The diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia by Liping Fan, Jiahao Chen, Chong Chen, Yongwei Zhang, Yeqing Yang, Zhe Chen

“…Abstract Background This study aimed to analyse the relationship of the blood lipid profile and interleukin-6 (IL-6) with osteoporosis and osteopenia and to explore the predictive value of the combined application of these biomarkers in osteoporosis and osteopenia. Methods Data from 276 patients treated in the orthopaedics department were retrospectively analysed. …”
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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

“…However, its role in patient response to ICI remains unclear. Methods We analysed whole exome and bulk RNA sequencing data from a pan‐cancer cohort of 25 775 patients and cutaneous melanoma cohorts (untreated: n = 471, anti‐progressive disease [PD]‐1 treated: n = 212). …”
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Perbedaan Rerata Kadar Profil Lipid pada Preeklampsia dengan Kehamilan Normal pada Etnik Minangkabau by Helen Evelina Siringoringo, Yusrawati ., Eva Chundrayetti Chundrayetti

“…Lipid profile was examined by using independent calorimetric methode. The data analyzed statistically by independent t-test. …”
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Evaluation of Southern African wild edible plants for potential herb-drug interactions through ex vivo p-glycoprotein and in vitro cytochrome P450 3A4 inhibitory effects by P.S. Kheoane, K.C. Mokhetho, S. Mokhele, K.C. Mbara, C.M. Leonard, T.H. Gadaga, C. Tarirai

“…This study investigated the ex vivo p-glycoprotein inhibition and the in vitro inhibition of cytochrome P450 3A4 (CYP3A4) isoezyme by selected wild edible plants to identify potential food/herb-drug interactions. Methods: Ethanolic extracts of 30 wild edible plants sourced from Lesotho, Eswatini and the Limpopo province of South Africa were used for the study. …”
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Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD by Mengya Zhang, Kun Li, Xiaoxing Huang, Dongqin Xu, Ruobin Zong, Qintong Hu, Xiaoyu Dong, Qinyong Zhang, Chaochen Jiang, Yue Ge, Changyong Li, Jie Ping

“…However, the role of hepatic regulatory T cells (Tregs) in MASLD initiation and the mechanisms responsible for their change are not completely understood. Methods: A mouse model subjected to a short-term high-fat diet (HFD) to mimic early steatosis, along with liver biopsy samples from patients with simple steatosis, and macrophage-specific Notch1-knockout mice (Notch1M-KO), were used to investigate the role of Tregs in early MASLD and the effect of hepatic macrophage Notch1 signaling on Treg frequency. …”
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Transition from paediatric to adult neurological care: What do we know? by A. Valero-Mut, M.M. Rosselló-Vadell, M. Caner-Faig, J. Rubies-Olives, M. Carmona-Belda, E. Córdoba-Borrás, M.A. Grimalt-Calatayud, E. Miravet-Fuster

“…The aim of this study is to evaluate the current level of consensus on the transition of neuropaediatric patients among neurology and paediatric professionals in the Balearic Islands. Material and methods: We conducted an observational, analytical, cross-sectional study through an anonymous questionnaire consisting of 27 questions, which was distributed to neurologists, paediatric neurologists, hospital paediatricians, and primary care paediatricians in the healthcare network of the Balearic Islands. …”
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Prévalence de l’état de stress post-traumatique (ESPT) au Canada pendant la pandémie de COVID-19 : résultats de l’Enquête sur la COVID-19 et la santé mentale by Murray Weeks, Danielle Marion, Anne-Marie Robert, R. Nicholas Carleton

“… IntroductionCette étude donne un aperçu descriptif de la prévalence de l’état de stress post-traumatique (ESPT) au Canada, en fonction des caractéristiques sociodémographiques, des variables liées à la santé mentale et des effets négatifs de la pandémie de COVID-19. MethodsLes données ont été obtenues à partir des cycles 1 et 2 de l’Enquête sur la COVID-19 et la santé mentale (ECSM), recueillies à l’automne 2020 (N = 14 689) et au printemps 2021 (N = 8 032). …”
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Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch... by Karl Michaëlsson, Rui Zheng, John A. Baron, Tove Fall, Alicja Wolk, Lars Lind, Jonas Höijer, Carl Brunius, Eva Warensjö Lemming, Olga E. Titova, Bodil Svennblad, Susanna C. Larsson, Shuai Yuan, Håkan Melhus, Liisa Byberg, Hannah L. Brooke

“…Poor bone quality, central obesity, sarcopenia, falls, and low grip strength are independent risk factors for hip and other fragility fractures and also for CVD and early death. Methods: We used proteomics and a cohort design combined with Mendelian randomisation analysis to understand shared mechanisms for developing CVD and fragility fractures, two significant sources of disease burden and health expenditure. …”
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Le Proyecto Mono Tocon : recherche, éducation et conservation, au Pérou by Audrey Gaultier, Rosario Huashuayo‑Llamocca, Antonio Boveda‑Penalba, Jan Vermeer

“…Les données éthologiques sont enregistrées avec les méthodes de Scan sampling et Focal. Des études botaniques viendront compléter ces données comportementales dans le but ultime de réaliser un plan de reforestation pour la région de San Martin. …”
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Clinical effect of auricular point pressing with beans combined with acupoint massage in the treatment of post-stroke constipation with Qi deficiency syndrome (耳穴压豆联合穴位按摩治疗中风后气虚便秘的... by LI Chenchen (李陈晨), YANG Yu (杨宇), FAN Yan (范艳), JIA Tieying (贾铁英), HU Shirong (胡世荣)

“…Objective To explore the effect of auricular point pressing with beans combined with acupoint massage in the treatment of post-stroke constipation with Qi deficiency syndrome. Methods Totally 120 patients with post-stroke constipation of Qi deficiency syndrome were randomly divided into control group and study group, with 60 cases in each group. …”
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First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer by Lini Pandite, Simon Metenou, Debra L Richardson, Erika Hamilton, Linda Van Le, Bo Ma, Fatima Rangwala, Nehal J Lakhani, Justin Call, Daphne Stewart, Lauren E Dockery, Guanfang Wang, Jade Huguet, Elliot Offman

“…A first-in-human phase I trial of SL-172154 was conducted in patients with platinum-resistant ovarian cancer.Methods SL-172154 was administered intravenously at 0.1, 0.3, 1.0, 3.0, and 10.0 mg/kg. …”
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Optimization of salinity range for rearing glass eel Anguilla bicolor bicolor by Ade Yulita Hesti Lukas, Daniel Djokosetiyanto, Tatag Budiardi, Agus Oman Sudrajat, Ridwan Affandi

“…ABSTRACT   Fasting is one of a method that used for measured growth of fish in a shorter period of time. …”
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Nursing experience of retraining patients with peritoneal dialysis-related peritonitis in a single center (单中心腹膜透析相关性腹膜炎患者再培训的护理体会) by RAN Lei (冉蕾), CHEN Ye (陈叶), LIU Maodong (刘茂东)

“…Objective To investigated when and how to retraining in peritoneal dialysis(PD) patients and its role in decreasing the incidence of peritonitis according to analysis of the characteristics of peritonitis in the PD center. Methods In a retrospective study, 2 years of data from 2019 before continuous quality improvement(CQI) and 2020 after CQI in our PD center were analyzed. …”
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Prolonged use of selective immunosuppressants in glacoma drainage surgery: experimental in vivo study by V.N. Germanova, E.V. Karlova, L.T. Volova, N.N. Sarbaeva, I.F. Nefedova, M.V. Radaykina

“…</i> </p> <p> <i><b>Patients and Methods: </b>the study was conducted on 52 rabbit eyes. …”
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Association between prognosis and the use of angiotensin‐converting enzyme inhibitors and/or angiotensin II receptor blockers in frail patients with heart failure with preserved ej... by Akihiro Sunaga, Shungo Hikoso, Shunsuke Tamaki, Masahiro Seo, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Hiroyuki Kurakami, Tomomi Yamada, Tetsuhisa Kitamura, Taiki Sato, Bolrathanak Oeun, Hirota Kida, Yohei Sotomi, Tomoharu Dohi, Katsuki Okada, Hiroya Mizuno, Daisaku Nakatani, Takahisa Yamada, Yoshio Yasumura, Yasushi Sakata, OCVC‐Heart Failure Investigators

“…In the present study, we examined the association between ACE‐I/ARB and prognosis in patients with HFpEF stratified by the presence or absence of frailty. Methods and results We examined the association between the use of ACE‐I/ARB and prognosis according to the presence [Clinical Frailty Scale (CFS) ≥ 5] or absence (CFS ≤ 4) of frailty in patients with HFpEF in a post hoc analysis of registry data. …”
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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…High expression of the receptor tyrosine kinase REarranged during Transfection (RET) has been associated with resistance to endocrine therapy in breast cancer, but the role of RET in CDK4/6i treatment response/resistance remains unexplored.MethodsTo identify gene expression alterations associated with resistance to combined endocrine therapy and CDK4/6i, we performed RNA sequencing of two ER+ breast cancer cell models resistant to this combined therapy. …”
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Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Inhibit Apoptosis of Pulmonary Microvascular Endothelial Cells in COPD Mice Through miR-30b/Wnt5a Pathway by Song Q, Zhou A, Cheng W, Zhao Y, Liu C, Zeng Y, Lin L, Zhou Z, Peng Y, Chen P

“…Therefore, the aim of this study was to explore the role of BMSCs-derived exosomes in the apoptosis of PMVECs in COPD and to investigate the potential mechanisms.Methods: We isolated and characterized normal mouse BMSCs-derived exosomes and PMVECs. …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…The main objective of this prospective study was to explore the effects of neoadjuvant relugolix on health-related quality of life in prostate cancer patients immediately prior to stereotactic body radiation therapy (SBRT).MethodsPatients treated at Georgetown between January 2021 and September 2023 with neoadjuvant relugolix per an institutional protocol were included in the study (IRB 12-1775). …”
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ADMINISTRATIVE PREREQUISITES FOR FINANCIAL MANAGEMENT AND MARKETING OF SMALL BUSINESSES AT THE REGIONAL LEVEL by Natalia Koval, Oksana Kubai, Natalia Germaniuk

“…Thus, it can be argued that the financial management of a small enterprise includes the following basic principles, methods, forms of effective and rational management of financial resources and relations of the enterprise. …”
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Efficacy of 5 µg and 10 µg Dexmedetomidine as Adjuvants to 3 mL 0.5% Hyperbaric Bupivacaine in Pelvic and Lower Limb Orthopaedic Surgeries: A Randomised Clinical Study by Jigisha Bharatbhai Mehta, Shreya Jatin Patel, Nilesh Vrajmohan Shah, Dinesh K Chauhan, Sara Mary Thomas

“…Aim: To compare the effects of intrathecal 5 μg dexmedetomidine versus 10 μg dexmedetomidine as adjuvants to 3 mL of 0.5% hyperbaric bupivacaine in pelvic and lower limb orthopaedic surgeries. Materials and Methods: This randomised clinical and single-blind study study was conducted at the Operation Theatre (OT) complex of Dheeraj Hospital, SBKS, and MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat, India in the Department of Anaesthesia over a period of 18 months, from September 2022 to March 2024 and total of 82 patients scheduled for lower limb and pelvic orthopaedic surgery who were to receive spinal anaesthesia were divided into Group D1 and D2. …”
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