Changes in the functionality of tear film and autorefractometry reading after instillations of artificial tear products of different viscosity by V.V. Brzheskiy, E.L. Efimova, M.A. Kopylova, P.V. Kocharina, A.A. Primak, V.P. Nikolaenko

“…</i> </p> <p> <i><b>Patients and Methods:</b> thirty patients aged 23–70 with mild bilateral DES were examined using the Visionix VX120+Dry Eye multi-diagnostic unit equipped with the TF-Scan to fix and assess tear film stability and tear breakup time (TBUT). …”
Get full text

Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…The physiopathology is poorly understood, and leptospirosis is often regarded as an inflammatory disease, like sepsis. Methods: To investigate the causes of death in lethal leptospirosis, we compared intraperitoneal infection of male and female C57BL6/J mice with 108 Leptospira of two strains of pathogenic L. interrogans. …”
Get full text

Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐cat... by Shaojun Chu, Lingling Jia, Yulong Li, Jiachao Xiong, Yulin Sun, Qin Zhou, Dexiang Du, Zihan Li, Xin Huang, Hua Jiang, Baojin Wu, Yufei Li

“…However, the molecular mechanism of HFSCs against AGA remains elusive. Methods The expression and prognosis of lncRNA AC010789.1 in AGA hair follicle tissues were assessed by qRT‐PCR analysis. …”
Get full text

Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…Herein, we evaluate the safety and efficacy of IBI110 (anti-LAG-3 antibody) with sintilimab (an anti-PD-1 antibody) in Chinese patients with advanced solid tumors. Methods In this open-label phase I study, phase Ia dose escalation of IBI110 monotherapy and phase Ib combination dose escalation of IBI110 plus sintilimab were conducted in patients with advanced solid tumors. …”
Get full text

The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study by Fausto Negri, Luca Boeri, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Massimiliano Raffo, Giuseppe Fallara, Eugenio Ventimiglia, Luigi Candela, Alessia d’Arma, Francesco Montorsi, Andrea Salonia

“…Purpose: We aimed to investigate the relationship between follicle stimulating hormone (FSH) and inhibin B (InhB). Materials and Methods: Data from 1,230 consecutive men presenting for primary couple’s infertility were analyzed. …”

Estimation of mangrove carbon stocks using unmanned aerial vehicle over coastal vegetation by S.H. Larekeng, M. Nursaputra, M.F. Mappiasse, S. Ishak, M. Basyuni, E. Sumarga, V.B. Arifanti, A.A. Aznawi, Y.I. Rahmila, M. Yulianti, R. Rahmania, A. Mubaraq, S.G. Salmo III, H. Ali, I. Yenny

“…Specifically, this study aims to assess the carbon absorption potential of the Lantebung mangrove ecosystem through field surveys, allometric calculations, and unmanned aerial vehicle imagery.METHODS: The methodology employed in this study consisted of field surveys, allometric calculations, and multispectral aerial imagery processing along the coastal of Makassar City, South Sulawesi, within the Lantebung mangrove ecosystem. …”
Get full text

Examining the therapeutic potential and side effects of calcium channel blockers in mortality and morbidity of patients with stroke: A systematic review of pre-clinical and clinica... by Sevak Hatamian, Asad Abdi, Fatemeh Sadat Seyedi Asl, Armin Tafazolimoghadam, Arian Tavasol, Seyed Ali Mousavi Nejad, Reza Madadi, Zohre Tajabadi, Mina Dehghani, Najmeh Ahmadpoor, Mobina Fathi, Mohammadreza Hajiesmaeili, Navid Nooraei

“…Objectives: This study's primary goal is to evaluate the effects of calcium channel blockers on reducing the risk, mortality, morbidity, and long-term outcomes of cerebrovascular events. Material and Methods: We conducted this systematic literature review by searching PubMed, Scopus, and Google Scholar databases. …”
Get full text

Global esophageal cancer epidemiology in 2022 and predictions for 2050: A comprehensive analysis and projections based on GLOBOCAN data by Ling Qi, Mengfei Sun, Weixin Liu, Xuefeng Zhang, Yongjun Yu, Ziqiang Tian, Zhiyu Ni, Rongshou Zheng, Yong Li, Xiangxiang Pan

“…The aim of this study is to analyze the current burden of esophageal cancer in 185 countries in 2022 and to project the trends up to the year 2050. Methods:. We extracted data on primary esophageal cancer cases and deaths from the GLOBOCAN 2022 database, which includes data from 185 countries. …”
Get full text

Efficacy and Safety of High-dose versus Standard-dose Prazosin in Paediatric Scorpion Envenomation: A Single-blinded Randomised Controlled Study by Apoorva Gayatri Abbadi, Hidaytullah R Bijapure, Chandrika R Doddihal, Bhavana B Lakhkar, Y Rohith, VJ Prakash, Kumar BM Prasanna, Mallanagouda Patil

“…Aim: To evaluate and compare the efficacy and safety of standard-dose versus high-dose prazosin protocols in managing paediatric scorpion envenomation in a tertiary care hospital in North Karnataka, India. Materials and Methods: A single-blinded randomised controlled study was conducted in Paediatric Intensive Care Unit (PICU) at BLDE DU Shri BM Patil Medical College Hospital and Research Centre, Vijayapur, Karnataka, India, from January 2017 to December 2022. …”
Get full text

Abnormal preoperative haematological parameters in Endometrial cancer; reflecting tumour aggressiveness or reduced response to radiotherapy? by Stephanie W. Vrede, Hannah Donkers, Casper Reijnen, Anke Smits, Nicole C.M. Visser, Peggy M. Geomini, Huy Ngo, Dennis van Hamont, Brenda M. Pijlman, Maria Caroline Vos, Marc P.L.M. Snijders, Roy Kruitwagen, Ruud L.M. Bekkers, Khadra Galaal, Johanna M.A. Pijnenborg

“…Secondary, to explore their predictive relevance in response to radiotherapy in EC.Methods A retrospective multicentre cohort study was performed within 10 hospitals. …”
Get full text

Syncopes and clinical outcome in heart failure: results from prospective clinical study data in Germany by Djawid Hashemi, Moritz Blum, Meinhard Mende, Stefan Störk, Christiane E. Angermann, Sabine Pankuweit, Elvis Tahirovic, Rolf Wachter, Burkert Pieske, Frank Edelmann, Hans‐Dirk Düngen, the German Competence Network for Heart Failure

“…We aimed to assess the impact of a history of syncope (HoS) on overall and hospitalization‐free survival of these patients. Methods and results We pooled the data of prospective, nationwide, multicentre studies conducted within the framework of the German Competence Network for Heart Failure including 11 335 subjects. …”
Get full text

Intimate partner violence among women of reproductive age during the COVID-19 pandemic in Ethiopia: a systematic review and meta-analysis by Gizachew Yilak, Alemayehu Sayih Belay, Aychew Kassie, Befkad Derese Tilahun, Ambaw Abebaw Emrie, Mulat Ayele, Eyob Shitie Lake, Legese Fekede Abza

“…The heterogeneity between studies was assessed using I2 test statistics and the random-effects meta-analysis was done using the restricted maximum likelihood method. Publication bias was assessed using funnel plots, and Egger’s and Begg’s tests.Result In this study, a total of 802 articles were identified using different electronic databases. …”
Get full text

Risk of hepatocellular carcinoma in Asian patients with primary biliary cholangitis: A nationwide and hospital cohort study by Jihye Lim, Ye-Jee Kim, Sehee Kim, Jonggi Choi

“…This study aimed to evaluate the incidence of HCC and its risk factors in a nationwide cohort. Methods: The data of 4,882 patients with PBC and 38,603 matched controls were extracted from the Korean National Health Insurance Service (2007–2020) and analyzed. …”
Get full text

Contribution of flood early warning response measures in reducing flood effects in Kilosa District, Tanzania by Japhet Ringo, Shadrack Sabai, Anesi Mahenge

“…Expanding the use of these locally available methods will improve response capacity and ensure that households receive timely warnings from multiple sources, allowing for early action and better preparedness. ● Response measures taken by household members in response to early flood warnings are crucial to reduce the number of deaths, injuries and property damage or loss. …”
Get full text

Effects of early pulmonary rehabilitation exercise on the lung function and indicators of arterial blood gas analysis in patients with severe chronic obstructive pulmonary disease... by XU Nannan (徐楠楠), HONG Hanhan (洪涵涵)

“…Objective To investigate the effect of early lung rehabilitation exercise and nursing interventions on the lung function and indicators of arterial blood gas analysis in patients with severe chronic obstructive pulmonary disease (COPD). Methods Seventy patients with severe COPD undergoing pulmonary rehabilitation were selected as the study objectis, and were randomly divided into the observation group and the control group, with 35 patients in each group. …”
Get full text

Precision Target Spraying System Integrated with Remote Deep Learning Recognition Model for Cabbage Plant Centers by ZHANG Hui, HU Jun, SHI Hang, LIU Changxi, WU Miao

“…This study aims to develop a targeted spray control system based on deep learning technology, explore the relationship between the advance speed, spray volume, and coverage of the sprayer, thereby addressing the uneven application issues caused by different nebulizer speeds by studying the real scenario of calcium administration to Chinese cabbage hearts.[Methods]The targeted spraying control system incorporates advanced sensors and computing equipment that were capable of obtaining real-time data regarding the location of crops and the surrounding environmental conditions. …”
Get full text

Selected results of a post-registration observational study on the clinical efficacy and tolerability of Bimicombi Antiglau ECO and Brim Antiglau ECO in different stages of primary... by A.V. Kuroyedov, M.V. Kosakovskaya, O.V. Gapon’ko, V.V. Gorodnichiy, D.N. Lovpache, I.A. Bulakh

“…</p> <p> <b>Patients and Methods: </b>data from 1036 patients were included in the final protocol of the multicenter combined scientific and clinical study. …”
Get full text

PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis by Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim

“…We investigated the mechanism by which preS1Del is related to liver disease progression and enhanced HBV replication, focusing on endoplasmic reticulum (ER) stress. Methods: The effects of HBV replicative capacity, ER stress signaling, inflammation, cell death, and tumorigenesis resulting from PreS1 deletions were investigated through in vitro and in vivo experiments. …”
Get full text

Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats by Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Jialehasibieke Sailike, Xin Sun, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi

“…This study evaluates the effects of composite probiotics derived from fermented camel milk (CPCM) on metabolic disturbances in a rat model of Type 2 diabetes (T2DM).MethodsT2DM was induced in Wistar rats using streptozotocin. …”
Get full text

Relationship between triglyceride glucose-body mass index baselines and variation with future cardiovascular diseases risk in the middle-aged and elderly individuals by Junpeng Qiao, Xueyu Chen, Jinhong Pang, Haicheng Fei, Zhang Liu, Fang Cheng, Qiaoqiao Chen, Yingying Zhao, Fengxue Shi, Hongying Jia, Hongying Jia, Weiwei Chi, Weiwei Chi

“…This study aims to analyze whether the baseline levels and fluctuations of triglyceride glucose-body mass index (TyG-BMI) are associated with the incidence of CVDs and their subtypes in a prospective cohort of middle-aged and elderly individuals.MethodsThe data for this study were obtained from the China Health and Retirement Longitudinal Study (CHARLS), which is an ongoing nationally representative prospective cohort study. …”
Get full text