andrew Wright, Philipp Lazen, Alireza Sadeghi-Tarakameh, Gilbert Hangel, Fabian Niess, Yigitcan Eryaman, Gregor Adriany, Gregory Metzger, Wolfgang Bogner, Małgorzata Marjańska

“…Here, we present the preliminary findings from 3D MR spectroscopic imaging (MRSI) of the human brain conducted with the world's first 10.5 T whole-body MR system. Methods: Employing a custom-built 16-channel transmit and 80-channel receive MR coil at 10.5 T, we conducted MRSI acquisitions in six healthy volunteers to map metabolic compounds in the human cerebrum in vivo. …”
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Studies on fatty acids and microbiota characterization of the gastrointestinal tract of Tianzhu white yaks by Chen Shaopeng, Cui Changze, Qi Youpeng, Mi Baohong, Zhang Meixian, Jiao Chenyue, Zhu Chune, Wang Xiangyan, Hu Jiang, Hu Jiang, Shi Bingang, Shi Bingang, Ma Xueming, Zhao Zhidong, Zhao Zhidong, Zhang Xiaolan

“…IntroductionThe gut microbiota significantly influences the host’s production performance and health status, with different gastrointestinal tissues exhibiting functional diversity reflected in their microbial diversity.MethodsIn this study, five adult male Tianzhu white yaks (4.5 years old) were selected and fed under the same nutritional conditions. …”
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Effect of acupoint application combined with acupoint massage on constipation of liver-qi stagnation after replantation of severed fingers (穴位贴敷联合按摩在断指再植术后肝郁气滞型便秘患者中的应用效果研究)... by TIAN Miaomiao (田苗苗), XIAO Junyan (肖俊艳)

“…Objective To observe the effect of acupoint application combined with acupoint massage on constipation of liver-qi stagnation after replantation of severed fingers. Methods Totally 60 patients with constipation of liver-qi stagnation after finger replantation were randomly divided into study group and control group, with 30 patients in each group. …”
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High-quality targeted temperature management combined with decompressive craniectomy in patients with poor-grade aneurysmal subarachnoid hemorrhage: a secondary analysis of a multi... by Yang Liu, Bingsha Han, Yanru Li, Zhiqiang Ren, Yong Chen, Ming Zhang, Jiao Li, Jv Wang, Fan Yang, Mengyuan Xu, Jiaqi Zhang, Pengzhao Zhang, Tiancai Wang, Jinying Tian, Guang Feng

“…This study aims to investigate the therapeutic outcomes of the combination of TTM and DC in patients with poor-grade aSAH.MethodsThis study represents a secondary analysis of the Multicenter Clinical Research on Targeted Temperature Management of Poor-grade Aneurysmal Subarachnoid Hemorrhage (High-Quality TTM for PaSAH), a multicenter prospective study conducted in China. …”
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Immune response and growth of Lates calcarifer fed on hydrolized protein-supplemented diet by Romi Novriadi, Tinggal Hermawan, , Ibtisam, , Dikrurrahman, Muh Kadari, Mikael Herault, Vincent Fournier, Paul Seguin

“…Challenge test was performed with Vibrio parahaemolyticus at a density of 105 sel/mL by using immersion method. The results showed that the the neutrofil, leukocyte and monocyte of the fish fed on protein hydrolisates were significantly higher than those non-supplemented group (P<0.05). …”
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[Artículo traducido] Análisis retrospectivo de supervivencia del uso de vástagos modulares cónicos no cementados para la revisión en fracturas periprotésicas tipo B de Vancouver. ¿... by J. Lixa, P. Vieira, P. Pereira, A. Pinho, M. Seara, A. Sousa, L. Vieira

“…We aimed to evaluate the survival of uncemented modular tapered stems in the treatment of periprosthetic Vancouver B2 and B3 type fractures and review the main complications and factors associated with decreased survival. Materials and methods: We performed a retrospective study of patients submitted to revision arthroplasty for treatment of periprosthetic femoral stem Vancouver B2 and B3 type fractures with an uncemented modular fluted tapered stem (MRP-Titan). …”
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Optimization and evaluation of precision distribution of loaned instruments and implants for orthopedic surgery (骨科外来器械及植入物精准配送的流程优化与效果评价)... by XIA Yesong (夏叶松), ZOU Xiufang (邹秀芳), FU Chaojuan (付朝娟)

“…Objective To optimize and evaluate the precision distribution of loaned instruments and implants for orthopedic surgery. Methods Distribution process of loaned instruments and implants for orthopedic surgery was optimized by interventions such as classification of loaned instruments package, “packaging-coding-sterilization-tracing-charging” management circle, point-to-point distribution and so on. …”
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Influence of Exposure to Different Green Rooftop Spaces on Stress Restoration of College Students by Zhixiong ZHUO, Liang DONG

“…Therefore, this research explores the influence of exposure to green rooftop space on the physical and psychological restoration of college students from both physiological and psychological perspectives through a field experiment.MethodsIn order to determine the restorative effects of green rooftops on physical and psychological health, three types of green rooftop spaces (water space, wooden plaza, and ecological sunroom) and a control group (non-green rooftop space) in the Experimental Building of Architecture Discipline of Huaqiao University are selected to explore the restorative potentials of green rooftop space. …”
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Économie végétale à partir des études carpologiques du boulevard Dr Henri-Henrot à Reims/Durocortorum by Véronique Matterne

“…The increase in the number of mortars testifies to the importance of spices and the preparation of spiced and carefully seasoned sauces; cooking methods favored for stews or other dishes that are simmered. …”
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Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflamma... by Chaokai Yang, Enlong Zhao, Hu Zhang, Liqi Duan, Xinyue Han, Hongli Ding, Yan Cheng, Dengkun Wang, Dengkun Wang, Dengkun Wang, Xiaojing Lei, Xiaojing Lei, Xiaojing Lei, Yongchang Diwu, Yongchang Diwu, Yongchang Diwu

“…This investigation sought to elucidate XXD’s impact on various aspects of AD pathology, including blood-brain barrier (BBB) impairment, neuroinflammatory processes, and amyloid-β (Aβ) deposition, as well as the molecular pathways involved in these effects.MethodsIn vitro experiments were conducted using hCMEC/D3 and HBVP cell coculture to establish an in vitro blood-brain barrier (BBB) model. …”
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Study on the status of liver function abnormalities and its related factors in patients with severe mental disorders in Shanghai community by ZHANG Yixuan, CHEN Chunmei, ZHU Youwei, ZHU Yi, HE Siyuan, LIU Yanli, WANG Na, CAI Jun, XIE Bin, ZHANG Weibo

“…ObjectiveTo investigate the status of liver function abnormalities in patients with severe mental disorder (SMD) in Shanghai community, to explore the related factors to abnormal liver function in patients with SMD, and to analyze the effects of the types of mental disorders and medication status on liver function abnormalities.MethodsThe patients with SMD in Jinshan District, Minhang District, Hongkou District and Xuhui District of Shanghai were selected as the research subjects. …”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…ObjectiveTo elucidate the targets and potential mechanism underlying the anti-pulmonary fibrosis efficacy of Dracocephalum moldavica L. extract by employing an amalgamation of network pharmacology and empirical verification. MethodsThe chemical composition of the extract of Dracocephalum moldavica L. was retrieved with the help of China National Knowledge Infrastructure (CNKI) and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). …”
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Determination of Zinc Requirement in Suckling Calves using Some Non-Linear Models by Mohammad Javad Elyasi, Khalil zaboli

“…The present study was carried out to determine the optimal requirement of Zn in Holstein suckling calves using some models. Materials and Methods: In this experiment, a total of 30 Holstein suckling calves (5 treatments, n=6 calves/treatment) aged from 4 (42.75 ± 3.26 kg mean body weight) to 70 days (93.52 ± 3.97 kg mean body weight) were used in a completely random design. …”
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Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions by XU Ziqi, HU Ruizhi, LI Junjian, WANG Hongxia, SANG Youzhou

“…This study aimed to investigate the expression of intermediate filament family orphan 1 (IFFO1), a methylation-driven gene (MDG) in pancreatic adenocarcinoma (PAAD), along with its effects on the invasion and metastasis of PAAD cells, as well as its potential as a diagnostic and prognostic biomarker. Methods: mRNA expression data (TCGA-PAAD-mRNA), DNA methylation data (TCGA-PAAD-meth, GSE53051, PACA-AU) of PAAD and adjacent normal tissues, as well as DNA methylation data of healthy individuals’ blood (GSE69270), were obtained from the The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC) and Gene Expression Omnibus (GEO) databases. …”
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Acupoint application of Xiefu prescription in the prevention of functional constipation in long-term bedridden patients with pelvic fracture (泻腑贴方穴位贴敷预防长期卧床骨盆骨折患者功能性便秘的临床研究)... by GU Tianjiao (顾天姣), LIU Yingchun (刘迎春), DONG Ziqing (董子青), DING Di (丁娣), DENG Lixia (邓丽霞), YANG Yanhui (杨燕辉), MAO Lingling (毛玲玲)

“…Objective To explore the effect of acupoint application of Xiefu prescription on prevention of functional constipation in long-term bedridden patients with pelvic fracture. Methods A total of 60 patients with pelvic fracture without abnormal defecation function and constipation main symptom score ≤3 were selected and randomly divided into two groups: 30 patients in the control group received routine prevention and nursing measures, and 30 patients in the treatment group received acupoint application of Xiefu prescription based on the routine nursing interventions. …”
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