Utility of left atrial and ventricular strain for diagnosis of transthyretin amyloid cardiomyopathy in aortic stenosis by Fumi Oike, Hiroki Usuku, Eiichiro Yamamoto, Kyohei Marume, Seiji Takashio, Masanobu Ishii, Noriaki Tabata, Koichiro Fujisue, Kenshi Yamanaga, Daisuke Sueta, Shinsuke Hanatani, Yuichiro Arima, Satoshi Araki, Seitaro Oda, Hiroaki Kawano, Hirofumi Soejima, Kenichi Matsushita, Mitsuharu Ueda, Toshihiro Fukui, Kenichi Tsujita

“…Abstract Aims To clarify the usefulness of left atrial (LA) function and left ventricular (LV) function obtained by two‐dimensional (2D) speckle tracking echocardiography to diagnose concomitant transthyretin amyloid cardiomyopathy (ATTR‐CM) in patients with aortic stenosis (AS). Methods and results We analysed 72 consecutive patients with moderate to severe AS who underwent 99mTc‐pyrophosphate (PYP) scintigraphy at Kumamoto University Hospital from January 2012 to September 2020. …”
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Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…We aimed to evaluate the feasibility and preliminary effectiveness of implementing nurse-enabled, shared-follow-up care between the acute and primary care setting for early-stage breast cancer. Methods: In this single-centre, open-label, phase II, pilot, randomised, controlled trial, individuals diagnosed with breast cancer (Stage 0–III) were randomised 1:1 to either usual care or intervention, which includes a 1) Specialist Nurse Consultation to co-develop a survivorship care plan (SCP), 2) Pharmacist Consultation, 3) Case Conference with General Practitioner (GP), and 4) shared follow-up care arrangements. …”
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AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection by Zhiyang Chen, Tingting Xie, Shuting Chen, Zhenhui Li, Su Yao, Xuanjun Lu, Wenfeng He, Chao Tang, Dacheng Yang, Shaohua Li, Feng Shi, Huan Lin, Zipei Li, Anant Madabhushi, Xiangtian Zhao, Zaiyi Liu, Cheng Lu

“…Given the heterogeneous outcomes in patients with HCC undergoing liver resection, this study aims to develop an AI-based system to quantify CD8+ TILs and assess their prognostic value for patients with HCC. Methods: We conducted a retrospective multicenter study on patients undergoing liver resection across three cohorts (N = 514). …”
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Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system by Xueqian Yang, Meiqi Wu, Menglin Liang, Haiqiong Zhang, Bo Li, Chenhui Mao, Liling Dong, Yuan Wang, Haiqun Xing, Chao Ren, Zhenghai Huang, Qingxiang Wen, Qi Ge, Zhengqing Yu, Feng Feng, Jing Gao, Li Huo

“…The study aims to establish a faster acquisition protocol for [18F]florbetapir PET imaging using digital PET/CT scanner uMI Panorama, while ensuring adequate image quality and amyloid-β (Aβ) detectability comparable to the standard 10-minute scan. Methods Thirty-eight participants (29 Aβ positive and 9 Aβ negative) from a prospective dementia cohort at Peking Union Medical University Hospital underwent routine [18F]florbetapir PET scans using the uMI Panorama PET/CT scanner and a T1-weighted brain MRI scan. …”
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Accelerometer-measured physical activity, sedentary behavior, and incidence of macrovascular and microvascular events in individuals with type 2 diabetes mellitus and prediabetes by Yannis Yan Liang, Yu He, Piao Huang, Hongliang Feng, Haiteng Li, Sizhi Ai, Jing Du, Huachen Xue, Yaping Liu, Jun Zhang, Lu Qi, Jihui Zhang

“…We aimed to describe the intensity-specific dose–response associations of PA and sedentary behavior (SB) with macrovascular and microvascular events among individuals with T2DM and prediabetes. Methods: This study included 11,474 individuals with T2DM and prediabetes from the UK Biobank. …”
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Promotion and practice of an online service offering Traditional Chinese Medicine constitution conditioning under the normalization of epidemic prevention and control (疫情防控常态化背景下中医... by MA Qian (马茜), YU Hong (俞红), XU Junhua (徐俊华), XU Lidan (许丽丹), FANG You (方友), ZHEN Yanping (郑艳平), LI Yanlan (李燕兰), LIANG Xiao (梁肖), LU Mingya (陆明雅), ZHANG Yijun (张轶俊)

“…Objective To explore the feasibility and effectiveness of an online service offering Traditional Chinese Medicine (TCM) physique conditioning under the normalization of epidemic prevention and control. Methods From March 1, 2020 to March 10, 2020, 190 subjects who were judged as "Qi deficiency" by "TCM constitution test" were recruited online. …”
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Convergent construct validity and test-retest reliability of both German versions of the original and the revised Niigata PPPD Questionnaire: NPQ and NPQ-R by Sarah Chételat, Sarah Chételat, Eve-Yaël Gerber, Eve-Yaël Gerber, Sarah El Khadlaoui, Frank Behrendt, Frank Behrendt, Michaela Stark, Michaela Stark, Stefan Schädler, Stefan Schädler, Maximilian Maywald, Lena Fabritius, Johannes Gerb, Johannes Gerb, Denis Grabova, Wiebke Trost, Andreas Zwergal, Andreas Zwergal, Ralf Strobl, Ralf Strobl, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Sandra Becker-Bense, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…The study's aim was to evaluate the concurrent construct validity and reliability [including test-retest reliability, internal consistency, standard error of measurement (SEM), and minimal detectable change (MDC)] of the German version of the NPQ (12 items) and its revised version, NPQ-R, which contains 19 items addressing additional symptoms and symptom behavior.MethodsThe Swiss Reha Rheinfelden and the German Center for Vertigo and Balance Disorders included 265 PPPD patients (mean age 50.2 ± 16.8 years, disease duration 46.3 ± 76.6 months). …”
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The added value of coupling anti-dsDNA and anti-chromatin antibodies in follow-up monitoring of systemic lupus erythematosus patients by Caroline Carlé, Françoise Fortenfant, Chloé Bost, Julie Belliere, Stanislas Faguer, Dominique Chauveau, Antoine Huart, David Ribes, Laurent Alric, Gregory Pugnet, Laurent Sailler, Yves Renaudineau

“…However, anti-dsDNA Ab biomarker performances are weak; therefore, coupling anti-dsDNA with anti-Chr Ab can be proposed, which is the aim of this study. Methods: In this single center study from 2009 to 2024, 269 SLE patients with follow-up information were retrospectively selected from a population of 646 individuals, including 325 SLE patients, who tested positive for anti-dsDNA and/or anti-Chr Ab (Bioplex 2200™). …”
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Unveiling genetic basis of seedling emergence from deep soil depth under dry direct- seeded conditions in rice (Oryza sativa L.) by Vagish Mishra, Vagish Mishra, Shilpi Dixit, Shilpi Dixit, Swati Tyagi, Swati Tyagi, Challa Venkateswarlu, Challa Venkateswarlu, Pronob J. Paul, Pronob J. Paul, Anoop Kishor Singh Gurjar, Anoop Kishor Singh Gurjar, Shalabh Dixit, Nitika Sandhu, Smita Kurup, Arvind Kumar, Arvind Kumar, Pallavi Sinha, Pallavi Sinha, Vikas Kumar Singh, Vikas Kumar Singh, Uma Maheshwar Singh, Uma Maheshwar Singh

“…Direct-seeded rice (DSR) is an efficient method that conserves water, reduces labor costs, and allows for full mechanization of cultivation. …”
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Study of anti-inflammatory, antioxidant, antimicrobial and mineralizing effects of an N-isopropenylimidazole zinc metal complex derivative in experimental endodontic-periodontal le... by Pavel A. Galenko-Yaroshevsky, Ivan I. Pavlyuchenko, Olga V. Shelemekh, Boris A. Trofimov, Lidiya N. Parshina, Viktor L. Popkov, Svetlana A. Demyanenko, Oleg V. Tsymbalov, Andrey V. Zadorozhniy, Anait V. Zelenskaya, Irina B. Nektarevskaya, Alina V. Sergeeva, Nikolay E. Korovaykin, Svetlana A. Lebedeva

“…The aim of the study was to examine the anti-inflammatory, antioxidant, antimicrobial and mineralizing effects of an N-isopropenylimidazole zinc metal complex derivative in experimental endodontic-periodontal lesions in rats. Materials and Methods: EPL simulation in experiments on the anesthetized rats was conducted in the following way: first, the pulp cavity of lower incisors was opened and left exposed to infection; then periodontal inflammation was induced using a ligature. …”
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Application of Shenling lotion in nursing of perineal injury after vaginal delivery (参苓洗液在经阴道分娩产妇产后会阴损伤护理中的应用效果研究) by TANG Yang (唐杨), PENG Hong (彭鸿), WU Qiuxiang (吴秋香), WANG Yan (王燕), WANG Mingyang (王明洋), CHEN Lingfang (陈陵芳)

“…Objective To investigate the effect of Shenling lotion in nursing of perineal injury after vaginal delivery. Methods A total of 200 puerperal women after vaginal delivery were randomly divided into the control group and observation group, with 100 cases in each group. …”
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Practice of continuing care with Traditional Chinese Medicine nursing for patients after surgical treatment of mixed hemorrhoids in the specialized outpatient clinic (基于专病门诊的混合痔术后患... by Qin Shasha (秦沙沙), E Haiyan (鄂海燕), WEI Yongchun (魏永春), PENG Yujie (彭雨洁), TANG Ling (唐玲), LI Ye (李野), WANG Yali (王亚丽), DONG Yuxia (董玉霞)

“…Objective To investigate the practice effect of continuing care with Traditional Chinese Medicine nursing for patients after surgical treatment of mixed hemorrhoids in the specialized outpatient clinic. Methods Totally 80 patients undergoing surgical treatment of mixed hemorrhoids of Damp-Heat type were randomly divided into the observation group and the control group, with 40 cases in each group. …”
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LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK by Joanna Filipowska, Zelda Cisneros, Sneha S. Varghese, Nancy Leon-Rivera, Peng Wang, Randy Kang, Geming Lu, Yate-Ching Yuan, Hung-Ping Shih, Supriyo Bhattacharya, Sangeeta Dhawan, Adolfo Garcia-Ocaña, Nagesha Guthalu Kondegowda, Rupangi C. Vasavada

“…In this study, we assessed the regulation of Lgr4 in islets, and the role of LGR4 and LGR4/RANK stoichiometry in β-cell health under basal and stress-induced conditions, in vitro and in vivo. Methods: We evaluated Lgr4 expression in mouse and human islets in response to acute (proinflammatory cytokines), or chronic (high fat fed mice, db/db mice, and aging) stress. …”
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Satellite quantification of methane emissions from South American countries: a high-resolution inversion of TROPOMI and GOSAT observations by S. E. Hancock, D. J. Jacob, Z. Chen, H. Nesser, A. Davitt, A. Davitt, D. J. Varon, M. P. Sulprizio, N. Balasus, L. A. Estrada, M. Cazorla, L. Dawidowski, S. Diez, J. D. East, E. Penn, C. A. Randles, C. A. Randles, J. Worden, I. Aben, R. J. Parker, R. J. Parker, J. D. Maasakkers

“…The livestock sector shows the largest difference<span id="page798"/> between our top-down estimate and the UNFCCC prior estimates, and even countries using complex bottom-up methods report UNFCCC emissions significantly lower than our posterior estimate. …”
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Evaluation of the adherence of municipalities and states to the Ministry of Health’s microplanning for high-quality vaccination activities and the increase in vaccination coverage... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Gustavo Velasquez-Melendez, Luciana Maiara Diogo Nascimento, Carla Conceição Ferraz, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…Objective To assess the adherence of states and municipalities to OM for HQVA and examine the relationship between adherence levels and increased vaccination coverage in Brazil. Methods Adopting an epidemiological approach with an ecological design, this study analyzed data on the adherence of the 27 Brazilian federative units to HQVA, as reported through the REDCap electronic form in 2023, as per an agreement with the Ministry of Health. …”
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A China dataset of soil properties for land surface modelling (version 2, CSDLv2) by G. Shi, W. Sun, W. Shangguan, Z. Wei, H. Yuan, L. Li, X. Sun, Y. Zhang, H. Liang, D. Li, F. Huang, Q. Li, Q. Li, Y. Dai

“…The results showed that the predicted maps were significantly more accurate and detailed compared to traditional soil type linkage methods (i.e. CSDLv1, the first version of the dataset), SoilGrids 2.0, and HWSD 2.0 products, effectively representing the spatial variation of soil properties across China. …”
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Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts by Kelley Weinfurtner, David Tischfield, George McClung, Jennifer Crainic, John Gordan, Jing Jiao, Emma E. Furth, Wuyan Li, Erena Tuzneen Supan, Gregory J. Nadolski, Stephen J. Hunt, David E. Kaplan, Terence P.F. Gade

“…We hypothesized that expression of human GM-CSF and IL-3 increases tumor immune cell infiltration, especially myeloid-derived cells, in humanized HCC patient-derived xenografts. Material and Methods: NOG (NOD/Shi-scid/IL-2Rγnull) and NOG-EXL (huGM-CSF/huIL-3 NOG) mice conditioned with busulfan underwent i.v. injection of human CD34+ cells. …”
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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

“…However, real-world data on its long-term efficacy remains sparse.Methods This study assessed 5-year outcomes of first-line pembrolizumab monotherapy in a large, multicenter, real-world cohort of patients with advanced NSCLC and PD-L1 TPS≥50%, referred to as Pembro-real 5Y. …”
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Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch... by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

“…Aim was to test feasibility of STEADY in a randomised controlled trial. Methods: Feasibility parallel-group, randomised (blocks of four) controlled open-label trial (RCT) of STEADY against usual care (Control) at King's College London, UK. …”
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Application of a deep learning algorithm for the diagnosis of HCC by Philip Leung Ho Yu, Keith Wan-Hang Chiu, Jianliang Lu, Gilbert C.S. Lui, Jian Zhou, Ho-Ming Cheng, Xianhua Mao, Juan Wu, Xin-Ping Shen, King Ming Kwok, Wai Kuen Kan, Y.C. Ho, Hung Tat Chan, Peng Xiao, Lung-Yi Mak, Vivien W.M. Tsui, Cynthia Hui, Pui Mei Lam, Zijie Deng, Jiaqi Guo, Li Ni, Jinhua Huang, Sarah Yu, Chengzhi Peng, Wai Keung Li, Man-Fung Yuen, Wai-Kay Seto

“…The Liver Imaging Reporting and Data System (LI-RADS) results in a considerable number of indeterminate observations, rendering an accurate diagnosis difficult. Methods: We developed four deep learning models for diagnosing HCC on computed tomography (CT) via a training–validation–testing approach. …”
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