Late gadolinium enhancement cardiovascular magnetic resonance with generative artificial intelligence by Omer Burak Demirel, Fahime Ghanbari, Christopher W. Hoeger, Connie W. Tsao, Adele Carty, Long H. Ngo, Patrick Pierce, Scott Johnson, Kathryn Arcand, Jordan Street, Jennifer Rodriguez, Tess E. Wallace, Kelvin Chow, Warren J. Manning, Reza Nezafat

“…In this study, we sought to evaluate a rapid two-dimensional (2D) LGE imaging protocol using a generative artificial intelligence (AI) algorithm with inline reconstruction. Methods: A generative AI-based image enhancement was used to improve the sharpness of 2D LGE images acquired with low spatial resolution in the phase-encode direction. …”
Get full text

LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy f... by Yanjun Wang, Xin Zhang, Mengmeng Ren, Shu He, Hengjie Bie, Mengyang Duan, Zhiyuan Chen, Qiaowei Jia, Boyu Chi, Xiongkang Gan, Chengcheng Li, Yahong Fu, Hanxiao Zhou, Sheng Zhang, Qian Zhang, Fenghui An, Xiumei Chen, Enzhi Jia

“…We explored autophagy-associated long noncoding RNA (lncRNA) and the mechanisms underlying oxidative stress-induced human coronary artery endothelial cells (HCAECs) injury. Methods (1) Autophagy-related proteins including LC3, p62, Beclin1, ATG5, and ATG7 were immunohistochemical stained in coronary specimens; (2) The levels and function of autophagy in the HCAEC oxidative stress model were evaluated using western blot (WB), transmission electron microscopy (TEM), and mRFP-GFP-LC3 adenovirus transfection experiments; (3) The competing endogenous RNA (ceRNA) network of lncRNA LUCAT1/hsa-miR-6776-5p/LRRC25 axis was constructed and validated; (4) The expression levels of above autophagy-related RNAs in peripheral blood mononuclear cells (PBMCs) were verified by qPCR, and their diagnostic performance was subsequently analyzed using receiver operating characteristic (ROC) analysis. …”
Get full text

Étude archéozoologique du quartier portuaire romain de Saint-Lupien à Rezé/Ratiatum (Loire-Atlantique) : les vestiges fauniques en pied de berge by Aurélia Borvon

“…In the different parts of “area 4”, various taxa have been identified, both large-sized ones such as cattle, and very small-sized ones such as fish or shrimp. The excavation method has a very strong influence on the representation of the latter, since without fine sieving of the sediments (1.1 mm mesh size), they would be almost undetectable. …”
Get full text

Investigating the Effect of Chicken Manure and Potassium Sulfate on the Physiological Properties of Fenugreek )Trigonella foenum-graecum L.( Medicinal Plant by Mohammad hossein Aminifard, Sajjad Nadafa, Hassan Hassan, Mehdi Jahani

“…Therefore, considering the mentioned cases and the lack of scientific information in the field of combining fertilizers, in this research, an attempt was made to find a suitable fertilizer combination consisting of chicken manure and potassium sulfate for the fenugreek plant.Materials and MethodsTo investigate the effect of chicken manure and potassium sulfate on the physiological characteristics of the fenugreek medicinal plant, factorial research was conducted based on randomized complete block design with three replications in the crop year 2021-2022 in Qochan city in the north of Razavi Khorasan province. …”
Get full text

Combined Effects of Humic Acid-Modified Magnetic Biochar and AMF on the Properties of Saline-Alkali Soil and Photosynthetic Parameters of Muskmelon by ZHANG Yating, LOU Xueyi, WU Jiarui, LIU Hongyuan, YE Binyu, XIAO Jiamin, LI Jiameng, MIAO Yining, CHEN Xinyan, LIU Yilin, TAN Yuyu, WANG Zhichao, LIU Peng

“…[Objective] To improve humic acid-modified magnetic biochar (HA-MBC) and explore the combined effects of modified biochar and arbuscular mycorrhizal fungi (AMF) on the properties of saline-alkali soils and the growth of muskmelon. [Methods] Through response surface methodology, the effects of the ratio of magnetic biochar to humic acid (1∶4, 1∶6, 1∶8), the concentration of FeCl3 and FeSO4 reagents (0.02, 0.04, 0.06 g/mL), and the cross-linking duration (48, 72, 96 h) on HA-MBC were analyzed, to procure the optimum amendment scheme suitable for combined application with AMF. …”
Get full text

<i>ACE</i> I/D Genotype and Risk of Non-Contact Injury in Moroccan Elite Athletes: A Pilot Study by El Mokhtar El Ouali, Jihan Kartibou, Juan Del Coso, Rashmi Supriya, Ismail Laher, Zineb El Kettani, Hassan Ghazal, Najib Al Idrissi, Ayoub Saeidi, Abdelhalem Mesfioui, Hassane Zouhal

“…This study investigated the possible association of <i>ACE</i> I/D genotypes with the risk of non-contact injury in elite Moroccan athletes. <i>Materials and Methods:</i> Forty-three elite male athletes (19 cyclists and 24 field hockey players) from the Moroccan national team participated voluntarily. …”
Get full text

Efficiency of lung cancer screening in early diagnosis and treatment program among community residents in Nanshan district, Shenzhen city: a cross-sectional and 2-year follow-up su... by Yarui YANG, Xujun GUO, Yuzheng FAN, Han WANG, Shengbin LI, Juan HE, Chang MA, Junbo BAI, Shengyuan LIU

“…ObjectiveTo evaluate the effectiveness of a lung cancer screening program for early diagnosis and treatment of the disease among community residents in Nanshan district, Shenzhen city, Guangdong province, and to provide evidence for optimizing regional lung cancer prevention and control policies. MethodsA total of 11 000 residents aged 40 – 74 years were recruited from 59 communities in Nanshan district, Shenzhen city, Guangdong province, through publicity and mobilization from December 2020 to January 2022. …”
Get full text

[Translated article] Approach and management of patients injured by bullfighting trauma by A. Martínez-Hernández, G. Jara-Benedetti, C. Roig-Martí, C. Ordóñez-Urgiles, J.M. Laguna-Sastre

“…In addition, it is important to know the kinematics of the injuries and their specific characteristics, in order to implement quality medical–surgical care. Methods: Scientific review of the literature to promote a comprehensive guide for the medical–surgical management of patients injured by bullfighting trauma. …”
Get full text

Trends in Mental Health Outcomes of College Students Amid the Pandemic (Roadmap mHealth App): Longitudinal Observational Study by Gautham Jayaraj, Xiao Cao, Adam Horwitz, Michelle Rozwadowski, Skyla Shea, Shira N Hanauer, David A Hanauer, Muneesh Tewari, Kerby Shedden, Sung Won Choi

“…ObjectiveThis study aimed to examine the trends in mental health and well-being outcomes over 3 years among college students, with an exploratory aim to assess the potential impact of the Roadmap mHealth app on these outcomes. MethodsA fully automated longitudinal observational study was conducted remotely from a large public academic institution in the Midwestern United States, evaluating mental health and well-being outcomes among college students using the Roadmap mHealth app over 3 fall semesters from 2020 to 2022. …”
Get full text

Survey on first-line therapeutic management of relapsing–remitting multiple sclerosis in clinical practice in Spain by M. Llaneza, G. Fontes, L. Benedito-Palos, E. Moral

“…However, the available information on factors influencing decision-making regarding first-line treatment remain poorly understood. Methods: Based on a review of the literature and the experience of a scientific committee made up by 2 neurologists, an ad hoc survey was developed and distributed to Spanish neurologists. …”
Get full text

4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models by Ignacio Melero, Alvaro Teijeira, Christian Klein, Maria E Rodriguez-Ruiz, Christina Claus, Pablo Umana, Tamara Tanos, Carlos E De Andrea, Carlos Luri-Rey, Paloma Sanchez-Mateos, Leticia Fernández-Rubio, María Collantes, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Antonio Rullan, Jon Ander Simon, Eneko Garate-Soraluze, Claudia del Pilar Herrero

“…We hypothesized that IR increases FAP expression in CAFs, therefore the combination of IR with targeted immunomodulators such as an agonistic anti-FAP-4-1BBL fusion protein could enhance the immune-mediated antitumoral effects of these treatments.Methods The murine transplantable TS/A tumor-cell-line co-engrafted with CAFs was used to investigate increases in FAP expression in tumors following irradiation using immunohistochemistry, real-time polymerase chain reaction (RT-PCR) and multiplex tissue immunofluorescence. …”
Get full text

Characteristics of Traditional Human Settlement Landscapes on Bedrock Islands in Guangdong Based on the “Ao” Unit by Ying PAN, Linxi CHEN, Ying SHI

“…By doing so, the research seeks to offer a valuable reference for the conservation and sustainable development of islands, so as to help ensure that they remain vibrant and resilient in the face of environmental and socio-economic challenges.MethodsThis research takes Nan’ao Island in Shantou City as an example to explore the characteristics of traditional human settlement landscapes. …”
Get full text

Effects of Intrathecal Bupivacaine with Adjuvants Midazolam versus Magnesium Sulphate in Tibia Fibula Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Aanal Sha, Dushyant Chavda, Dinesh K Chauhan

“…Aim: To observe the efficacy of intrathecal 2.5 mg midazolam and 50 mg magnesium sulphate as adjuvants to 0.5% hyperbaric bupivacaine in tibia-fibula surgeries and haemodynamic stability in both groups. Materials and Methods: The present double-blind, prospective randomised clinical study was conducted in the Department of Anaesthesiology, Dhiraj Hospital, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India, from February 2021 to December 2022. …”
Get full text

The sense of safety theoretical framework: a trauma-informed and healing-oriented approach for whole person care by Johanna M. Lynch, Kurt C. Stange, Christopher Dowrick, Linn Getz, Pamela J. Meredith, Mieke L. Van Driel, Meredith G. Harris, Meredith G. Harris, Kate Tillack, Caley Tapp, Caley Tapp

“…ObjectivesThis research describes four aspects of the development of the Sense of Safety Theoretical Framework for whole person care: exploring the meaning of the phrase “sense of safety”—the whole person language; the range of human experience that impacts sense of safety—whole person scope; the dynamics that build sense of safety—the healing goals; and the personal and cross-disciplinary trauma-informed practitioner skills and attitudes that facilitate sense of safety.MethodsThis qualitative participatory study was conducted in two phases. …”
Get full text

The efficacy of LASIK and secondary piggyback IOL implantation for the enhancement after cataract surgery by E.P. Gurmizov, K.B. Pershin, N.F. Pashinova, A.Yu. Tsygankov

“…</i> </p> <p> <i><b>Patients and Methods:</b> prospective open-label study included 74 patients (98 eyes) who underwent cataract surgery (53 eyes) or refractive lens exchange (45 eyes) with the implantation of various IOL models. …”
Get full text

Design and Implementation of a Deep Learning-Based Hand Gesture Recognition System for Rehabilitation Internet-of-Things (RIoT) Environments Using MediaPipe by Nurul Hanis Mohd Dhuzuki, Ahmad Anwar Zainuddin, Nur Anis Sofea Kamarul Zaman, Alin Nur Maisarah Ahmad Razmi, Wonderful Shammah Kaitane, Asmarani Ahmad Puzi, Mohd Naqiuddin Johar, Maslina Yazid, Nor Azlin Mohd Nordin, Shahrul Naim Sidek, Hasan Firdaus Mohd Zaki

“…Lastly, latency issues and accuracy challenges at extended distances are alleviated by employing innovative calibration methods and adaptive adjustments. Initial trials demonstrate promising results, though further testing is required under real-world conditions to validate the system's effectiveness fully. …”
Get full text

Safety and efficacy of the therapeutic DNA-based vaccine VB10.16 in combination with atezolizumab in persistent, recurrent or metastatic HPV16-positive cervical cancer: a multicent... by Hannelore Denys, Frederik Marmé, Frederic Forget, Lukas Rob, Pawel Blecharz, Kristina Lindemann, Peter Hillemanns, Linn Wölber, Theresa Link, Jean-Francois Baurain, Mariusz Bidziński, Linn Woelber, Michal ZikÁN, Josef Chovanec, Christian Dannecker, Stéphanie Henry, Hannelore G Denys, Velko Minchev, Anders Rosholm, Kaja C G Berg, Roberto S Oliveri, Marchela Koleva, Bozhil Robev

“…We investigated the safety, efficacy, and immunogenicity of the therapeutic DNA-based vaccine VB10.16 combined with the immune checkpoint inhibitor atezolizumab in patients with human papillomavirus (HPV)16-positive r/m cervical cancer.Patients and methods This multicenter, single-arm, phase 2a study (NCT04405349, registered 26 May 2020) enrolled adult patients with persistent, r/m HPV16-positive cervical cancer. …”
Get full text

Relationship between four healthy lifestyle factors and all-cause and cardiovascular disease mortality among residents aged 35 – 75 years in Hebei province by Yuhuan LIU, Lijuan TANG, Xiaoying LU, Jingjing ZHAO, Yajing CAO, Xiaoli LIU, Dongsheng JIANG

“…ObjectiveTo investigate the relationship between four healthy lifestyle factors and all-cause and cardiovascular disease (CVD) mortality among residents aged 35 – 75 years in Hebei province, and to provide scientific evidence for promoting healthy lifestyles. MethodsData were collected from 48 377 residents aged 35 – 75 years in 11 districts and counties of Hebei province (Daming county, Handan city; Qinghe county, Xingtai city; Xuanhua district, Zhangjiakou city; Yuhua district, Shijiazhuang city; Chengde county, Chengde city; Sanhe city, Langfang city; Quyang county, Baoding city; Huanghua city, Cangzhou city; Shenzhou city, Hengshui city; Zunhua city, Tangshan city; and Funing district, Qinhuangdao city) who participated in the National Early Screening and Comprehensive Intervention Program for High-Risk Populations of CVD from September 2016 to December 2022. …”
Get full text

Short- and long-term effects of transcutaneous spinal cord stimulation on autonomic cardiovascular control and arm-crank exercise capacity in individuals with a spinal cord injury... by Samuel J E Lucas, Tom E Nightingale, Jet J C S Veldhuijzen van Zanten, Shin-Yi Chiou, Alex J Wadley, Rebekah A I Lucas, Daniel D Hodgkiss, Shane J T Balthazaar, Joseph F Welch, Phoebe A Cox

“…Therefore, this study aims to explore the efficacy of acute TSCS for restoring autonomic function at rest and during arm-crank exercise to exhaustion (AIM 1) and investigate its longer-term impact on cardiorespiratory fitness and its concomitant benefits on cardiometabolic health and health-related quality of life (HRQoL) outcomes following an 8-week exercise intervention (AIM 2).Methods and analysis Sixteen individuals aged ≥16 years with a chronic, motor-complete SCI between the fifth cervical and sixth thoracic segments will undergo a baseline TSCS mapping session followed by an autonomic nervous system (ANS) stress test battery, with and without cardiovascular-optimised TSCS (CV-TSCS). …”
Get full text

Exemples d’habitats aristocratiques sur les sites des rues Eugène-Desteuque et Ponsardin à Reims/Durocortorum by Magalie Cavé, Stéphane Sindonino, Sabine Groetembril

“…It is, of course, still challenged by the inherent difficulties excavations face in stratified contexts, as well as the consequences of methodical and systematic recovery of building materials at the end of Antiquity, which render reading and interpreting plans of architectural remains difficult. …”
Get full text